RU2269520C2 - Соединения пиперазиндиона - Google Patents

Соединения пиперазиндиона Download PDF

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Publication number
RU2269520C2
RU2269520C2 RU2002132897/04A RU2002132897A RU2269520C2 RU 2269520 C2 RU2269520 C2 RU 2269520C2 RU 2002132897/04 A RU2002132897/04 A RU 2002132897/04A RU 2002132897 A RU2002132897 A RU 2002132897A RU 2269520 C2 RU2269520 C2 RU 2269520C2
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RU
Russia
Prior art keywords
compound
aryl
double bond
alkyl
compound according
Prior art date
Application number
RU2002132897/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2002132897A (ru
Inventor
Чэ-Мин ТЭН (CN)
Чэ-Мин ТЭН
Хуэй-По ВАН (CN)
Хуэй-По ВАН
Эрик И. С. ЛИ (CN)
Эрик И. С. ЛИ
Он ЛЕЕ (CN)
Он ЛЕЕ
Цзих-Хва ГУХ (CN)
Цзих-Хва ГУХ
Хуэй-Тин ЧЭНЬ (CN)
Хуэй-Тин ЧЭНЬ
Янь-Бин ФАНЬ (CN)
Янь-Бин ФАНЬ
Я-Лань ЧЭНЬ (CN)
Я-Лань ЧЭНЬ
Original Assignee
Эдфарма, Инк.
Чэ-Мин ТЭН
Хуэй-По ВАН
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эдфарма, Инк., Чэ-Мин ТЭН, Хуэй-По ВАН filed Critical Эдфарма, Инк.
Publication of RU2002132897A publication Critical patent/RU2002132897A/ru
Application granted granted Critical
Publication of RU2269520C2 publication Critical patent/RU2269520C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Saccharide Compounds (AREA)
RU2002132897/04A 2000-05-09 2001-05-08 Соединения пиперазиндиона RU2269520C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30419100P 2000-05-09 2000-05-09
US60/304,191 2000-05-09

Publications (2)

Publication Number Publication Date
RU2002132897A RU2002132897A (ru) 2004-06-27
RU2269520C2 true RU2269520C2 (ru) 2006-02-10

Family

ID=23175471

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002132897/04A RU2269520C2 (ru) 2000-05-09 2001-05-08 Соединения пиперазиндиона

Country Status (14)

Country Link
US (1) US6635649B2 (enExample)
EP (1) EP1282609B1 (enExample)
JP (1) JP5101781B2 (enExample)
KR (1) KR100852965B1 (enExample)
CN (1) CN100522949C (enExample)
AT (1) ATE417614T1 (enExample)
BR (1) BR0110745A (enExample)
CZ (1) CZ301743B6 (enExample)
DE (1) DE60137037D1 (enExample)
HU (1) HUP0302358A3 (enExample)
NO (1) NO326341B1 (enExample)
RU (1) RU2269520C2 (enExample)
WO (1) WO2001095858A2 (enExample)
ZA (1) ZA200209917B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519948C2 (ru) * 2008-08-22 2014-06-20 Бритиш Коламбиа Кэнсер Эйдженси Бранч Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов

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US7288545B2 (en) * 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
PT1311269E (pt) 2000-08-04 2012-05-10 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composição que contém as mesmas
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en) * 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
EP1571970B1 (en) * 2002-10-02 2011-08-17 DMI Biosciences, Inc. Diagnosis and monitoring of diseases
KR20120101164A (ko) 2003-05-15 2012-09-12 디엠아이 바이오사이언시스, 인크 Ｔ-세포 매개성 질환의 치료 방법
CA2538352A1 (en) * 2003-09-25 2005-04-07 Dmi Biosciences Inc. Methods and products which utilize n-acyl-l-aspartic acid
WO2005077940A1 (en) * 2004-02-04 2005-08-25 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
US8129527B2 (en) * 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
BRPI1013328A2 (pt) * 2009-04-16 2016-03-29 Telik Inc 4-amino-benzoil-2-(fenilamino) tiofeno-3-carbonitrilas substituídas e 4-a-mino-5benzoil-2-(fenilamino) tiofeno-3-carboxamidas substituídas como inibidores da polimerização de tubulina
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
US8710062B2 (en) * 2011-03-11 2014-04-29 Taipei Medical University Piperazinedione compounds
EP2766029B1 (en) 2011-10-10 2020-03-25 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
MX2014003856A (es) 2011-10-10 2015-01-16 Ampio Pharmaceuticals Inc Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos.
SG11201400283RA (en) 2011-10-28 2014-03-28 Ampio Pharmaceuticals Inc Treatment of rhinitis
AU2014232728B2 (en) 2013-03-15 2019-02-21 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
JP6311097B2 (ja) * 2013-07-31 2018-04-18 学校法人東京薬科大学 微小管脱重合剤
EP3183240A4 (en) 2014-08-18 2018-06-27 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
CN104356077B (zh) * 2014-09-11 2016-09-14 中国科学院南海海洋研究所 一类不对称酰基保护的2,5-二酮哌嗪衍生物及其制备方法和应用
RU2728796C2 (ru) 2015-03-06 2020-07-31 Бейондспринг Фармасьютикалс, Инк. Способ лечения опухоли головного мозга
CN107530341B (zh) 2015-03-06 2021-10-01 大连万春布林医药有限公司 治疗与ras突变相关的癌症的方法
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
DK3334726T3 (da) 2015-07-13 2022-05-16 Beyondspring Pharmaceuticals Inc Plinabulinsammensætninger
AU2017217426B2 (en) 2016-02-08 2022-12-01 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
SG11201810872UA (en) 2016-06-06 2019-01-30 Beyondspring Pharmaceuticals Inc Composition and method for reducing neutropenia
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
CN110381938A (zh) 2017-02-01 2019-10-25 大连万春布林医药有限公司 减少中性粒细胞缺乏症的方法
CA3089226A1 (en) 2018-01-24 2019-08-01 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia via the administration of plinabulin
CN109580801B (zh) * 2018-06-26 2021-09-07 深圳海王医药科技研究院有限公司 一种检测微管蛋白抑制剂及相关杂质的高效液相色谱法
CN112010930B (zh) * 2019-05-28 2022-08-02 首都医科大学 Rgd修饰的五环哌嗪二酮及其制备和应用
EP4319751A4 (en) 2021-04-09 2025-02-26 Beyondspring Pharmaceuticals, Inc. THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS
CN117285516A (zh) * 2022-06-16 2023-12-26 大连万众益生大健康有限公司 脱氢苯基阿夕斯汀类化合物、其制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004512A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines
US5902812A (en) * 1994-02-14 1999-05-11 Xenova Limited Pharmaceutical piperazine compounds

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JPS5973574A (ja) * 1982-10-21 1984-04-25 Grelan Pharmaceut Co Ltd 環状ジペプチド類
US4806538A (en) * 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
GB8609908D0 (en) * 1986-04-23 1986-05-29 Fujisawa Pharmaceutical Co Piperazine compound
DK181687A (da) * 1986-04-23 1987-10-24 Fujisawa Pharmaceutical Co Piperazinderivater og fremgangsmaade til fremstiling deraf
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
JP3795093B2 (ja) * 1994-11-25 2006-07-12 キッセイ薬品工業株式会社 １−ヒドロキシインドール誘導体
JP3131574B2 (ja) * 1996-09-04 2001-02-05 新日本製鐵株式会社 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004512A1 (en) * 1992-08-14 1994-03-03 Xenova Limited Pharmaceutically active diketopiperazines
US5902812A (en) * 1994-02-14 1999-05-11 Xenova Limited Pharmaceutical piperazine compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519948C2 (ru) * 2008-08-22 2014-06-20 Бритиш Коламбиа Кэнсер Эйдженси Бранч Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов

Also Published As

Publication number Publication date
CN1441789A (zh) 2003-09-10
US6635649B2 (en) 2003-10-21
NO20025373D0 (no) 2002-11-08
WO2001095858A3 (en) 2002-03-21
HUP0302358A3 (en) 2007-09-28
NO326341B1 (no) 2008-11-10
CZ301743B6 (cs) 2010-06-09
BR0110745A (pt) 2003-12-30
JP2004510701A (ja) 2004-04-08
CZ20023693A3 (cs) 2003-05-14
EP1282609A2 (en) 2003-02-12
JP5101781B2 (ja) 2012-12-19
KR100852965B1 (ko) 2008-08-19
HUP0302358A2 (hu) 2003-11-28
ATE417614T1 (de) 2009-01-15
DE60137037D1 (de) 2009-01-29
CN100522949C (zh) 2009-08-05
WO2001095858A2 (en) 2001-12-20
US20020028819A1 (en) 2002-03-07
EP1282609B1 (en) 2008-12-17
NO20025373L (no) 2002-12-13
ZA200209917B (en) 2004-04-28
EP1282609A4 (en) 2003-06-04
KR20030005336A (ko) 2003-01-17

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