RU2264383C2 - Лекарственные вещества и фармацевтические композиции на их основе для использования в случаях окислительного стресса - Google Patents

Лекарственные вещества и фармацевтические композиции на их основе для использования в случаях окислительного стресса Download PDF

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RU2264383C2
RU2264383C2 RU2002103509/04A RU2002103509A RU2264383C2 RU 2264383 C2 RU2264383 C2 RU 2264383C2 RU 2002103509/04 A RU2002103509/04 A RU 2002103509/04A RU 2002103509 A RU2002103509 A RU 2002103509A RU 2264383 C2 RU2264383 C2 RU 2264383C2
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RU2002103509A (ru
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СОЛДАТО Пьеро ДЕЛ (IT)
Солдато Пьеро Дел
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Никокс С.А.
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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RU2002103509/04A 1999-08-12 2000-07-27 Лекарственные вещества и фармацевтические композиции на их основе для использования в случаях окислительного стресса RU2264383C2 (ru)

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ITMI99A001817 1999-08-12
IT1999MI001817A IT1314184B1 (it) 1999-08-12 1999-08-12 Composizioni farmaceutiche per la terapia di condizioni di stressossidativo

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RU2002103509A RU2002103509A (ru) 2003-09-20
RU2264383C2 true RU2264383C2 (ru) 2005-11-20

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RU2340597C1 (ru) * 2007-03-21 2008-12-10 Институт физиологически активных веществ Российской Академии наук Нитроксиалкиламинокислоты
RU2364394C1 (ru) * 2008-03-19 2009-08-20 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции клопидогрелем при l-name индуцированном дефиците оксида азота
RU2468019C2 (ru) * 2006-07-18 2012-11-27 Антиб Терапьютикс Инк. Сероводородные производные нестероидных противовоспалительных лекарственных средств
RU2709067C1 (ru) * 2018-07-23 2019-12-13 федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" Способ термосиловой обработки длинномерных осесимметричных деталей и устройство для его осуществления

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
CN100486573C (zh) 1999-12-23 2009-05-13 硝化医药股份有限公司 硝基化的和亚硝基化的环加氧酶-2抑制剂、组合物及其用途
IT1317735B1 (it) * 2000-01-26 2003-07-15 Nicox Sa Sali di agenti antimicrobici.
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2004528337A (ja) 2001-05-02 2004-09-16 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法
AU2008201838B2 (en) * 2001-05-02 2010-07-29 Nicox S.A. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
SE0101702D0 (sv) 2001-05-15 2001-05-15 Ardenia Investments Ltd Novel potentiating compounds
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie
RU2004126950A (ru) 2002-02-04 2005-06-27 АЛФАМА-Инвестигасау и Дезенволвименту де Продутош Фармасеутикуш Лда. (PT) Использование выделяющих co соединений при изготовлении лекарственного средства для лечения воспалительных заболеваний
US20030203915A1 (en) * 2002-04-05 2003-10-30 Xinqin Fang Nitric oxide donors, compositions and methods of use related applications
JP2005530819A (ja) 2002-05-02 2005-10-13 オステオスクリーン，インコーポレイテッド 一酸化窒素を放出するビスホスホネート結合体（ｎｏ−ビスホスホネート）を使用して骨増殖を刺激するための、方法および組成物
US7220749B2 (en) 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003279622A1 (en) 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1534278A4 (en) 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
AU2004246821A1 (en) 2003-06-19 2004-12-23 Nicox S.A. Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases
CA2536173A1 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
JP2007511581A (ja) * 2003-11-20 2007-05-10 ニコックス エス エイ パラセタモールのニトロオキシ誘導体類の新しい製造方法
BRPI0416584A (pt) * 2003-12-02 2007-01-30 Nicox Sa composto, uso do mesmo, e composição farmacêutica
AR047264A1 (es) * 2003-12-02 2006-01-11 Nicox Sa Nitrooxiderivados de drogas antihipertensivas
CA2554716A1 (en) * 2004-01-22 2005-08-04 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
KR100503443B1 (ko) * 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
WO2006008196A1 (en) 2004-07-20 2006-01-26 Nicox S.A. Process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates, intermediates useful in said process and preparation thereof
AU2005281359A1 (en) 2004-08-26 2006-03-16 Apparao Satyam Prodrugs and codrugs containing novel bio-cleavable disulfide linkers
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
TW200831079A (en) 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
US20080317673A1 (en) * 2007-06-20 2008-12-25 Fatema Salem Al-Thallab Method for diagnosing and treating bronchial asthma
US20080319221A1 (en) * 2007-06-22 2008-12-25 Bernd Junker Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
JP2010532780A (ja) 2007-07-09 2010-10-14 ニコックス エス エイ 慢性疼痛の治療における酸化窒素放出化合物の使用
WO2009024998A1 (en) 2007-08-17 2009-02-26 Council Of Scientific & Industrial Research Nitric oxide releasing derivatives of paracetamol
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
EP2240018B1 (en) 2008-01-04 2016-05-25 Schabar Research Associates LLC Composition comprising an analgesic and an antihistamine
EP2291076A4 (en) * 2008-05-15 2012-03-21 Merck Sharp & Dohme Angiotensin-II Receptor Antagonists
US8198292B2 (en) 2008-07-03 2012-06-12 Osteogenex, Inc. Vinpocetine and eburnamonine derivatives for promoting bone growth, treating renal damage and cancer, and devices thereof
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
PL2306995T3 (pl) * 2008-08-01 2014-12-31 Onconox Aps Właściwości przeciwnowotworowe inhibitorów proteazy zmodyfikowanych NO
WO2010108843A1 (en) 2009-03-27 2010-09-30 Nicox S.A. Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies
FR2953145B1 (fr) * 2009-11-30 2013-07-19 Inst Francais Du Petrole Solution absorbante contenant un inhibiteur de degradation derive de la pyrimidine ou de la triazine et procede d'absorption de composes acides contenus dans un effluent gazeux
CN101863900B (zh) * 2010-06-29 2012-07-25 天津药物研究院 一氧化氮供体型噻吩并吡啶衍生物、其制备方法和用途
CN102442908A (zh) * 2010-10-14 2012-05-09 天津药物研究院 制备萘普西诺的中间体及方法
WO2012060396A1 (ja) * 2010-11-02 2012-05-10 財団法人名古屋産業科学研究所 トランス－２－デセン酸誘導体及びこれを含有する医薬
JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
JP5978291B2 (ja) 2011-04-19 2016-08-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化炭素放出分子およびその使用
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
CN102557967A (zh) * 2011-12-28 2012-07-11 合肥科尚医药科技有限公司 一种盐酸氨溴索的制备方法
CA2919892C (en) 2013-08-12 2019-06-18 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
EP3006453A1 (en) 2014-10-08 2016-04-13 Cosmo Technologies Ltd. 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
US10881654B2 (en) 2015-04-24 2021-01-05 University Of Louisville Research Foundation, Inc. Selective PFKFB4 inhibitors for the treatment of cancer
WO2018161039A1 (en) 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
EP3676253B1 (en) 2017-08-31 2022-07-13 University Of Louisville Research Foundation, Inc. Quinoline derivative, compositions comprising this compound and uses thereof in the treatment of cancer
US10774046B2 (en) 2017-10-26 2020-09-15 University Of Louisville Research Foundation, Inc. Inhibitors for the treatment of cancer and related methods
EP4181912A1 (en) 2020-07-15 2023-05-24 Schabar Research Associates LLC Unit oral dose compositions composed of ibuprofen and famotidine for the treatment of acute pain and the reduction of the severity and/or risk of heartburn
US11324727B2 (en) 2020-07-15 2022-05-10 Schabar Research Associates, Llc Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn
CN112316158B (zh) * 2020-11-19 2021-09-21 四川大学 一种利用超分子包合剂关闭胶原溶液中抗菌剂活性的方法
CN116270562B (zh) * 2022-03-18 2025-07-01 北京诺和德美医药科技有限公司 一种制备稳定的吸入用2-氨基-3,5-二溴苯甲胺衍生物溶液的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597847A (en) * 1992-08-20 1997-01-28 Corlay S.L. Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino) phenylacetic acid and process for their preparation
US5861426A (en) * 1994-05-10 1999-01-19 Nicox S.A. Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
ATE2269T1 (de) 1978-12-21 1983-02-15 Gruppo Lepetit S.P.A. 3h-naphtho(1,2-d)imidazole, verfahren zu deren herstellung, verbindungen zur verwendung als entzuendungshemmende und antimikrobielle mittel und sie enthaltende zusammensetzungen zu dieser verwendung.
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
HU218923B (hu) 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
JPH09202764A (ja) * 1996-01-24 1997-08-05 Chugai Pharmaceut Co Ltd ニトロ化合物
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1311923B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597847A (en) * 1992-08-20 1997-01-28 Corlay S.L. Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino) phenylacetic acid and process for their preparation
RU2109009C1 (ru) * 1992-08-20 1998-04-20 Корлай С.Л. Производные 2-(2,6-дигалофениламино)фенилуксусной кислоты и способ их получения
US5861426A (en) * 1994-05-10 1999-01-19 Nicox S.A. Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2468019C2 (ru) * 2006-07-18 2012-11-27 Антиб Терапьютикс Инк. Сероводородные производные нестероидных противовоспалительных лекарственных средств
RU2340597C1 (ru) * 2007-03-21 2008-12-10 Институт физиологически активных веществ Российской Академии наук Нитроксиалкиламинокислоты
RU2364394C1 (ru) * 2008-03-19 2009-08-20 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции клопидогрелем при l-name индуцированном дефиците оксида азота
RU2709067C1 (ru) * 2018-07-23 2019-12-13 федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" Способ термосиловой обработки длинномерных осесимметричных деталей и устройство для его осуществления

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