RU2292155C2 - Способ гидролиза молочных белков - Google Patents
Способ гидролиза молочных белков Download PDFInfo
- Publication number
- RU2292155C2 RU2292155C2 RU2004104639/13A RU2004104639A RU2292155C2 RU 2292155 C2 RU2292155 C2 RU 2292155C2 RU 2004104639/13 A RU2004104639/13 A RU 2004104639/13A RU 2004104639 A RU2004104639 A RU 2004104639A RU 2292155 C2 RU2292155 C2 RU 2292155C2
- Authority
- RU
- Russia
- Prior art keywords
- protein
- casein
- hydrolyzed
- hydrolysis
- whey
- Prior art date
Links
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 34
- 230000007062 hydrolysis Effects 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims abstract description 18
- 102000014171 Milk Proteins Human genes 0.000 title abstract description 11
- 108010011756 Milk Proteins Proteins 0.000 title abstract description 11
- 235000021239 milk protein Nutrition 0.000 title abstract description 11
- 102000011632 Caseins Human genes 0.000 claims abstract description 83
- 108010076119 Caseins Proteins 0.000 claims abstract description 83
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 67
- 235000021240 caseins Nutrition 0.000 claims abstract description 67
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 63
- 239000005018 casein Substances 0.000 claims abstract description 62
- 235000018102 proteins Nutrition 0.000 claims abstract description 61
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 61
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 61
- 101710118538 Protease Proteins 0.000 claims abstract description 55
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 49
- 239000000203 mixture Substances 0.000 claims abstract description 43
- 235000021119 whey protein Nutrition 0.000 claims abstract description 40
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract description 32
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract description 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 27
- 235000013305 food Nutrition 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 7
- 239000005862 Whey Substances 0.000 claims description 23
- 235000020183 skimmed milk Nutrition 0.000 claims description 17
- 235000013361 beverage Nutrition 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 3
- 235000014214 soft drink Nutrition 0.000 claims description 3
- 235000011496 sports drink Nutrition 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims 1
- 235000019658 bitter taste Nutrition 0.000 abstract description 23
- 235000013336 milk Nutrition 0.000 abstract description 10
- 239000008267 milk Substances 0.000 abstract description 10
- 210000004080 milk Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 43
- 238000011534 incubation Methods 0.000 description 35
- 239000000047 product Substances 0.000 description 34
- 102000004190 Enzymes Human genes 0.000 description 20
- 108090000790 Enzymes Proteins 0.000 description 20
- 229940088598 enzyme Drugs 0.000 description 20
- 102000004196 processed proteins & peptides Human genes 0.000 description 19
- 230000002378 acidificating effect Effects 0.000 description 14
- 235000019640 taste Nutrition 0.000 description 12
- 238000005119 centrifugation Methods 0.000 description 11
- 235000020247 cow milk Nutrition 0.000 description 11
- 102000018389 Exopeptidases Human genes 0.000 description 10
- 108010091443 Exopeptidases Proteins 0.000 description 10
- 229940071162 caseinate Drugs 0.000 description 10
- 230000002779 inactivation Effects 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 9
- 230000007071 enzymatic hydrolysis Effects 0.000 description 9
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 230000002209 hydrophobic effect Effects 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 239000003531 protein hydrolysate Substances 0.000 description 7
