KR101313395B1 - 피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물 - Google Patents

피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물 Download PDF

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KR101313395B1
KR101313395B1 KR1020087008450A KR20087008450A KR101313395B1 KR 101313395 B1 KR101313395 B1 KR 101313395B1 KR 1020087008450 A KR1020087008450 A KR 1020087008450A KR 20087008450 A KR20087008450 A KR 20087008450A KR 101313395 B1 KR101313395 B1 KR 101313395B1
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pharmaceutical composition
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KR20080055897A (ko
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차알스 토쿤보 아데수이
로벨라세 홀만
올리비에 램버트
브루스 해밀턴 리츠고우
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액테리온 파마슈티칼 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020087008450A 2005-09-12 2006-09-11 피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물 Active KR101313395B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2005009775 2005-09-12
WOPCT/EP2005/009775 2005-09-12
PCT/IB2006/053210 WO2007031933A2 (en) 2005-09-12 2006-09-11 Stable pharmaceutical composition comprising a pyrimidine-sulfamide

Publications (2)

Publication Number Publication Date
KR20080055897A KR20080055897A (ko) 2008-06-19
KR101313395B1 true KR101313395B1 (ko) 2013-10-02

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KR1020087008450A Active KR101313395B1 (ko) 2005-09-12 2006-09-11 피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물

Country Status (23)

Country Link
US (6) US20080233188A1 (enExample)
EP (2) EP1928409B1 (enExample)
JP (2) JP4955685B2 (enExample)
KR (1) KR101313395B1 (enExample)
CN (1) CN101262847B (enExample)
AU (1) AU2006290309B2 (enExample)
BR (1) BRPI0615898B8 (enExample)
CA (1) CA2621273C (enExample)
CY (1) CY1113395T1 (enExample)
DK (1) DK1928409T3 (enExample)
ES (1) ES2393117T3 (enExample)
HR (1) HRP20120957T1 (enExample)
IL (1) IL190072A (enExample)
MY (1) MY151003A (enExample)
NO (1) NO341325B1 (enExample)
NZ (1) NZ567188A (enExample)
PL (1) PL1928409T3 (enExample)
PT (1) PT1928409E (enExample)
RU (1) RU2424805C2 (enExample)
SI (1) SI1928409T1 (enExample)
TW (1) TWI323661B (enExample)
WO (1) WO2007031933A2 (enExample)
ZA (1) ZA200802947B (enExample)

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KR101313395B1 (ko) 2005-09-12 2013-10-02 액테리온 파마슈티칼 리미티드 피리미딘-설파마이드를 함유하는 안정한 제약학적 조성물
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TW202042818A (zh) 2019-01-25 2020-12-01 瑞士商艾克泰聯製藥有限公司 用於治療慢性血栓性肺高血壓之醫藥組成物
RS66002B1 (sr) 2019-05-22 2024-10-31 Wuxi Biocity Biopharmaceutics Co Ltd Kristalni oblik jedinjenja pirimidin sulfonamida i postupak za njegovu pripremu
AU2020309223B2 (en) 2019-07-05 2025-05-29 TECNIMEDE - Sociedade Técnico-Medicinal, S.A Compressed macitentan compositions, methods and uses thereof
TW202133851A (zh) 2019-11-29 2021-09-16 瑞士商艾克泰聯製藥有限公司 治療肺動脈高血壓之方法
WO2022238375A1 (en) 2021-05-11 2022-11-17 Actelion Pharmaceuticals Ltd Methods of treating pulmonary hypertension
TW202317119A (zh) * 2021-06-11 2023-05-01 瑞士商艾克泰聯製藥有限公司 用於口服投予之分散錠
CN117835971A (zh) 2021-08-25 2024-04-05 巴斯夫欧洲公司 直接压片用辅料组合物
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053557A1 (en) * 2000-12-18 2002-07-11 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
KR20030041577A (ko) * 2001-11-20 2003-05-27 디디에스텍주식회사 난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물

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BRPI0615898B1 (pt) 2020-02-18
US10117870B2 (en) 2018-11-06
US20180263980A1 (en) 2018-09-20
MY151003A (en) 2014-03-31
CA2621273C (en) 2014-07-29
TWI323661B (en) 2010-04-21
CA2621273A1 (en) 2007-03-22
NO341325B1 (no) 2017-10-16
US20080233188A1 (en) 2008-09-25
RU2008113869A (ru) 2009-10-20
TW200803860A (en) 2008-01-16
US20130190336A1 (en) 2013-07-25
US9265762B2 (en) 2016-02-23
JP4955685B2 (ja) 2012-06-20
JP2009519893A (ja) 2009-05-21
NZ567188A (en) 2011-04-29
WO2007031933A3 (en) 2007-10-18
US20210186966A1 (en) 2021-06-24
SI1928409T1 (sl) 2012-12-31
PL1928409T3 (pl) 2013-02-28
HK1121950A1 (en) 2009-05-08
WO2007031933A2 (en) 2007-03-22
NO20081724L (no) 2008-04-09
AU2006290309B2 (en) 2012-04-05
RU2424805C2 (ru) 2011-07-27
JP5054061B2 (ja) 2012-10-24
EP2292209A2 (en) 2011-03-09
US10946015B2 (en) 2021-03-16
US20160136163A1 (en) 2016-05-19
DK1928409T3 (da) 2012-11-05
PT1928409E (pt) 2012-11-27
CY1113395T1 (el) 2016-06-22
EP2292209A3 (en) 2011-05-04
IL190072A (en) 2013-08-29
US11648249B2 (en) 2023-05-16
US20100004274A1 (en) 2010-01-07
EP1928409B1 (en) 2012-09-12
AU2006290309A1 (en) 2007-03-22
CN101262847B (zh) 2010-11-24
ZA200802947B (en) 2009-12-30
HRP20120957T1 (hr) 2012-12-31
IL190072A0 (en) 2008-08-07
ES2393117T3 (es) 2012-12-18
JP2009235073A (ja) 2009-10-15
CN101262847A (zh) 2008-09-10
US8367685B2 (en) 2013-02-05
EP1928409A2 (en) 2008-06-11
KR20080055897A (ko) 2008-06-19
BRPI0615898B8 (pt) 2021-05-25
BRPI0615898A2 (pt) 2011-05-31

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