RU2469723C2 - Лекарственное средство, содержащее производное карбостирила и донепезил, для лечения болезни альцгеймера - Google Patents

Лекарственное средство, содержащее производное карбостирила и донепезил, для лечения болезни альцгеймера Download PDF

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Publication number
RU2469723C2
RU2469723C2 RU2009147456/15A RU2009147456A RU2469723C2 RU 2469723 C2 RU2469723 C2 RU 2469723C2 RU 2009147456/15 A RU2009147456/15 A RU 2009147456/15A RU 2009147456 A RU2009147456 A RU 2009147456A RU 2469723 C2 RU2469723 C2 RU 2469723C2
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Russia
Prior art keywords
donepezil
disease
salt
alzheimer
therapeutic agent
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RU2009147456/15A
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English (en)
Russian (ru)
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RU2009147456A (ru
Inventor
Хейи АРАИ
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Оцука Фармасьютикал Ко., Лтд.
Дзунтендо Юниверсити
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2009147456/15A 2007-05-22 2008-05-21 Лекарственное средство, содержащее производное карбостирила и донепезил, для лечения болезни альцгеймера RU2469723C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007135367 2007-05-22
JP2007-135367 2007-05-22
PCT/JP2008/059763 WO2008143361A1 (en) 2007-05-22 2008-05-21 A medicament comprising a carbostyril derivative and donepezil for treating alzheimer's disease

Publications (2)

Publication Number Publication Date
RU2009147456A RU2009147456A (ru) 2011-06-27
RU2469723C2 true RU2469723C2 (ru) 2012-12-20

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RU2009147456/15A RU2469723C2 (ru) 2007-05-22 2008-05-21 Лекарственное средство, содержащее производное карбостирила и донепезил, для лечения болезни альцгеймера

Country Status (27)

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US (1) US20100298375A1 (enExample)
EP (2) EP2937085B1 (enExample)
JP (1) JP5153870B2 (enExample)
KR (1) KR101441725B1 (enExample)
CN (1) CN101754758B (enExample)
AR (1) AR066664A1 (enExample)
AU (1) AU2008253977B2 (enExample)
BR (1) BRPI0811919A2 (enExample)
CA (1) CA2687289C (enExample)
CO (1) CO6251249A2 (enExample)
CY (1) CY1116683T1 (enExample)
DK (1) DK2157973T3 (enExample)
ES (1) ES2545959T3 (enExample)
HR (1) HRP20150843T1 (enExample)
HU (1) HUE025902T2 (enExample)
IL (1) IL202053A (enExample)
MX (1) MX2009012583A (enExample)
MY (1) MY146407A (enExample)
NZ (1) NZ581099A (enExample)
PL (1) PL2157973T3 (enExample)
PT (1) PT2157973E (enExample)
RU (1) RU2469723C2 (enExample)
SI (1) SI2157973T1 (enExample)
TW (2) TWI423802B (enExample)
UA (1) UA96633C2 (enExample)
WO (1) WO2008143361A1 (enExample)
ZA (1) ZA200908202B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2776366C2 (ru) * 2017-05-24 2022-07-19 Х. Лундбекк А/С Комбинация антагониста 5-ht6-рецептора и ингибитора ацетилхолинэстеразы для применения при лечении болезни альцгеймера у субпопуляции пациентов, которые являются носителями аллелей apoe4
US11464759B2 (en) 2017-05-24 2022-10-11 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of alzheimer's disease in patient subpopulation carrying APOE4 alleles

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Publication number Priority date Publication date Assignee Title
EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
US9387206B2 (en) 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
SI2560631T1 (sl) 2011-03-01 2014-06-30 Pharnext Na baklofenu in akamprosatu temeljeäśa terapija nevroloĺ kih nepravilnosti
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
MX2014015310A (es) 2012-06-15 2015-07-06 Found Biomedical Res & Innov Agente profilactico y/o terapeutico para el deterioro cognoscitivo leve.
WO2015100255A2 (en) * 2013-12-23 2015-07-02 Holaday John W Disposable container for air hydration
CN109310688B (zh) 2016-05-19 2023-09-01 国立研究开发法人国立循环器病研究中心 用于预防和/或治疗痴呆症的药物
CN107602523B (zh) * 2017-09-11 2020-08-18 安徽中医药大学 京尼平类似物、制备方法及其应用
PL237739B1 (pl) 2018-06-06 2021-05-17 Univ Gdanski Genisteina do zastosowania do leczenia choroby Alzheimera
NL2024431B1 (en) 2019-12-11 2021-09-07 Sulfateq Bv Compounds for treatment of alzheimer’s disease
CN117797095A (zh) * 2023-11-30 2024-04-02 浙江大学 一种长效脂质液晶植入物及其治疗阿尔茨海默症的用途

