CN101754758B - 一种用于治疗阿尔茨海默氏症的包含喹诺酮衍生物和多奈哌齐的药物 - Google Patents

一种用于治疗阿尔茨海默氏症的包含喹诺酮衍生物和多奈哌齐的药物 Download PDF

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Publication number
CN101754758B
CN101754758B CN2008800167568A CN200880016756A CN101754758B CN 101754758 B CN101754758 B CN 101754758B CN 2008800167568 A CN2008800167568 A CN 2008800167568A CN 200880016756 A CN200880016756 A CN 200880016756A CN 101754758 B CN101754758 B CN 101754758B
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China
Prior art keywords
donepezil
salt
disease
alzheimer
quinolone
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Expired - Fee Related
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CN2008800167568A
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English (en)
Chinese (zh)
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CN101754758A (zh
Inventor
新井平伊
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Otsuka Pharmaceutical Co Ltd
Juntendo Educational Foundation
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Otsuka Pharmaceutical Co Ltd
Juntendo Educational Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008800167568A 2007-05-22 2008-05-21 一种用于治疗阿尔茨海默氏症的包含喹诺酮衍生物和多奈哌齐的药物 Expired - Fee Related CN101754758B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP135367/2007 2007-05-22
JP2007135367 2007-05-22
PCT/JP2008/059763 WO2008143361A1 (en) 2007-05-22 2008-05-21 A medicament comprising a carbostyril derivative and donepezil for treating alzheimer's disease

Publications (2)

Publication Number Publication Date
CN101754758A CN101754758A (zh) 2010-06-23
CN101754758B true CN101754758B (zh) 2012-10-24

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CN2008800167568A Expired - Fee Related CN101754758B (zh) 2007-05-22 2008-05-21 一种用于治疗阿尔茨海默氏症的包含喹诺酮衍生物和多奈哌齐的药物

Country Status (27)

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US (1) US20100298375A1 (enExample)
EP (2) EP2157973B1 (enExample)
JP (1) JP5153870B2 (enExample)
KR (1) KR101441725B1 (enExample)
CN (1) CN101754758B (enExample)
AR (1) AR066664A1 (enExample)
AU (1) AU2008253977B2 (enExample)
BR (1) BRPI0811919A2 (enExample)
CA (1) CA2687289C (enExample)
CO (1) CO6251249A2 (enExample)
CY (1) CY1116683T1 (enExample)
DK (1) DK2157973T3 (enExample)
ES (1) ES2545959T3 (enExample)
HR (1) HRP20150843T1 (enExample)
HU (1) HUE025902T2 (enExample)
IL (1) IL202053A (enExample)
MX (1) MX2009012583A (enExample)
MY (1) MY146407A (enExample)
NZ (1) NZ581099A (enExample)
PL (1) PL2157973T3 (enExample)
PT (1) PT2157973E (enExample)
RU (1) RU2469723C2 (enExample)
SI (1) SI2157973T1 (enExample)
TW (2) TWI423802B (enExample)
UA (1) UA96633C2 (enExample)
WO (1) WO2008143361A1 (enExample)
ZA (1) ZA200908202B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
US9387206B2 (en) 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
ES2665569T3 (es) 2011-03-01 2018-04-26 Pharnext Tratamiento de la isquemia cerebral
RU2015101100A (ru) * 2012-06-15 2016-08-10 Фаундейшн Фор Байомедикал Рисерч Энд Инновейшн Профилактическое и/или терапевтическое средство для умеренного когнитивного нарушения
US20160331922A1 (en) * 2013-12-23 2016-11-17 John W. Holaday Disposable container for air hydration
EP3459545A4 (en) 2016-05-19 2020-02-26 National Cerebral and Cardiovascular Center MEDICATION FOR PREVENTING AND / OR TREATING DEMENTIA
CN111032038A (zh) 2017-05-24 2020-04-17 H.隆德贝克有限公司 用于治疗阿尔茨海默氏病的药物组合
CN107602523B (zh) * 2017-09-11 2020-08-18 安徽中医药大学 京尼平类似物、制备方法及其应用
PL237739B1 (pl) 2018-06-06 2021-05-17 Univ Gdanski Genisteina do zastosowania do leczenia choroby Alzheimera
NL2024431B1 (en) 2019-12-11 2021-09-07 Sulfateq Bv Compounds for treatment of alzheimer’s disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075897A1 (en) * 2003-02-25 2004-09-10 Otsuka Pharmaceutical Co., Ltd. Pten inhibitor or maxi-k channels opener
CN1607952A (zh) * 2001-12-27 2005-04-20 大塚制药株式会社 包含多官能磷酸二酯酶抑制剂和腺苷吸收抑制剂的药物组合物

