EP1351573A4 - Methods for modulating tumor growth and metastasis - Google Patents

Methods for modulating tumor growth and metastasis

Info

Publication number
EP1351573A4
EP1351573A4 EP01994435A EP01994435A EP1351573A4 EP 1351573 A4 EP1351573 A4 EP 1351573A4 EP 01994435 A EP01994435 A EP 01994435A EP 01994435 A EP01994435 A EP 01994435A EP 1351573 A4 EP1351573 A4 EP 1351573A4
Authority
EP
European Patent Office
Prior art keywords
metastasis
methods
tumor growth
modulating tumor
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01994435A
Other languages
German (de)
French (fr)
Other versions
EP1351573A1 (en
Inventor
Francis Y Lee
Ronald Peck
David Chaplin
Ronald Pero
Klaus Edvardsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Oxi Gene Inc
Original Assignee
Bristol Myers Squibb Co
Oxi Gene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Oxi Gene Inc filed Critical Bristol Myers Squibb Co
Publication of EP1351573A1 publication Critical patent/EP1351573A1/en
Publication of EP1351573A4 publication Critical patent/EP1351573A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP01994435A 2000-12-22 2001-12-20 Methods for modulating tumor growth and metastasis Withdrawn EP1351573A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25819500P 2000-12-22 2000-12-22
US258195P 2000-12-22
PCT/US2001/050261 WO2002056692A1 (en) 2000-12-22 2001-12-20 Methods for modulating tumor growth and metastasis

Publications (2)

Publication Number Publication Date
EP1351573A1 EP1351573A1 (en) 2003-10-15
EP1351573A4 true EP1351573A4 (en) 2007-03-28

Family

ID=22979500

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01994435A Withdrawn EP1351573A4 (en) 2000-12-22 2001-12-20 Methods for modulating tumor growth and metastasis

Country Status (5)

Country Link
EP (1) EP1351573A4 (en)
JP (2) JP2004523517A (en)
AU (1) AU2002246827B2 (en)
CA (1) CA2432792C (en)
WO (1) WO2002056692A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4470321B2 (en) 1998-04-03 2010-06-02 味の素株式会社 Antitumor agent
JP2004517821A (en) 2000-10-27 2004-06-17 アベンティス・ファーマ・ソシエテ・アノニム Combinations of camptothecin and stilbene derivatives for cancer treatment
US20050209310A1 (en) * 2000-12-22 2005-09-22 Chaplin David J Methods for modulating tumor growth and metastasis
WO2002056692A1 (en) * 2000-12-22 2002-07-25 Bristol-Myers Squibb Company Methods for modulating tumor growth and metastasis
US20020183266A1 (en) * 2001-03-15 2002-12-05 Aventis Pharma, S.A. Combination comprising combretastatin and anticancer agents
JP2006503852A (en) * 2002-09-25 2006-02-02 ユニバーシティー オブ ロチェスター Caspase inhibitors as anticancer drugs
WO2004032947A1 (en) * 2002-10-09 2004-04-22 Unibioscreen S.A. Extract with anti-tumor and anti-poisonous activity
TWI323662B (en) * 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
US9050378B2 (en) 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
EP2047858A1 (en) * 2007-10-10 2009-04-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) Combination products for treating cancer
DK2219451T3 (en) * 2007-11-21 2015-01-12 Oxigene Inc A method for the treatment of hematopoietic neoplasms
US20090209496A1 (en) * 2008-02-15 2009-08-20 David Chaplin Methods and compositions for enhancing the efficacy of rtk inhibitors
FR2939665B1 (en) 2008-12-12 2011-10-07 Sanofi Aventis ANTITUMOR COMBINATION ASSOCIATING WITH AVE8062A AND DOCETAXEL
EP3337495A4 (en) 2015-08-18 2019-04-10 Mateon Therapeutics, Inc. Use of vdas to enhance immunomodulating therapies against tumors
CN107773556B (en) * 2016-08-26 2020-08-18 广州安好医药科技有限公司 Combined medicine with anti-tumor medicine efficacy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048591A1 (en) * 1999-02-16 2000-08-24 Angiogene Pharmaceuticals Ltd. Combinations for the treatment of diseases involving angiogenesis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996237A (en) 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
CA1338645C (en) 1987-01-06 1996-10-15 George R. Pettit Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
US5561122A (en) 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
WO1999035150A1 (en) 1998-01-09 1999-07-15 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Synthesis of combretastatin a-4 prodrugs and trans-isomers thereo f
AU776511B2 (en) 1999-02-18 2004-09-09 Baylor University Compositions and methods for use in targeting vascular destruction
WO2002056692A1 (en) * 2000-12-22 2002-07-25 Bristol-Myers Squibb Company Methods for modulating tumor growth and metastasis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048591A1 (en) * 1999-02-16 2000-08-24 Angiogene Pharmaceuticals Ltd. Combinations for the treatment of diseases involving angiogenesis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHAPLIN D J ET AL: "ANTI-VASCULAR APPROACHES TO SOLID TUMOUR THERAPY: EVALUATION OF COMBRETASTATIN A4 PHOSPHATE", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 19, no. 1A, January 1999 (1999-01-01), pages 189 - 196, XP008013078, ISSN: 0250-7005 *
HORSMAN M R ET AL: "COMBRETASTATINS NOVEL VASCULAR TARGETING DRUGS FOR IMPROVING ANTI-CANCER THERAPY COMBRETASTATINS AND CONVENTIONAL THERAPY", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, US, vol. 476, 2000, pages 311 - 323, XP008013085, ISSN: 0065-2598 *
LINGYUN LI, B.S. AND OTHERS: "Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY, BIOLOGY, PHYSICS, vol. 42, no. 4, 1998, pages 899 - 903, XP002419739 *
NELKIN B D ET AL: "COMBRETASTATIN A-4 AND DOXORUBICIN COMBINATION TREATMENT IF EFFECTIVE IN A PRECLINICAL MODEL OF HUMAN MEDULLARY THYROID CARCINOMA", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, ATHENS, GR, vol. 8, no. 1, January 2001 (2001-01-01), pages 157 - 160, XP008013083, ISSN: 1021-335X *
See also references of WO02056692A1 *

Also Published As

Publication number Publication date
JP2009102350A (en) 2009-05-14
WO2002056692A1 (en) 2002-07-25
CA2432792C (en) 2012-04-03
AU2002246827B2 (en) 2008-02-21
EP1351573A1 (en) 2003-10-15
CA2432792A1 (en) 2002-07-25
JP2004523517A (en) 2004-08-05

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Legal Events

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Ipc: A61K 45/06 20060101AFI20070214BHEP

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Effective date: 20071219

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Effective date: 20130702