MX2007000744A - Conjugados quelantes de n4 mejorados. - Google Patents

Conjugados quelantes de n4 mejorados.

Info

Publication number
MX2007000744A
MX2007000744A MX2007000744A MX2007000744A MX2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A MX 2007000744 A MX2007000744 A MX 2007000744A
Authority
MX
Mexico
Prior art keywords
chelator
amine
radiopharmaceuticals
functionalised
chelators
Prior art date
Application number
MX2007000744A
Other languages
English (en)
Inventor
Anthony Eamonn Storey
Harry Wadsworth
Nigel Anthony Powell
Philip Duncanson
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2007000744A publication Critical patent/MX2007000744A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invencion proporciona conjugados quelantes de tetra amina con porciones biologicas dirigidas, enlazadas por medio de un grupo enlazante, y complejos de tecnecio de ellos como radiofarmacos. El grupo enlazante es tal que el quelante esta mono-funcionalizado en la posicion de cabeza del puente y proporciona tanto flexibilidad como ausencia de grupos arilo, para reducir al minimo la lipofilicidad y el volumen esterico. Se proporcionan versiones protegidas de los quelantes, que permiten la conjugacion con una amplia gama de moleculas dirigidas sin reacciones que interfieran con los nitrogenos de amina del quelante tetra-amina. Se describe la sintesis de los quelantes funcionalizados, junto con precursores de quelato bifuncionales. Se describen composiciones radiofarmaceuticas que contienen los complejos metalicos de tecnecio de la invencion junto con estuches no radiactivos para la preparacion de dichos radiofarmacos.
MX2007000744A 2004-07-19 2005-07-19 Conjugados quelantes de n4 mejorados. MX2007000744A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates
PCT/GB2005/002807 WO2006008496A2 (en) 2004-07-19 2005-07-19 Improved n4 chelator conjugates

Publications (1)

Publication Number Publication Date
MX2007000744A true MX2007000744A (es) 2007-06-25

Family

ID=32893775

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007000744A MX2007000744A (es) 2004-07-19 2005-07-19 Conjugados quelantes de n4 mejorados.

Country Status (14)

Country Link
US (1) US7767796B2 (es)
EP (1) EP1768708B1 (es)
JP (1) JP5557425B2 (es)
KR (2) KR20130024963A (es)
CN (1) CN101128219B (es)
AU (1) AU2005263942B2 (es)
BR (1) BRPI0513456A (es)
CA (1) CA2573384C (es)
ES (1) ES2628935T3 (es)
GB (1) GB0416062D0 (es)
MX (1) MX2007000744A (es)
NO (1) NO20070348L (es)
RU (1) RU2360701C2 (es)
WO (1) WO2006008496A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей
CN112105393A (zh) 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3680924D1 (de) * 1985-01-14 1991-09-26 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
ATE107862T1 (de) * 1987-04-02 1994-07-15 Centocor Inc Methode zur markierung von antikörpern mit einem metallion.
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
SK2094A3 (en) * 1993-01-12 1995-01-12 Sandoz Ag Somatostatine polypeptides, method of their preparing and using
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2232411A1 (en) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. (radio) labelled biotin derivatives
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
CA2452923C (en) 2001-07-10 2012-02-07 Amersham Health As Peptide-based compounds for targeting integrin receptors
GB0116815D0 (en) 2001-07-10 2001-08-29 Nycomed Amersham Plc Improved chelator conjugates
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
JP2007510643A (ja) * 2003-11-06 2007-04-26 ジーイー・ヘルスケア・アクスイェ・セルスカプ 医薬化合物
EP1699494A2 (en) * 2003-11-24 2006-09-13 GE Healthcare AS Contrast agent imaging angiotensin ii receptors
DE602005017475D1 (de) * 2004-03-04 2009-12-17 Ge Healthcare As Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie

Also Published As

Publication number Publication date
KR20130024963A (ko) 2013-03-08
EP1768708B1 (en) 2017-05-17
AU2005263942B2 (en) 2009-02-26
CN101128219A (zh) 2008-02-20
GB0416062D0 (en) 2004-08-18
AU2005263942A1 (en) 2006-01-26
ES2628935T3 (es) 2017-08-04
CA2573384A1 (en) 2006-01-26
CN101128219B (zh) 2012-06-20
RU2360701C2 (ru) 2009-07-10
WO2006008496A3 (en) 2006-07-27
RU2007101515A (ru) 2008-08-27
EP1768708A2 (en) 2007-04-04
US20080131368A1 (en) 2008-06-05
JP5557425B2 (ja) 2014-07-23
KR20070034064A (ko) 2007-03-27
CA2573384C (en) 2013-09-10
NO20070348L (no) 2007-02-16
US7767796B2 (en) 2010-08-03
JP2008510683A (ja) 2008-04-10
WO2006008496A2 (en) 2006-01-26
BRPI0513456A (pt) 2008-05-06

Similar Documents

Publication Publication Date Title
MX2007000744A (es) Conjugados quelantes de n4 mejorados.
AU629178B2 (en) Tri-aza macrocycles and metal complexes thereof
Alves et al. Pyrazolyl derivatives as bifunctional chelators for labeling tumor-seeking peptides with the fac-[M (CO) 3]+ moiety (M= 99mTc, Re): synthesis, characterization, and biological behavior
WO2007064345A3 (en) Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
Pirmettis et al. Synthesis and characterization of oxotechnetium (V) mixed-ligand complexes containing a tridentate N-substituted bis (2-mercaptoethyl) amine and a monodentate thiol
NO20051811L (no) Conjugates of TC complexes and targeting moiettes and their use in mri diagnostic
IL181529A0 (en) Diagnostic compounds
NZ597136A (en) Novel conjugates, preparation thereof, and therapeutic use thereof
US20170166591A1 (en) Therapeutic agent for treating tumors
ES2962520T3 (es) Agentes quelantes bifuncionales
MX340566B (es) Composiciones para formacion de imagen objetivo y terapia.
WO2007106544A3 (en) Chelating conjugates having a substituted aromatic moiety and derivatives thereof
TW200740781A (en) Novel compounds
HUP0401265A2 (hu) Javított kelátképző vegyületek
MX2023006274A (es) Agentes de imagenes de diagnostico del cancer.
Boss et al. Comparative studies of three pairs of α-and γ-conjugated folic acid derivatives labeled with fluorine-18
MX2021013055A (es) Inhibidores de antigenos de membrana especificos de prostata (psma) como agentes diagnosticos y terapeuticos con radionuclidos.
Desbouis et al. Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1
Hayes et al. Influence of functionalized pyridine ligands on the radio/chemical behavior of [MI (CO) 3]+(M= Re and 99mTc) 2+ 1 complexes
Chong et al. Novel bimodal bifunctional ligands for radioimmunotherapy and targeted MRI
Bottorff et al. PH-controlled coordination mode rearrangements of “Clickable” huisgen-based multidentate ligands with [MI (CO) 3]+(M= Re, 99mTc)
Bernhardt et al. C-substituted macrocycles as candidates for radioimmunotherapy
Abhayawardhana et al. Complexes possessing rare “tertiary” sulfonamide nitrogen-to-metal bonds of normal length: fac-[Re (CO) 3 (N (SO2R) dien)] PF6 complexes with hydrophilic sulfonamide ligands
Bhatt et al. Phosphonate pendant armed propylene cross-bridged cyclam: synthesis and evaluation as a chelator for Cu-64
TW200722418A (en) Novel compounds

Legal Events

Date Code Title Description
FG Grant or registration