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WO2004075897A1 (en) * 2003-02-25 2004-09-10 Otsuka Pharmaceutical Co., Ltd. Pten inhibitor or maxi-k channels opener
US20040229913A1 (en) * 2002-12-13 2004-11-18 Eisal Co., Ltd. Therapeutic agent for severe Alzheimer's dementia
RU2005121909A (ru) * 2002-12-12 2006-01-20 Авентис Фарма С.А. (Fr) Профилактика и лечение болезни альцгеймера

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JP2004131469A (ja) * 2002-07-01 2004-04-30 Chemagis Ltd ドネペジルヒドロクロリドを含有する医薬組成物
RU2005121909A (ru) * 2002-12-12 2006-01-20 Авентис Фарма С.А. (Fr) Профилактика и лечение болезни альцгеймера
US20040229913A1 (en) * 2002-12-13 2004-11-18 Eisal Co., Ltd. Therapeutic agent for severe Alzheimer's dementia
WO2004075897A1 (en) * 2003-02-25 2004-09-10 Otsuka Pharmaceutical Co., Ltd. Pten inhibitor or maxi-k channels opener

Non-Patent Citations (1)

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Forchetti CM. "Treating patients with moderate to severe Alzheimer's disease: implications of recent pharmacologic studies", Prim Care Companion J Clin Psychiatry. 2005; 7(4):155-61. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2776366C2 (ru) * 2017-05-24 2022-07-19 Х. Лундбекк А/С Комбинация антагониста 5-ht6-рецептора и ингибитора ацетилхолинэстеразы для применения при лечении болезни альцгеймера у субпопуляции пациентов, которые являются носителями аллелей apoe4
US11464759B2 (en) 2017-05-24 2022-10-11 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of alzheimer's disease in patient subpopulation carrying APOE4 alleles

Also Published As

Publication number Publication date
NZ581099A (en) 2012-03-30
HUE025902T2 (en) 2016-05-30
MX2009012583A (es) 2010-03-08
EP2937085A1 (en) 2015-10-28
EP2937085B1 (en) 2019-07-10
CN101754758A (zh) 2010-06-23
CY1116683T1 (el) 2017-03-15
RU2009147456A (ru) 2011-06-27
WO2008143361A1 (en) 2008-11-27
PL2157973T3 (pl) 2015-12-31
TWI423802B (zh) 2014-01-21
CO6251249A2 (es) 2011-02-21
HK1215384A1 (en) 2016-08-26
HRP20150843T1 (hr) 2015-09-11
SI2157973T1 (sl) 2015-10-30
AU2008253977B2 (en) 2013-08-22
JP5153870B2 (ja) 2013-02-27
ES2545959T3 (es) 2015-09-17
KR101441725B1 (ko) 2014-09-18
DK2157973T3 (en) 2015-08-17
KR20100020482A (ko) 2010-02-22
CA2687289C (en) 2015-09-15
PT2157973E (pt) 2015-10-14
ZA200908202B (en) 2010-07-28
BRPI0811919A2 (pt) 2014-11-18
TWI489983B (zh) 2015-07-01
US20100298375A1 (en) 2010-11-25
EP2157973B1 (en) 2015-07-15
JP2010527993A (ja) 2010-08-19
AU2008253977A1 (en) 2008-11-27
HK1140422A1 (en) 2010-10-15
CN101754758B (zh) 2012-10-24
IL202053A0 (en) 2010-06-16
EP2157973A1 (en) 2010-03-03
IL202053A (en) 2016-04-21
UA96633C2 (uk) 2011-11-25
CA2687289A1 (en) 2008-11-27
MY146407A (en) 2012-08-15
AR066664A1 (es) 2009-09-02
TW201412315A (zh) 2014-04-01
TW200904428A (en) 2009-02-01

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20170522