RU2424805C2 - Стабильные фармацевтические композиции, включающие пиримидинсульфамид - Google Patents

Стабильные фармацевтические композиции, включающие пиримидинсульфамид Download PDF

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RU2424805C2
RU2424805C2 RU2008113869/15A RU2008113869A RU2424805C2 RU 2424805 C2 RU2424805 C2 RU 2424805C2 RU 2008113869/15 A RU2008113869/15 A RU 2008113869/15A RU 2008113869 A RU2008113869 A RU 2008113869A RU 2424805 C2 RU2424805 C2 RU 2424805C2
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pharmaceutical composition
formula
compound
total weight
tablets
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RU2008113869/15A
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Russian (ru)
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RU2008113869A (ru
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Чарлз Токунбо АДЕСУЙИ (GB)
Чарлз Токунбо АДЕСУЙИ
Ловлейс ХОЛМАН (CH)
Ловлейс ХОЛМАН
Оливье ЛАМБЕР (FR)
Оливье Ламбер
Брюс Хамилтон ЛАЙТГОУ (GB)
Брюс Хамилтон ЛАЙТГОУ
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Актелион Фармасьютиклз Лтд
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2008113869/15A 2005-09-12 2006-09-11 Стабильные фармацевтические композиции, включающие пиримидинсульфамид RU2424805C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPTC/EP2005/009775 2005-09-12
EP2005009775 2005-09-12

Publications (2)

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RU2008113869A RU2008113869A (ru) 2009-10-20
RU2424805C2 true RU2424805C2 (ru) 2011-07-27

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RU2008113869/15A RU2424805C2 (ru) 2005-09-12 2006-09-11 Стабильные фармацевтические композиции, включающие пиримидинсульфамид

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US (6) US20080233188A1 (enExample)
EP (2) EP1928409B1 (enExample)
JP (2) JP4955685B2 (enExample)
KR (1) KR101313395B1 (enExample)
CN (1) CN101262847B (enExample)
AU (1) AU2006290309B2 (enExample)
BR (1) BRPI0615898B8 (enExample)
CA (1) CA2621273C (enExample)
CY (1) CY1113395T1 (enExample)
DK (1) DK1928409T3 (enExample)
ES (1) ES2393117T3 (enExample)
HR (1) HRP20120957T1 (enExample)
IL (1) IL190072A (enExample)
MY (1) MY151003A (enExample)
NO (1) NO341325B1 (enExample)
NZ (1) NZ567188A (enExample)
PL (1) PL1928409T3 (enExample)
PT (1) PT1928409E (enExample)
RU (1) RU2424805C2 (enExample)
SI (1) SI1928409T1 (enExample)
TW (1) TWI323661B (enExample)
WO (1) WO2007031933A2 (enExample)
ZA (1) ZA200802947B (enExample)

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HUE047767T2 (hu) * 2008-08-13 2020-05-28 Actelion Pharmaceuticals Ltd Macitentánt tartalmazó terápiás készítmények
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CN105388244B (zh) * 2015-12-10 2017-03-08 合肥久诺医药科技有限公司 一种马西替坦有关物质的高效液相色谱分析方法
WO2018153925A1 (en) 2017-02-22 2018-08-30 Amneal Pharmaceuticals Company Gmbh Stable pharmaceutical compositions comprising macitentan
SI3897646T1 (sl) 2018-12-21 2024-08-30 ACTELION PHARMACEUTICALS lTD, Makitentan za zdravljenje pljučne arterijske hipertenzije
TW202042818A (zh) 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
RS66002B1 (sr) 2019-05-22 2024-10-31 Wuxi Biocity Biopharmaceutics Co Ltd Kristalni oblik jedinjenja pirimidin sulfonamida i postupak za njegovu pripremu
AU2020309223B2 (en) 2019-07-05 2025-05-29 TECNIMEDE - Sociedade Técnico-Medicinal, S.A Compressed macitentan compositions, methods and uses thereof
TW202133851A (zh) 2019-11-29 2021-09-16 瑞士商艾克泰聯製藥有限公司 治療肺動脈高血壓之方法
WO2022238375A1 (en) 2021-05-11 2022-11-17 Actelion Pharmaceuticals Ltd Methods of treating pulmonary hypertension
TW202317119A (zh) * 2021-06-11 2023-05-01 瑞士商艾克泰聯製藥有限公司 用於口服投予之分散錠
CN117835971A (zh) 2021-08-25 2024-04-05 巴斯夫欧洲公司 直接压片用辅料组合物
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BRPI0615898B1 (pt) 2020-02-18
US10117870B2 (en) 2018-11-06
US20180263980A1 (en) 2018-09-20
MY151003A (en) 2014-03-31
CA2621273C (en) 2014-07-29
TWI323661B (en) 2010-04-21
CA2621273A1 (en) 2007-03-22
NO341325B1 (no) 2017-10-16
US20080233188A1 (en) 2008-09-25
RU2008113869A (ru) 2009-10-20
TW200803860A (en) 2008-01-16
US20130190336A1 (en) 2013-07-25
US9265762B2 (en) 2016-02-23
JP4955685B2 (ja) 2012-06-20
JP2009519893A (ja) 2009-05-21
NZ567188A (en) 2011-04-29
WO2007031933A3 (en) 2007-10-18
US20210186966A1 (en) 2021-06-24
SI1928409T1 (sl) 2012-12-31
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US8367685B2 (en) 2013-02-05
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BRPI0615898B8 (pt) 2021-05-25
BRPI0615898A2 (pt) 2011-05-31

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