RU2409588C2 - Бактерицидные содержащие амидные группы макроциклы v - Google Patents
Бактерицидные содержащие амидные группы макроциклы v Download PDFInfo
- Publication number
- RU2409588C2 RU2409588C2 RU2007139760/04A RU2007139760A RU2409588C2 RU 2409588 C2 RU2409588 C2 RU 2409588C2 RU 2007139760/04 A RU2007139760/04 A RU 2007139760/04A RU 2007139760 A RU2007139760 A RU 2007139760A RU 2409588 C2 RU2409588 C2 RU 2409588C2
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- group
- binding
- indicates
- formula
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract 6
- 125000003368 amide group Chemical group 0.000 title abstract 2
- 150000002678 macrocyclic compounds Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 72
- 239000001257 hydrogen Substances 0.000 claims abstract 72
- 229910052799 carbon Inorganic materials 0.000 claims abstract 24
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 19
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 8
- 150000002431 hydrogen Chemical group 0.000 claims 53
- 229910052757 nitrogen Inorganic materials 0.000 claims 22
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 22
- 125000003277 amino group Chemical group 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 7
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 2
- 238000007039 two-step reaction Methods 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005014245.1 | 2005-03-30 | ||
| DE102005014245A DE102005014245A1 (de) | 2005-03-30 | 2005-03-30 | Antibakterielle Amid-Makrozyklen V |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007139760A RU2007139760A (ru) | 2009-05-10 |
| RU2409588C2 true RU2409588C2 (ru) | 2011-01-20 |
Family
ID=36572224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007139760/04A RU2409588C2 (ru) | 2005-03-30 | 2006-03-22 | Бактерицидные содержащие амидные группы макроциклы v |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080275018A1 (OSRAM) |
| EP (1) | EP1869068A1 (OSRAM) |
| JP (1) | JP2008534540A (OSRAM) |
| KR (1) | KR20070116169A (OSRAM) |
| CN (1) | CN101228182A (OSRAM) |
| AU (1) | AU2006228751A1 (OSRAM) |
| BR (1) | BRPI0612219A2 (OSRAM) |
| CA (1) | CA2602755A1 (OSRAM) |
| DE (1) | DE102005014245A1 (OSRAM) |
| IL (1) | IL185899A0 (OSRAM) |
| MX (1) | MX2007012146A (OSRAM) |
| NO (1) | NO20075270L (OSRAM) |
| NZ (1) | NZ562003A (OSRAM) |
| RU (1) | RU2409588C2 (OSRAM) |
| UA (1) | UA91541C2 (OSRAM) |
| WO (1) | WO2006103015A1 (OSRAM) |
| ZA (1) | ZA200709336B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10358824A1 (de) | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
| DE102005032781A1 (de) * | 2005-07-14 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Markozyklen VII |
| KR20130105659A (ko) | 2010-09-15 | 2013-09-25 | 더 스크립스 리서치 인스티튜트 | 광범위 스펙트럼 항생제 아릴로마이신 유사체 |
| WO2012166665A2 (en) * | 2011-05-27 | 2012-12-06 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| CA2892027A1 (en) | 2012-11-21 | 2014-05-30 | Rqx Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| RU2016146581A (ru) | 2014-05-20 | 2018-06-21 | АрКьюЭкс ФАРМАСЪЮТИКЛС, ИНК. | Макроциклические антибиотики широкого спектра действия |
| CR20180232A (es) | 2015-10-27 | 2018-05-31 | Hoffmann La Roche | Macrociclos peptídicos contra acinetobacter baumannii |
| EP3377474B1 (en) | 2015-11-20 | 2023-08-16 | RQX Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| EP3388444A1 (en) * | 2017-04-10 | 2018-10-17 | F. Hoffmann-La Roche AG | Anti-bacterial peptide macrocycles and use thereof |
| AU2018321548B2 (en) | 2017-08-21 | 2023-03-09 | Celgene Corporation | Processes for preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate |
| US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| US11819532B2 (en) | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| IL295889B2 (en) | 2019-05-28 | 2025-01-01 | Hoffmann La Roche | Broad-spectrum macrocyclic antibiotic |
| WO2024262518A1 (ja) * | 2023-06-20 | 2024-12-26 | 国立大学法人北海道大学 | スキャニング用アミノ酸化合物、スキャニング用改変ペプチド、スキャニング用キット及びペプチドの活性部位のスキャニング方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840682A (en) * | 1994-05-20 | 1998-11-24 | Rhone-Poulenc Rorer S.A. | Peptide antagonists of neurotensin |
| RU2005100954A (ru) * | 2002-06-17 | 2005-07-10 | Байер ХельсКер АГ (DE) | Антибактериальные амидные макроциклы |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452136A (en) * | 1968-04-17 | 1969-06-24 | American Cyanamid Co | Antibiotic af283 and production thereof |
| DE10234422A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Antibakterielle Ester-Makrozyklen |
| JP2008502583A (ja) * | 2003-10-01 | 2008-01-31 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 抗細菌性アミド大員環 |
| DE10358824A1 (de) * | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
| DE102005014240A1 (de) * | 2004-09-24 | 2006-03-30 | Bayer Healthcare Ag | Antibakterielle Amid-Makrozyklen IV |
-
2005
- 2005-03-30 DE DE102005014245A patent/DE102005014245A1/de not_active Withdrawn
-
2006
- 2006-03-22 UA UAA200711765A patent/UA91541C2/ru unknown
- 2006-03-22 BR BRPI0612219-1A patent/BRPI0612219A2/pt not_active IP Right Cessation
- 2006-03-22 RU RU2007139760/04A patent/RU2409588C2/ru not_active IP Right Cessation
- 2006-03-22 MX MX2007012146A patent/MX2007012146A/es not_active Application Discontinuation
- 2006-03-22 JP JP2008503408A patent/JP2008534540A/ja not_active Withdrawn
- 2006-03-22 WO PCT/EP2006/002617 patent/WO2006103015A1/de not_active Ceased
- 2006-03-22 CA CA002602755A patent/CA2602755A1/en not_active Abandoned
- 2006-03-22 ZA ZA200709336A patent/ZA200709336B/xx unknown
- 2006-03-22 NZ NZ562003A patent/NZ562003A/en unknown
- 2006-03-22 AU AU2006228751A patent/AU2006228751A1/en not_active Abandoned
- 2006-03-22 CN CNA2006800188391A patent/CN101228182A/zh active Pending
- 2006-03-22 EP EP06723614A patent/EP1869068A1/de not_active Withdrawn
- 2006-03-22 KR KR1020077025008A patent/KR20070116169A/ko not_active Ceased
-
2007
- 2007-09-11 IL IL185899A patent/IL185899A0/en unknown
- 2007-09-28 US US11/906,088 patent/US20080275018A1/en not_active Abandoned
- 2007-10-15 NO NO20075270A patent/NO20075270L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840682A (en) * | 1994-05-20 | 1998-11-24 | Rhone-Poulenc Rorer S.A. | Peptide antagonists of neurotensin |
| RU2005100954A (ru) * | 2002-06-17 | 2005-07-10 | Байер ХельсКер АГ (DE) | Антибактериальные амидные макроциклы |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006103015A1 (de) | 2006-10-05 |
| CA2602755A1 (en) | 2006-10-05 |
| NZ562003A (en) | 2010-11-26 |
| JP2008534540A (ja) | 2008-08-28 |
| AU2006228751A1 (en) | 2006-10-05 |
| KR20070116169A (ko) | 2007-12-06 |
| BRPI0612219A2 (pt) | 2009-01-13 |
| NO20075270L (no) | 2007-12-18 |
| ZA200709336B (en) | 2009-09-30 |
| RU2007139760A (ru) | 2009-05-10 |
| EP1869068A1 (de) | 2007-12-26 |
| US20080275018A1 (en) | 2008-11-06 |
| UA91541C2 (ru) | 2010-08-10 |
| CN101228182A (zh) | 2008-07-23 |
| IL185899A0 (en) | 2008-12-29 |
| MX2007012146A (es) | 2007-12-10 |
| DE102005014245A1 (de) | 2006-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2409588C2 (ru) | Бактерицидные содержащие амидные группы макроциклы v | |
| RU2395500C2 (ru) | 2,4-пиримидиндиамины, применяемые в лечении неопластических болезней, воспалительных и иммунных расстройств | |
| EP2423207A3 (en) | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | |
| MY148145A (en) | Methods of synthesis and/or purification of diaminophenothiazinium compounds | |
| CA2473070A1 (en) | Proline compounds as ns3-serine protease inhibitors for use in treatment of hepatites c virus infection | |
| EP1862458A3 (en) | Therapeutic agents useful for treating pain | |
| CY1107146T1 (el) | Μεθοδοι για προληψη και θεραπεια ασθενειας alzheimer (ad) | |
| EP1887007A3 (en) | Imidazo- and Thiazolopyridine as JAK3 Kinase Inhibitors | |
| EA200200716A1 (ru) | Арилконденсированные азаполициклические соединения | |
| DE602004014791D1 (de) | Zur behandlung von schmerzen geeignete phenylcarbonsäureamidverbindungen | |
| SE0300119D0 (sv) | Novel compounds | |
| MXPA04005209A (es) | Antagonistas del receptor de adenosina a2a. | |
| MXPA04005156A (es) | Antagonistas del receptor de adenosina a2a. | |
| MXPA03011484A (es) | Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades. | |
| WO2005056524A3 (en) | Therapeutic agents useful for treating pain | |
| EA200501098A1 (ru) | Антибактериальные агенты | |
| EA200500007A1 (ru) | Пролекарства возбуждающих аминокислот | |
| MXPA05010440A (es) | Amidas del acido isoquinolina-5-sulfonico como inhibidores de la akt (proteina quinasa b). | |
| TW200738698A (en) | Organic compounds | |
| UA84879C2 (ru) | Изотиазолохинолоны и родственные соединения с противомикробным действием | |
| EP1857459A3 (en) | Pyrazolopyrimidine compound and a process for preparing the same | |
| EA200800444A1 (ru) | 8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ | |
| EA200301203A1 (ru) | Новые соединения и композиции как ингибиторы катепсина | |
| BRPI0410837A (pt) | composto, composição farmacêutica, e, método para tratar ou prevenir uma doença ou condição | |
| EP1184035A3 (en) | Use of growth hormone secretagogues for treatment of physical performance decline |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120323 |