EP1272173A4 - Methods for inhibiting angiogenesis and tumor growth - Google Patents

Methods for inhibiting angiogenesis and tumor growth

Info

Publication number
EP1272173A4
EP1272173A4 EP01922734A EP01922734A EP1272173A4 EP 1272173 A4 EP1272173 A4 EP 1272173A4 EP 01922734 A EP01922734 A EP 01922734A EP 01922734 A EP01922734 A EP 01922734A EP 1272173 A4 EP1272173 A4 EP 1272173A4
Authority
EP
European Patent Office
Prior art keywords
methods
tumor growth
inhibiting angiogenesis
angiogenesis
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01922734A
Other languages
German (de)
French (fr)
Other versions
EP1272173A1 (en
Inventor
Dale L Boger
David A Cheresh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of EP1272173A1 publication Critical patent/EP1272173A1/en
Publication of EP1272173A4 publication Critical patent/EP1272173A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
EP01922734A 2000-03-27 2001-03-27 Methods for inhibiting angiogenesis and tumor growth Withdrawn EP1272173A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19226000P 2000-03-27 2000-03-27
US192260P 2000-03-27
PCT/US2001/009785 WO2001072297A1 (en) 2000-03-27 2001-03-27 Methods for inhibiting angiogenesis and tumor growth

Publications (2)

Publication Number Publication Date
EP1272173A1 EP1272173A1 (en) 2003-01-08
EP1272173A4 true EP1272173A4 (en) 2006-05-03

Family

ID=22708924

Family Applications (2)

Application Number Title Priority Date Filing Date
EP01922734A Withdrawn EP1272173A4 (en) 2000-03-27 2001-03-27 Methods for inhibiting angiogenesis and tumor growth
EP01924359A Ceased EP1276713A4 (en) 2000-03-27 2001-03-27 Inhibition of angiogenesis and tumor growth

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP01924359A Ceased EP1276713A4 (en) 2000-03-27 2001-03-27 Inhibition of angiogenesis and tumor growth

Country Status (15)

Country Link
EP (2) EP1272173A4 (en)
JP (2) JP2003528850A (en)
KR (2) KR100767616B1 (en)
CN (2) CN1245967C (en)
AU (4) AU2001249499B2 (en)
CA (3) CA2403871C (en)
CZ (2) CZ20023509A3 (en)
HU (2) HUP0301797A3 (en)
MX (2) MXPA02009504A (en)
NO (2) NO328969B1 (en)
PL (2) PL205134B1 (en)
RU (2) RU2276133C2 (en)
SK (2) SK14852002A3 (en)
WO (2) WO2001072297A1 (en)
ZA (2) ZA200208626B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06004489A (en) 2003-10-23 2006-06-20 Otsuka Pharma Co Ltd Controlled release sterile injectable aripiprazole formulation and method.
HUE036214T2 (en) 2007-07-31 2018-06-28 Otsuka Pharma Co Ltd Methods for producing aripiprazole suspension and freeze-dried formulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511504A (en) * 1983-04-26 1985-04-16 G.D. Searle & Co. Carboxyalkyl peptide derivatives
WO1994025435A1 (en) * 1993-04-27 1994-11-10 Celltech Limited Peptidyl derivatives and their use as metalloproteinase inhibitors
US5442110A (en) * 1991-11-06 1995-08-15 Yamanouchi Pharmaceutical Co., Ltd. Hydroxamic acid derivative
WO1998035231A1 (en) * 1997-02-07 1998-08-13 The Scripps Research Institute Convergent synthesis of combinatorial library

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405076D0 (en) * 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
AUPO104496A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Angiogenic inhibitory compounds
EP0929542A1 (en) * 1996-09-04 1999-07-21 Warner-Lambert Company Compounds for and a method of inhibiting matrix metalloproteinases
ATE353640T1 (en) * 1998-03-27 2007-03-15 Genentech Inc ANTAGONISTS FOR THE TREATMENT OF CD11/CD18 ADHESION RECEPTOR-MEDIATED DISEASES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511504A (en) * 1983-04-26 1985-04-16 G.D. Searle & Co. Carboxyalkyl peptide derivatives
US5442110A (en) * 1991-11-06 1995-08-15 Yamanouchi Pharmaceutical Co., Ltd. Hydroxamic acid derivative
WO1994025435A1 (en) * 1993-04-27 1994-11-10 Celltech Limited Peptidyl derivatives and their use as metalloproteinase inhibitors
WO1998035231A1 (en) * 1997-02-07 1998-08-13 The Scripps Research Institute Convergent synthesis of combinatorial library

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOGER D L ET AL: "Higher order iminodiacetic acid libraries for probing protein-protein interactions.", BIOORGANIC & MEDICINAL CHEMISTRY. AUG 1998, vol. 6, no. 8, August 1998 (1998-08-01), pages 1347 - 1378, XP002369171, ISSN: 0968-0896 *
BOGER D L ET AL: "Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin.alpha.V.beta.3", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 123, no. 7, 2001, pages 1280 - 1288, XP002215423, ISSN: 0002-7863 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002369179, retrieved from STN accession no. 1998:550559 Database accession no. 129:189127 *
See also references of WO0172297A1 *

Also Published As

Publication number Publication date
CA2403871A1 (en) 2001-10-04
CN1441777A (en) 2003-09-10
AU2001249499B2 (en) 2005-04-21
ZA200208626B (en) 2004-02-16
CN1245967C (en) 2006-03-22
HUP0301797A2 (en) 2003-09-29
NO20024576D0 (en) 2002-09-24
PL358272A1 (en) 2004-08-09
NO20024576L (en) 2002-11-20
JP2003528850A (en) 2003-09-30
WO2001072699A1 (en) 2001-10-04
RU2276133C2 (en) 2006-05-10
KR20020091156A (en) 2002-12-05
KR100776185B1 (en) 2007-11-16
WO2001072297A1 (en) 2001-10-04
MXPA02009504A (en) 2003-05-21
CZ20023510A3 (en) 2003-03-12
CA2403630C (en) 2009-05-26
EP1272173A1 (en) 2003-01-08
CN1229339C (en) 2005-11-30
HUP0301621A3 (en) 2009-06-29
HUP0301621A2 (en) 2003-09-29
PL205134B1 (en) 2010-03-31
CZ20023509A3 (en) 2003-06-18
JP2003528140A (en) 2003-09-24
MXPA02009510A (en) 2003-05-21
PL366316A1 (en) 2005-01-24
RU2269339C2 (en) 2006-02-10
RU2002128751A (en) 2004-03-10
CN1429106A (en) 2003-07-09
NO328969B1 (en) 2010-06-28
KR100767616B1 (en) 2007-10-18
ZA200208628B (en) 2004-02-12
KR20020084258A (en) 2002-11-04
AU2001251018B2 (en) 2005-12-01
EP1276713A4 (en) 2006-05-03
SK14852002A3 (en) 2003-06-03
CA2403871C (en) 2010-05-11
AU4949901A (en) 2001-10-08
NO20024578D0 (en) 2002-09-24
NO20024578L (en) 2002-11-20
EP1276713A1 (en) 2003-01-22
SK14842002A3 (en) 2003-04-01
HUP0301797A3 (en) 2010-09-28
AU5101801A (en) 2001-10-08
CA2659030A1 (en) 2001-10-04
CA2403630A1 (en) 2001-10-04

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Ipc: C07C 261/00 20060101AFI20060227BHEP

Ipc: A61K 38/00 20060101ALI20060227BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20060317

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Effective date: 20061002

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18W Application withdrawn

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