CY1114703T1 - Φαρμακευτικη συνθεση περιλαμβανουσα (1s)-1,5-ανυδρο-1-[5-(4-αιθοξυβενζυλ)-2-μεθοξυ-4-μεθυλφαινυλ]-1-θειο-d-γλυκιτολη και μετφορμινη και χρησεις αυτης στη θεραπεια διαβητη - Google Patents
Φαρμακευτικη συνθεση περιλαμβανουσα (1s)-1,5-ανυδρο-1-[5-(4-αιθοξυβενζυλ)-2-μεθοξυ-4-μεθυλφαινυλ]-1-θειο-d-γλυκιτολη και μετφορμινη και χρησεις αυτης στη θεραπεια διαβητηInfo
- Publication number
- CY1114703T1 CY1114703T1 CY20131101103T CY131101103T CY1114703T1 CY 1114703 T1 CY1114703 T1 CY 1114703T1 CY 20131101103 T CY20131101103 T CY 20131101103T CY 131101103 T CY131101103 T CY 131101103T CY 1114703 T1 CY1114703 T1 CY 1114703T1
- Authority
- CY
- Cyprus
- Prior art keywords
- insulin
- pharmaceutical composition
- anhyro
- ethoxybenzyl
- sulfuryl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 4-Ethoxybenzyl Chemical group 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000004877 Insulin Human genes 0.000 abstract 3
- 108090001061 Insulin Proteins 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 3
- 229940125396 insulin Drugs 0.000 abstract 2
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 abstract 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 abstract 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
- 229940122199 Insulin secretagogue Drugs 0.000 abstract 1
- 229940122355 Insulin sensitizer Drugs 0.000 abstract 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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- A61K9/2022—Organic macromolecular compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Φαρμακευτική σύνθεση περιλαμβάνουσα συνδυασμό (Α) ένωσης 1-θειο-D- γλυκιτόλης που αντιπροσωπεύεται από το γενικό τύπο (Ι) και (Β) τουλάχιστον ένα μέλος της ομάδας που αποτελείται από διουγανίδια, εκκριταγωγά ινσουλίνης, ευαισθητοποιητές ινσουλίνης, ινσουλίνες, αναστολείς διπεπτιδύλ πεπτιδάσης IV, αναστολείς α-γλυκοσιδάσης και GLΡ-1 μιμητικά, έχει ανώτερη αποτελεσματικότητα στην πρόληψη ή τη θεραπεία σακχαρώδους διαβήτη, ασθενειών που συνδυάζονται με σακχαρώδη διαβήτη ή επιπλοκών σακχαρώδους διαβήτη και εισέτι δεν προκαλεί αξιόλογες παρενέργειες.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009100210 | 2009-04-16 | ||
| EP10764570.7A EP2419097B1 (en) | 2009-04-16 | 2010-04-16 | Pharmaceutical composition comprising (1s)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-d-glucitol and metformin and uses thereof in the treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114703T1 true CY1114703T1 (el) | 2016-10-05 |
Family
ID=42982643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131101103T CY1114703T1 (el) | 2009-04-16 | 2013-12-05 | Φαρμακευτικη συνθεση περιλαμβανουσα (1s)-1,5-ανυδρο-1-[5-(4-αιθοξυβενζυλ)-2-μεθοξυ-4-μεθυλφαινυλ]-1-θειο-d-γλυκιτολη και μετφορμινη και χρησεις αυτης στη θεραπεια διαβητη |
| CY20151100045T CY1115907T1 (el) | 2009-04-16 | 2015-01-16 | Φαρμακευτικες συνθεσεις me (1s)-1, 5-anyδpo-1-[5-(4-αιθοξυβενζυλ)-2-μεθοξυ-4-μεθυλφαινυλ]-1-θειο-d-γλυκιτολη και εκκριταγωγο ινσουλινης |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100045T CY1115907T1 (el) | 2009-04-16 | 2015-01-16 | Φαρμακευτικες συνθεσεις me (1s)-1, 5-anyδpo-1-[5-(4-αιθοξυβενζυλ)-2-μεθοξυ-4-μεθυλφαινυλ]-1-θειο-d-γλυκιτολη και εκκριταγωγο ινσουλινης |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20120040898A1 (el) |
| EP (3) | EP2601949B1 (el) |
| JP (4) | JP5077786B2 (el) |
| KR (2) | KR20150046382A (el) |
| CN (7) | CN102395364A (el) |
| AR (1) | AR076317A1 (el) |
| AU (1) | AU2010237748B2 (el) |
| BR (1) | BRPI1012539A2 (el) |
| CA (1) | CA2755392A1 (el) |
| CY (2) | CY1114703T1 (el) |
| DK (2) | DK2419097T3 (el) |
| ES (2) | ES2431300T3 (el) |
| HK (6) | HK1217302A1 (el) |
| HR (2) | HRP20131120T1 (el) |
| ME (2) | ME01555B (el) |
| MX (1) | MX2011010901A (el) |
| MY (3) | MY156679A (el) |
| NZ (4) | NZ710575A (el) |
| PH (3) | PH12015500235A1 (el) |
| PL (2) | PL2419097T3 (el) |
| PT (2) | PT2601949E (el) |
| RS (2) | RS53056B (el) |
| RU (2) | RU2532330C2 (el) |
| SG (6) | SG2014012553A (el) |
| SI (2) | SI2419097T1 (el) |
| SM (1) | SMT201500015B (el) |
| TW (3) | TW201622720A (el) |
| UA (2) | UA111742C2 (el) |
| WO (1) | WO2010119990A1 (el) |
| ZA (1) | ZA201106727B (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| IN2012DN02751A (el) | 2009-09-30 | 2015-09-18 | Boehringer Ingelheim Int | |
| US10610489B2 (en) | 2009-10-02 | 2020-04-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof |
| US20120283169A1 (en) * | 2010-11-08 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| TR201101809A1 (tr) * | 2010-12-21 | 2012-07-23 | Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Vildagliptin ve glimepirid kombinasyonları. |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| JP6234443B2 (ja) | 2012-05-17 | 2017-11-22 | ブイティーブイ・セラピューティクス・エルエルシー | 糖尿病治療のためのグルコキナーゼ活性化因子組成物 |
| CN104780942A (zh) * | 2012-08-30 | 2015-07-15 | 大正制药株式会社 | Sglt2抑制剂和抗高血压药的组合 |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| ES2702174T3 (es) | 2013-04-05 | 2019-02-27 | Boehringer Ingelheim Int | Usos terapéuticos de empagliflozina |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| KR102309654B1 (ko) | 2013-04-18 | 2021-10-08 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 조성물, 치료 방법 및 이의 용도 |
| TW201636015A (zh) * | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
| SG11201707008SA (en) * | 2015-02-27 | 2017-09-28 | Asan Found | Composition for preventing or treating valve calcification, containing dpp-4 inhibitor |
| CN105963280B (zh) * | 2016-06-30 | 2018-11-06 | 合肥华方医药科技有限公司 | 一种伏格列波糖口腔速溶膜及其制备方法 |
| US20210212968A1 (en) | 2016-10-19 | 2021-07-15 | Boehringer Ingelheim International Gmbh | Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof |
| US11439689B2 (en) * | 2016-11-14 | 2022-09-13 | Kaohsiung Medical University | Method for detecting whether glucose metabolism is abnormal, and prevention and treatment therefor |
| US20210113561A1 (en) | 2018-04-17 | 2021-04-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| KR20190137343A (ko) | 2018-06-01 | 2019-12-11 | 김유찬 | 계량 인덕션 |
| KR20210020866A (ko) | 2018-06-12 | 2021-02-24 | 브이티브이 테라퓨틱스 엘엘씨 | 인슐린 또는 인슐린 유사체와 조합된 글루코키나제 활성제의 치료적 용도 |
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| DE4432757A1 (de) | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
| JP2003520759A (ja) | 1999-08-31 | 2003-07-08 | アンドルックス ファーマスーティカルズ インコーポレーテッド | 単位核を有する徐放性錠剤 |
| WO2002080936A1 (en) * | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and ppar modulators |
| AU2002254567B2 (en) * | 2001-04-11 | 2007-10-11 | Bristol-Myers Squibb Company | Amino acid complexes of C-aryl glucosides for treatment of diabetes and method |
| TW200637839A (en) * | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
| CA2655937A1 (en) * | 2006-06-29 | 2008-01-03 | Taisho Pharmaceutical Co., Ltd. | C-phenyl 1-thioglucitol compound |
| JP5194588B2 (ja) * | 2006-07-06 | 2013-05-08 | 大正製薬株式会社 | １−チオ−ｄ−グルシトール誘導体を有効成分として含有する糖尿病の予防又は治療剤 |
| EP2054426A1 (en) * | 2006-08-15 | 2009-05-06 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture |
| WO2008055940A2 (en) * | 2006-11-09 | 2008-05-15 | Boehringer Ingelheim International Gmbh | Combination therapy with sglt-2 inhibitors and their pharmaceutical compositions |
| EP2103607A4 (en) * | 2006-12-14 | 2011-01-05 | Taisho Pharmaceutical Co Ltd | 1-phenyl-1-thio-D-GLUCITOLDERIVAT |
| PE20090603A1 (es) | 2007-08-16 | 2009-06-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de sglt2 y un inhibidor de dpp iv |
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
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