RU2276133C2 - Соединения, фармацевтическая композиция и способ ингибирования опухолевого роста (варианты) - Google Patents

Соединения, фармацевтическая композиция и способ ингибирования опухолевого роста (варианты) Download PDF

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Publication number
RU2276133C2
RU2276133C2 RU2002128751/04A RU2002128751A RU2276133C2 RU 2276133 C2 RU2276133 C2 RU 2276133C2 RU 2002128751/04 A RU2002128751/04 A RU 2002128751/04A RU 2002128751 A RU2002128751 A RU 2002128751A RU 2276133 C2 RU2276133 C2 RU 2276133C2
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RU
Russia
Prior art keywords
compound
covalent bond
mmp2
trifluoromethyl
tumor growth
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RU2002128751/04A
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English (en)
Russian (ru)
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RU2002128751A (ru
Inventor
Дейл Л. БОГЕР (US)
Дейл Л. БОГЕР
Дэвид А. ЧЕРЕШ (US)
Дэвид А. Череш
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Дзе Скриппс Рисерч Инститьют
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Publication of RU2002128751A publication Critical patent/RU2002128751A/ru
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Publication of RU2276133C2 publication Critical patent/RU2276133C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
RU2002128751/04A 2000-03-27 2001-03-27 Соединения, фармацевтическая композиция и способ ингибирования опухолевого роста (варианты) RU2276133C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19226000P 2000-03-27 2000-03-27
US60/192,260 2000-03-27

Publications (2)

Publication Number Publication Date
RU2002128751A RU2002128751A (ru) 2004-03-10
RU2276133C2 true RU2276133C2 (ru) 2006-05-10

Family

ID=22708924

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2002128751/04A RU2276133C2 (ru) 2000-03-27 2001-03-27 Соединения, фармацевтическая композиция и способ ингибирования опухолевого роста (варианты)
RU2002128736/15A RU2269339C2 (ru) 2000-03-27 2001-03-27 Способы ингибирования ангиогенеза и роста опухолей

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2002128736/15A RU2269339C2 (ru) 2000-03-27 2001-03-27 Способы ингибирования ангиогенеза и роста опухолей

Country Status (15)

Country Link
EP (2) EP1272173A4 (hu)
JP (2) JP2003528850A (hu)
KR (2) KR100767616B1 (hu)
CN (2) CN1229339C (hu)
AU (4) AU5101801A (hu)
CA (3) CA2659030A1 (hu)
CZ (2) CZ20023510A3 (hu)
HU (2) HUP0301621A3 (hu)
MX (2) MXPA02009510A (hu)
NO (2) NO328969B1 (hu)
PL (2) PL358272A1 (hu)
RU (2) RU2276133C2 (hu)
SK (2) SK14852002A3 (hu)
WO (2) WO2001072699A1 (hu)
ZA (2) ZA200208628B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2315721T5 (es) 2003-10-23 2012-08-24 Otsuka Pharmaceutical Co., Ltd. Formulación de aripiprazol inyectable estéril de liberación controlada y procedimiento
UA97286C2 (ru) 2007-07-31 2012-01-25 Оцука Фармасьютикал Ко., Лтд. Способ изготовления суспензии арипипразола и лиофилизированного состава

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
JPH05125029A (ja) 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
GB9308695D0 (en) * 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
GB9405076D0 (en) * 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
AUPO104496A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Angiogenic inhibitory compounds
KR20000068415A (ko) * 1996-09-04 2000-11-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 매트릭스 메탈로프로테이나제 억제용 화합물 및 방법
EP0968423A4 (en) * 1997-02-07 2002-10-30 Scripps Research Inst CONVERGENT SYNTHESIS OF COMBINATORIAL BANKING
KR100596109B1 (ko) * 1998-03-27 2006-07-05 제넨테크, 인크. Ｃｄ11/ｃｄ18 부착 수용체 매개 질환 치료용 길항제

Also Published As

Publication number Publication date
CA2403630C (en) 2009-05-26
JP2003528850A (ja) 2003-09-30
CA2659030A1 (en) 2001-10-04
EP1272173A4 (en) 2006-05-03
CN1245967C (zh) 2006-03-22
EP1272173A1 (en) 2003-01-08
AU2001251018B2 (en) 2005-12-01
WO2001072699A1 (en) 2001-10-04
MXPA02009504A (es) 2003-05-21
AU4949901A (en) 2001-10-08
CZ20023510A3 (cs) 2003-03-12
KR20020091156A (ko) 2002-12-05
KR20020084258A (ko) 2002-11-04
AU2001249499B2 (en) 2005-04-21
CA2403630A1 (en) 2001-10-04
AU5101801A (en) 2001-10-08
NO20024578L (no) 2002-11-20
CZ20023509A3 (cs) 2003-06-18
SK14852002A3 (sk) 2003-06-03
CA2403871C (en) 2010-05-11
HUP0301797A3 (en) 2010-09-28
ZA200208626B (en) 2004-02-16
NO20024576L (no) 2002-11-20
CA2403871A1 (en) 2001-10-04
CN1229339C (zh) 2005-11-30
PL358272A1 (en) 2004-08-09
RU2269339C2 (ru) 2006-02-10
CN1429106A (zh) 2003-07-09
CN1441777A (zh) 2003-09-10
PL366316A1 (en) 2005-01-24
KR100767616B1 (ko) 2007-10-18
NO328969B1 (no) 2010-06-28
SK14842002A3 (sk) 2003-04-01
KR100776185B1 (ko) 2007-11-16
JP2003528140A (ja) 2003-09-24
HUP0301621A2 (hu) 2003-09-29
NO20024576D0 (no) 2002-09-24
NO20024578D0 (no) 2002-09-24
WO2001072297A1 (en) 2001-10-04
EP1276713A1 (en) 2003-01-22
HUP0301621A3 (en) 2009-06-29
RU2002128751A (ru) 2004-03-10
HUP0301797A2 (hu) 2003-09-29
EP1276713A4 (en) 2006-05-03
PL205134B1 (pl) 2010-03-31
ZA200208628B (en) 2004-02-12
MXPA02009510A (es) 2003-05-21

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20110328