MX2007000744A - Conjugados quelantes de n4 mejorados. - Google Patents
Conjugados quelantes de n4 mejorados.Info
- Publication number
- MX2007000744A MX2007000744A MX2007000744A MX2007000744A MX2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A
- Authority
- MX
- Mexico
- Prior art keywords
- chelator
- amine
- radiopharmaceuticals
- functionalised
- chelators
- Prior art date
Links
- 239000002738 chelating agent Substances 0.000 title abstract 6
- 239000012217 radiopharmaceutical Substances 0.000 abstract 3
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 3
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 3
- KSSJBGNOJJETTC-UHFFFAOYSA-N COC1=C(C=CC=C1)N(C1=CC=2C3(C4=CC(=CC=C4C=2C=C1)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC(=CC=C1C=1C=CC(=CC=13)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)OC Chemical compound COC1=C(C=CC=C1)N(C1=CC=2C3(C4=CC(=CC=C4C=2C=C1)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC(=CC=C1C=1C=CC(=CC=13)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)OC KSSJBGNOJJETTC-UHFFFAOYSA-N 0.000 abstract 2
- 125000005647 linker group Chemical group 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000003495 technetium Chemical class 0.000 abstract 1
- 229910052713 technetium Inorganic materials 0.000 abstract 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0416062.8A GB0416062D0 (en) | 2004-07-19 | 2004-07-19 | Improved N4 chelator conjugates |
| PCT/GB2005/002807 WO2006008496A2 (en) | 2004-07-19 | 2005-07-19 | Improved n4 chelator conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007000744A true MX2007000744A (es) | 2007-06-25 |
Family
ID=32893775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007000744A MX2007000744A (es) | 2004-07-19 | 2005-07-19 | Conjugados quelantes de n4 mejorados. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7767796B2 (https=) |
| EP (1) | EP1768708B1 (https=) |
| JP (1) | JP5557425B2 (https=) |
| KR (2) | KR20130024963A (https=) |
| CN (1) | CN101128219B (https=) |
| AU (1) | AU2005263942B2 (https=) |
| BR (1) | BRPI0513456A (https=) |
| CA (1) | CA2573384C (https=) |
| ES (1) | ES2628935T3 (https=) |
| GB (1) | GB0416062D0 (https=) |
| MX (1) | MX2007000744A (https=) |
| NO (1) | NO20070348L (https=) |
| RU (1) | RU2360701C2 (https=) |
| WO (1) | WO2006008496A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI448284B (zh) * | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| CN101732736B (zh) * | 2009-12-02 | 2012-04-04 | 北京师范大学 | 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用 |
| GB0922014D0 (en) | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel integrin binders |
| GB201016206D0 (en) * | 2010-09-27 | 2010-11-10 | Ge Healthcare Ltd | Apoptosis imaging agents |
| RU2465011C1 (ru) * | 2011-04-27 | 2012-10-27 | Общество с ограниченной ответственностью "ИНТЕРА-МЕД" | Радиофармацевтический препарат для диагностики меланомы и ее метастазов |
| GB201110767D0 (en) | 2011-06-24 | 2011-08-10 | Ge Healthcare Ltd | Infection imaging |
| GB201600161D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope purification method |
| RU2655392C1 (ru) * | 2017-03-02 | 2018-05-28 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей |
| EP3793619A4 (en) | 2018-05-16 | 2022-01-12 | Emory University | Styrylbenzothiazole derivatives and uses in imaging |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0188256B1 (en) * | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5053493A (en) * | 1987-04-02 | 1991-10-01 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labeling antibodies with a metal ion |
| DE3850497T2 (de) * | 1987-04-02 | 1995-02-23 | Centocor Inc | Methode zur markierung von antikörpern mit einem metallion. |
| US4952393A (en) * | 1987-04-02 | 1990-08-28 | The General Hospital Corporation | Organ infarct imaging with technetium labelled glucarate |
| US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
| US5489425A (en) * | 1987-06-24 | 1996-02-06 | The Dow Chemical Company | Functionalized polyamine chelants |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| NZ250653A (en) * | 1993-01-12 | 1995-12-21 | Sandoz Ltd | Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions |
| US5650134A (en) * | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
| CA2232411A1 (en) * | 1995-09-18 | 1997-03-27 | Mallinckrodt Medical, Inc. | (radio) labelled biotin derivatives |
| GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
| WO2003006491A2 (en) * | 2001-07-10 | 2003-01-23 | Amersham Health As | Peptide-based compounds for targeting intergin receptors |
| GB0116815D0 (en) * | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
| GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| EP1699495A2 (en) * | 2003-11-06 | 2006-09-13 | Amersham Health AS | Conjugates of angiotensin ii and an imaging moiety |
| JP2007512321A (ja) * | 2003-11-24 | 2007-05-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| JP2007526300A (ja) * | 2004-03-04 | 2007-09-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 医薬化合物 |
-
2004
