RU2301066C2 - Лечение желудочно-кишечных стромальных опухолей - Google Patents

Лечение желудочно-кишечных стромальных опухолей Download PDF

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Publication number
RU2301066C2
RU2301066C2 RU2003114752/15A RU2003114752A RU2301066C2 RU 2301066 C2 RU2301066 C2 RU 2301066C2 RU 2003114752/15 A RU2003114752/15 A RU 2003114752/15A RU 2003114752 A RU2003114752 A RU 2003114752A RU 2301066 C2 RU2301066 C2 RU 2301066C2
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RU
Russia
Prior art keywords
treatment
salt
methyl
benzamide
ylmethyl
Prior art date
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RU2003114752/15A
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English (en)
Russian (ru)
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RU2003114752A (ru
Inventor
Элизабет БУХДУНГЕР (DE)
Элизабет БУХДУНГЕР
Рено КАПДЕВИЛЛЬ (FR)
Рено КАПДЕВИЛЛЬ
Джордж Даниел ДЕМЕТРИ (US)
Джордж Даниел ДЕМЕТРИ
Саса ДИМИТРЬЕВИС (FR)
Саса ДИМИТРЬЕВИС
Брайан Дж. ДРУКЕР (US)
Брайан Дж. ДРУКЕР
Джонатан А. ФЛЕТЧЕР (US)
Джонатан А. ФЛЕТЧЕР
Хейкки ЙОЕНСУУ (FI)
Хейкки ЙОЕНСУУ
Сандра Лита СИЛБЕРМАН (US)
Сандра Лита СИЛБЕРМАН
Дейвид ТУВЕСОН (US)
Дейвид ТУВЕСОН
Майкл С. ХЕЙНРИЧ (US)
Майкл С. ХЕЙНРИЧ
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2003114752A publication Critical patent/RU2003114752A/ru
Application granted granted Critical
Publication of RU2301066C2 publication Critical patent/RU2301066C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
RU2003114752/15A 2000-10-27 2001-10-26 Лечение желудочно-кишечных стромальных опухолей RU2301066C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
US60/243,810 2000-10-27

Publications (2)

Publication Number Publication Date
RU2003114752A RU2003114752A (ru) 2004-09-10
RU2301066C2 true RU2301066C2 (ru) 2007-06-20

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003114752/15A RU2301066C2 (ru) 2000-10-27 2001-10-26 Лечение желудочно-кишечных стромальных опухолей

Country Status (25)

Country Link
US (1) US6958335B2 (https=)
EP (1) EP1332137B1 (https=)
JP (1) JP4386635B2 (https=)
KR (1) KR100885129B1 (https=)
CN (1) CN1276754C (https=)
AT (1) ATE321556T1 (https=)
AU (2) AU1826202A (https=)
BR (1) BRPI0114870B8 (https=)
CA (1) CA2424470C (https=)
CY (1) CY1105055T1 (https=)
CZ (1) CZ303944B6 (https=)
DE (1) DE60118430T2 (https=)
DK (1) DK1332137T3 (https=)
ES (1) ES2260317T3 (https=)
HU (1) HU229106B1 (https=)
IL (2) IL155029A0 (https=)
MX (1) MXPA03003703A (https=)
NO (1) NO324948B1 (https=)
NZ (1) NZ525254A (https=)
PL (1) PL209733B1 (https=)
PT (1) PT1332137E (https=)
RU (1) RU2301066C2 (https=)
SK (1) SK287335B6 (https=)
WO (1) WO2002034727A2 (https=)
ZA (1) ZA200302155B (https=)

