RU2296122C2 - Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция - Google Patents

Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция Download PDF

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RU2296122C2
RU2296122C2 RU2004104627/04A RU2004104627A RU2296122C2 RU 2296122 C2 RU2296122 C2 RU 2296122C2 RU 2004104627/04 A RU2004104627/04 A RU 2004104627/04A RU 2004104627 A RU2004104627 A RU 2004104627A RU 2296122 C2 RU2296122 C2 RU 2296122C2
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oxopyrrolidin
enyl
acid
hydroxyoct
derivatives
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RU2004104627/04A
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Russian (ru)
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RU2004104627A (ru
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Тодд Ричард ЭЛУОРТИ (US)
Тодд Ричард ЭЛУОРТИ
Майкл Гаррет РОПЕЛ (US)
Майкл Гаррет РОПЕЛ
Дейвид Бернард СМИТ (US)
Дейвид Бернард СМИТ
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Ф.Хоффманн-Ля Рош Аг
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2004104627/04A 2001-07-16 2002-07-11 Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция RU2296122C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30576201P 2001-07-16 2001-07-16
US60/305,762 2001-07-16

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RU2004104627A RU2004104627A (ru) 2005-07-10
RU2296122C2 true RU2296122C2 (ru) 2007-03-27

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US (1) US6849657B2 (https=)
EP (1) EP1408961B1 (https=)
JP (2) JP4211605B2 (https=)
KR (1) KR100702368B1 (https=)
CN (1) CN100371322C (https=)
AT (1) ATE366571T1 (https=)
AU (1) AU2002328338C1 (https=)
BR (1) BR0211167A (https=)
CA (1) CA2451393C (https=)
DE (1) DE60221130T2 (https=)
DK (1) DK1408961T3 (https=)
ES (1) ES2289140T3 (https=)
GT (1) GT200200152A (https=)
MX (1) MXPA04000454A (https=)
PA (1) PA8550501A1 (https=)
PE (1) PE20030286A1 (https=)
PL (1) PL215425B1 (https=)
PT (1) PT1408961E (https=)
RU (1) RU2296122C2 (https=)
WO (1) WO2003007941A1 (https=)

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EP1847533B1 (en) * 2005-01-27 2013-08-14 Asahi Kasei Pharma Corporation Six-membered heterocyclic compound and the use thereof
US8524731B2 (en) * 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
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WO2008027463A1 (en) 2006-08-30 2008-03-06 Eastman Chemical Company Sealant compositions having a novel plasticizer
CN102850968B (zh) * 2006-08-30 2015-09-09 伊士曼化工公司 乙酸乙烯酯聚合物组合物中作为增塑剂的对苯二甲酸酯
AU2008246579A1 (en) 2007-05-08 2008-11-13 National University Corporation, Hamamatsu University School Of Medicine Cytotoxic T cell activator comprising EP4 agonist
US20120142684A1 (en) * 2010-12-02 2012-06-07 Allergan, Inc. Compounds and methods for skin repair
JP6052175B2 (ja) 2011-08-02 2016-12-27 小野薬品工業株式会社 左室拡張機能改善剤
CN107802623B (zh) 2012-07-19 2020-10-30 开曼化学股份有限公司 用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物
WO2014144610A1 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
EP3235817B1 (en) 2013-03-15 2018-12-12 Cayman Chemical Company, Incorporated Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
JP6368351B2 (ja) 2013-03-15 2018-08-01 ケイマン ケミカル カンパニー， インコーポレーテッド ジフルオロラクタムアナログを合成する方法
JP2016527006A (ja) 2013-07-19 2016-09-08 ケイマン ケミカル カンパニー， インコーポレーテッド 骨成長を促進するための方法、システム、及び組成物
CN111511736B (zh) 2017-12-25 2023-03-24 旭化成制药株式会社 含氮6元环化合物

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