BRPI0513456A - complexo de tecnécio, conjugado quelador, radiofármaco, kit para a preparação do radiofármaco, e, composto - Google Patents

complexo de tecnécio, conjugado quelador, radiofármaco, kit para a preparação do radiofármaco, e, composto

Info

Publication number
BRPI0513456A
BRPI0513456A BRPI0513456-0A BRPI0513456A BRPI0513456A BR PI0513456 A BRPI0513456 A BR PI0513456A BR PI0513456 A BRPI0513456 A BR PI0513456A BR PI0513456 A BRPI0513456 A BR PI0513456A
Authority
BR
Brazil
Prior art keywords
radiopharmaceutical
chelator
chelators
tetraamine
functionalized
Prior art date
Application number
BRPI0513456-0A
Other languages
English (en)
Inventor
Anthony Eamonn Storey
Harry Wadsworth
Nigel Anthony Powell
Philip Duncanson
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of BRPI0513456A publication Critical patent/BRPI0513456A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

COMPLEXO DE TECNéCIO, CONJUGADO QUELADOR, RADIOFáRMACO, KIT PARA A PREPARAçãO DO RADIOFáRMACO, E, COMPOSTO A presente invenção fornece conjugados queladores de tetra-amina com porções alvejantes biológicas, ligadas por intermédio de um grupo de ligador e seus complexos de tecnécio como radiofármacos. O grupo ligador é tal que o quelador é mono-funcionalizado na posição de cabeça de ponte e fornece tanto flexibilidade quanto falta ou grupos arila, para minimizar a lipofilicidade e carga estérica. As versões protegidas dos queladores são fornecidas, permitindo a conjugação com uma ampla faixa de moléculas alvejantes sem interferir nas reações com os amino nitrogênios do quelador de tetra-amina. A síntese dos queladores funcionalizados é descrita, junto com precursores quelados bifuncionais. As composições radiofarmacêuticas que compreendem os complexos metálicos de tecnécio da invenção são descritos, junto com kits não radioativos para a preparação de tais radiofármacos.
BRPI0513456-0A 2004-07-19 2005-07-19 complexo de tecnécio, conjugado quelador, radiofármaco, kit para a preparação do radiofármaco, e, composto BRPI0513456A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates
PCT/GB2005/002807 WO2006008496A2 (en) 2004-07-19 2005-07-19 Improved n4 chelator conjugates

Publications (1)

Publication Number Publication Date
BRPI0513456A true BRPI0513456A (pt) 2008-05-06

Family

ID=32893775

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513456-0A BRPI0513456A (pt) 2004-07-19 2005-07-19 complexo de tecnécio, conjugado quelador, radiofármaco, kit para a preparação do radiofármaco, e, composto

Country Status (14)

Country Link
US (1) US7767796B2 (pt)
EP (1) EP1768708B1 (pt)
JP (1) JP5557425B2 (pt)
KR (2) KR20130024963A (pt)
CN (1) CN101128219B (pt)
AU (1) AU2005263942B2 (pt)
BR (1) BRPI0513456A (pt)
CA (1) CA2573384C (pt)
ES (1) ES2628935T3 (pt)
GB (1) GB0416062D0 (pt)
MX (1) MX2007000744A (pt)
NO (1) NO20070348L (pt)
RU (1) RU2360701C2 (pt)
WO (1) WO2006008496A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей
CN112105393A (zh) 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途

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ATE107862T1 (de) * 1987-04-02 1994-07-15 Centocor Inc Methode zur markierung von antikörpern mit einem metallion.
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Also Published As

Publication number Publication date
KR20130024963A (ko) 2013-03-08
EP1768708B1 (en) 2017-05-17
MX2007000744A (es) 2007-06-25
AU2005263942B2 (en) 2009-02-26
CN101128219A (zh) 2008-02-20
GB0416062D0 (en) 2004-08-18
AU2005263942A1 (en) 2006-01-26
ES2628935T3 (es) 2017-08-04
CA2573384A1 (en) 2006-01-26
CN101128219B (zh) 2012-06-20
RU2360701C2 (ru) 2009-07-10
WO2006008496A3 (en) 2006-07-27
RU2007101515A (ru) 2008-08-27
EP1768708A2 (en) 2007-04-04
US20080131368A1 (en) 2008-06-05
JP5557425B2 (ja) 2014-07-23
KR20070034064A (ko) 2007-03-27
CA2573384C (en) 2013-09-10
NO20070348L (no) 2007-02-16
US7767796B2 (en) 2010-08-03
JP2008510683A (ja) 2008-04-10
WO2006008496A2 (en) 2006-01-26

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2315 DE 19-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.