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DE60215648T2 (de) * 2001-06-29 2007-08-23 Ab Science Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen
EP1401412A2 (en) * 2001-06-29 2004-03-31 AB Science Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
ES2266553T3 (es) * 2001-06-29 2007-03-01 Ab Science Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias.
JP2004537536A (ja) * 2001-06-29 2004-12-16 アブ サイエンス アレルギー疾患を治療するためのチロシンキナーゼ阻害剤の使用方法
JP2005500041A (ja) * 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
DE60227701D1 (de) * 2001-09-20 2008-08-28 Ab Science Die verwendung von c-kithemmern zur förderung des haarwuchses
EP1427379B1 (en) * 2001-09-20 2008-08-13 AB Science Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
DK1478380T3 (da) * 2002-02-27 2006-11-27 Ab Science Anvendelse af tyrosinkinase-inhibitorer til behandling af CNS-lidelser
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
CA2538523A1 (en) * 2003-09-19 2005-03-31 Novartis Ag Treatment of gastrointestinal stromal tumors with imatinib and midostaurin
US20100210596A1 (en) * 2006-02-01 2010-08-19 Bluestone Jeffrey A Use of aminopyrimidine compounds in the treatment of immune disorders
EP2061772A4 (en) * 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
AU2007296743B2 (en) * 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
BR112013022552B1 (pt) 2011-03-04 2021-11-23 Newgen Therapeutics, Inc Compostos de quinazolina substituídos com alcino, seu uso, composição farmacêutica, e kit
WO2012155339A1 (zh) 2011-05-17 2012-11-22 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
US20160015708A1 (en) 2012-02-21 2016-01-21 Ranbaxy Laboratories Limited Stable dosage forms of imatinib mesylate
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
BR112015001838B1 (pt) 2012-07-27 2022-10-25 Izumi Technology, Llc Composição de inibidor de efluxo
JP6799201B2 (ja) 2013-07-31 2020-12-16 アヴァリン ファーマ インク． エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
IL276398B2 (en) 2018-01-31 2026-03-01 Deciphera Pharmaceuticals Llc Combination therapy for mastocytosis
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
EP3938363A1 (en) 2019-03-11 2022-01-19 Teva Pharmaceuticals International GmbH Solid state forms of ripretinib
EP4725489A2 (en) 2019-08-02 2026-04-15 OneHealthCompany, Inc. Treatment of canine cancers
PT4013412T (pt) 2019-08-12 2026-03-18 Deciphera Pharmaceuticals Llc Ripretinib para o tratamento de tumores estromais gastrointestinais
LT4013412T (lt) 2019-08-12 2026-03-25 Deciphera Pharmaceuticals, Llc Ripretinibas, skirtas virškinamojo trakto stromos navikų gydymui
HRP20231699T1 (hr) 2019-12-30 2024-05-10 Deciphera Pharmaceuticals, Llc Formulacije inhibitora amorfne kinaze i postupci njihove primjene
CN115243681B (zh) 2019-12-30 2024-08-16 德西费拉制药有限责任公司 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
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Citations (2)

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SU1528449A1 (ru) * 1985-06-05 1989-12-15 Центральный институт усовершенствования врачей Способ релаксации илеоцекального отдела кишечника
WO1999003854A1 (en) * 1997-07-18 1999-01-28 Novartis Ag Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use

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JP2002523455A (ja) * 1998-08-31 2002-07-30 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての幾何学的に制限された２−インドリノン誘導体

Patent Citations (2)

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SU1528449A1 (ru) * 1985-06-05 1989-12-15 Центральный институт усовершенствования врачей Способ релаксации илеоцекального отдела кишечника
WO1999003854A1 (en) * 1997-07-18 1999-01-28 Novartis Ag Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use

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Also Published As

Publication number Publication date
US20040023976A1 (en) 2004-02-05
CY1105055T1 (el) 2010-03-03
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
BRPI0114870B8 (pt) 2021-05-25
AU2002218262B2 (en) 2005-09-29
ES2260317T3 (es) 2006-11-01
PT1332137E (pt) 2006-07-31
US6958335B2 (en) 2005-10-25
JP4386635B2 (ja) 2009-12-16
CA2424470A1 (en) 2002-05-02
JP2004512328A (ja) 2004-04-22
KR20030051656A (ko) 2003-06-25
IL155029A0 (en) 2003-10-31
CN1622808A (zh) 2005-06-01
EP1332137B1 (en) 2006-03-29
DE60118430D1 (de) 2006-05-18
NO324948B1 (no) 2008-01-07
IL155029A (en) 2009-09-22
AU1826202A (en) 2002-05-06
DK1332137T3 (da) 2006-07-17
CN1276754C (zh) 2006-09-27
ZA200302155B (en) 2004-04-22
ATE321556T1 (de) 2006-04-15
CZ20031152A3 (en) 2004-04-14
WO2002034727A2 (en) 2002-05-02
HK1058193A1 (en) 2004-05-07
SK287335B6 (sk) 2010-07-07
CZ303944B6 (cs) 2013-07-10
CA2424470C (en) 2009-06-09
KR100885129B1 (ko) 2009-02-23
BR0114870A (pt) 2004-02-17
EP1332137A2 (en) 2003-08-06
PL209733B1 (pl) 2011-10-31
SK5182003A3 (en) 2004-02-03
MXPA03003703A (es) 2005-01-25
BRPI0114870B1 (pt) 2020-06-16
DE60118430T2 (de) 2006-10-26
NZ525254A (en) 2006-02-24
NO20031833L (no) 2003-04-24
HU229106B1 (en) 2013-07-29
PL362148A1 (en) 2004-10-18
HUP0301512A2 (hu) 2003-11-28

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Effective date: 20130211

TK4A Correction to the publication in the bulletin (patent)

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MZ4A Patent is void

Effective date: 20150202