RU2401661C9 - Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор - Google Patents

Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор Download PDF

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Publication number
RU2401661C9
RU2401661C9 RU2007105987/14A RU2007105987A RU2401661C9 RU 2401661 C9 RU2401661 C9 RU 2401661C9 RU 2007105987/14 A RU2007105987/14 A RU 2007105987/14A RU 2007105987 A RU2007105987 A RU 2007105987A RU 2401661 C9 RU2401661 C9 RU 2401661C9
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cells
poly
apoptosis
tlr
tlr3
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RU2007105987/14A
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English (en)
Russian (ru)
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RU2007105987A (ru
RU2401661C2 (ru
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Серж ЛЕБЕК (FR)
Серж ЛЕБЕК
Туфик РЕННО (FR)
Туфик РЕННО
Брюно САЛОН (CH)
Брюно САЛОН
Изабель КОСТ-ИНВЕРНИЦЦИ (FR)
Изабель КОСТ-ИНВЕРНИЦЦИ
Мари-Клотильд РИССОАН (FR)
Мари-Клотильд РИССОАН
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Шеринг Корпорейшн
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2007105987/14A 2004-07-20 2005-07-19 Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор RU2401661C9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58961604P 2004-07-20 2004-07-20
US60/589,616 2004-07-20

Publications (3)

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RU2007105987A RU2007105987A (ru) 2008-08-27
RU2401661C2 RU2401661C2 (ru) 2010-10-20
RU2401661C9 true RU2401661C9 (ru) 2011-01-27

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RU2007105987/14A RU2401661C9 (ru) 2004-07-20 2005-07-19 Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор

Country Status (12)

Country Link
US (2) US20060147456A1 (cg-RX-API-DMAC10.html)
EP (1) EP1768699A1 (cg-RX-API-DMAC10.html)
JP (1) JP2008507530A (cg-RX-API-DMAC10.html)
KR (1) KR20070043795A (cg-RX-API-DMAC10.html)
CN (1) CN101018567B (cg-RX-API-DMAC10.html)
AT (1) ATE511859T1 (cg-RX-API-DMAC10.html)
AU (2) AU2005269733B2 (cg-RX-API-DMAC10.html)
CA (1) CA2574176A1 (cg-RX-API-DMAC10.html)
MX (1) MX2007000770A (cg-RX-API-DMAC10.html)
NO (1) NO20070945L (cg-RX-API-DMAC10.html)
RU (1) RU2401661C9 (cg-RX-API-DMAC10.html)
WO (1) WO2006014653A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826262C2 (ru) * 2018-05-04 2024-09-09 Толлиз Лиганды tlr3, которые активируют как эпителиальные, так и миелоидные клетки

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258712A3 (en) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
JP2006522806A (ja) * 2003-03-26 2006-10-05 マルチセル・イミュノセラピューティクス，インコーポレイテッド 細胞死及び／又はアポトーシスを誘導するための、選択されたｒｎａモチーフ
WO2006054129A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
US20120189643A1 (en) * 2004-11-30 2012-07-26 Carton Jill M Toll Like Receptor 3 Antagonists, Methods and Uses
EP1993553B1 (en) 2006-03-02 2013-05-08 Agency for Science, Technology and Research Methods for cancer therapy and stem cell modulation
AU2007249698A1 (en) 2006-05-15 2007-11-22 University Of Kentucky Toll-like receptor (TLR) stimulation for ocular angiogenesis and macular degeneration
EP1881080A1 (en) * 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof
US20080124366A1 (en) * 2006-08-06 2008-05-29 Ohlfest John R Methods and Compositions for Treating Tumors
JP5115921B2 (ja) * 2007-02-28 2013-01-09 株式会社ペルセウスプロテオミクス 腎癌の診断薬および治療薬
AU2008242540A1 (en) * 2007-04-24 2008-10-30 John Wayne Cancer Institute Functional toll-like receptors (TLR) on melanocytes and melanoma cells and uses thereof
JP2011504462A (ja) * 2007-11-02 2011-02-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 腫瘍の予防および治療のための方法および化合物
WO2009073152A1 (en) * 2007-11-28 2009-06-11 Smart Tube, Inc. Devices, systems and methods for the collection, stimulation, stabilization, and analysis of a biological sample
AU2009215795A1 (en) * 2008-02-21 2009-08-27 University Of Kentucky Research Foundation Ultra-small RNAs as toll-like receptor-3 antagonists
AU2009239655B2 (en) 2008-04-25 2014-05-22 Innate Pharma Improved TLR3 agonist compositions
WO2010020590A1 (en) * 2008-08-20 2010-02-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
GB0820698D0 (en) * 2008-11-12 2008-12-17 Ludwig Inst Cancer Res Uses of immunomodulators
US8628762B2 (en) 2008-12-10 2014-01-14 Icahn School Of Medicine At Mount Sinai T-helper cell type 17 lineage-specific adjuvants, compositions and methods
CN102639700A (zh) 2009-09-30 2012-08-15 哈佛大学校长及研究员协会 通过调节自噬增强基因产物调节自噬的方法
US9090897B2 (en) * 2009-12-18 2015-07-28 Bavarian Nordic A/S Production of IFN-lambda by conventional dendritic cells
KR101250419B1 (ko) * 2010-12-16 2013-04-05 강원대학교산학협력단 Ｔｌｒ 작동제를 포함하는 유방암 방사선 치료 보조제
RU2014103159A (ru) * 2011-07-22 2015-08-27 Павел КАЛИНСКИЙ Опухолесективная модуляция хемокинов
CN102652802A (zh) * 2012-04-18 2012-09-05 南京中医药大学 癌毒方在制备调控肝癌细胞TLRs／NF-κB信号转导药物中的应用
EP2879669A4 (en) 2012-07-29 2016-04-13 Univ Colorado Regents ANTAGONISTS OF THE TOLL LIKE RECEPTOR 1/2 COMPLEX
US10105305B2 (en) * 2014-02-19 2018-10-23 The Johns Hopkins University Compositions and methods for promoting skin regeneration and hair growth
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN105796594A (zh) * 2016-03-28 2016-07-27 南京大学 一种组合物在制备治疗肿瘤药物中的应用及该组合物的使用方法
CN106191238B (zh) * 2016-07-08 2020-01-10 中国医学科学院基础医学研究所 Tlr3预测肿瘤转移、评估预后和选择防治方案的应用
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
CN108295060A (zh) * 2018-04-08 2018-07-20 王长国 一种tlr7激动剂在增强cik细胞对肿瘤细胞杀伤力方面的应用
US11969402B2 (en) 2019-05-16 2024-04-30 The Johns Hopkins University Compositions and methods for skin rejuvenation
CN111117966A (zh) * 2020-03-02 2020-05-08 南通大学 一种利用乳酸的体外细胞培养方法
CN111579538B (zh) * 2020-04-22 2022-12-30 山东第一医科大学(山东省医学科学院) 一种利用凋亡试剂盒检测循环肿瘤细胞的方法
KR20220158640A (ko) * 2021-05-24 2022-12-01 주식회사 차백신연구소 리포펩타이드와 폴리(i:c) 아쥬번트를 이용하는 면역항암치료제 조성물
CN115820646A (zh) * 2022-12-20 2023-03-21 武汉光谷中源药业有限公司 一种增强免疫能力的免疫激动剂及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2136278C1 (ru) * 1998-04-07 1999-09-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Противоопухолевое средство

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
CN1040504A (zh) * 1988-06-22 1990-03-21 Hem研究公司 用双链核糖核酸调节淋巴激活素抗性细胞状态
US20040006242A1 (en) * 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
EP1412390A2 (en) * 2001-07-26 2004-04-28 Tanox, Inc. Agents that activate or inhibit toll-like receptor 9
TW200303759A (en) * 2001-11-27 2003-09-16 Schering Corp Methods for treating cancer
WO2004047612A2 (en) * 2002-11-22 2004-06-10 Nuvelo, Inc. Methods of therapy and diagnosis
JP3810731B2 (ja) * 2002-11-29 2006-08-16 独立行政法人科学技術振興機構 哺乳動物のＴｏｌｌ様受容体３に結合する新規アダプタータンパク質およびその遺伝子

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2136278C1 (ru) * 1998-04-07 1999-09-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Противоопухолевое средство

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDRE F. et al. Targeting Toll like receptor 3 by double stranded RNA in breast cancer: Results from in vitro studies and randomized trial // Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition), vol 22, No 14S (July 15 Supplement), 2004: 9619, abstract. *
MATSUMOTO M. et al. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling // Biochem Biophys Res Commun. 2002 May 24; 293(5), p.1364-1369, abstract. CHO C-H et al. Antitumor Effect of Monophosphoryl Lipid A Polyadenylic - Polyuridylic Acid and Cisplatin on В 16 Melanoma - induced Pulmonary Metastasis in Mice // Journal of Bacteriology and Virology, 1994, vol.29, №2, p.231-244, abstract. YOUN J.K. et al. Adjuvant treatment of operable stomach cancer with polyadenylic. polyuridylic acid in addition to chemotherapeutic agents: a preliminary report // Int J Immunopharmacol. 1990; 12(3), p.289-295, abstract. MOTZER R.J. et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma // J Clin Oncol. 2002 Jan 1; 20(1), p.289-296, abstract. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826262C2 (ru) * 2018-05-04 2024-09-09 Толлиз Лиганды tlr3, которые активируют как эпителиальные, так и миелоидные клетки

Also Published As

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EP1768699A1 (en) 2007-04-04
CN101018567B (zh) 2011-07-27
AU2005269733A1 (en) 2006-02-09
US20090285779A1 (en) 2009-11-19
AU2005269733B2 (en) 2008-10-30
MX2007000770A (es) 2007-03-26
US20060147456A1 (en) 2006-07-06
JP2008507530A (ja) 2008-03-13
RU2007105987A (ru) 2008-08-27
RU2401661C2 (ru) 2010-10-20
CA2574176A1 (en) 2006-02-09
KR20070043795A (ko) 2007-04-25
CN101018567A (zh) 2007-08-15
NO20070945L (no) 2007-02-19
ATE511859T1 (de) 2011-06-15
WO2006014653A1 (en) 2006-02-09
AU2008249173A1 (en) 2008-12-11

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Effective date: 20120720