- 230000000975 bioactive effect Effects 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 108010009736 Protein Hydrolysates Proteins 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 5
- 229940021722 caseins Drugs 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 238000000464 low-speed centrifugation Methods 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 229940080237 sodium caseinate Drugs 0.000 description 5
- 241000228212 Aspergillus Species 0.000 description 4
- 241000228245 Aspergillus niger Species 0.000 description 4
- UTXSFKPOIVELPQ-SFHVURJKSA-N benzyl n-[2-[(2s)-2-[(4-nitrophenyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamate Chemical compound C1=CC([N+](=O)[O-])=CC=C1NC(=O)[C@H]1N(C(=O)CNC(=O)OCC=2C=CC=CC=2)CCC1 UTXSFKPOIVELPQ-SFHVURJKSA-N 0.000 description 4
- 238000003776 cleavage reaction Methods 0.000 description 4
- 238000010908 decantation Methods 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 235000019645 odor Nutrition 0.000 description 4
- 230000020477 pH reduction Effects 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 230000007017 scission Effects 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- AQFATCCHOXBYNK-UHFFFAOYSA-N 2-piperidin-1-ium-1-ylethyl 1-cyclohexylcyclohexane-1-carboxylate;chloride Chemical compound [Cl-].C1CCCCC1(C1CCCCC1)C(=O)OCC[NH+]1CCCCC1 AQFATCCHOXBYNK-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 241000193389 Bacillus thermoproteolyticus Species 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 235000008452 baby food Nutrition 0.000 description 3
- 235000008504 concentrate Nutrition 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 235000021107 fermented food Nutrition 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000693 micelle Substances 0.000 description 3
- 238000001728 nano-filtration Methods 0.000 description 3
- 238000009928 pasteurization Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- 102000004400 Aminopeptidases Human genes 0.000 description 2
- 108090000915 Aminopeptidases Proteins 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 102100026189 Beta-galactosidase Human genes 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108090000317 Chymotrypsin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 108010059881 Lactase Proteins 0.000 description 2
- 108010060630 Lactoglobulins Proteins 0.000 description 2
- 102000008192 Lactoglobulins Human genes 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108090000787 Subtilisin Proteins 0.000 description 2
- 108090001109 Thermolysin Proteins 0.000 description 2
- 230000002009 allergenic effect Effects 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 229960002376 chymotrypsin Drugs 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000000909 electrodialysis Methods 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 229940116108 lactase Drugs 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 238000010979 pH adjustment Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229940108461 rennet Drugs 0.000 description 2
- 108010058314 rennet Proteins 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 108090000145 Bacillolysin Proteins 0.000 description 1
- 108091005658 Basic proteases Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 101800004361 Lactoferricin-B Proteins 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 201000010859 Milk allergy Diseases 0.000 description 1
- 239000012901 Milli-Q water Substances 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108091005507 Neutral proteases Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 101001039269 Rattus norvegicus Glycine N-methyltransferase Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 108010056079 Subtilisins Proteins 0.000 description 1
