RU2490014C2 - Способ уменьшения отложения амилоида, амилоидной нейротоксичности и микроглиоза с помощью (-)-энантиомера нилвадипина - Google Patents

Способ уменьшения отложения амилоида, амилоидной нейротоксичности и микроглиоза с помощью (-)-энантиомера нилвадипина Download PDF

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RU2490014C2
RU2490014C2 RU2010117634/15A RU2010117634A RU2490014C2 RU 2490014 C2 RU2490014 C2 RU 2490014C2 RU 2010117634/15 A RU2010117634/15 A RU 2010117634/15A RU 2010117634 A RU2010117634 A RU 2010117634A RU 2490014 C2 RU2490014 C2 RU 2490014C2
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Russia
Prior art keywords
nilvadipine
approximately
animal
enantiomerically enriched
therapeutically effective
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RU2010117634/15A
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English (en)
Russian (ru)
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RU2010117634A (ru
Inventor
Майкл Дж. МУЛЛАН
Даниель ПАРИ
Роберт А. АЙВИ III
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Альцгеймер'С Инститьют Оф Америка, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
RU2010117634/15A 2007-10-05 2008-10-03 Способ уменьшения отложения амилоида, амилоидной нейротоксичности и микроглиоза с помощью (-)-энантиомера нилвадипина RU2490014C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97795307P 2007-10-05 2007-10-05
US60/977,953 2007-10-05
US4610908P 2008-04-18 2008-04-18
US61/046,109 2008-04-18
PCT/US2008/078786 WO2009046323A1 (en) 2007-10-05 2008-10-03 Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer

Publications (2)

Publication Number Publication Date
RU2010117634A RU2010117634A (ru) 2011-11-10
RU2490014C2 true RU2490014C2 (ru) 2013-08-20

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RU2010117634/15A RU2490014C2 (ru) 2007-10-05 2008-10-03 Способ уменьшения отложения амилоида, амилоидной нейротоксичности и микроглиоза с помощью (-)-энантиомера нилвадипина

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Country Link
US (2) US8236346B2 (https=)
EP (1) EP2214666B1 (https=)
JP (1) JP5411145B2 (https=)
KR (1) KR101417200B1 (https=)
CN (1) CN101883564B (https=)
AU (1) AU2008308519B2 (https=)
BR (1) BRPI0817516A2 (https=)
CA (1) CA2701620C (https=)
DK (1) DK2214666T3 (https=)
ES (1) ES2449594T3 (https=)
MX (1) MX2010003669A (https=)
NZ (1) NZ584729A (https=)
PL (1) PL2214666T3 (https=)
RU (1) RU2490014C2 (https=)
TW (1) TWI500422B (https=)
WO (1) WO2009046323A1 (https=)

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US20140286910A1 (en) * 2013-03-19 2014-09-25 Nikolai Tankovich Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity
CN112826794B (zh) 2019-11-06 2022-02-11 上海交通大学医学院 一种靶向修复神经血管病变的纳米复合物及其制备与应用

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US5508413A (en) * 1987-08-27 1996-04-16 Fujisawa Pharmaceutical Co., Ltd. (+)-5-isopropyl 3-methyl 2-cyano-6 methyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate

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TWI500422B (zh) 2015-09-21
AU2008308519B2 (en) 2014-09-11
JP2010540661A (ja) 2010-12-24
US8236347B2 (en) 2012-08-07
JP5411145B2 (ja) 2014-02-12
MX2010003669A (es) 2010-11-25
EP2214666A4 (en) 2010-12-08
US20090092667A1 (en) 2009-04-09
EP2214666A1 (en) 2010-08-11
BRPI0817516A2 (pt) 2015-06-16
ES2449594T3 (es) 2014-03-20
NZ584729A (en) 2012-12-21
EP2214666B1 (en) 2013-12-11
DK2214666T3 (da) 2014-01-27
CN101883564B (zh) 2013-10-16
US8236346B2 (en) 2012-08-07
US20100183711A1 (en) 2010-07-22
RU2010117634A (ru) 2011-11-10
AU2008308519A1 (en) 2009-04-09
PL2214666T3 (pl) 2014-06-30
KR101417200B1 (ko) 2014-08-01
KR20100067683A (ko) 2010-06-21
TW200920364A (en) 2009-05-16
CA2701620A1 (en) 2009-04-09
CA2701620C (en) 2014-12-09
AU2008308519A2 (en) 2010-04-29
CN101883564A (zh) 2010-11-10
WO2009046323A1 (en) 2009-04-09

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