RU2360701C2 - Усовершенствованные конъюгаты n4 хелатообразующих агентов - Google Patents

Усовершенствованные конъюгаты n4 хелатообразующих агентов Download PDF

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Publication number
RU2360701C2
RU2360701C2 RU2007101515/04A RU2007101515A RU2360701C2 RU 2360701 C2 RU2360701 C2 RU 2360701C2 RU 2007101515/04 A RU2007101515/04 A RU 2007101515/04A RU 2007101515 A RU2007101515 A RU 2007101515A RU 2360701 C2 RU2360701 C2 RU 2360701C2
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RU
Russia
Prior art keywords
technetium
acid
conjugate
compound
group
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RU2007101515/04A
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English (en)
Russian (ru)
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RU2007101515A (ru
Inventor
Энтони Эймонн СТОРИ (GB)
Энтони Эймонн СТОРИ
Гарри УОДСВОРТ (GB)
Гарри УОДСВОРТ
Найджел Энтони ПАУЭЛЛ (GB)
Найджел Энтони Пауэлл
Филип ДУНКАНСОН (GB)
Филип ДУНКАНСОН
Original Assignee
Джи-И Хелткер Лимитед
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Publication of RU2007101515A publication Critical patent/RU2007101515A/ru
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Publication of RU2360701C2 publication Critical patent/RU2360701C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2007101515/04A 2004-07-19 2005-07-19 Усовершенствованные конъюгаты n4 хелатообразующих агентов RU2360701C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0416062.8 2004-07-19
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates

Publications (2)

Publication Number Publication Date
RU2007101515A RU2007101515A (ru) 2008-08-27
RU2360701C2 true RU2360701C2 (ru) 2009-07-10

Family

ID=32893775

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007101515/04A RU2360701C2 (ru) 2004-07-19 2005-07-19 Усовершенствованные конъюгаты n4 хелатообразующих агентов

Country Status (14)

Country Link
US (1) US7767796B2 (https=)
EP (1) EP1768708B1 (https=)
JP (1) JP5557425B2 (https=)
KR (2) KR20070034064A (https=)
CN (1) CN101128219B (https=)
AU (1) AU2005263942B2 (https=)
BR (1) BRPI0513456A (https=)
CA (1) CA2573384C (https=)
ES (1) ES2628935T3 (https=)
GB (1) GB0416062D0 (https=)
MX (1) MX2007000744A (https=)
NO (1) NO20070348L (https=)
RU (1) RU2360701C2 (https=)
WO (1) WO2006008496A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей

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TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
US11844846B2 (en) 2018-05-16 2023-12-19 Emory University Styrylbenzothiazole derivatives and uses in imaging methods

Citations (5)

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US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
EP0296522B1 (en) * 1987-06-24 1996-09-25 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
RU2171117C2 (ru) * 1995-03-31 2001-07-27 Диатайд, Инк. Меченые радиоактивным изотопом пептиды для диагностики и терапии
EP1181936A1 (en) * 2000-05-25 2002-02-27 N.C.S.R. "DEMOKRITOS"-Institute of Radioisotopes & Radiodiagnostic Products Synthesis, biological and preclinical evaluation of (D-Phe6,Leu-NHEt13,des-Met14)bombesin(6-14) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m for application in oncology

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US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
CA2232411A1 (en) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. (radio) labelled biotin derivatives
GB0116815D0 (en) * 2001-07-10 2001-08-29 Nycomed Amersham Plc Improved chelator conjugates
BRPI0210886B8 (pt) * 2001-07-10 2021-05-25 Amersham Health As composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
WO2005044313A2 (en) * 2003-11-06 2005-05-19 Amersham Health As Conjugates of angiotensin ii and an imaging moiety
JP2007512321A (ja) * 2003-11-24 2007-05-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
ATE447417T1 (de) * 2004-03-04 2009-11-15 Ge Healthcare As Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
EP0296522B1 (en) * 1987-06-24 1996-09-25 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
RU2171117C2 (ru) * 1995-03-31 2001-07-27 Диатайд, Инк. Меченые радиоактивным изотопом пептиды для диагностики и терапии
EP1181936A1 (en) * 2000-05-25 2002-02-27 N.C.S.R. "DEMOKRITOS"-Institute of Radioisotopes & Radiodiagnostic Products Synthesis, biological and preclinical evaluation of (D-Phe6,Leu-NHEt13,des-Met14)bombesin(6-14) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m for application in oncology

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THEODOSIA MAINA ET ALL, European Journal of Nuclear Medicine, 2002, Vol.29, №6, 742-753. A.HEPPELER ET ALL, Current medicinal chemistry, 2000, 7, 971-994. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей

Also Published As

Publication number Publication date
JP5557425B2 (ja) 2014-07-23
AU2005263942A1 (en) 2006-01-26
WO2006008496A2 (en) 2006-01-26
EP1768708A2 (en) 2007-04-04
CN101128219A (zh) 2008-02-20
CA2573384A1 (en) 2006-01-26
CN101128219B (zh) 2012-06-20
US7767796B2 (en) 2010-08-03
BRPI0513456A (pt) 2008-05-06
EP1768708B1 (en) 2017-05-17
ES2628935T3 (es) 2017-08-04
CA2573384C (en) 2013-09-10
KR20130024963A (ko) 2013-03-08
WO2006008496A3 (en) 2006-07-27
RU2007101515A (ru) 2008-08-27
JP2008510683A (ja) 2008-04-10
AU2005263942B2 (en) 2009-02-26
KR20070034064A (ko) 2007-03-27
NO20070348L (no) 2007-02-16
MX2007000744A (es) 2007-06-25
GB0416062D0 (en) 2004-08-18
US20080131368A1 (en) 2008-06-05

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Effective date: 20140720