AU2003267349B2 - A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same - Google Patents

A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same Download PDF

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Publication number
AU2003267349B2
AU2003267349B2 AU2003267349A AU2003267349A AU2003267349B2 AU 2003267349 B2 AU2003267349 B2 AU 2003267349B2 AU 2003267349 A AU2003267349 A AU 2003267349A AU 2003267349 A AU2003267349 A AU 2003267349A AU 2003267349 B2 AU2003267349 B2 AU 2003267349B2
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AU
Australia
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formula
compound
compounds
obtaining
meanings
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Ceased
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AU2003267349A
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AU2003267349A1 (en
Inventor
Guido Koch
Olivier Loiseleur
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Novartis AG
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Novartis AG
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Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2003267349A1 publication Critical patent/AU2003267349A1/en
Application granted granted Critical
Publication of AU2003267349B2 publication Critical patent/AU2003267349B2/en
Priority to AU2008203451A priority Critical patent/AU2008203451A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2003267349A 2002-09-13 2003-09-12 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same Ceased AU2003267349B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008203451A AU2008203451A1 (en) 2002-09-13 2008-08-01 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0221312.2A GB0221312D0 (en) 2002-09-13 2002-09-13 Organic compounds
GB0221312.2 2002-09-13
PCT/EP2003/010171 WO2004024735A2 (en) 2002-09-13 2003-09-12 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2008203451A Division AU2008203451A1 (en) 2002-09-13 2008-08-01 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Publications (2)

Publication Number Publication Date
AU2003267349A1 AU2003267349A1 (en) 2004-04-30
AU2003267349B2 true AU2003267349B2 (en) 2008-05-01

Family

ID=9944042

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2003267349A Ceased AU2003267349B2 (en) 2002-09-13 2003-09-12 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same
AU2008203451A Abandoned AU2008203451A1 (en) 2002-09-13 2008-08-01 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2008203451A Abandoned AU2008203451A1 (en) 2002-09-13 2008-08-01 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Country Status (29)

Country Link
US (1) US7470792B2 (enExample)
EP (1) EP1539768B1 (enExample)
JP (1) JP4628102B2 (enExample)
KR (1) KR20050042500A (enExample)
CN (1) CN100522968C (enExample)
AR (1) AR041231A1 (enExample)
AT (1) ATE373663T1 (enExample)
AU (2) AU2003267349B2 (enExample)
BR (1) BR0314263A (enExample)
CA (1) CA2497119C (enExample)
CY (1) CY1107794T1 (enExample)
DE (1) DE60316456T2 (enExample)
DK (1) DK1539768T3 (enExample)
EC (1) ECSP055652A (enExample)
ES (1) ES2290489T3 (enExample)
GB (1) GB0221312D0 (enExample)
IL (1) IL166829A (enExample)
MX (1) MXPA05002785A (enExample)
MY (1) MY140442A (enExample)
NO (1) NO20051794L (enExample)
NZ (1) NZ538612A (enExample)
PE (1) PE20050052A1 (enExample)
PL (1) PL375039A1 (enExample)
PT (1) PT1539768E (enExample)
RU (2) RU2343155C2 (enExample)
SG (1) SG155770A1 (enExample)
TW (1) TWI289563B (enExample)
WO (1) WO2004024735A2 (enExample)
ZA (1) ZA200501008B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2496477C (en) 2002-08-23 2012-10-16 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054330A1 (en) * 1998-04-21 1999-10-28 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
WO2001007439A2 (en) * 1999-07-22 2001-02-01 Schering Aktiengesellschaft Process for the production of epothiolone b and derivatives as well as intermediate products for this process

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716610B2 (en) * 1996-08-30 2000-03-02 Novartis Ag Method for producing epothilones, and intermediate products obtained during the production process
US6380394B1 (en) * 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
NZ337195A (en) * 1997-02-25 2001-05-25 Biotechnolog Forschung Gmbh Epothilones with a modified side chain
GB9810659D0 (en) * 1998-05-18 1998-07-15 Ciba Geigy Ag Organic compounds
ES2207983T3 (es) * 1998-12-22 2004-06-01 Novartis Ag Derivados de epotilona y su uso como agentes antitumorales.
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
CA2425828A1 (en) * 2000-10-13 2002-04-18 The University Of Mississippi Synthesis of epothilones and related analogs
IL166039A0 (en) * 2002-07-31 2006-01-15 Schering Ag New effector conjugates process for their production and their pharmaceutical use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054330A1 (en) * 1998-04-21 1999-10-28 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
WO2001007439A2 (en) * 1999-07-22 2001-02-01 Schering Aktiengesellschaft Process for the production of epothiolone b and derivatives as well as intermediate products for this process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hoefle, G. et al., Pure and Applied Chemistry (1999) 71(11): 2019-2024 *

Also Published As

Publication number Publication date
AR041231A1 (es) 2005-05-11
RU2005110925A (ru) 2006-01-20
TW200413388A (en) 2004-08-01
NO20051794D0 (no) 2005-04-12
GB0221312D0 (en) 2002-10-23
DK1539768T3 (da) 2008-01-07
KR20050042500A (ko) 2005-05-09
CN100522968C (zh) 2009-08-05
BR0314263A (pt) 2005-07-05
ZA200501008B (en) 2006-12-27
RU2008129613A (ru) 2010-01-27
IL166829A (en) 2011-01-31
PT1539768E (pt) 2007-12-17
US7470792B2 (en) 2008-12-30
SG155770A1 (en) 2009-10-29
ECSP055652A (es) 2005-05-30
EP1539768B1 (en) 2007-09-19
CA2497119A1 (en) 2004-03-25
DE60316456T2 (de) 2008-06-19
CY1107794T1 (el) 2013-06-19
NZ538612A (en) 2008-01-31
CA2497119C (en) 2011-08-02
TWI289563B (en) 2007-11-11
PE20050052A1 (es) 2005-03-28
AU2008203451A1 (en) 2008-08-21
PL375039A1 (en) 2005-11-14
WO2004024735A3 (en) 2004-07-22
JP2006511469A (ja) 2006-04-06
JP4628102B2 (ja) 2011-02-09
ES2290489T3 (es) 2008-02-16
EP1539768A2 (en) 2005-06-15
MXPA05002785A (es) 2005-06-03
MY140442A (en) 2009-12-31
NO20051794L (no) 2005-04-12
WO2004024735A2 (en) 2004-03-25
RU2404985C2 (ru) 2010-11-27
ATE373663T1 (de) 2007-10-15
DE60316456D1 (de) 2007-10-31
HK1078853A1 (en) 2006-03-24
RU2343155C2 (ru) 2009-01-10
CN1681824A (zh) 2005-10-12
AU2003267349A1 (en) 2004-04-30
US20060106073A1 (en) 2006-05-18

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired