JP4927733B2 - 置換ヒダントイン - Google Patents

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Publication number

JP4927733B2

JP4927733B2 JP2007526351A JP2007526351A JP4927733B2 JP 4927733 B2 JP4927733 B2 JP 4927733B2 JP 2007526351 A JP2007526351 A JP 2007526351A JP 2007526351 A JP2007526351 A JP 2007526351A JP 4927733 B2 JP4927733 B2 JP 4927733B2

Authority

JP

Japan

Prior art keywords

phenyl

dioxo

imidazolidin

thiazol

butyramide

Prior art date

2004-08-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 229940091173 hydantoin Drugs 0.000 title description 3
• 150000001469 hydantoins Chemical class 0.000 title description 3
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 270
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 148
• 150000001875 compounds Chemical class 0.000 claims description 124
• 239000000203 mixture Substances 0.000 claims description 100
• -1 2,3-dihydro-benzo [1,4] dioxin-6-yl Chemical group 0.000 claims description 96
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 74
• 125000000217 alkyl group Chemical group 0.000 claims description 58
• 239000002904 solvent Substances 0.000 claims description 29
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 24
• 125000001424 substituent group Chemical group 0.000 claims description 21
• 125000003545 alkoxy group Chemical group 0.000 claims description 19
• 239000001257 hydrogen Substances 0.000 claims description 18
• 229910052739 hydrogen Inorganic materials 0.000 claims description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 15
• 125000003118 aryl group Chemical group 0.000 claims description 15
• 125000001072 heteroaryl group Chemical group 0.000 claims description 14
• 150000003839 salts Chemical class 0.000 claims description 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
• 125000000623 heterocyclic group Chemical group 0.000 claims description 12
• HCUYBXPSSCRKRF-UHFFFAOYSA-N diphosgene Chemical compound ClC(=O)OC(Cl)(Cl)Cl HCUYBXPSSCRKRF-UHFFFAOYSA-N 0.000 claims description 9
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
• 125000005415 substituted alkoxy group Chemical group 0.000 claims description 9
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 8
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 8
• 125000003386 piperidinyl group Chemical group 0.000 claims description 8
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 8
• 229910052736 halogen Inorganic materials 0.000 claims description 7
• 150000002367 halogens Chemical class 0.000 claims description 7
• 230000003287 optical effect Effects 0.000 claims description 6
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 6
• VKJCLKODXRCZBO-DLPLYFIVSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)N1 VKJCLKODXRCZBO-DLPLYFIVSA-N 0.000 claims description 5
• UMXZLBLGVVFRBS-AJHZIAPWSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-[2-(2-methoxyethylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCC(=O)NCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)N1 UMXZLBLGVVFRBS-AJHZIAPWSA-N 0.000 claims description 5
• BNBBUNOMDOUOGX-IMRHEYAYSA-N (2s,3s)-n-(4-ethylsulfanyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound CCSC1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 BNBBUNOMDOUOGX-IMRHEYAYSA-N 0.000 claims description 5
• UOTMFRIADITBII-IPAURDGOSA-N (2s,3s)-n-(4-ethylsulfinyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound CCS(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 UOTMFRIADITBII-IPAURDGOSA-N 0.000 claims description 5
