BRPI1013328A2 - 4-amino-benzoil-2-(fenilamino) tiofeno-3-carbonitrilas substituídas e 4-a-mino-5benzoil-2-(fenilamino) tiofeno-3-carboxamidas substituídas como inibidores da polimerização de tubulina - Google Patents
4-amino-benzoil-2-(fenilamino) tiofeno-3-carbonitrilas substituídas e 4-a-mino-5benzoil-2-(fenilamino) tiofeno-3-carboxamidas substituídas como inibidores da polimerização de tubulinaInfo
- Publication number
- BRPI1013328A2 BRPI1013328A2 BRPI1013328A BRPI1013328A BRPI1013328A2 BR PI1013328 A2 BRPI1013328 A2 BR PI1013328A2 BR PI1013328 A BRPI1013328 A BR PI1013328A BR PI1013328 A BRPI1013328 A BR PI1013328A BR PI1013328 A2 BRPI1013328 A2 BR PI1013328A2
- Authority
- BR
- Brazil
- Prior art keywords
- phenylamino
- thiophene
- substituted
- 5benzoyl
- carbonitriles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
- C07D333/10—Thiophene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16978509P | 2009-04-16 | 2009-04-16 | |
| PCT/US2010/023561 WO2010120400A2 (en) | 2009-04-16 | 2010-02-09 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1013328A2 true BRPI1013328A2 (pt) | 2016-03-29 |
Family
ID=42983059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1013328A BRPI1013328A2 (pt) | 2009-04-16 | 2010-02-09 | 4-amino-benzoil-2-(fenilamino) tiofeno-3-carbonitrilas substituídas e 4-a-mino-5benzoil-2-(fenilamino) tiofeno-3-carboxamidas substituídas como inibidores da polimerização de tubulina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8410163B2 (pt) |
| EP (1) | EP2419424A4 (pt) |
| JP (1) | JP2012524066A (pt) |
| KR (1) | KR20120006543A (pt) |
| CN (1) | CN102395581A (pt) |
| AU (1) | AU2010236980A1 (pt) |
| BR (1) | BRPI1013328A2 (pt) |
| CA (1) | CA2757573A1 (pt) |
| IL (1) | IL215552A0 (pt) |
| SG (1) | SG175198A1 (pt) |
| WO (1) | WO2010120400A2 (pt) |
| ZA (1) | ZA201107487B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768595B (zh) * | 2014-01-27 | 2016-03-02 | 中国医学科学院医学生物学研究所 | 唑来膦酸佐剂及含唑来膦酸佐剂的疫苗 |
| WO2017181974A1 (zh) * | 2016-04-20 | 2017-10-26 | 苏州苏领生物医药有限公司 | 五元杂环类化合物及其制备方法、药物组合物和用途 |
| CN107304202A (zh) * | 2016-04-20 | 2017-10-31 | 苏州苏领生物医药有限公司 | 五元杂环类化合物及其制备方法、药物组合物和用途 |
| CN108358864B (zh) * | 2017-12-15 | 2020-07-17 | 五邑大学 | 一种2-酰基-5-苯基噁唑类微管蛋白抑制剂的制备方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2269520C2 (ru) * | 2000-05-09 | 2006-02-10 | Эдфарма, Инк. | Соединения пиперазиндиона |
| AUPR283801A0 (en) * | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| MXPA04004064A (es) * | 2001-10-30 | 2004-09-06 | Pharmacia Corp | Derivados heteroaromaticos de carboxamida para el tratramiento de la inflamacion. |
| US20050085531A1 (en) | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| WO2006078287A2 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
-
2010
- 2010-02-09 WO PCT/US2010/023561 patent/WO2010120400A2/en active Application Filing
- 2010-02-09 AU AU2010236980A patent/AU2010236980A1/en not_active Abandoned
- 2010-02-09 SG SG2011074499A patent/SG175198A1/en unknown
- 2010-02-09 JP JP2012505897A patent/JP2012524066A/ja active Pending
- 2010-02-09 KR KR1020117026836A patent/KR20120006543A/ko not_active Application Discontinuation
- 2010-02-09 CA CA2757573A patent/CA2757573A1/en not_active Abandoned
- 2010-02-09 EP EP10764789.3A patent/EP2419424A4/en not_active Withdrawn
