JP2010527993A - カルボスチリル誘導体およびドネペジルを含むアルツハイマー病治療剤 - Google Patents
カルボスチリル誘導体およびドネペジルを含むアルツハイマー病治療剤 Download PDFInfo
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- JP2010527993A JP2010527993A JP2010509026A JP2010509026A JP2010527993A JP 2010527993 A JP2010527993 A JP 2010527993A JP 2010509026 A JP2010509026 A JP 2010509026A JP 2010509026 A JP2010509026 A JP 2010509026A JP 2010527993 A JP2010527993 A JP 2010527993A
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- donepezil
- alzheimer
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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Abstract
Description
で示されるカルボスチリル誘導体またはその塩、およびドネペジルまたはその塩を有効成分とするアルツハイマー病治療剤を提供する。
のテトラゾリルアルコキシ−ジヒドロカルボスチリル誘導体またはその塩である。
上記で挙げられた添加剤の具体的な例示、調製方法等については、これに制限されないが、特開平10−175864号公報に開示されているものが挙げられる。
Claims (7)
- カルボスチリル誘導体が6−[4−(1−シクロヘキシル−1H−テトラゾール−5−イル)ブトキシ]−3,4−ジヒドロカルボスチリルまたはその塩である請求項1に記載の治療剤。
- ドネペジルの塩が塩酸ドネペジルである請求項1または2に記載の治療剤。
- アルツハイマー病治療剤の製造における、請求項1または2に記載のカルボスチリル誘導体またはその塩と、塩酸ドネベジルまたはその塩の使用。
- ドネペジルの塩が塩酸ドネペジルである請求項4に記載の使用。
- 治療が必要な患者に請求項1または2に記載のカルボスチリル誘導体またはその塩と、塩酸ドネベジルまたはその塩の有効量を投与することを特徴とする、アルツハイマー病の治療方法。
- ドネペジルの塩が塩酸ドネペジルである請求項6に記載の治療方法。
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PCT/JP2008/059763 WO2008143361A1 (en) | 2007-05-22 | 2008-05-21 | A medicament comprising a carbostyril derivative and donepezil for treating alzheimer's disease |
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US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
DK2560631T3 (da) | 2011-03-01 | 2014-02-10 | Pharnext | Baclofen- og acamprosat-baseret af neurologiske forstyrrelser |
WO2015100255A2 (en) * | 2013-12-23 | 2015-07-02 | Holaday John W | Disposable container for air hydration |
EP3459545A4 (en) | 2016-05-19 | 2020-02-26 | National Cerebral and Cardiovascular Center | MEDICINES FOR PREVENTING AND / OR TREATING DEMENTIA |
SG11201909895UA (en) | 2017-05-24 | 2019-11-28 | H Lundbeck As | Combination of a 5-ht6 receptor antagonist and an acetylcholinesterase inhibitor for use in the treatment of alzheimer's disease in a patient subpopulation carrying apoe4 alleles |
CN107602523B (zh) * | 2017-09-11 | 2020-08-18 | 安徽中医药大学 | 京尼平类似物、制备方法及其应用 |
PL237739B1 (pl) | 2018-06-06 | 2021-05-17 | Univ Gdanski | Genisteina do zastosowania do leczenia choroby Alzheimera |
NL2024431B1 (en) | 2019-12-11 | 2021-09-07 | Sulfateq Bv | Compounds for treatment of alzheimer’s disease |
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