CN101128219B - 改进的n4螯合剂缀合物 - Google Patents

改进的n4螯合剂缀合物 Download PDF

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Publication number
CN101128219B
CN101128219B CN2005800297360A CN200580029736A CN101128219B CN 101128219 B CN101128219 B CN 101128219B CN 2005800297360 A CN2005800297360 A CN 2005800297360A CN 200580029736 A CN200580029736 A CN 200580029736A CN 101128219 B CN101128219 B CN 101128219B
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CN
China
Prior art keywords
technetium
compound
group
chelator
technetium complex
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN2005800297360A
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English (en)
Chinese (zh)
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CN101128219A (zh
Inventor
A·E·斯托里
H·沃兹沃思
N·A·鲍威尔
P·邓坎森
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of CN101128219A publication Critical patent/CN101128219A/zh
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Publication of CN101128219B publication Critical patent/CN101128219B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2005800297360A 2004-07-19 2005-07-19 改进的n4螯合剂缀合物 Expired - Lifetime CN101128219B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0416062.8A GB0416062D0 (en) 2004-07-19 2004-07-19 Improved N4 chelator conjugates
GB0416062.8 2004-07-19
PCT/GB2005/002807 WO2006008496A2 (en) 2004-07-19 2005-07-19 Improved n4 chelator conjugates

Publications (2)

Publication Number Publication Date
CN101128219A CN101128219A (zh) 2008-02-20
CN101128219B true CN101128219B (zh) 2012-06-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800297360A Expired - Lifetime CN101128219B (zh) 2004-07-19 2005-07-19 改进的n4螯合剂缀合物

Country Status (14)

Country Link
US (1) US7767796B2 (https=)
EP (1) EP1768708B1 (https=)
JP (1) JP5557425B2 (https=)
KR (2) KR20130024963A (https=)
CN (1) CN101128219B (https=)
AU (1) AU2005263942B2 (https=)
BR (1) BRPI0513456A (https=)
CA (1) CA2573384C (https=)
ES (1) ES2628935T3 (https=)
GB (1) GB0416062D0 (https=)
MX (1) MX2007000744A (https=)
NO (1) NO20070348L (https=)
RU (1) RU2360701C2 (https=)
WO (1) WO2006008496A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101732736B (zh) * 2009-12-02 2012-04-04 北京师范大学 制备锝-99m标记的DTPA-LSA的药盒及制备方法和应用
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
GB201016206D0 (en) * 2010-09-27 2010-11-10 Ge Healthcare Ltd Apoptosis imaging agents
RU2465011C1 (ru) * 2011-04-27 2012-10-27 Общество с ограниченной ответственностью "ИНТЕРА-МЕД" Радиофармацевтический препарат для диагностики меланомы и ее метастазов
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
RU2655392C1 (ru) * 2017-03-02 2018-05-28 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ получения комплекса технеция-99м с октреотидом для диагностики нейроэндокринных опухолей
EP3793619A4 (en) 2018-05-16 2022-01-12 Emory University Styrylbenzothiazole derivatives and uses in imaging

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
EP0296522B1 (en) * 1987-06-24 1996-09-25 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
CN1527727A (zh) * 2001-07-10 2004-09-08 ��Ĭɳķ�������޹�˾ 改进的螯合剂共轭物
CN1622830A (zh) * 2001-07-10 2005-06-01 安盛药业有限公司 肽基化合物

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
EP0188256B1 (en) * 1985-01-14 1991-08-21 NeoRx Metal radionuclide labeled proteins for diagnosis and therapy
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
DE3850497T2 (de) * 1987-04-02 1995-02-23 Centocor Inc Methode zur markierung von antikörpern mit einem metallion.
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
NZ250653A (en) * 1993-01-12 1995-12-21 Sandoz Ltd Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2232411A1 (en) * 1995-09-18 1997-03-27 Mallinckrodt Medical, Inc. (radio) labelled biotin derivatives
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
GB0130305D0 (en) 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
EP1699495A2 (en) * 2003-11-06 2006-09-13 Amersham Health AS Conjugates of angiotensin ii and an imaging moiety
JP2007512321A (ja) * 2003-11-24 2007-05-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
JP2007526300A (ja) * 2004-03-04 2007-09-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 医薬化合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489425A (en) * 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
EP0296522B1 (en) * 1987-06-24 1996-09-25 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
CN1527727A (zh) * 2001-07-10 2004-09-08 ��Ĭɳķ�������޹�˾ 改进的螯合剂共轭物
CN1622830A (zh) * 2001-07-10 2005-06-01 安盛药业有限公司 肽基化合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEPPELER A ET AL.RECEPTOR TARGETING FOR TUMOR LOCALISATIONAND THERAPY WITH RADIOPETIDES.CURRENT MEDICINAL CHEMISTRY7 9.2000,7(9),971-978.
HEPPELER A ET AL.RECEPTOR TARGETING FOR TUMOR LOCALISATIONAND THERAPY WITH RADIOPETIDES.CURRENT MEDICINAL CHEMISTRY7 9.2000,7(9),971-978. *
MAINA THEODOSIA ET AL.[99mTc]Demotate, a new 99mTc-based[Tyr3]octreotateanalogue for the detection of somatostatin receptor-positivetumours: synthesis and preclinical results.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING29 6.2002,29(6),742-753. *
MAINATHEODOSIAETAL.[99mTc]Demotate a new 99mTc-based[Tyr3]octreotateanalogue for the detection of somatostatin receptor-positivetumours: synthesis and preclinical results.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING29 6.2002

Also Published As

Publication number Publication date
EP1768708B1 (en) 2017-05-17
BRPI0513456A (pt) 2008-05-06
KR20070034064A (ko) 2007-03-27
JP5557425B2 (ja) 2014-07-23
KR20130024963A (ko) 2013-03-08
US7767796B2 (en) 2010-08-03
CA2573384A1 (en) 2006-01-26
AU2005263942A1 (en) 2006-01-26
ES2628935T3 (es) 2017-08-04
CN101128219A (zh) 2008-02-20
NO20070348L (no) 2007-02-16
RU2360701C2 (ru) 2009-07-10
MX2007000744A (es) 2007-06-25
JP2008510683A (ja) 2008-04-10
WO2006008496A3 (en) 2006-07-27
GB0416062D0 (en) 2004-08-18
US20080131368A1 (en) 2008-06-05
RU2007101515A (ru) 2008-08-27
EP1768708A2 (en) 2007-04-04
WO2006008496A2 (en) 2006-01-26
CA2573384C (en) 2013-09-10
AU2005263942B2 (en) 2009-02-26

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Granted publication date: 20120620