- 2004-07-19 GB GBGB0416062.8A patent/GB0416062D0/en not_active Ceased
-
2005
- 2005-07-19 ES ES05763654.0T patent/ES2628935T3/es not_active Expired - Lifetime
- 2005-07-19 MX MX2007000744A patent/MX2007000744A/es active IP Right Grant
- 2005-07-19 EP EP05763654.0A patent/EP1768708B1/en not_active Expired - Lifetime
- 2005-07-19 BR BRPI0513456-0A patent/BRPI0513456A/pt not_active IP Right Cessation
- 2005-07-19 JP JP2007522011A patent/JP5557425B2/ja not_active Expired - Lifetime
- 2005-07-19 KR KR1020137002190A patent/KR20130024963A/ko not_active Ceased
- 2005-07-19 KR KR1020077001298A patent/KR20070034064A/ko not_active Ceased
- 2005-07-19 CA CA2573384A patent/CA2573384C/en not_active Expired - Fee Related
- 2005-07-19 RU RU2007101515/04A patent/RU2360701C2/ru not_active IP Right Cessation
- 2005-07-19 WO PCT/GB2005/002807 patent/WO2006008496A2/en not_active Ceased
- 2005-07-19 AU AU2005263942A patent/AU2005263942B2/en not_active Ceased
- 2005-07-19 US US11/572,161 patent/US7767796B2/en not_active Expired - Lifetime
- 2005-07-19 CN CN2005800297360A patent/CN101128219B/zh not_active Expired - Lifetime
-
2007
- 2007-01-18 NO NO20070348A patent/NO20070348L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101128219B (zh) | 2012-06-20 |
| EP1768708B1 (en) | 2017-05-17 |
| BRPI0513456A (pt) | 2008-05-06 |
| KR20070034064A (ko) | 2007-03-27 |
| JP5557425B2 (ja) | 2014-07-23 |
| KR20130024963A (ko) | 2013-03-08 |
| US7767796B2 (en) | 2010-08-03 |
| CA2573384A1 (en) | 2006-01-26 |
| AU2005263942A1 (en) | 2006-01-26 |
| ES2628935T3 (es) | 2017-08-04 |
| CN101128219A (zh) | 2008-02-20 |
| NO20070348L (no) | 2007-02-16 |
| RU2360701C2 (ru) | 2009-07-10 |
| JP2008510683A (ja) | 2008-04-10 |
| WO2006008496A3 (en) | 2006-07-27 |
| GB0416062D0 (en) | 2004-08-18 |
| US20080131368A1 (en) | 2008-06-05 |
| RU2007101515A (ru) | 2008-08-27 |
| EP1768708A2 (en) | 2007-04-04 |
| WO2006008496A2 (en) | 2006-01-26 |
| CA2573384C (en) | 2013-09-10 |
| AU2005263942B2 (en) | 2009-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20070348L (no) | Improved N4 Chelator Conjugates | |
| AU629178B2 (en) | Tri-aza macrocycles and metal complexes thereof | |
| MX2023006274A (es) | Agentes de imagenes de diagnostico del cancer. | |
| EP4424378A3 (en) | Dual mode radiotracer and -therapeutics | |
| WO2007064345A3 (en) | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | |
| IL181529A0 (en) | Diagnostic compounds | |
| US20170166591A1 (en) | Therapeutic agent for treating tumors | |
| NZ597136A (en) | Novel conjugates, preparation thereof, and therapeutic use thereof | |
| MX2021013055A (es) | Inhibidores de antigenos de membrana especificos de prostata (psma) como agentes diagnosticos y terapeuticos con radionuclidos. | |
| Pirmettis et al. | Synthesis and characterization of oxotechnetium (V) mixed-ligand complexes containing a tridentate N-substituted bis (2-mercaptoethyl) amine and a monodentate thiol | |
| Van Staveren et al. | S‐Functionalized Cysteine: Powerful Ligands for the Labelling of Bioactive Molecules with Triaquatricarbonyltechnetium‐99m (1+)([99mTc (OH2) 3 (CO) 3]+) | |
| WO2007106544A3 (en) | Chelating conjugates having a substituted aromatic moiety and derivatives thereof | |
| Gillet et al. | A bispidol chelator with a phosphonate pendant arm: synthesis, Cu (II) complexation, and 64Cu labeling | |
| GB0116815D0 (en) | Improved chelator conjugates | |
| ES2962520T3 (es) | Agentes quelantes bifuncionales | |
| Hayes et al. | Influence of functionalized pyridine ligands on the radio/chemical behavior of [MI (CO) 3]+(M= Re and 99mTc) 2+ 1 complexes | |
| Abhayawardhana et al. | Complexes possessing rare “tertiary” sulfonamide nitrogen-to-metal bonds of normal length: fac-[Re (CO) 3 (N (SO2R) dien)] PF6 complexes with hydrophilic sulfonamide ligands | |
| NO20051811L (no) | Conjugates of TC complexes and targeting moiettes and their use in mri diagnostic | |
| Hayes et al. | Photo-initiated thiol-ene click reactions as a potential strategy for incorporation of [MI (CO) 3]+(M= Re, 99mTc) complexes | |
| CA2381123A1 (en) | Actinium-225 complexes and conjugates for radioimmunotherapy | |
| JP5152821B2 (ja) | 放射線治療用化学毒性剤としての金属トリカルボニル錯体の使用 | |
| Mishra et al. | Synthesis of novel bifunctional Schiff-base ligands derived from condensation of 1-(p-nitrobenzyl) ethylenediamine and 2-(p-nitrobenzyl)-3-monooxo-1, 4, 7-triazaheptane with salicylaldehyde | |
| Ansari et al. | Synthesis of 2-(p-aminobenzyl) derivatives of 1, 4, 7-triazacyclononane-N, N′, N ″-triacetic acid (NOTA) and 1, 4, 7, 10-tetraazacyclododecane-N, N′, N ″, N ″′-tetraacetic acid (DOTA): macrocyclic bifunctional chelating agents useful for antibodies labeling | |
| TW200722418A (en) | Novel compounds | |
| Wei et al. | Rhenium tricarbonyl core complexes with ligands derived from arylpiperazines. The structures of [Re (CO) 3 {NC5H4CH2N (H) CH2CH2–Fphenpip}] Br,[Re (CO) 3 {(NC5H4CH2) 2N (CH2) 3–CH3OphenpipH}] Br2 and [Re (CO) 3 {(CH3N2C3H2CH2)(O2CCH2) N (CH2) 3–CH3OphenpipH2}] BrCl |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |