RU2404985C2 - Способ получения производных эпотилона, новые производные эпотилона, а также новые промежуточные соединения для реализации способа и способы их получения - Google Patents

Способ получения производных эпотилона, новые производные эпотилона, а также новые промежуточные соединения для реализации способа и способы их получения Download PDF

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Publication number
RU2404985C2
RU2404985C2 RU2008129613/04A RU2008129613A RU2404985C2 RU 2404985 C2 RU2404985 C2 RU 2404985C2 RU 2008129613/04 A RU2008129613/04 A RU 2008129613/04A RU 2008129613 A RU2008129613 A RU 2008129613A RU 2404985 C2 RU2404985 C2 RU 2404985C2
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Russia
Prior art keywords
formula
compounds
compound
heteroatoms
alkyl
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RU2008129613/04A
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English (en)
Russian (ru)
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RU2008129613A (ru
Inventor
Гуидо КОХ (CH)
Гуидо Кох
Оливье ЛАУЗЕЛЁР (FR)
Оливье ЛАУЗЕЛЁР
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Новартис Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2008129613/04A 2002-09-13 2003-09-12 Способ получения производных эпотилона, новые производные эпотилона, а также новые промежуточные соединения для реализации способа и способы их получения RU2404985C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221312.2A GB0221312D0 (en) 2002-09-13 2002-09-13 Organic compounds
GB0221312.2 2002-09-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2005110925/04A Division RU2343155C2 (ru) 2002-09-13 2003-09-12 Способ получения производных эпотилона

Publications (2)

Publication Number Publication Date
RU2008129613A RU2008129613A (ru) 2010-01-27
RU2404985C2 true RU2404985C2 (ru) 2010-11-27

Family

ID=9944042

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2005110925/04A RU2343155C2 (ru) 2002-09-13 2003-09-12 Способ получения производных эпотилона
RU2008129613/04A RU2404985C2 (ru) 2002-09-13 2003-09-12 Способ получения производных эпотилона, новые производные эпотилона, а также новые промежуточные соединения для реализации способа и способы их получения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2005110925/04A RU2343155C2 (ru) 2002-09-13 2003-09-12 Способ получения производных эпотилона

Country Status (29)

Country Link
US (1) US7470792B2 (enExample)
EP (1) EP1539768B1 (enExample)
JP (1) JP4628102B2 (enExample)
KR (1) KR20050042500A (enExample)
CN (1) CN100522968C (enExample)
AR (1) AR041231A1 (enExample)
AT (1) ATE373663T1 (enExample)
AU (2) AU2003267349B2 (enExample)
BR (1) BR0314263A (enExample)
CA (1) CA2497119C (enExample)
CY (1) CY1107794T1 (enExample)
DE (1) DE60316456T2 (enExample)
DK (1) DK1539768T3 (enExample)
EC (1) ECSP055652A (enExample)
ES (1) ES2290489T3 (enExample)
GB (1) GB0221312D0 (enExample)
IL (1) IL166829A (enExample)
MX (1) MXPA05002785A (enExample)
MY (1) MY140442A (enExample)
NO (1) NO20051794L (enExample)
NZ (1) NZ538612A (enExample)
PE (1) PE20050052A1 (enExample)
PL (1) PL375039A1 (enExample)
PT (1) PT1539768E (enExample)
RU (2) RU2343155C2 (enExample)
SG (1) SG155770A1 (enExample)
TW (1) TWI289563B (enExample)
WO (1) WO2004024735A2 (enExample)
ZA (1) ZA200501008B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2496477C (en) 2002-08-23 2012-10-16 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008849A1 (de) * 1996-08-30 1998-03-05 Novartis Aktiengesellschaft Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
WO1998025929A1 (en) * 1996-12-13 1998-06-18 Novartis Ag Epothilone analogs
WO1999067252A2 (en) * 1998-06-22 1999-12-29 Novartis Ag Epothilone derivatives and their synthesis and use
RU99120378A (ru) * 1997-02-25 2001-07-20 Гезелльшафт Фюр Биотехнологише Форшунг Мбх (Гбф) Модифицированные в боковой цепи эпотилоны
WO2002030356A2 (en) * 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ337195A (en) * 1997-02-25 2001-05-25 Biotechnolog Forschung Gmbh Epothilones with a modified side chain
US6498257B1 (en) * 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
GB9810659D0 (en) * 1998-05-18 1998-07-15 Ciba Geigy Ag Organic compounds
ES2207983T3 (es) * 1998-12-22 2004-06-01 Novartis Ag Derivados de epotilona y su uso como agentes antitumorales.
AU6233600A (en) * 1999-07-22 2001-02-13 Schering Aktiengesellschaft Process for the production of epothiolone b and derivatives as well as intermediate products for this process
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
IL166039A0 (en) * 2002-07-31 2006-01-15 Schering Ag New effector conjugates process for their production and their pharmaceutical use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008849A1 (de) * 1996-08-30 1998-03-05 Novartis Aktiengesellschaft Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
WO1998025929A1 (en) * 1996-12-13 1998-06-18 Novartis Ag Epothilone analogs
RU99120378A (ru) * 1997-02-25 2001-07-20 Гезелльшафт Фюр Биотехнологише Форшунг Мбх (Гбф) Модифицированные в боковой цепи эпотилоны
WO1999067252A2 (en) * 1998-06-22 1999-12-29 Novartis Ag Epothilone derivatives and their synthesis and use
WO2002030356A2 (en) * 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs

Also Published As

Publication number Publication date
AR041231A1 (es) 2005-05-11
RU2005110925A (ru) 2006-01-20
TW200413388A (en) 2004-08-01
AU2003267349B2 (en) 2008-05-01
NO20051794D0 (no) 2005-04-12
GB0221312D0 (en) 2002-10-23
DK1539768T3 (da) 2008-01-07
KR20050042500A (ko) 2005-05-09
CN100522968C (zh) 2009-08-05
BR0314263A (pt) 2005-07-05
ZA200501008B (en) 2006-12-27
RU2008129613A (ru) 2010-01-27
IL166829A (en) 2011-01-31
PT1539768E (pt) 2007-12-17
US7470792B2 (en) 2008-12-30
SG155770A1 (en) 2009-10-29
ECSP055652A (es) 2005-05-30
EP1539768B1 (en) 2007-09-19
CA2497119A1 (en) 2004-03-25
DE60316456T2 (de) 2008-06-19
CY1107794T1 (el) 2013-06-19
NZ538612A (en) 2008-01-31
CA2497119C (en) 2011-08-02
TWI289563B (en) 2007-11-11
PE20050052A1 (es) 2005-03-28
AU2008203451A1 (en) 2008-08-21
PL375039A1 (en) 2005-11-14
WO2004024735A3 (en) 2004-07-22
JP2006511469A (ja) 2006-04-06
JP4628102B2 (ja) 2011-02-09
ES2290489T3 (es) 2008-02-16
EP1539768A2 (en) 2005-06-15
MXPA05002785A (es) 2005-06-03
MY140442A (en) 2009-12-31
NO20051794L (no) 2005-04-12
WO2004024735A2 (en) 2004-03-25
ATE373663T1 (de) 2007-10-15
DE60316456D1 (de) 2007-10-31
HK1078853A1 (en) 2006-03-24
RU2343155C2 (ru) 2009-01-10
CN1681824A (zh) 2005-10-12
AU2003267349A1 (en) 2004-04-30
US20060106073A1 (en) 2006-05-18

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20130913