- 102000005158 Subtilisins Human genes 0.000 description 1
- 239000012505 Superdex™ Substances 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- VICOIDBHGVJOPN-PPHPATTJSA-N [N+](=O)([O-])C1=CC=C(NC([C@H]2NCCC2)=O)C=C1.C(=O)(OCC1=CC=CC=C1)NCC(=O)O Chemical compound [N+](=O)([O-])C1=CC=C(NC([C@H]2NCCC2)=O)C=C1.C(=O)(OCC1=CC=CC=C1)NCC(=O)O VICOIDBHGVJOPN-PPHPATTJSA-N 0.000 description 1
- 239000002535 acidifier Substances 0.000 description 1
- 229940095602 acidifiers Drugs 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000003241 endoproteolytic effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- -1 immunopeptides Proteins 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- CFFMZOZGXDAXHP-HOKBLYKWSA-N lactoferricin Chemical compound C([C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)N[C@H](C(N[C@H](C(=O)N1)[C@@H](C)O)=O)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CFFMZOZGXDAXHP-HOKBLYKWSA-N 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000019520 non-alcoholic beverage Nutrition 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 102000007739 porin activity proteins Human genes 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202749 | 2001-07-18 | ||
| EP01202749.6 | 2001-07-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004104639A RU2004104639A (ru) | 2005-05-10 |
| RU2292155C2 true RU2292155C2 (ru) | 2007-01-27 |
Family
ID=8180654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004104639/13A RU2292155C2 (ru) | 2001-07-18 | 2002-07-18 | Способ гидролиза молочных белков |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7648721B2 (https=) |
| EP (1) | EP1406509B1 (https=) |
| JP (1) | JP2004521653A (https=) |
| KR (1) | KR20040026683A (https=) |
| CN (1) | CN1231137C (https=) |
| AT (1) | ATE372689T1 (https=) |
| AU (1) | AU2002325890B2 (https=) |
| BR (1) | BR0210680A (https=) |
| CA (1) | CA2452765C (https=) |
| DE (1) | DE60222420T2 (https=) |
| ES (1) | ES2291493T3 (https=) |
| MX (1) | MXPA04000480A (https=) |
| NZ (1) | NZ530165A (https=) |
| RU (1) | RU2292155C2 (https=) |
| WO (1) | WO2003007730A1 (https=) |
| ZA (1) | ZA200400287B (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2341109C1 (ru) * | 2007-08-28 | 2008-12-20 | Государственное образовательное учреждение высшего профессионального образования Кемеровский технологический институт пищевой промышленности | Способ получения пищевого продукта для больных фенилкетонурией |
| RU2460310C2 (ru) * | 2006-06-15 | 2012-09-10 | Нестек С.А. | Гидролизованные яичные белки |
| RU2477612C2 (ru) * | 2008-10-17 | 2013-03-20 | Нестек С.А. | Композиции из сывороточного белка, способы и применение |
| RU2588477C2 (ru) * | 2010-03-11 | 2016-06-27 | Н.В. Нютрисиа | Контроль текстуры богатых белком питательных композиций, включающих мицеллярный казеин |
| RU2692549C2 (ru) * | 2014-06-25 | 2019-06-25 | Нестек С.А. | Жидкая молочная смесь для кулинарных пищевых продуктов |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1231137C (zh) | 2001-07-18 | 2005-12-14 | Dsmip资产有限公司 | 乳类蛋白质水解的方法 |
| DE10331202A1 (de) | 2003-07-10 | 2005-03-31 | S.K. Enterprise Gmbh | Verwendung von Molkenpermeat zur Behandlung des Metabolischen Syndroms |
| DK1663298T3 (da) * | 2003-09-23 | 2019-10-14 | Dsm Ip Assets Bv | Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner |
| ATE551048T1 (de) * | 2004-06-28 | 2012-04-15 | Dsm Ip Assets Bv | Proteinhydrolysate enthaltende kosmetische zusammensetzungen |
| CA2569926A1 (en) * | 2004-07-12 | 2006-01-19 | Dsm Ip Assets B.V. | Blood pressure lowering protein hydrolysates |
| NL1026931C2 (nl) * | 2004-08-31 | 2006-03-01 | Friesland Brands Bv | ACE-remmende wei-hydrolysaten. |
| JP4723638B2 (ja) * | 2005-04-26 | 2011-07-13 | マッセイ ユニバーシティー | 脂質封入 |
| CN101193562B (zh) * | 2005-06-10 | 2012-10-10 | 卡尔皮斯株式会社 | 饮料用组合物的防异臭方法 |