• RKKBPPTYPGTSEA-FNVCAUGXSA-N RO4927350 Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCO)=CC=2)=O)=N1 RKKBPPTYPGTSEA-FNVCAUGXSA-N 0.000 claims description 5
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 5
• LFKDJXLFVYVEFG-UHFFFAOYSA-N tert-butyl carbamate Chemical group CC(C)(C)OC(N)=O LFKDJXLFVYVEFG-UHFFFAOYSA-N 0.000 claims description 5
• ZVJVPWWPRFINEV-IPVSCWGHSA-N (2s,3s)-2-[(4r)-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dioxoimidazolidin-1-yl]-n-[4-(1-hydroxypropyl)-1,3-thiazol-2-yl]-3-phenylbutanamide Chemical compound CCC(O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=C3OCCOC3=CC=2)=O)=N1 ZVJVPWWPRFINEV-IPVSCWGHSA-N 0.000 claims description 4
• IMAFKJGJDAVAAF-ARBPTSGCSA-N (2s,3s)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OC)=CC=2)=O)=N1 IMAFKJGJDAVAAF-ARBPTSGCSA-N 0.000 claims description 4
• RJZPPHJGWOCMBW-MUEKUWCCSA-N (2s,3s)-2-[(4r)-4-[4-(2-ethoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound C1=CC(OCCOCC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)CC)C(=O)N1 RJZPPHJGWOCMBW-MUEKUWCCSA-N 0.000 claims description 4
• WQDCOBMQXXDLQY-GHSRMECKSA-N (2s,3s)-2-[2,5-dioxo-4-[4-(2-piperidin-1-ylethoxy)phenyl]imidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C(C(NC2=O)C=2C=CC(OCCN3CCCCC3)=CC=2)=O)=N1 WQDCOBMQXXDLQY-GHSRMECKSA-N 0.000 claims description 4
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 4
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
• PPMXETHXODZNIC-WOJBJXKFSA-N methyl 2-[[(2s)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-methyl-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@@H](N2C([C@H](NC2=O)C=2C=CC(OC)=CC=2)=O)C(C)(C)C=2C=CC=CC=2)=N1 PPMXETHXODZNIC-WOJBJXKFSA-N 0.000 claims description 4
• CUQZQHVLJVTAOI-DLPLYFIVSA-N methyl 2-[[(2s,3s)-2-[(4r)-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=C3OCCOC3=CC=2)=O)=N1 CUQZQHVLJVTAOI-DLPLYFIVSA-N 0.000 claims description 4
• CLCDQYYRHRVFEF-VZDHWGDASA-N n-[4-(2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OC)=CC=C1[C@@H]1C(=O)N(C(C(C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)(C)O)C(=O)N1 CLCDQYYRHRVFEF-VZDHWGDASA-N 0.000 claims description 4
• GKDVIQCISXZIDJ-XYHYBEPMSA-N (2s,3r)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylmethoxy-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)OCC=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 GKDVIQCISXZIDJ-XYHYBEPMSA-N 0.000 claims description 3
• UWIMTNBKRFQIBP-PIVNMMCNSA-N (2s,3s)-2-[(4r)-2,5-dioxo-4-[4-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]imidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)N3CCCC3)=CC=2)=O)=N1 UWIMTNBKRFQIBP-PIVNMMCNSA-N 0.000 claims description 3
• FAOHSPUFQXWJSD-RVHYNSKXSA-N (2s,3s)-2-[(4r)-2,5-dioxo-4-phenylimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC=CC=2)=O)=N1 FAOHSPUFQXWJSD-RVHYNSKXSA-N 0.000 claims description 3
• HAZKEOXELTWJOJ-FNVCAUGXSA-N (2s,3s)-2-[(4r)-4-(4-ethoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound C1=CC(OCC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)CC)C(=O)N1 HAZKEOXELTWJOJ-FNVCAUGXSA-N 0.000 claims description 3
• RTIYENHYKKZGAW-DLPLYFIVSA-N (2s,3s)-2-[(4r)-4-(4-hydroxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(O)=CC=2)=O)=N1 RTIYENHYKKZGAW-DLPLYFIVSA-N 0.000 claims description 3
• LJFHMSZDUOLYML-FNVCAUGXSA-N (2s,3s)-2-[(4r)-4-(4-methoxy-3-methylphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=C(C)C(OC)=CC=2)=O)=N1 LJFHMSZDUOLYML-FNVCAUGXSA-N 0.000 claims description 3
• BJJARBIKZKHELT-USCONSEESA-N (2s,3s)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-n-[4-(2-methylpropanoyl)-1,3-thiazol-2-yl]-3-phenylbutanamide Chemical compound C1=CC(OC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)C(C)C)C(=O)N1 BJJARBIKZKHELT-USCONSEESA-N 0.000 claims description 3
• BGIUACCETCLDJH-VWMXVWASSA-N (2s,3s)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 BGIUACCETCLDJH-VWMXVWASSA-N 0.000 claims description 3
• FEBIHWITJUHRRD-PIVNMMCNSA-N (2s,3s)-2-[(4r)-4-[4-(2-morpholin-4-yl-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)N3CCOCC3)=CC=2)=O)=N1 FEBIHWITJUHRRD-PIVNMMCNSA-N 0.000 claims description 3
• AMPKJLPGYRHJKY-YZYNAAERSA-N (2s,3s)-2-[(4r)-4-[4-[2-(2-methoxyethoxy)ethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOCCOC)=CC=2)=O)=N1 AMPKJLPGYRHJKY-YZYNAAERSA-N 0.000 claims description 3
• IAUOMVZXRVQRFV-IMDCKVJKSA-N (2s,3s)-2-[(4r)-4-[4-[2-(2-methoxyethylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)NCCOC)=CC=2)=O)=N1 IAUOMVZXRVQRFV-IMDCKVJKSA-N 0.000 claims description 3
• VDVGIQBCLJZKGN-IMDCKVJKSA-N (2s,3s)-2-[(4r)-4-[4-[2-(azetidin-1-yl)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)N3CCC3)=CC=2)=O)=N1 VDVGIQBCLJZKGN-IMDCKVJKSA-N 0.000 claims description 3
• CAMWINXAXRFDEZ-AJHZIAPWSA-N (2s,3s)-2-[(4r)-4-[4-[2-(dimethylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)N(C)C)=CC=2)=O)=N1 CAMWINXAXRFDEZ-AJHZIAPWSA-N 0.000 claims description 3
• MZUVQFITLDJWGN-GHEQTVGYSA-N (2s,3s)-2-[(4r)-4-[4-[2-(methylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)NC)=CC=2)=O)=N1 MZUVQFITLDJWGN-GHEQTVGYSA-N 0.000 claims description 3
• RKKBPPTYPGTSEA-GMWOSMDTSA-N (2s,3s)-2-[(4s)-4-[4-(2-hydroxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@@H](NC2=O)C=2C=CC(OCCO)=CC=2)=O)=N1 RKKBPPTYPGTSEA-GMWOSMDTSA-N 0.000 claims description 3
• BGIUACCETCLDJH-DPSWKAHMSA-N (2s,3s)-2-[(4s)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 BGIUACCETCLDJH-DPSWKAHMSA-N 0.000 claims description 3
• OEJOYGTVAKZGIC-VNYPPZAHSA-N (2s,3s)-2-[4-(4-morpholin-4-ylphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C(C(NC2=O)C=2C=CC(=CC=2)N2CCOCC2)=O)=N1 OEJOYGTVAKZGIC-VNYPPZAHSA-N 0.000 claims description 3
• XLUICOHNWYWEFQ-JUJMCKSGSA-N (2s,3s)-2-[4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-methyl-n-(4-propanoyl-1,3-thiazol-2-yl)pentanamide Chemical compound O=C1N([C@@H]([C@@H](C)CC)C(=O)NC=2SC=C(N=2)C(=O)CC)C(=O)NC1C1=CC=C(OCCOC)C=C1 XLUICOHNWYWEFQ-JUJMCKSGSA-N 0.000 claims description 3
• VKWWTAMMAHEBEQ-AXFKQKATSA-N (2s,3s)-2-[4-[4-(2-morpholin-4-ylethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C(C(NC2=O)C=2C=CC(OCCN3CCOCC3)=CC=2)=O)=N1 VKWWTAMMAHEBEQ-AXFKQKATSA-N 0.000 claims description 3
• NYPKIANNZDNFPU-XLXODUMSSA-N (2s,3s)-2-[4-[4-(4-hydroxypiperidin-1-yl)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C(C(NC2=O)C=2C=CC(=CC=2)N2CCC(O)CC2)=O)=N1 NYPKIANNZDNFPU-XLXODUMSSA-N 0.000 claims description 3
• PZDHZYLTWQSYHM-VNYPPZAHSA-N (2s,3s)-2-[4-[4-[2-methoxyethyl(methyl)amino]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C(C(NC2=O)C=2C=CC(=CC=2)N(C)CCOC)=O)=N1 PZDHZYLTWQSYHM-VNYPPZAHSA-N 0.000 claims description 3
• VAAZPRCSKQZJQC-GHEQTVGYSA-N (2s,3s)-3-(3-fluorophenyl)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=C(F)C=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 VAAZPRCSKQZJQC-GHEQTVGYSA-N 0.000 claims description 3