- 2010-02-09 US US13/263,489 patent/US8410163B2/en not_active Expired - Fee Related
- 2010-02-09 CN CN2010800163865A patent/CN102395581A/zh active Pending
- 2010-02-09 BR BRPI1013328A patent/BRPI1013328A2/pt not_active IP Right Cessation
-
2011
- 2011-10-05 IL IL215552A patent/IL215552A0/en unknown
- 2011-10-12 ZA ZA2011/07487A patent/ZA201107487B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120101286A1 (en) | 2012-04-26 |
| JP2012524066A (ja) | 2012-10-11 |
| SG175198A1 (en) | 2011-12-29 |
| ZA201107487B (en) | 2012-06-27 |
| EP2419424A4 (en) | 2014-01-08 |
| WO2010120400A2 (en) | 2010-10-21 |
| KR20120006543A (ko) | 2012-01-18 |
| CN102395581A (zh) | 2012-03-28 |
| CA2757573A1 (en) | 2010-10-21 |
| WO2010120400A3 (en) | 2011-01-20 |
| AU2010236980A1 (en) | 2011-11-10 |
| US8410163B2 (en) | 2013-04-02 |
| EP2419424A2 (en) | 2012-02-22 |
| IL215552A0 (en) | 2011-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2012000114A (es) | Inhibidor bromodominio de benzodiazepina | |
| BRPI1015238A2 (pt) | diamidas de azetidilina como inibidores de monoaciglicerol lipase | |
| BR112013009496A2 (pt) | artigos absorventes e métodos de fabricação dos mesmos | |
| CR20130192A (es) | Derivados de bencimidazol como inhibidores de cinasa p13 | |
| BR112013013167A2 (pt) | inibidores de bromodomínio e usos dos mesmos | |
| BR112012000525A2 (pt) | inibidores da bace | |
| BRPI1008029A2 (pt) | dispositivo de exibição e método de fabricação do mesmo | |
| BR112012015827A2 (pt) | novos compostos de pirimidina como inibidores de mtor e p13k | |
| BRPI1008744A2 (pt) | hidrotratamento de caboidratos | |
| BR112013008886A2 (pt) | pirrolidinonas como inibidores de metap-2 | |
| UY33155A (es) | Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa | |
| FI20096058A0 (fi) | Koostumuksia ja niihin liittyviä menetelmiä ja käyttöjä | |
| BR112012025149A2 (pt) | artigo absorvente e método de fabricação de um artigo absorvente | |
| BR112012010201A2 (pt) | formulação de libertação modificada da lacosamida | |
| ECSP10010558A (es) | Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa | |
| DK3597650T3 (da) | Aldosereduktasehæmmere og anvendelser deraf | |
| BR112012014277A2 (pt) | fabricação e montagem de artigos absorventes com múltiplos componentes impressos | |
| BRPI1014683A2 (pt) | marcador e stent | |
| DK2516435T3 (da) | Inhibitorer af AKT-aktivitet | |
| BRPI1006486A2 (pt) | dispositivo e método de localizar de descargas parciais | |
| ECSP12011970A (es) | NUEVOS DERIVADOS DE (HETEROCICLO-PIPERIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA O DE (HETEROCICLO-PIRROLIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA Y SU UTILIZACIÓN COMO INHIBIDORES DE p75 | |
| BR112012003584A2 (pt) | método e disposito para utilização de biomassa | |
| BRPI1009132A2 (pt) | derivados de rosuvastatina e atorvastatina | |
| BRPI1013328A2 (pt) | 4-amino-benzoil-2-(fenilamino) tiofeno-3-carbonitrilas substituídas e 4-a-mino-5benzoil-2-(fenilamino) tiofeno-3-carboxamidas substituídas como inibidores da polimerização de tubulina | |
| BR112012009858A2 (pt) | conjunto de um primeiro equipamento e de um segundo equipamento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2367 DE 17-05-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |