RU2243226C2 - Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции - Google Patents
Новые производные бензимидазола и содержащие эти соединения фармацевтические композицииInfo
- Publication number
- RU2243226C2 RU2243226C2 RU2001131104/04A RU2001131104A RU2243226C2 RU 2243226 C2 RU2243226 C2 RU 2243226C2 RU 2001131104/04 A RU2001131104/04 A RU 2001131104/04A RU 2001131104 A RU2001131104 A RU 2001131104A RU 2243226 C2 RU2243226 C2 RU 2243226C2
- Authority
- RU
- Russia
- Prior art keywords
- piperazinyl
- alkyl
- benzimidazole
- phenyl
- carboxylate
- Prior art date
Links
- 0 *c1cc(*(C*2)c3c2cc(C(O)O*)cc3)ccc1 Chemical compound *c1cc(*(C*2)c3c2cc(C(O)O*)cc3)ccc1 0.000 description 5
- OQHWKAMJEGNJPD-UHFFFAOYSA-N CC(C(C=CC12)=CC1N=CN2c1cccc(N2CCNCC2)c1)=O Chemical compound CC(C(C=CC12)=CC1N=CN2c1cccc(N2CCNCC2)c1)=O OQHWKAMJEGNJPD-UHFFFAOYSA-N 0.000 description 1
- SBRHZGGBIBUPBC-UHFFFAOYSA-N CCN(CC1)CC=C1c1cccc(Nc(c(N)c2)ccc2C(OCOC)=O)c1 Chemical compound CCN(CC1)CC=C1c1cccc(Nc(c(N)c2)ccc2C(OCOC)=O)c1 SBRHZGGBIBUPBC-UHFFFAOYSA-N 0.000 description 1
- DOFNEDSQQBBBFQ-UHFFFAOYSA-N CCN(CC1)CC=C1c1cccc(Nc(ccc(C(OCOC)=O)c2)c2[N+]([O-])=O)c1 Chemical compound CCN(CC1)CC=C1c1cccc(Nc(ccc(C(OCOC)=O)c2)c2[N+]([O-])=O)c1 DOFNEDSQQBBBFQ-UHFFFAOYSA-N 0.000 description 1
- SWUAUESANMWSRU-UHFFFAOYSA-N CCOC(CN(CC1)CCN1C(CC(C1)C2CCCCC2)CC1[n]1c(ccc(-c2c[o]cc2)c2)c2nc1)=O Chemical compound CCOC(CN(CC1)CCN1C(CC(C1)C2CCCCC2)CC1[n]1c(ccc(-c2c[o]cc2)c2)c2nc1)=O SWUAUESANMWSRU-UHFFFAOYSA-N 0.000 description 1
- WRUQTHIYVYGQJX-UHFFFAOYSA-N Cc1n[o]c(CN(CC2)CCN2c2cc(-[n]3c(ccc(-c4c[o]cc4)c4)c4nc3)ccc2)n1 Chemical compound Cc1n[o]c(CN(CC2)CCN2c2cc(-[n]3c(ccc(-c4c[o]cc4)c4)c4nc3)ccc2)n1 WRUQTHIYVYGQJX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199900888 | 1999-06-22 | ||
| DKPA199900888 | 1999-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001131104A RU2001131104A (ru) | 2003-07-20 |
| RU2243226C2 true RU2243226C2 (ru) | 2004-12-27 |
Family
ID=8098669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001131104/04A RU2243226C2 (ru) | 1999-06-22 | 2000-06-22 | Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6649609B2 (https=) |
| EP (1) | EP1194410B1 (https=) |
| JP (1) | JP2003502405A (https=) |
| CN (1) | CN1167686C (https=) |
| AT (1) | ATE316076T1 (https=) |
| AU (1) | AU777961B2 (https=) |
| BR (1) | BR0011823A (https=) |
| CA (1) | CA2373921A1 (https=) |
| DE (1) | DE60025604T2 (https=) |
| IL (2) | IL146403A0 (https=) |
| MX (1) | MXPA02000107A (https=) |
| NZ (1) | NZ515543A (https=) |
| RU (1) | RU2243226C2 (https=) |
| WO (1) | WO2000078728A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2435759C2 (ru) * | 2006-03-24 | 2011-12-10 | НьюроСёрч А/С | Производные бензимидазолов и их применение для модуляции гамка-рецепторного комплекса |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| CN1167686C (zh) * | 1999-06-22 | 2004-09-22 | 神经研究公司 | 苯并咪唑衍生物和包括这些化合物的药物组合物 |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| GB0117277D0 (en) | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| CA2427779A1 (en) * | 2000-11-10 | 2002-05-16 | Merck Sharp & Dohme Limited | Imidazo-triazine derivatives as ligands for gaba receptors |
| AU2002221566A1 (en) * | 2000-12-20 | 2002-07-01 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| US6743796B2 (en) * | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
| AUPR625901A0 (en) * | 2001-07-10 | 2001-08-02 | Mcgregor, Neil | A method for treatment and/or prophylaxis |
| GB0212048D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004087690A2 (en) | 2003-04-03 | 2004-10-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex |
| US7335777B2 (en) | 2003-04-03 | 2008-02-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| EP1615896B1 (en) * | 2003-04-10 | 2008-04-23 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| US7700638B2 (en) | 2003-10-23 | 2010-04-20 | N. V. Organon | 1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| EP1678145A2 (en) | 2003-10-28 | 2006-07-12 | Vertex Pharmaceuticals Incorporated | Benzimidazoles useful as modulators of ion channels |
| EP2338490A3 (en) * | 2003-11-03 | 2012-06-06 | Probiodrug AG | Combinations useful for the treatment of neuronal disorders |
| US20060185357A1 (en) * | 2004-05-07 | 2006-08-24 | Kovacevich Ian D | Independently drawing and tensioning lines with bi-directional rotary device having two spools |
| DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| CA2584831C (en) | 2004-10-13 | 2013-09-17 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
| WO2006081332A1 (en) | 2005-01-25 | 2006-08-03 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
| PL1877052T3 (pl) * | 2005-04-13 | 2010-01-29 | Neurosearch As | Pochodne benzimidazolu i ich zastosowanie do modulowania kompleksu receptora GABAA |
| US20090062304A1 (en) * | 2005-04-19 | 2009-03-05 | Lene Teuber | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex |
| EP1874758A1 (en) | 2005-04-19 | 2008-01-09 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| WO2006111517A1 (en) * | 2005-04-19 | 2006-10-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| WO2007042544A2 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Imidazole derivatives and their use for modulating the gabaa receptor complex |
| US7939556B2 (en) | 2005-10-14 | 2011-05-10 | Neurosearch A/S | Imidazole derivatives and their use for modulating the GABAA receptor complex |
| DK1996556T3 (da) * | 2005-12-05 | 2010-04-06 | Neurosearch As | Benzimidazoiderivater og deres anvendelse til modulering af GABAA-receptorkomplekset |
| AU2008258560C1 (en) * | 2007-06-08 | 2014-04-10 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| ES2536406T3 (es) * | 2007-06-08 | 2015-05-25 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
| ES2558152T3 (es) | 2007-06-08 | 2016-02-02 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
| JO2972B1 (en) * | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| ES2617619T3 (es) | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
| CN102206204B (zh) * | 2011-04-08 | 2012-12-12 | 奇方(天津)医药科技有限公司 | 一种苯并咪唑类化合物及其医药用途 |
| MX347209B (es) | 2011-12-08 | 2017-04-19 | Teva Pharmaceuticals Int Gmbh | La sal de bromhidrato de pridopidina. |
| HK1206297A1 (en) | 2012-04-04 | 2016-01-08 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for combination therapy |
| KR20200023034A (ko) * | 2018-08-24 | 2020-03-04 | 일양약품주식회사 | 이속사졸 유도체 및 그의 제조방법 |
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| RU2059623C1 (ru) * | 1989-02-02 | 1996-05-10 | Яманути Фармасьютикал Ко., Лтд. | Тетрагидробензимидазольное производное или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе, проявляющая активность 5-ht3-антагониста |
| EP0616807B1 (en) * | 1993-03-24 | 1998-07-08 | Neurosearch A/S | Benzimidazole useful in the treatment of central nervous system disorders |
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| DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0525129A4 (en) * | 1990-04-13 | 1993-03-24 | Smith-Kline Beecham Corporation | Substituted benzimidazoles |
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| DE4237656A1 (de) * | 1992-06-13 | 1993-12-16 | Merck Patent Gmbh | Benzimidazolderivate |
| US5554630A (en) * | 1993-03-24 | 1996-09-10 | Neurosearch A/S | Benzimidazole compounds |
| RU2135493C1 (ru) * | 1995-04-21 | 1999-08-27 | Нюросерч А/С | Производное бензимидазола, фармацевтический состав и способ модуляции гамка-рецепторного комплекса |
