RU2330844C2 - Способ получения монофторированных сложных бета-кетоэфиров пиридинила и пиримидинила - Google Patents
Способ получения монофторированных сложных бета-кетоэфиров пиридинила и пиримидинила Download PDFInfo
- Publication number
- RU2330844C2 RU2330844C2 RU2005131007/04A RU2005131007A RU2330844C2 RU 2330844 C2 RU2330844 C2 RU 2330844C2 RU 2005131007/04 A RU2005131007/04 A RU 2005131007/04A RU 2005131007 A RU2005131007 A RU 2005131007A RU 2330844 C2 RU2330844 C2 RU 2330844C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- carried out
- reaction
- ethyl
- oxo
- Prior art date
Links
- 0 COC(C(*)(C(*)=O)F)=O Chemical compound COC(C(*)(C(*)=O)F)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290568A EP1454900A1 (en) | 2003-03-07 | 2003-03-07 | Process for the preparation of pyridinyl and pyrimidinyl mono-fluorinated beta keto-esters |
| EP03290568.9 | 2003-03-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005131007A RU2005131007A (ru) | 2006-06-27 |
| RU2330844C2 true RU2330844C2 (ru) | 2008-08-10 |
Family
ID=32799102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005131007/04A RU2330844C2 (ru) | 2003-03-07 | 2004-03-05 | Способ получения монофторированных сложных бета-кетоэфиров пиридинила и пиримидинила |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7135569B2 (https=) |
| EP (2) | EP1454900A1 (https=) |
| JP (1) | JP4805809B2 (https=) |
| CN (1) | CN100398518C (https=) |
| AT (1) | ATE353877T1 (https=) |
| DE (1) | DE602004004767T2 (https=) |
| ES (1) | ES2281786T3 (https=) |
| RU (1) | RU2330844C2 (https=) |
| WO (1) | WO2004078725A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU556140A1 (ru) * | 1975-01-06 | 1977-04-30 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср | (1-Оксоинданил-2)-пиридины в качестве промежуточных продуктов дл синтеза биологически активных соединений с способ их получени |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6300511B1 (en) * | 1997-07-18 | 2001-10-09 | F2 Chemicals Limited | Catalyzed fluorination of carbonyl compounds |
| US6455728B1 (en) * | 1999-11-01 | 2002-09-24 | Air Products And Chemicals, Inc. | Direct fluorination process for preparing high purity 2-fluoro-1,3-dicarbonyl compounds using oxygen as a radical scavenger |
| EP1295885A1 (en) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives |
| AU2002350487C1 (en) * | 2001-09-21 | 2008-10-02 | Mitsubishi Pharma Corporation | Substituted 2-pyridinyl-6,7,8,9- tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives |
| EP1295884A1 (en) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives |
-
2003
- 2003-03-07 EP EP03290568A patent/EP1454900A1/en not_active Withdrawn
-
2004
- 2004-03-05 DE DE602004004767T patent/DE602004004767T2/de not_active Expired - Lifetime
- 2004-03-05 AT AT04717645T patent/ATE353877T1/de not_active IP Right Cessation
- 2004-03-05 RU RU2005131007/04A patent/RU2330844C2/ru not_active IP Right Cessation
- 2004-03-05 WO PCT/EP2004/003052 patent/WO2004078725A1/en not_active Ceased
- 2004-03-05 ES ES04717645T patent/ES2281786T3/es not_active Expired - Lifetime
- 2004-03-05 CN CNB200480009687XA patent/CN100398518C/zh not_active Expired - Fee Related
- 2004-03-05 JP JP2006504814A patent/JP4805809B2/ja not_active Expired - Fee Related
- 2004-03-05 EP EP04717645A patent/EP1603876B1/en not_active Expired - Lifetime
-
2005
- 2005-09-07 US US11/221,023 patent/US7135569B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU556140A1 (ru) * | 1975-01-06 | 1977-04-30 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср | (1-Оксоинданил-2)-пиридины в качестве промежуточных продуктов дл синтеза биологически активных соединений с способ их получени |
Non-Patent Citations (1)
| Title |
|---|
| Linderman, Russell J. et al. Oxidation of fluoroalkyl-substituted carbinols by the Dess-Martin reagent, Journal of Organic Chemistry, 1989, 54 (3), 661-668. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2281786T3 (es) | 2007-10-01 |
| JP2006519815A (ja) | 2006-08-31 |
| EP1454900A1 (en) | 2004-09-08 |
| DE602004004767D1 (de) | 2007-03-29 |
| US7135569B2 (en) | 2006-11-14 |
| EP1603876A1 (en) | 2005-12-14 |
| RU2005131007A (ru) | 2006-06-27 |
| CN1771229A (zh) | 2006-05-10 |
| EP1603876B1 (en) | 2007-02-14 |
| ATE353877T1 (de) | 2007-03-15 |
| CN100398518C (zh) | 2008-07-02 |
| JP4805809B2 (ja) | 2011-11-02 |
| US20060058526A1 (en) | 2006-03-16 |
| WO2004078725A1 (en) | 2004-09-16 |
| DE602004004767T2 (de) | 2007-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20180306 |