AU2005263942B2 - Improved N4 chelator conjugates - Google Patents

Improved N4 chelator conjugates Download PDF

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Publication number
AU2005263942B2
AU2005263942B2 AU2005263942A AU2005263942A AU2005263942B2 AU 2005263942 B2 AU2005263942 B2 AU 2005263942B2 AU 2005263942 A AU2005263942 A AU 2005263942A AU 2005263942 A AU2005263942 A AU 2005263942A AU 2005263942 B2 AU2005263942 B2 AU 2005263942B2
Authority
AU
Australia
Prior art keywords
technetium
compound
radiopharmaceutical
complex
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005263942A
Other languages
English (en)
Other versions
AU2005263942A1 (en
Inventor
Philip Duncanson
Nigel Anthony Powell
Anthony Eamonn Storey
Harry Wadsworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of AU2005263942A1 publication Critical patent/AU2005263942A1/en
Application granted granted Critical
Publication of AU2005263942B2 publication Critical patent/AU2005263942B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2005263942A 2004-07-19 2005-07-19 Improved N4 chelator conjugates Ceased AU2005263942B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0416062.8 2004-07-19
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates
PCT/GB2005/002807 WO2006008496A2 (en) 2004-07-19 2005-07-19 Improved n4 chelator conjugates

Publications (2)

Publication Number Publication Date
AU2005263942A1 AU2005263942A1 (en) 2006-01-26
AU2005263942B2 true AU2005263942B2 (en) 2009-02-26

Family

ID=32893775

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005263942A Ceased AU2005263942B2 (en) 2004-07-19 2005-07-19 Improved N4 chelator conjugates

Country Status (14)

Country Link
US (1) US7767796B2 (https=)
EP (1) EP1768708B1 (https=)
JP (1) JP5557425B2 (https=)
KR (2) KR20070034064A (https=)
CN (1) CN101128219B (https=)
AU (1) AU2005263942B2 (https=)
BR (1) BRPI0513456A (https=)
CA (1) CA2573384C (https=)
ES (1) ES2628935T3 (https=)
GB (1) GB0416062D0 (https=)
MX (1) MX2007000744A (https=)
NO (1) NO20070348L (https=)
RU (1) RU2360701C2 (https=)
WO (1) WO2006008496A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей
US11844846B2 (en) 2018-05-16 2023-12-19 Emory University Styrylbenzothiazole derivatives and uses in imaging methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296522A2 (en) * 1987-06-24 1988-12-28 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants

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US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
CA2232411A1 (en) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. (radio) labelled biotin derivatives
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
GB0116815D0 (en) * 2001-07-10 2001-08-29 Nycomed Amersham Plc Improved chelator conjugates
BRPI0210886B8 (pt) * 2001-07-10 2021-05-25 Amersham Health As composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
WO2005044313A2 (en) * 2003-11-06 2005-05-19 Amersham Health As Conjugates of angiotensin ii and an imaging moiety
JP2007512321A (ja) * 2003-11-24 2007-05-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
ATE447417T1 (de) * 2004-03-04 2009-11-15 Ge Healthcare As Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296522A2 (en) * 1987-06-24 1988-12-28 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants

Also Published As

Publication number Publication date
JP5557425B2 (ja) 2014-07-23
AU2005263942A1 (en) 2006-01-26
WO2006008496A2 (en) 2006-01-26
EP1768708A2 (en) 2007-04-04
CN101128219A (zh) 2008-02-20
RU2360701C2 (ru) 2009-07-10
CA2573384A1 (en) 2006-01-26
CN101128219B (zh) 2012-06-20
US7767796B2 (en) 2010-08-03
BRPI0513456A (pt) 2008-05-06
EP1768708B1 (en) 2017-05-17
ES2628935T3 (es) 2017-08-04
CA2573384C (en) 2013-09-10
KR20130024963A (ko) 2013-03-08
WO2006008496A3 (en) 2006-07-27
RU2007101515A (ru) 2008-08-27
JP2008510683A (ja) 2008-04-10
KR20070034064A (ko) 2007-03-27
NO20070348L (no) 2007-02-16
MX2007000744A (es) 2007-06-25
GB0416062D0 (en) 2004-08-18
US20080131368A1 (en) 2008-06-05

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired