RU2530561C2 - Способы лечения склеродермии - Google Patents
Способы лечения склеродермии Download PDFInfo
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- RU2530561C2 RU2530561C2 RU2010122644/15A RU2010122644A RU2530561C2 RU 2530561 C2 RU2530561 C2 RU 2530561C2 RU 2010122644/15 A RU2010122644/15 A RU 2010122644/15A RU 2010122644 A RU2010122644 A RU 2010122644A RU 2530561 C2 RU2530561 C2 RU 2530561C2
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| SI2250279T1 (sl) | 2008-02-08 | 2016-10-28 | Medimmune, Llc | Protitelesa anti-IFNAR1 z zmanjšano afiniteto do FC liganda |
| RU2013157177A (ru) * | 2011-05-25 | 2015-06-27 | МЕДИММЬЮН, ЭлЭлСи | Способы лечения системной красной волчанки, склеродермии и миозита |
| KR102320059B1 (ko) * | 2012-06-13 | 2021-11-01 | 아스트라제네카 아베 | 항-i형 인터페론 수용체(ifnar) 항체에 대한 고정 투여 계획 |
| CA3043823A1 (en) * | 2015-11-17 | 2017-05-26 | The Regents Of The University Of Colorado, A Body Corporate | Novel multiplex assays to diagnose or evaluate diseases or disorders in mammals |
| EP4306541A3 (en) | 2021-04-23 | 2024-03-27 | Astrazeneca AB | Anti-ifnar1 dosing regime for subcutaneous injection |
| CN118320101B (zh) * | 2024-06-14 | 2024-09-17 | 天津嘉氏堂科技有限公司 | iNOS抑制剂在制备治疗硬皮病胶原沉积药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265305A1 (en) * | 2001-07-24 | 2004-12-30 | Vaishnaw Akshay K. | Method for treating or preventing sclerotic disorders using cd-2 binding agents |
| RU2004114882A (ru) * | 2001-11-14 | 2005-04-20 | Сентокор, Инк. (Us) | Антитела против il-6, композиции, способы и применение |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3461808A (en) | 1967-07-03 | 1969-08-19 | Wood John Co | Diaphragm hand pumps |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| WO1984003106A1 (en) | 1983-02-04 | 1984-08-16 | Wadley Inst Of Molecular Medic | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| DE3668186D1 (de) | 1985-04-01 | 1990-02-15 | Celltech Ltd | Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert. |
| ATE78262T1 (de) | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3923126A1 (de) | 1989-07-13 | 1991-01-17 | Stark Henric | Lautsprecherbox |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| ATE356869T1 (de) | 1990-01-12 | 2007-04-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US4997008A (en) | 1990-04-26 | 1991-03-05 | Moen Incorporated | Faucet spout assembly |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| AU2238292A (en) | 1991-06-14 | 1993-01-12 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
| DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
| EP1291360A1 (en) | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5888511A (en) * | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| JPH09506262A (ja) | 1993-12-08 | 1997-06-24 | ジェンザイム・コーポレイション | 特異的抗体の製造方法 |
| PT1231268E (pt) | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US7285526B2 (en) * | 1995-07-14 | 2007-10-23 | Meiogen Biotechnology Corporation | Interferon antagonists useful for the treatment of interferon related diseases |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| US6713609B1 (en) | 1996-07-16 | 2004-03-30 | Genentech, Inc. | Monoclonal antibodies to type I interferon receptor |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP2314625B1 (en) | 1996-12-03 | 2014-05-07 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| SI0970126T1 (en) | 1997-04-14 | 2001-08-31 | Micromet Ag | Novel method for the production of antihuman antigen receptors and uses thereof |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| US6311415B1 (en) | 1998-09-14 | 2001-11-06 | Lind Shoe Company | Bowling shoe with replaceable tip |
| DK1355919T3 (da) | 2000-12-12 | 2011-03-14 | Medimmune Llc | Molekyler med længere halveringstider, sammensætninger og anvendelser deraf |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| US20030088884A1 (en) * | 2001-08-17 | 2003-05-08 | Hsu Sheau Yu | Mammalian relaxin receptors |
| NZ547157A (en) | 2003-12-10 | 2009-07-31 | Medarex Inc | Interferon Alpha Antibodies and their uses |
| WO2005067963A1 (en) * | 2003-12-23 | 2005-07-28 | Intermune, Inc. | Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens |
| US7662381B2 (en) | 2004-06-21 | 2010-02-16 | Medarex, Inc. | Interferon alpha receptor 1 antibodies and their uses |
| AU2006262289A1 (en) * | 2005-06-22 | 2007-01-04 | Genentech, Inc. | Methods and compositions for targeting IFNAR2 |
| EP2327792B9 (en) * | 2005-08-05 | 2013-12-18 | Genentech, Inc. | Methods and compositions for detecting auto-immune disorders |
| RU2527068C2 (ru) | 2006-12-06 | 2014-08-27 | Медиммун, Ллк | Фармакодинамические маркеры, индуцированные интерфероном альфа |
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- 2008-11-05 CA CA2703705A patent/CA2703705A1/en not_active Abandoned
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- 2014-04-01 JP JP2014075310A patent/JP2014144966A/ja active Pending
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- 2016-01-11 CY CY20161100012T patent/CY1117251T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265305A1 (en) * | 2001-07-24 | 2004-12-30 | Vaishnaw Akshay K. | Method for treating or preventing sclerotic disorders using cd-2 binding agents |
| RU2004114882A (ru) * | 2001-11-14 | 2005-04-20 | Сентокор, Инк. (Us) | Антитела против il-6, композиции, способы и применение |
Non-Patent Citations (1)
| Title |
|---|
| POGUE S.L. et al. The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells // J Interferon Cytokine Res., 2004, Feb;24(2), abstract * |
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| CN101909444B (zh) | 2013-09-18 |
| AU2008324800A1 (en) | 2009-05-14 |
| IL205452A (en) | 2016-02-29 |
| PL2219452T3 (pl) | 2016-04-29 |
| BRPI0819195A2 (pt) | 2017-05-23 |
| HRP20151403T1 (hr) | 2016-02-12 |
| HK1151190A1 (zh) | 2012-04-05 |
| RU2010122644A (ru) | 2011-12-20 |
| PT2219452E (pt) | 2016-01-26 |
| IL205452A0 (en) | 2010-12-30 |
| WO2009061818A1 (en) | 2009-05-14 |
| KR20100098620A (ko) | 2010-09-08 |
| ES2557352T3 (es) | 2016-01-25 |
| NZ585064A (en) | 2012-08-31 |
| EP2219452A4 (en) | 2012-05-02 |
| MX2010004814A (es) | 2010-08-10 |
| CA2703705A1 (en) | 2009-05-14 |
| JP2011503008A (ja) | 2011-01-27 |
| EP2219452A1 (en) | 2010-08-25 |
| US20110008365A1 (en) | 2011-01-13 |
| CN101909444A (zh) | 2010-12-08 |
| JP2014144966A (ja) | 2014-08-14 |
| AU2008324800B2 (en) | 2014-03-27 |
| DK2219452T3 (en) | 2016-01-11 |
| EP2219452B1 (en) | 2015-10-14 |
| HUE025787T2 (en) | 2016-05-30 |
| SI2219452T1 (sl) | 2016-03-31 |
| JP5767475B2 (ja) | 2015-08-19 |
| CY1117251T1 (el) | 2017-04-26 |
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