| MX9708147A (es) * | 1995-04-21 | 1997-12-31 | Neurosearch As | Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa. |
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| JP2001502675A (ja) * | 1996-10-21 | 2001-02-27 | ニューロサーチ・アクティーゼルスカブ | １―フエニル―ベンズイミダゾール化合物及びこれをｂａｇａ▲下ａ▼―レセプターモデュレーターとして使用する方法 |
| FR2755364B1 (fr) * | 1996-11-06 | 1999-01-22 | Eugene Perma Sa | Composition pour la deformation permanente des fibres keratiniques, obtention et mise en oeuvre |
| GB9702524D0 (en) * | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| AU742172B2 (en) * | 1997-10-10 | 2001-12-20 | Neurosearch A/S | Benzimidazole compounds, pharmaceutical compositions containing the comp ounds and their use |
| US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| CN1167686C (zh) * | 1999-06-22 | 2004-09-22 | 神经研究公司 | 苯并咪唑衍生物和包括这些化合物的药物组合物 |
| DE10060292A1 (de) * | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
-
2000
- 2000-06-22 CN CNB008091730A patent/CN1167686C/zh not_active Expired - Fee Related
- 2000-06-22 MX MXPA02000107A patent/MXPA02000107A/es active IP Right Grant
- 2000-06-22 WO PCT/DK2000/000333 patent/WO2000078728A1/en not_active Ceased
- 2000-06-22 NZ NZ515543A patent/NZ515543A/en not_active IP Right Cessation
- 2000-06-22 DE DE60025604T patent/DE60025604T2/de not_active Expired - Lifetime
- 2000-06-22 BR BR0011823-0A patent/BR0011823A/pt not_active Application Discontinuation
- 2000-06-22 AT AT00938584T patent/ATE316076T1/de not_active IP Right Cessation
- 2000-06-22 AU AU53910/00A patent/AU777961B2/en not_active Ceased
- 2000-06-22 CA CA002373921A patent/CA2373921A1/en not_active Abandoned
- 2000-06-22 RU RU2001131104/04A patent/RU2243226C2/ru not_active IP Right Cessation
- 2000-06-22 EP EP00938584A patent/EP1194410B1/en not_active Expired - Lifetime
- 2000-06-22 IL IL14640300A patent/IL146403A0/xx active IP Right Grant
- 2000-06-22 JP JP2001504895A patent/JP2003502405A/ja not_active Ceased
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2001
- 2001-11-08 IL IL146403A patent/IL146403A/en not_active IP Right Cessation
- 2001-12-12 US US10/012,490 patent/US6649609B2/en not_active Expired - Fee Related
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2003
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2059623C1 (ru) * | 1989-02-02 | 1996-05-10 | Яманути Фармасьютикал Ко., Лтд. | Тетрагидробензимидазольное производное или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе, проявляющая активность 5-ht3-антагониста |
| EP0616807B1 (en) * | 1993-03-24 | 1998-07-08 | Neurosearch A/S | Benzimidazole useful in the treatment of central nervous system disorders |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2435759C2 (ru) * | 2006-03-24 | 2011-12-10 | НьюроСёрч А/С | Производные бензимидазолов и их применение для модуляции гамка-рецепторного комплекса |
| US8288418B2 (en) | 2006-03-24 | 2012-10-16 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1356987A (zh) | 2002-07-03 |
| CN1167686C (zh) | 2004-09-22 |
| NZ515543A (en) | 2003-11-28 |
| US20040097570A1 (en) | 2004-05-20 |
| ATE316076T1 (de) | 2006-02-15 |
| CA2373921A1 (en) | 2000-12-28 |
| IL146403A (en) | 2007-08-19 |
| DE60025604D1 (de) | 2006-04-06 |
| US6936613B2 (en) | 2005-08-30 |
| IL146403A0 (en) | 2002-07-25 |
| BR0011823A (pt) | 2002-03-19 |
| AU777961B2 (en) | 2004-11-04 |
| MXPA02000107A (es) | 2002-07-02 |
| AU5391000A (en) | 2001-01-09 |
| US20030055055A1 (en) | 2003-03-20 |
| US6649609B2 (en) | 2003-11-18 |
| JP2003502405A (ja) | 2003-01-21 |
| WO2000078728A1 (en) | 2000-12-28 |
| EP1194410B1 (en) | 2006-01-18 |
| EP1194410A1 (en) | 2002-04-10 |
| DE60025604T2 (de) | 2006-07-27 |
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