| ES2463724T3 (es) * | 2005-10-11 | 2014-05-29 | Probiotical S.P.A. | Procedimiento de preparación de cultivos bacterianos probióticos analérgicos y uso relacionado |
| AU2007211641B2 (en) * | 2006-02-02 | 2012-09-06 | Dsm Ip Assets B.V. | Food product comprising a proline specific protease |
| EP2003989A1 (en) | 2006-03-31 | 2008-12-24 | DSMIP Assets B.V. | Process for the hydrolysis of milk proteins |
| DE102006036285A1 (de) * | 2006-08-03 | 2008-02-07 | "S.U.K." Beteiligungs Gmbh | Fraktionen aus Molkepermeat und deren Verwendung zur Prävention und Therapie des Typ-2 Diabetes und des Metabolischen Syndroms |
| CN101925674A (zh) * | 2007-11-23 | 2010-12-22 | 帝斯曼知识产权资产管理有限公司 | 改进的生物活性肽生产 |
| ATE539150T1 (de) | 2008-06-03 | 2012-01-15 | Novozymes As | Verfahren zur herstellung eines caseinhydrolysats |
| US8498729B2 (en) | 2008-08-29 | 2013-07-30 | Smp Logic Systems Llc | Manufacturing execution system for use in manufacturing baby formula |
| JP5657200B2 (ja) * | 2008-09-05 | 2015-01-21 | サントリー食品インターナショナル株式会社 | 乳清タンパク質の含有量が低減された乳組成物及び乳入り飲料 |
| EP2165713B1 (en) * | 2008-09-19 | 2012-11-14 | Nestec S.A. | Whey and thymus function |
| JP5329280B2 (ja) * | 2009-03-31 | 2013-10-30 | テルモ株式会社 | 酸性タイプ液状経腸栄養剤 |
| JP5892948B2 (ja) | 2010-01-29 | 2016-03-23 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | カルシウムｈｍｂを含む栄養エマルジョン |
| BR112012018174A2 (pt) | 2010-01-29 | 2019-08-27 | Abbott Lab | líquidos nutricionais embalados assepticamente compreendendo hmb. |
| US9693577B2 (en) | 2010-01-29 | 2017-07-04 | Abbott Laboratories | Method of preparing a nutritional powder comprising spray dried HMB |
| TWI526161B (zh) * | 2010-06-10 | 2016-03-21 | 亞培公司 | 包含鈣ｈｍｂ及可溶性蛋白質之實質上透明營養液 |
| FI124323B (fi) * | 2011-02-18 | 2014-06-30 | Valio Oy | Maitopohjainen tuote ja menetelmä sen valmistamiseksi |
| WO2014060495A1 (en) * | 2012-10-19 | 2014-04-24 | Dsm Ip Assets B.V. | Process for the production of an infant formula |
| CN104046673B (zh) * | 2013-03-14 | 2020-07-21 | 中国食品发酵工业研究院 | 一种含CPPs的低致敏性酪蛋白肽全粉工业化制造方法及其应用 |
| US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
| US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
| US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
| US9345741B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
| US9345727B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
| US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
| US20140328970A1 (en) * | 2013-05-03 | 2014-11-06 | Mead Johnson Nutrition Company | Nutritional Composition Comprising Whey and Hydrolyzed Casein and Uses Thereof |
| AU2014318367A1 (en) * | 2013-09-16 | 2016-05-12 | Glanbia Nutritionals (Ireland) PLC | Method for inhibiting aggregate formation during protein hydrolysis |
| KR101559448B1 (ko) | 2013-09-17 | 2015-10-13 | 동서식품 주식회사 | 커피 크리머용 우유 단백질의 제조방법 및 이를 이용한 커피 크리머 제조방법 |
| US20170156369A1 (en) * | 2014-07-14 | 2017-06-08 | Rebecca Lynn Scotland | Isolation of Plant Oligopeptides and Uses Thereof |
| US10820618B2 (en) * | 2015-12-18 | 2020-11-03 | Societe Des Produits Nestle S.A. | Heat sterilized high protein compositions with hydrolyzed protein from a continuous process with at least one endopeptidase |
| CN106857819A (zh) * | 2016-10-21 | 2017-06-20 | 帝斯曼知识产权资产管理有限公司 | 易消化牛奶及其制备方法 |
| CN108588156A (zh) * | 2018-04-24 | 2018-09-28 | 浙江大学 | 一种水牛乳酪蛋白抗氧化活性肽的制备方法 |
| WO2020130803A1 (en) * | 2018-12-21 | 2020-06-25 | N.V. Nutricia | Protein compositions with high isoelectric proteins |
| CN114540449B (zh) * | 2022-03-02 | 2024-04-02 | 江南大学 | 消化率提升的高谷氨酰胺含量的水解乳清蛋白粉及其制备 |
| CN115404258A (zh) * | 2022-08-26 | 2022-11-29 | 华南理工大学 | 一种改性玉米蛋白及其制备方法与应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU738583A1 (ru) * | 1977-12-05 | 1980-06-05 | Московский технологический институт мясной и молочной промышленности | Способ получени гидролизата казеина |
| EP0610411B1 (en) * | 1991-11-08 | 1996-09-11 | Novo Nordisk A/S | Casein hydrolyzate and method for production of such casein hydrolyzate |
| US6005076A (en) * | 1996-01-31 | 1999-12-21 | B.M.W.Canola Inc. | Oil seed protein extraction |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4600588A (en) | 1980-08-20 | 1986-07-15 | Ernster John H | Milk protein hydrolysate and process of preparation |
| US5405756A (en) | 1982-03-30 | 1995-04-11 | Meiji Seika Kaisha, Ltd. | Transparent acid drink containing acid-soluble casein phosphopeptide |
| GB8528100D0 (en) | 1985-11-14 | 1985-12-18 | Imp Biotechnology | Zenymatic hydrolysis of proteins |
| DE3905194A1 (de) | 1989-02-21 | 1990-08-23 | Roehm Gmbh | Verfahren zur herstellung von protein-hydrolysaten mit niedrigem gehalt an bitterstoffen |
| JPH0517368A (ja) * | 1991-07-05 | 1993-01-26 | Morinaga Milk Ind Co Ltd | 抗アレルギー性母乳強化組成物 |
| FI94089C (fi) | 1992-12-10 | 1995-07-25 | Valio Oy | Menetelmä allergiaa aiheuttavien yhdisteiden poistamiseksi proteiinipitoisista koostumuksista |
| US5405637A (en) * | 1993-06-30 | 1995-04-11 | Bristol-Myers Squibb Company | Milk protein partial hydrolysate and infant formula containing same |
| EP0785726B1 (en) | 1994-10-26 | 2004-01-07 | Novozymes A/S | Method for production of a milk protein hydrolyzate |
| ATE218036T1 (de) | 1996-12-23 | 2002-06-15 | Dsm Nv | Verfahren zur herstellung eines proteinhydrolysates |
| JPH11243866A (ja) | 1998-03-05 | 1999-09-14 | Morinaga Milk Ind Co Ltd | カゼイン加水分解物及びその製造法 |
| EP1062873A1 (en) * | 1999-12-13 | 2000-12-27 | N.V. Nutricia | Improved infant formula, protein hydrolysate for use in such an infant formula, and method for producing such a hydrolysate |
| WO2002032231A1 (en) | 2000-10-19 | 2002-04-25 | Edens, Luppo | Protein hydrolysates |
| CA2706364A1 (en) | 2000-12-07 | 2002-06-13 | Dsm Ip Assets B.V. | Method for the prevention or reduction of haze in beverages |
| ATE475324T1 (de) | 2000-12-07 | 2010-08-15 | Dsm Ip Assets Bv | Mit carboxy-terminal prolin peptide angereicherte proteinhydrolysate |
| WO2002068623A2 (en) | 2001-02-23 | 2002-09-06 | Dsm Ip Assets B.V. | Genes encoding proteolytic enzymes from aspargilli |
| CN1231137C (zh) | 2001-07-18 | 2005-12-14 | Dsmip资产有限公司 | 乳类蛋白质水解的方法 |
| ES2540926T3 (es) | 2002-06-04 | 2015-07-14 | Dsm Ip Assets B.V. | Hidrolizado de proteínas rico en tripéptidos |
| AU2003228145B2 (en) | 2002-06-07 | 2009-10-08 | Dsm Ip Assets B.V. | Improved method for the prevention or reduction of haze in beverages |
| AU2003264256A1 (en) | 2002-09-04 | 2004-03-29 | Dsm Ip Assets B.V. | A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction |
| DK1663298T3 (da) | 2003-09-23 | 2019-10-14 | Dsm Ip Assets Bv | Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner |
-
2002
- 2002-07-18 CN CNB028141520A patent/CN1231137C/zh not_active Expired - Fee Related
- 2002-07-18 ES ES02760254T patent/ES2291493T3/es not_active Expired - Lifetime
- 2002-07-18 BR BR0210680-9A patent/BR0210680A/pt not_active IP Right Cessation
- 2002-07-18 EP EP02760254A patent/EP1406509B1/en not_active Expired - Lifetime
- 2002-07-18 JP JP2003513349A patent/JP2004521653A/ja active Pending
- 2002-07-18 MX MXPA04000480A patent/MXPA04000480A/es active IP Right Grant
- 2002-07-18 US US10/483,948 patent/US7648721B2/en not_active Expired - Fee Related
- 2002-07-18 WO PCT/EP2002/008072 patent/WO2003007730A1/en not_active Ceased
- 2002-07-18 KR KR10-2004-7000730A patent/KR20040026683A/ko not_active Withdrawn
- 2002-07-18 AT AT02760254T patent/ATE372689T1/de not_active IP Right Cessation
- 2002-07-18 DE DE60222420T patent/DE60222420T2/de not_active Expired - Lifetime
- 2002-07-18 RU RU2004104639/13A patent/RU2292155C2/ru not_active IP Right Cessation