• CWBSOUADJQDOSQ-SVIJTADQSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-(4-hydroxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)=CC=C(O)C=C1 CWBSOUADJQDOSQ-SVIJTADQSA-N 0.000 claims description 3
• AYTSWSRJBHEGRA-CUJSYCCXSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-(2-amino-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)=CC=C(OCC(N)=O)C=C1 AYTSWSRJBHEGRA-CUJSYCCXSA-N 0.000 claims description 3
• NTHXESUFIMQJEQ-IMDCKVJKSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-(2-morpholin-4-yl-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)=CC=C1OCC(=O)N1CCOCC1 NTHXESUFIMQJEQ-IMDCKVJKSA-N 0.000 claims description 3
• IVEOUGNWZPSZFV-MUEKUWCCSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-[2-(2-methoxyethoxy)ethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCCOCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)N1 IVEOUGNWZPSZFV-MUEKUWCCSA-N 0.000 claims description 3
• PWLYBDLYHRZXGA-GHEQTVGYSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-[2-(dimethylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)=CC=C(OCC(=O)N(C)C)C=C1 PWLYBDLYHRZXGA-GHEQTVGYSA-N 0.000 claims description 3
• COENBVRHWRZWRY-BJQRDSPESA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-[2-(methylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCC(=O)NC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)N1 COENBVRHWRZWRY-BJQRDSPESA-N 0.000 claims description 3
• BRTXZYZIRRXRIJ-QEKIYOMCSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[4-[4-(dimethylamino)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound O=C1N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)NC1C1=CC=C(N(C)C)C=C1 BRTXZYZIRRXRIJ-QEKIYOMCSA-N 0.000 claims description 3
• BGAGIUFVXNPXBW-IMRHEYAYSA-N (2s,3s)-n-(4-ethylsulfonyl-1,3-thiazol-2-yl)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound CCS(=O)(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCOC)=CC=2)=O)=N1 BGAGIUFVXNPXBW-IMRHEYAYSA-N 0.000 claims description 3
• CSXJWCCKICAWRW-FNVCAUGXSA-N (2s,3s)-n-[4-(2-hydroxyacetyl)-1,3-thiazol-2-yl]-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)CO)C(=O)N1 CSXJWCCKICAWRW-FNVCAUGXSA-N 0.000 claims description 3
• FYAINSINUCXREV-VWMXVWASSA-N (2s,3s)-n-[4-(cyclopropanecarbonyl)-1,3-thiazol-2-yl]-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)C2CC2)C(=O)N1 FYAINSINUCXREV-VWMXVWASSA-N 0.000 claims description 3
• WZYXLAVDBCMKRS-GHEQTVGYSA-N (2s,3s)-n-[4-(cyclopropanecarbonyl)-1,3-thiazol-2-yl]-2-[(4r)-4-[4-[2-(methylamino)-2-oxoethoxy]phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCC(=O)NC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)C2CC2)C(=O)N1 WZYXLAVDBCMKRS-GHEQTVGYSA-N 0.000 claims description 3
• XFQXSMXNNQHINY-OPILKIMUSA-N 2-[4-[2,5-dioxo-1-[(2s,3s)-1-oxo-3-phenyl-1-[(4-propanoyl-1,3-thiazol-2-yl)amino]butan-2-yl]imidazolidin-4-yl]phenoxy]acetic acid Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C(C(NC2=O)C=2C=CC(OCC(O)=O)=CC=2)=O)=N1 XFQXSMXNNQHINY-OPILKIMUSA-N 0.000 claims description 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• YDQDLFQOHXRYFT-GHEQTVGYSA-N methyl 2-[4-[(4r)-2,5-dioxo-1-[(2s,3s)-1-oxo-3-phenyl-1-[(4-propanoyl-1,3-thiazol-2-yl)amino]butan-2-yl]imidazolidin-4-yl]phenoxy]acetate Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCC(=O)OC)=CC=2)=O)=N1 YDQDLFQOHXRYFT-GHEQTVGYSA-N 0.000 claims description 3
