JP5101781B2 - ピペラジンジオン化合物 - Google Patents
ピペラジンジオン化合物 Download PDFInfo
- Publication number
- JP5101781B2 JP5101781B2 JP2002510040A JP2002510040A JP5101781B2 JP 5101781 B2 JP5101781 B2 JP 5101781B2 JP 2002510040 A JP2002510040 A JP 2002510040A JP 2002510040 A JP2002510040 A JP 2002510040A JP 5101781 B2 JP5101781 B2 JP 5101781B2
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- JP
- Japan
- Prior art keywords
- compound
- heteroaryl
- piperazinedione
- aryl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical class O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 title abstract description 32
- 150000001875 compounds Chemical class 0.000 claims abstract description 59
- -1 piperazinedione compound Chemical class 0.000 claims abstract description 57
- 125000003118 aryl group Chemical group 0.000 claims abstract description 45
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 28
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 16
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 12
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000004202 carbamide Substances 0.000 claims description 4
- 235000013877 carbamide Nutrition 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 125000003282 alkyl amino group Chemical group 0.000 claims description 3
- 125000001769 aryl amino group Chemical group 0.000 claims description 3
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- 229910052736 halogen Inorganic materials 0.000 claims description 3
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- YJGIIKCIHRJORZ-UHFFFAOYSA-N thiocyanatosulfamic acid Chemical compound C(#N)SNS(=O)(=O)O YJGIIKCIHRJORZ-UHFFFAOYSA-N 0.000 claims description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US30419100P | 2000-05-09 | 2000-05-09 | |
| US60/304,191 | 2000-05-09 | ||
| PCT/US2001/014721 WO2001095858A2 (en) | 2000-05-09 | 2001-05-08 | Piperazinedione compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510701A JP2004510701A (ja) | 2004-04-08 |
| JP2004510701A5 JP2004510701A5 (enExample) | 2008-04-17 |
| JP5101781B2 true JP5101781B2 (ja) | 2012-12-19 |
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| JP2002510040A Expired - Fee Related JP5101781B2 (ja) | 2000-05-09 | 2001-05-08 | ピペラジンジオン化合物 |
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|---|---|
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| EP (1) | EP1282609B1 (enExample) |
| JP (1) | JP5101781B2 (enExample) |
| KR (1) | KR100852965B1 (enExample) |
| CN (1) | CN100522949C (enExample) |
| AT (1) | ATE417614T1 (enExample) |
| BR (1) | BR0110745A (enExample) |
| CZ (1) | CZ301743B6 (enExample) |
| DE (1) | DE60137037D1 (enExample) |
| HU (1) | HUP0302358A3 (enExample) |
| NO (1) | NO326341B1 (enExample) |
| RU (1) | RU2269520C2 (enExample) |
| WO (1) | WO2001095858A2 (enExample) |
| ZA (1) | ZA200209917B (enExample) |
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| US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
| PT1311269E (pt) | 2000-08-04 | 2012-05-10 | Dmi Biosciences Inc | Método de utilização de dicetopiperazinas e composição que contém as mesmas |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| EP1571970B1 (en) * | 2002-10-02 | 2011-08-17 | DMI Biosciences, Inc. | Diagnosis and monitoring of diseases |
| KR20120101164A (ko) | 2003-05-15 | 2012-09-12 | 디엠아이 바이오사이언시스, 인크 | Ｔ-세포 매개성 질환의 치료 방법 |
| CA2538352A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize n-acyl-l-aspartic acid |
| WO2005077940A1 (en) * | 2004-02-04 | 2005-08-25 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| RU2519948C2 (ru) * | 2008-08-22 | 2014-06-20 | Бритиш Коламбиа Кэнсер Эйдженси Бранч | Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов |
| BRPI1013328A2 (pt) * | 2009-04-16 | 2016-03-29 | Telik Inc | 4-amino-benzoil-2-(fenilamino) tiofeno-3-carbonitrilas substituídas e 4-a-mino-5benzoil-2-(fenilamino) tiofeno-3-carboxamidas substituídas como inibidores da polimerização de tubulina |
| CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
| US8710062B2 (en) * | 2011-03-11 | 2014-04-29 | Taipei Medical University | Piperazinedione compounds |
