NO20051794L - Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike - Google Patents
Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slikeInfo
- Publication number
- NO20051794L NO20051794L NO20051794A NO20051794A NO20051794L NO 20051794 L NO20051794 L NO 20051794L NO 20051794 A NO20051794 A NO 20051794A NO 20051794 A NO20051794 A NO 20051794A NO 20051794 L NO20051794 L NO 20051794L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- processes
- epothilone derivatives
- novel intermediates
- optionally substituted
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000003883 epothilone derivatives Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221312.2A GB0221312D0 (en) | 2002-09-13 | 2002-09-13 | Organic compounds |
| PCT/EP2003/010171 WO2004024735A2 (en) | 2002-09-13 | 2003-09-12 | A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20051794D0 NO20051794D0 (no) | 2005-04-12 |
| NO20051794L true NO20051794L (no) | 2005-04-12 |
Family
ID=9944042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051794A NO20051794L (no) | 2002-09-13 | 2005-04-12 | Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7470792B2 (enExample) |
| EP (1) | EP1539768B1 (enExample) |
| JP (1) | JP4628102B2 (enExample) |
| KR (1) | KR20050042500A (enExample) |
| CN (1) | CN100522968C (enExample) |
| AR (1) | AR041231A1 (enExample) |
| AT (1) | ATE373663T1 (enExample) |
| AU (2) | AU2003267349B2 (enExample) |
| BR (1) | BR0314263A (enExample) |
| CA (1) | CA2497119C (enExample) |
| CY (1) | CY1107794T1 (enExample) |
| DE (1) | DE60316456T2 (enExample) |
| DK (1) | DK1539768T3 (enExample) |
| EC (1) | ECSP055652A (enExample) |
| ES (1) | ES2290489T3 (enExample) |
| GB (1) | GB0221312D0 (enExample) |
| IL (1) | IL166829A (enExample) |
| MX (1) | MXPA05002785A (enExample) |
| MY (1) | MY140442A (enExample) |
| NO (1) | NO20051794L (enExample) |
| NZ (1) | NZ538612A (enExample) |
| PE (1) | PE20050052A1 (enExample) |
| PL (1) | PL375039A1 (enExample) |
| PT (1) | PT1539768E (enExample) |
| RU (2) | RU2404985C2 (enExample) |
| SG (1) | SG155770A1 (enExample) |
| TW (1) | TWI289563B (enExample) |
| WO (1) | WO2004024735A2 (enExample) |
| ZA (1) | ZA200501008B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0977563B1 (en) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2004018478A2 (en) | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998008849A1 (de) * | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
| US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| WO1998038192A1 (de) * | 1997-02-25 | 1998-09-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Seitenkettenmodifizierte epothilone |
| US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| GB9810659D0 (en) * | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| AU2795000A (en) * | 1998-12-22 | 2000-07-12 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
| EP1226142A2 (en) | 1999-07-22 | 2002-07-31 | Schering Aktiengesellschaft | Process for the production of epothiolone b and derivatives as well as intermediate products for this process |
| US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
| JP2005500974A (ja) | 2000-10-13 | 2005-01-13 | ザ ユニバーシテイ オブ ミシシッピー | エポシロン類及び関連類似体の合成 |
| PL374528A1 (en) * | 2002-07-31 | 2005-10-31 | Schering Aktiengesellschaft | New effector conjugates, process for their production and their pharmaceutical use |
-
2002
- 2002-09-13 GB GBGB0221312.2A patent/GB0221312D0/en not_active Ceased
-
2003
- 2003-09-11 PE PE2003000922A patent/PE20050052A1/es not_active Application Discontinuation
- 2003-09-11 AR ARP030103290A patent/AR041231A1/es active IP Right Grant
- 2003-09-12 BR BR0314263-9A patent/BR0314263A/pt not_active IP Right Cessation
- 2003-09-12 AU AU2003267349A patent/AU2003267349B2/en not_active Ceased
- 2003-09-12 ES ES03748015T patent/ES2290489T3/es not_active Expired - Lifetime
- 2003-09-12 WO PCT/EP2003/010171 patent/WO2004024735A2/en not_active Ceased
- 2003-09-12 CN CNB038215837A patent/CN100522968C/zh not_active Expired - Fee Related
- 2003-09-12 JP JP2004535499A patent/JP4628102B2/ja not_active Expired - Fee Related
- 2003-09-12 PL PL03375039A patent/PL375039A1/xx not_active Application Discontinuation
- 2003-09-12 CA CA2497119A patent/CA2497119C/en not_active Expired - Fee Related
- 2003-09-12 RU RU2008129613/04A patent/RU2404985C2/ru not_active IP Right Cessation
- 2003-09-12 NZ NZ538612A patent/NZ538612A/en not_active IP Right Cessation
- 2003-09-12 DE DE60316456T patent/DE60316456T2/de not_active Expired - Lifetime
- 2003-09-12 TW TW092125250A patent/TWI289563B/zh not_active IP Right Cessation
- 2003-09-12 KR KR1020057004237A patent/KR20050042500A/ko not_active Ceased
- 2003-09-12 SG SG200701814-6A patent/SG155770A1/en unknown
- 2003-09-12 PT PT03748015T patent/PT1539768E/pt unknown
- 2003-09-12 MX MXPA05002785A patent/MXPA05002785A/es active IP Right Grant
- 2003-09-12 RU RU2005110925/04A patent/RU2343155C2/ru not_active IP Right Cessation
- 2003-09-12 AT AT03748015T patent/ATE373663T1/de active
- 2003-09-12 DK DK03748015T patent/DK1539768T3/da active
- 2003-09-12 US US10/526,283 patent/US7470792B2/en not_active Expired - Fee Related
- 2003-09-12 EP EP03748015A patent/EP1539768B1/en not_active Expired - Lifetime
- 2003-09-13 MY MYPI20033494A patent/MY140442A/en unknown
-
2005
- 2005-02-03 ZA ZA200501008A patent/ZA200501008B/xx unknown
- 2005-02-10 IL IL166829A patent/IL166829A/en not_active IP Right Cessation
- 2005-03-09 EC EC2005005652A patent/ECSP055652A/es unknown
- 2005-04-12 NO NO20051794A patent/NO20051794L/no not_active Application Discontinuation
-
2007
- 2007-11-08 CY CY20071101447T patent/CY1107794T1/el unknown
-
2008
- 2008-08-01 AU AU2008203451A patent/AU2008203451A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20081464L (no) | 1-heterocyklusulfonyl, 2-aminometyl, 5-(hetero-)aryl subsidiert 1-H-pyrrol-derivater som syresekresjonsinhibitorer | |
| WO2003045929A1 (en) | Bicyclic derivative, process for producing the same, and use | |
| EA200601852A1 (ru) | Тетрагидрохинолиновые производные и способ их получения | |
| EA200602170A1 (ru) | Производные пиперидина, композиции на их основе, способы их применения | |
| NO20080717L (no) | Oksimderivat og fremgangsmate for fremstilling av dette | |
| DE60311821D1 (de) | Dibenzylaminverbindung und deren medizinische verwendung | |
| NO20065537L (no) | Heterosykliske amidforbindelser og anvendelse derav som en MMP-13-inhibitor | |
| CA2213124A1 (en) | Benzoyl derivatives | |
| NO20076660L (no) | Fremgangsmate for fremstilling av rosuvastatin og mellomprodukter | |
| ÖZDEMİR et al. | Novel analogues of 2-pyrazoline: synthesis, characterization, and antimycobacterial evaluation | |
| EP1566384A4 (en) | NEW AZOL DERIVATIVES | |
| YU47555B (sh) | Derivati tetrahidrobenzimidazola i postupak za njihovo dobijanje | |
| El‐Gaby | Syntheses of hitherto unknown Thiazole, Ylidene and Pyridinethione derivatives having a Piperidin‐1‐yl moiety and their use as antimicrobial agents | |
| NO20051794L (no) | Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike | |
| NO20000373D0 (no) | Nye cyano-indol serotinin-reopptaks-inhibitorforbindelser, fremgangsmåte for deres fremstilling og farmasoeytiske sammensetninger inneholdende dem | |
| Mashelkar et al. | Synthesis of some novel 4-substituted coumarins having potential biological activity (Part III) | |
| HK1077520A1 (zh) | 用作p38促细胞分裂原活化蛋白激酶抑制剂的吲哚类衍生物 | |
| DK1116719T3 (da) | 3-(1-hydroxy-pentyliden)-5-nitro-3H-benzofuran-2-on, fremgangsmåde til fremstilling deraf og anvendelse deraf | |
| NO20063111L (no) | Fremgangsmate for fremstilling av tiazolpyrimidiner | |
| Abdel-Hafez | Synthesis, Antimicrobial Activity of Some New 2-Amino-4-(4′-phenylsulfanyl-phenyl)-thiazole Derivatives and Theoretical Studies of Their Schiff's Base | |
| Kriplani et al. | Microwave assisted synthesis of some biologically active benzothiazolotriazine derivatives | |
| Singh et al. | The facile and efficient synthesis of novel monocyclic cis-β-lactam conjugates with a 1-methyl-1 H-imidazole-2-thiol nucleus | |
| TW200612912A (en) | Benzyloxy derivatives as maob inhibitors | |
| Salvi et al. | Synthesis of phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl) ethyl} amino]-1, 3-thiazolidin-5-yl] ethanoate and their antimicrobial activities | |
| Ayyash | Synthesis And Characterization Of Some New Quinolin-2 (1H)-Ones And Imidazoles Containing 1, 3, 4-Thiadiazoline Ring Derived From Thiosemicarbazone. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |