RU2383542C2 - Замещенные гидантоины - Google Patents
Замещенные гидантоины Download PDFInfo
- Publication number
- RU2383542C2 RU2383542C2 RU2007109651/04A RU2007109651A RU2383542C2 RU 2383542 C2 RU2383542 C2 RU 2383542C2 RU 2007109651/04 A RU2007109651/04 A RU 2007109651/04A RU 2007109651 A RU2007109651 A RU 2007109651A RU 2383542 C2 RU2383542 C2 RU 2383542C2
- Authority
- RU
- Russia
- Prior art keywords
- dioxoimidazolidin
- phenyl
- lower alkyl
- propionylthiazol
- phenylbutyramide
- Prior art date
Links
- 0 CC(*)C(C(Nc1nc(*)c(*)[s]1)=O)N(C(C(*)(*)N1)=O)C1=O Chemical compound CC(*)C(C(Nc1nc(*)c(*)[s]1)=O)N(C(C(*)(*)N1)=O)C1=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60217504P | 2004-08-17 | 2004-08-17 | |
| US60/602,175 | 2004-08-17 | ||
| US68299705P | 2005-05-20 | 2005-05-20 | |
| US60/682,997 | 2005-05-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007109651A RU2007109651A (ru) | 2008-09-27 |
| RU2383542C2 true RU2383542C2 (ru) | 2010-03-10 |
Family
ID=35589619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007109651/04A RU2383542C2 (ru) | 2004-08-17 | 2005-08-09 | Замещенные гидантоины |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7427635B2 (enExample) |
| EP (1) | EP1781649B1 (enExample) |
| JP (1) | JP4927733B2 (enExample) |
| KR (2) | KR100889721B1 (enExample) |
| AR (1) | AR050297A1 (enExample) |
| AT (1) | ATE404556T1 (enExample) |
| AU (1) | AU2005274390B2 (enExample) |
| BR (1) | BRPI0514515A (enExample) |
| CA (1) | CA2576599A1 (enExample) |
| DE (1) | DE602005008986D1 (enExample) |
| ES (1) | ES2313389T3 (enExample) |
| MX (1) | MX2007001846A (enExample) |
| PL (1) | PL1781649T3 (enExample) |
| RU (1) | RU2383542C2 (enExample) |
| TW (1) | TW200621764A (enExample) |
| WO (1) | WO2006018188A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200621766A (en) * | 2004-09-17 | 2006-07-01 | Hoffmann La Roche | Substituted hydantoins |
| US7612212B2 (en) * | 2006-02-22 | 2009-11-03 | Hoffmann-La Roche Inc. | Substituted hydantoins |
| CA2686756A1 (en) * | 2007-05-11 | 2008-11-20 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions for poorly soluble drugs |
| ES2383927T3 (es) * | 2007-08-16 | 2012-06-27 | F. Hoffmann-La Roche Ag | Hidantoínas sustituidas |
| CA2707650A1 (en) * | 2007-12-20 | 2009-07-02 | F. Hoffmann-La Roche Ag | Substituted hydantoins as mek kinase inhibitors |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| DK2303021T3 (en) * | 2008-06-16 | 2019-04-08 | Univ Tennessee Res Found | RELATIONSHIPS FOR TREATING CANCER |
| JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｅｋ阻害剤に対する耐性を付与するｍｅｋ突然変異 |
| WO2011000945A2 (en) * | 2009-07-03 | 2011-01-06 | Nensius Research A/S | Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns |
| ES2674682T3 (es) | 2010-02-25 | 2018-07-03 | Dana-Farber Cancer Institute, Inc. | Mutaciones de BRAF que confieren resistencia a inhibidores de BRAF |
| MX377405B (es) | 2010-03-01 | 2025-03-07 | Gtx Inc | Compuestos para el tratamiento de cáncer. |
| WO2011112678A1 (en) | 2010-03-09 | 2011-09-15 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
| CN102971314B (zh) | 2010-04-28 | 2016-03-23 | 拜耳知识产权有限责任公司 | 酮基杂芳基哌啶和酮基杂芳基哌嗪衍生物作为杀菌剂 |
| WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| UA125427C2 (uk) * | 2018-09-17 | 2022-03-02 | Юнґдзин Фарм. Ко., Лтд. | Похідні тіазолу і їх фармацевтично прийнятні солі |