| EP2766029B1 (en) | 2011-10-10 | 2020-03-25 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| MX2014003856A (es) | 2011-10-10 | 2015-01-16 | Ampio Pharmaceuticals Inc | Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos. |
| SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
| AU2014232728B2 (en) | 2013-03-15 | 2019-02-21 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| JP6311097B2 (ja) * | 2013-07-31 | 2018-04-18 | 学校法人東京薬科大学 | 微小管脱重合剤 |
| EP3183240A4 (en) | 2014-08-18 | 2018-06-27 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| CN104356077B (zh) * | 2014-09-11 | 2016-09-14 | 中国科学院南海海洋研究所 | 一类不对称酰基保护的2,5-二酮哌嗪衍生物及其制备方法和应用 |
| RU2728796C2 (ru) | 2015-03-06 | 2020-07-31 | Бейондспринг Фармасьютикалс, Инк. | Способ лечения опухоли головного мозга |
| CN107530341B (zh) | 2015-03-06 | 2021-10-01 | 大连万春布林医药有限公司 | 治疗与ras突变相关的癌症的方法 |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| DK3334726T3 (da) | 2015-07-13 | 2022-05-16 | Beyondspring Pharmaceuticals Inc | Plinabulinsammensætninger |
| AU2017217426B2 (en) | 2016-02-08 | 2022-12-01 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| SG11201810872UA (en) | 2016-06-06 | 2019-01-30 | Beyondspring Pharmaceuticals Inc | Composition and method for reducing neutropenia |
| CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
| CN110381938A (zh) | 2017-02-01 | 2019-10-25 | 大连万春布林医药有限公司 | 减少中性粒细胞缺乏症的方法 |
| CA3089226A1 (en) | 2018-01-24 | 2019-08-01 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
| CN109580801B (zh) * | 2018-06-26 | 2021-09-07 | 深圳海王医药科技研究院有限公司 | 一种检测微管蛋白抑制剂及相关杂质的高效液相色谱法 |
| CN112010930B (zh) * | 2019-05-28 | 2022-08-02 | 首都医科大学 | Rgd修饰的五环哌嗪二酮及其制备和应用 |
| EP4319751A4 (en) | 2021-04-09 | 2025-02-26 | Beyondspring Pharmaceuticals, Inc. | THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS |
| CN117285516A (zh) * | 2022-06-16 | 2023-12-26 | 大连万众益生大健康有限公司 | 脱氢苯基阿夕斯汀类化合物、其制备方法及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5973574A (ja) * | 1982-10-21 | 1984-04-25 | Grelan Pharmaceut Co Ltd | 環状ジペプチド類 |
| US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
| GB8609908D0 (en) * | 1986-04-23 | 1986-05-29 | Fujisawa Pharmaceutical Co | Piperazine compound |
| DK181687A (da) * | 1986-04-23 | 1987-10-24 | Fujisawa Pharmaceutical Co | Piperazinderivater og fremgangsmaade til fremstiling deraf |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
| IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
| GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| JP3795093B2 (ja) * | 1994-11-25 | 2006-07-12 | キッセイ薬品工業株式会社 | １−ヒドロキシインドール誘導体 |
| JP3131574B2 (ja) * | 1996-09-04 | 2001-02-05 | 新日本製鐵株式会社 | 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤 |
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2001
- 2001-05-08 WO PCT/US2001/014721 patent/WO2001095858A2/en not_active Ceased
- 2001-05-08 HU HU0302358A patent/HUP0302358A3/hu unknown
- 2001-05-08 KR KR1020027015025A patent/KR100852965B1/ko not_active Expired - Fee Related
- 2001-05-08 CZ CZ20023693A patent/CZ301743B6/cs not_active IP Right Cessation
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- 2001-05-08 RU RU2002132897/04A patent/RU2269520C2/ru not_active IP Right Cessation
- 2001-05-08 DE DE60137037T patent/DE60137037D1/de not_active Expired - Lifetime
- 2001-05-08 BR BR0110745-3A patent/BR0110745A/pt not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2269520C2 (ru) | 2006-02-10 |
| CN1441789A (zh) | 2003-09-10 |
| US6635649B2 (en) | 2003-10-21 |
| NO20025373D0 (no) | 2002-11-08 |
| WO2001095858A3 (en) | 2002-03-21 |
| HUP0302358A3 (en) | 2007-09-28 |
| NO326341B1 (no) | 2008-11-10 |
| CZ301743B6 (cs) | 2010-06-09 |
| BR0110745A (pt) | 2003-12-30 |
| JP2004510701A (ja) | 2004-04-08 |
| CZ20023693A3 (cs) | 2003-05-14 |
| EP1282609A2 (en) | 2003-02-12 |
| KR100852965B1 (ko) | 2008-08-19 |
| HUP0302358A2 (hu) | 2003-11-28 |
| ATE417614T1 (de) | 2009-01-15 |
| DE60137037D1 (de) | 2009-01-29 |
| CN100522949C (zh) | 2009-08-05 |
| WO2001095858A2 (en) | 2001-12-20 |
| US20020028819A1 (en) | 2002-03-07 |
| EP1282609B1 (en) | 2008-12-17 |
| NO20025373L (no) | 2002-12-13 |
| ZA200209917B (en) | 2004-04-28 |
| EP1282609A4 (en) | 2003-06-04 |
| KR20030005336A (ko) | 2003-01-17 |
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