DK2214666T3 - Fremgangsmåde til reducering af amyloid-afsætning, amyloid-neurotoksicitet og mikrogliose med (-)-nilvadipin-enantiomer - Google Patents

Fremgangsmåde til reducering af amyloid-afsætning, amyloid-neurotoksicitet og mikrogliose med (-)-nilvadipin-enantiomer

Info

Publication number
DK2214666T3
DK2214666T3 DK08836256.1T DK08836256T DK2214666T3 DK 2214666 T3 DK2214666 T3 DK 2214666T3 DK 08836256 T DK08836256 T DK 08836256T DK 2214666 T3 DK2214666 T3 DK 2214666T3
Authority
DK
Denmark
Prior art keywords
amyloid
enantiomes
nilvadipin
microgliosis
neurotoxicity
Prior art date
Application number
DK08836256.1T
Other languages
Danish (da)
English (en)
Inventor
Michael J Mullan
Daniel Paris
Robert A Ivey Iii
Original Assignee
Alzheimer S Inst Of America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alzheimer S Inst Of America Inc filed Critical Alzheimer S Inst Of America Inc
Application granted granted Critical
Publication of DK2214666T3 publication Critical patent/DK2214666T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK08836256.1T 2007-10-05 2008-10-03 Fremgangsmåde til reducering af amyloid-afsætning, amyloid-neurotoksicitet og mikrogliose med (-)-nilvadipin-enantiomer DK2214666T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97795307P 2007-10-05 2007-10-05
US4610908P 2008-04-18 2008-04-18
PCT/US2008/078786 WO2009046323A1 (en) 2007-10-05 2008-10-03 Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer

Publications (1)

Publication Number Publication Date
DK2214666T3 true DK2214666T3 (da) 2014-01-27

Family

ID=40523447

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08836256.1T DK2214666T3 (da) 2007-10-05 2008-10-03 Fremgangsmåde til reducering af amyloid-afsætning, amyloid-neurotoksicitet og mikrogliose med (-)-nilvadipin-enantiomer

Country Status (16)

Country Link
US (2) US8236346B2 (https=)
EP (1) EP2214666B1 (https=)
JP (1) JP5411145B2 (https=)
KR (1) KR101417200B1 (https=)
CN (1) CN101883564B (https=)
AU (1) AU2008308519B2 (https=)
BR (1) BRPI0817516A2 (https=)
CA (1) CA2701620C (https=)
DK (1) DK2214666T3 (https=)
ES (1) ES2449594T3 (https=)
MX (1) MX2010003669A (https=)
NZ (1) NZ584729A (https=)
PL (1) PL2214666T3 (https=)
RU (1) RU2490014C2 (https=)
TW (1) TWI500422B (https=)
WO (1) WO2009046323A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140286910A1 (en) * 2013-03-19 2014-09-25 Nikolai Tankovich Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity
CN112826794B (zh) 2019-11-06 2022-02-11 上海交通大学医学院 一种靶向修复神经血管病变的纳米复合物及其制备与应用

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Also Published As

Publication number Publication date
TWI500422B (zh) 2015-09-21
AU2008308519B2 (en) 2014-09-11
JP2010540661A (ja) 2010-12-24
US8236347B2 (en) 2012-08-07
JP5411145B2 (ja) 2014-02-12
RU2490014C2 (ru) 2013-08-20
MX2010003669A (es) 2010-11-25
EP2214666A4 (en) 2010-12-08
US20090092667A1 (en) 2009-04-09
EP2214666A1 (en) 2010-08-11
BRPI0817516A2 (pt) 2015-06-16
ES2449594T3 (es) 2014-03-20
NZ584729A (en) 2012-12-21
EP2214666B1 (en) 2013-12-11
CN101883564B (zh) 2013-10-16
US8236346B2 (en) 2012-08-07
US20100183711A1 (en) 2010-07-22
RU2010117634A (ru) 2011-11-10
AU2008308519A1 (en) 2009-04-09
PL2214666T3 (pl) 2014-06-30
KR101417200B1 (ko) 2014-08-01
KR20100067683A (ko) 2010-06-21
TW200920364A (en) 2009-05-16
CA2701620A1 (en) 2009-04-09
CA2701620C (en) 2014-12-09
AU2008308519A2 (en) 2010-04-29
CN101883564A (zh) 2010-11-10
WO2009046323A1 (en) 2009-04-09

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