| KR20210116325A (ko) * | 2020-03-13 | 2021-09-27 | 영진약품 주식회사 | 티아졸 유도체 또는 이의 약제학적으로 허용가능한 염을 포함하는 암의 예방 또는 치료용 약학 조성물 |
| WO2021182914A1 (ko) * | 2020-03-13 | 2021-09-16 | 영진약품 주식회사 | 신규한 cdk7 억제 화합물 및 이의 약제학적으로 허용가능한 염 |
| KR20210146144A (ko) | 2020-05-26 | 2021-12-03 | 엘지전자 주식회사 | 카트부 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| WO2001083478A2 (en) * | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Hydantoin-containing glucokinase activators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ501276A (en) | 1997-07-01 | 2000-10-27 | Warner Lambert Co | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders |
| ATE345341T1 (de) * | 2001-07-19 | 2006-12-15 | Pfizer Italia Srl | Phenylacetamido-thiazole verbindungen, verfahren zu ihren herstellung und ihre anwendung als antitumor mittel |
-
2005
- 2005-08-09 JP JP2007526351A patent/JP4927733B2/ja not_active Expired - Fee Related
- 2005-08-09 CA CA002576599A patent/CA2576599A1/en not_active Abandoned
- 2005-08-09 BR BRPI0514515-5A patent/BRPI0514515A/pt not_active IP Right Cessation
- 2005-08-09 KR KR1020077004075A patent/KR100889721B1/ko not_active Expired - Fee Related
- 2005-08-09 KR KR1020087032084A patent/KR20090006885A/ko not_active Ceased
- 2005-08-09 PL PL05771890T patent/PL1781649T3/pl unknown
- 2005-08-09 AU AU2005274390A patent/AU2005274390B2/en not_active Ceased
- 2005-08-09 ES ES05771890T patent/ES2313389T3/es not_active Expired - Lifetime
- 2005-08-09 EP EP05771890A patent/EP1781649B1/en not_active Expired - Lifetime
- 2005-08-09 DE DE602005008986T patent/DE602005008986D1/de not_active Expired - Lifetime
- 2005-08-09 RU RU2007109651/04A patent/RU2383542C2/ru not_active IP Right Cessation
- 2005-08-09 AT AT05771890T patent/ATE404556T1/de active
- 2005-08-09 MX MX2007001846A patent/MX2007001846A/es active IP Right Grant
- 2005-08-09 WO PCT/EP2005/008633 patent/WO2006018188A2/en not_active Ceased
- 2005-08-11 US US11/202,299 patent/US7427635B2/en not_active Expired - Fee Related
- 2005-08-15 TW TW094127672A patent/TW200621764A/zh unknown
- 2005-08-16 AR ARP050103440A patent/AR050297A1/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| WO2001083478A2 (en) * | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Hydantoin-containing glucokinase activators |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090006885A (ko) | 2009-01-15 |
| WO2006018188A2 (en) | 2006-02-23 |
| ATE404556T1 (de) | 2008-08-15 |
| JP4927733B2 (ja) | 2012-05-09 |
| EP1781649A2 (en) | 2007-05-09 |
| DE602005008986D1 (de) | 2008-09-25 |
| WO2006018188A3 (en) | 2006-05-18 |
| AU2005274390B2 (en) | 2012-01-19 |
| JP2008509950A (ja) | 2008-04-03 |
| US7427635B2 (en) | 2008-09-23 |
| EP1781649B1 (en) | 2008-08-13 |
| MX2007001846A (es) | 2007-03-28 |
| KR100889721B1 (ko) | 2009-03-23 |
| AR050297A1 (es) | 2006-10-11 |
| US20060041146A1 (en) | 2006-02-23 |
| BRPI0514515A (pt) | 2008-06-10 |
| CA2576599A1 (en) | 2006-02-23 |
| RU2007109651A (ru) | 2008-09-27 |
| PL1781649T3 (pl) | 2009-01-30 |
| TW200621764A (en) | 2006-07-01 |
| ES2313389T3 (es) | 2009-03-01 |
| AU2005274390A1 (en) | 2006-02-23 |
| KR20070034635A (ko) | 2007-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20130810 |