• RQRLHETVEAMLLF-LYRGGWFBSA-N methyl 2-[[(2s,3r)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-methylpentanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@H](C)CC)C(=O)NC=2SC=C(N=2)C(=O)OC)=CC=C(OC)C=C1 RQRLHETVEAMLLF-LYRGGWFBSA-N 0.000 claims description 3
• YUHMIVPGCKUVSN-ZMYBRWDISA-N methyl 2-[[(2s,3r)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-[(2-methylpropan-2-yl)oxy]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)OC(C)(C)C)C(=O)NC=2SC=C(N=2)C(=O)OC)C(=O)N1 YUHMIVPGCKUVSN-ZMYBRWDISA-N 0.000 claims description 3
• WGDWYZSBVAQWQN-ZQMYSKGWSA-N methyl 2-[[(2s,3r)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylmethoxybutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)OCC=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)OC)C(=O)N1 WGDWYZSBVAQWQN-ZQMYSKGWSA-N 0.000 claims description 3
• HVAHSGWGDBJCHI-FZQKWOKYSA-N methyl 2-[[(2s,3r)-3-hydroxy-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)O)N2C([C@H](NC2=O)C=2C=CC(OC)=CC=2)=O)=N1 HVAHSGWGDBJCHI-FZQKWOKYSA-N 0.000 claims description 3
• JJUBLXHBGVUHGS-LYRGGWFBSA-N methyl 2-[[(2s,3r)-3-hydroxy-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)O)C(=O)NC=2SC=C(N=2)C(=O)OC)C(=O)N1 JJUBLXHBGVUHGS-LYRGGWFBSA-N 0.000 claims description 3
• CMPBBNZVDPTSJX-JLZZUVOBSA-N methyl 2-[[(2s,3r)-3-methoxy-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)OC)C(=O)NC=2SC=C(N=2)C(=O)OC)C(=O)N1 CMPBBNZVDPTSJX-JLZZUVOBSA-N 0.000 claims description 3
• PGXLBJUAUFKALR-USCONSEESA-N methyl 2-[[(2s,3s)-2-[(4r)-2,5-dioxo-4-(4-propan-2-yloxyphenyl)imidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OC(C)C)=CC=2)=O)=N1 PGXLBJUAUFKALR-USCONSEESA-N 0.000 claims description 3
• HWEQFBVEAVUCCM-DLPLYFIVSA-N methyl 2-[[(2s,3s)-2-[(4r)-4-(4-acetamidophenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(NC(C)=O)=CC=2)=O)=N1 HWEQFBVEAVUCCM-DLPLYFIVSA-N 0.000 claims description 3
• GUVRHNNNBJYKSK-BKTGTZMESA-N methyl 2-[[(2s,3s)-2-[(4r)-4-(4-hydroxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(O)=CC=2)=O)=N1 GUVRHNNNBJYKSK-BKTGTZMESA-N 0.000 claims description 3
• RQRLHETVEAMLLF-XZJROXQQSA-N methyl 2-[[(2s,3s)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-methylpentanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)NC=2SC=C(N=2)C(=O)OC)=CC=C(OC)C=C1 RQRLHETVEAMLLF-XZJROXQQSA-N 0.000 claims description 3
• RNQOXMDLWNHJTE-KPOBHBOGSA-N methyl 2-[[(2s,3s)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OC)=CC=2)=O)=N1 RNQOXMDLWNHJTE-KPOBHBOGSA-N 0.000 claims description 3
• NINQMMPLKCFPKC-RVHYNSKXSA-N methyl 2-[[(2s,3s)-2-[(4r)-4-[4-(2-hydroxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCCO)=CC=2)=O)=N1 NINQMMPLKCFPKC-RVHYNSKXSA-N 0.000 claims description 3
• UWQOCAVQZYAIFW-VHSSKADRSA-N methyl 2-[[(2s,3s)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-methylpentanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)CC)C(=O)NC=2SC=C(N=2)C(=O)OC)=CC=C(OCCOC)C=C1 UWQOCAVQZYAIFW-VHSSKADRSA-N 0.000 claims description 3
• GYOZDUDRHGPQBS-USCONSEESA-N methyl 2-[[(2s,3s)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)OC)C(=O)N1 GYOZDUDRHGPQBS-USCONSEESA-N 0.000 claims description 3
• FTSHKUAMSVGXLP-USCONSEESA-N methyl 2-[[(2s,3s)-2-[(4r)-4-[4-(dimethoxyphosphorylmethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCP(=O)(OC)OC)=CC=2)=O)=N1 FTSHKUAMSVGXLP-USCONSEESA-N 0.000 claims description 3
• BBUCEHDVMJNHMU-ARBPTSGCSA-N methyl 2-[[(2s,3s)-3-(4-fluorophenyl)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1=CC(OCCOC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC(F)=CC=2)C(=O)NC=2SC=C(N=2)C(=O)OC)C(=O)N1 BBUCEHDVMJNHMU-ARBPTSGCSA-N 0.000 claims description 3
• MYZYOAYFZLVXEM-BJQRDSPESA-N (2s,3s)-2-[(4r)-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=C3OCCOC3=CC=2)=O)=N1 MYZYOAYFZLVXEM-BJQRDSPESA-N 0.000 claims description 2
• RKSDGUHTDQMJOZ-VWMXVWASSA-N (2s,3s)-2-[(4r)-4-[4-(dimethoxyphosphorylmethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-n-(4-propanoyl-1,3-thiazol-2-yl)butanamide Chemical compound CCC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=CC(OCP(=O)(OC)OC)=CC=2)=O)=N1 RKSDGUHTDQMJOZ-VWMXVWASSA-N 0.000 claims description 2
• ZLLIAKYXUIPBIT-ARBPTSGCSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-(4-ethoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(OCC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)N1 ZLLIAKYXUIPBIT-ARBPTSGCSA-N 0.000 claims description 2
• KVKDDSXNZUDXOA-NNWRFLSQSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylpentanamide Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](CC)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)=CC=C(OC)C=C1 KVKDDSXNZUDXOA-NNWRFLSQSA-N 0.000 claims description 2
• TYDPBHFDHQJMBG-LZCUNHEZSA-N (2s,3s)-n-(4-acetyl-1,3-thiazol-2-yl)-2-[4-(4-diethoxyphosphorylphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanamide Chemical compound C1=CC(P(=O)(OCC)OCC)=CC=C1C1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(C)=O)C(=O)N1 TYDPBHFDHQJMBG-LZCUNHEZSA-N 0.000 claims description 2
• 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims description 2
• FPZWZCWUIYYYBU-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethyl acetate Chemical group CCOCCOCCOC(C)=O FPZWZCWUIYYYBU-UHFFFAOYSA-N 0.000 claims description 2
• YHFQRWKRHLCXJR-RVHYNSKXSA-N 2-[[(2s,3s)-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-n,n-dimethyl-1,3-thiazole-4-carboxamide Chemical compound C1=CC(OC)=CC=C1[C@@H]1C(=O)N([C@@H]([C@@H](C)C=2C=CC=CC=2)C(=O)NC=2SC=C(N=2)C(=O)N(C)C)C(=O)N1 YHFQRWKRHLCXJR-RVHYNSKXSA-N 0.000 claims description 2
• CUQZQHVLJVTAOI-IFZYUDKTSA-N methyl 2-[[(2s,3r)-2-[(4r)-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dioxoimidazolidin-1-yl]-3-phenylbutanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@H](C)C=2C=CC=CC=2)N2C([C@H](NC2=O)C=2C=C3OCCOC3=CC=2)=O)=N1 CUQZQHVLJVTAOI-IFZYUDKTSA-N 0.000 claims description 2
• UWQOCAVQZYAIFW-XWIAVFTESA-N methyl 2-[[(2s,3r)-2-[(4r)-4-[4-(2-methoxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-methylpentanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@H](C)CC)C(=O)NC=2SC=C(N=2)C(=O)OC)=CC=C(OCCOC)C=C1 UWQOCAVQZYAIFW-XWIAVFTESA-N 0.000 claims description 2
• JDIUNKBCVACKEH-KMUNFCNLSA-N methyl 2-[[(2s,3r)-3-methoxy-2-[(4r)-4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound C1([C@H]2NC(=O)N(C2=O)[C@@H]([C@@H](C)OC)C(=O)NC=2SC=C(N=2)C(=O)OC)=CC=C(OC)C=C1 JDIUNKBCVACKEH-KMUNFCNLSA-N 0.000 claims description 2
• AAEDIUPCKIHNOW-YZIZEKMBSA-N methyl 2-[[(2s,3s)-3-(2-methoxyphenyl)-2-[4-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]butanoyl]amino]-1,3-thiazole-4-carboxylate Chemical compound COC(=O)C1=CSC(NC(=O)[C@H]([C@@H](C)C=2C(=CC=CC=2)OC)N2C(C(NC2=O)C=2C=CC(OC)=CC=2)=O)=N1 AAEDIUPCKIHNOW-YZIZEKMBSA-N 0.000 claims description 2
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