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JPS5535019A (en) 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS5649378A (en) 1979-08-25 1981-05-02 Otsuka Pharmaceut Co Ltd Tetrazolylalkoxycarbostyril derivative
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JP2574099B2 (ja) 1992-05-21 1997-01-22 大塚製薬株式会社 アレルギー疾患治療剤
JPH10175864A (ja) 1996-12-16 1998-06-30 Otsuka Pharmaceut Co Ltd 慢性閉塞性肺疾患治療剤
US6428488B1 (en) * 1997-08-28 2002-08-06 Kenneth Kensey Dual riser/dual capillary viscometer for newtonian and non-newtonian fluids
US6322525B1 (en) * 1997-08-28 2001-11-27 Visco Technologies, Inc. Method of analyzing data from a circulating blood viscometer for determining absolute and effective blood viscosity
US6019735A (en) * 1997-08-28 2000-02-01 Visco Technologies, Inc. Viscosity measuring apparatus and method of use
US6322524B1 (en) * 1997-08-28 2001-11-27 Visco Technologies, Inc. Dual riser/single capillary viscometer
ES2237078T3 (es) * 1998-01-16 2005-07-16 Eisai Co., Ltd. Procedimiento para producir derivados de donepezilo.
US6187790B1 (en) * 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6484565B2 (en) * 1999-11-12 2002-11-26 Drexel University Single riser/single capillary viscometer using mass detection or column height detection
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
IL150509A (en) * 2002-07-01 2007-07-04 Joseph Kaspi Pharmaceutical preparations containing donafazil hydrochloride
US6743806B2 (en) * 2002-10-23 2004-06-01 Otsuka Pharmaceutical Company, Limited Active oxygen scavenger
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
JP2004189706A (ja) * 2002-12-13 2004-07-08 Eisai Co Ltd 高度アルツハイマー型痴呆治療剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1607952A (zh) * 2001-12-27 2005-04-20 大塚制药株式会社 包含多官能磷酸二酯酶抑制剂和腺苷吸收抑制剂的药物组合物
WO2004075897A1 (en) * 2003-02-25 2004-09-10 Otsuka Pharmaceutical Co., Ltd. Pten inhibitor or maxi-k channels opener

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jeong Hyun Lee et al..Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats.《Brain Research》.2007,第1185卷第246-255页. *

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AU2008253977B2 (en) 2013-08-22
ZA200908202B (en) 2010-07-28
MX2009012583A (es) 2010-03-08
HRP20150843T1 (hr) 2015-09-11
KR20100020482A (ko) 2010-02-22
EP2937085A1 (en) 2015-10-28
US20100298375A1 (en) 2010-11-25
CA2687289C (en) 2015-09-15
TWI423802B (zh) 2014-01-21
RU2469723C2 (ru) 2012-12-20
WO2008143361A1 (en) 2008-11-27
AU2008253977A1 (en) 2008-11-27
TWI489983B (zh) 2015-07-01
NZ581099A (en) 2012-03-30
RU2009147456A (ru) 2011-06-27
AR066664A1 (es) 2009-09-02
EP2157973B1 (en) 2015-07-15
KR101441725B1 (ko) 2014-09-18
TW200904428A (en) 2009-02-01
JP5153870B2 (ja) 2013-02-27
EP2937085B1 (en) 2019-07-10
CN101754758A (zh) 2010-06-23
PT2157973E (pt) 2015-10-14
IL202053A (en) 2016-04-21
EP2157973A1 (en) 2010-03-03
CO6251249A2 (es) 2011-02-21
BRPI0811919A2 (pt) 2014-11-18
DK2157973T3 (en) 2015-08-17
SI2157973T1 (sl) 2015-10-30
IL202053A0 (en) 2010-06-16
UA96633C2 (uk) 2011-11-25
MY146407A (en) 2012-08-15
TW201412315A (zh) 2014-04-01
PL2157973T3 (pl) 2015-12-31
CA2687289A1 (en) 2008-11-27
CY1116683T1 (el) 2017-03-15
HUE025902T2 (en) 2016-05-30
HK1140422A1 (en) 2010-10-15
ES2545959T3 (es) 2015-09-17
JP2010527993A (ja) 2010-08-19
HK1215384A1 (en) 2016-08-26

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