- 2002-07-18 CA CA2452765A patent/CA2452765C/en not_active Expired - Fee Related
- 2002-07-18 AU AU2002325890A patent/AU2002325890B2/en not_active Ceased
- 2002-07-18 NZ NZ530165A patent/NZ530165A/en not_active IP Right Cessation
-
2004
- 2004-01-14 ZA ZA200400287A patent/ZA200400287B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU738583A1 (ru) * | 1977-12-05 | 1980-06-05 | Московский технологический институт мясной и молочной промышленности | Способ получени гидролизата казеина |
| EP0610411B1 (en) * | 1991-11-08 | 1996-09-11 | Novo Nordisk A/S | Casein hydrolyzate and method for production of such casein hydrolyzate |
| US6005076A (en) * | 1996-01-31 | 1999-12-21 | B.M.W.Canola Inc. | Oil seed protein extraction |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2460310C2 (ru) * | 2006-06-15 | 2012-09-10 | Нестек С.А. | Гидролизованные яичные белки |
| RU2341109C1 (ru) * | 2007-08-28 | 2008-12-20 | Государственное образовательное учреждение высшего профессионального образования Кемеровский технологический институт пищевой промышленности | Способ получения пищевого продукта для больных фенилкетонурией |
| RU2477612C2 (ru) * | 2008-10-17 | 2013-03-20 | Нестек С.А. | Композиции из сывороточного белка, способы и применение |
| RU2588477C2 (ru) * | 2010-03-11 | 2016-06-27 | Н.В. Нютрисиа | Контроль текстуры богатых белком питательных композиций, включающих мицеллярный казеин |
| RU2692549C2 (ru) * | 2014-06-25 | 2019-06-25 | Нестек С.А. | Жидкая молочная смесь для кулинарных пищевых продуктов |
| US10709147B2 (en) | 2014-06-25 | 2020-07-14 | Societe Des Produits Nestle S.A. | Liquid dairy blend for culinary food products |
| US12127567B2 (en) | 2014-06-25 | 2024-10-29 | Societe Des Produits Nestle S.A. | Liquid dairy blend for culinary food products |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222420D1 (de) | 2007-10-25 |
| JP2004521653A (ja) | 2004-07-22 |
| ES2291493T3 (es) | 2008-03-01 |
| KR20040026683A (ko) | 2004-03-31 |
| CA2452765C (en) | 2010-09-28 |
| CN1231137C (zh) | 2005-12-14 |
| DE60222420T2 (de) | 2008-06-12 |
| NZ530165A (en) | 2004-08-27 |
| US20050175622A1 (en) | 2005-08-11 |
| WO2003007730A1 (en) | 2003-01-30 |
| ZA200400287B (en) | 2004-10-14 |
| BR0210680A (pt) | 2004-09-21 |
| EP1406509A1 (en) | 2004-04-14 |
| ATE372689T1 (de) | 2007-09-15 |
| EP1406509B1 (en) | 2007-09-12 |
| RU2004104639A (ru) | 2005-05-10 |
| MXPA04000480A (es) | 2004-07-23 |
| AU2002325890B2 (en) | 2007-10-04 |
| US7648721B2 (en) | 2010-01-19 |
| CN1527669A (zh) | 2004-09-08 |
| CA2452765A1 (en) | 2003-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2292155C2 (ru) | Способ гидролиза молочных белков | |
| AU2002325890A1 (en) | Process for the hydrolysis of milk proteins | |
| EP0226221B1 (en) | A peptide preparation, a process for producing it and use of the peptide preparation | |
| JP7748287B2 (ja) | 味が良い（Ｐａｌａｔａｂｌｅ）高度に加水分解されたホエイタンパク質加水分解物 | |
| EP2380581B1 (en) | Muscle-building agent | |
| EP2271222B1 (en) | Process for the preparation of packaged heat-preserved aqueous drink comprising casein micelles and tryptophan-rich peptides, and product so obtained | |
| WO1996011584A1 (en) | Peptide mixture and products thereof | |
| EP2282641B1 (en) | Composition comprising carbohydrates and peptides which comprise tryptophan | |
| US20100233318A1 (en) | Process for the hydrolysis of milk proteins | |
| RU2428047C1 (ru) | Способ получения гидролизата сывороточных белков с высокой степенью гидролиза и гидролизат сывороточных белков с высокой степенью гидролиза | |
| JP2959747B2 (ja) | 風味良好な乳清蛋白加水分解物及びその製造法 | |
| CN102573880A (zh) | 脂肪累积抑制剂 | |
| JP7252733B2 (ja) | 乳蛋白質加水分解物の製造方法 | |
| KR20260058208A (ko) | 펩티드의 제조 방법, 펩티드를 포함하는 조성물 및 그것을 사용한 음식품 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20130719 |