RU2190605C2 - Способ получения мономезилатной соли n-(5-циклопропил-1-хинолин-5-ил-1н-пиразол-4-карбонил)гуанидина - Google Patents

Способ получения мономезилатной соли n-(5-циклопропил-1-хинолин-5-ил-1н-пиразол-4-карбонил)гуанидина Download PDF

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Publication number
RU2190605C2
RU2190605C2 RU2000126970/04A RU2000126970A RU2190605C2 RU 2190605 C2 RU2190605 C2 RU 2190605C2 RU 2000126970/04 A RU2000126970/04 A RU 2000126970/04A RU 2000126970 A RU2000126970 A RU 2000126970A RU 2190605 C2 RU2190605 C2 RU 2190605C2
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RU
Russia
Prior art keywords
cyclopropyl
quinolin
pyrazole
carboxylic acid
guanidine
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RU2000126970/04A
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English (en)
Russian (ru)
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RU2000126970A (ru
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Норма Жаклин ТОМ (US)
Норма Жаклин ТОМ
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Пфайзер Продактс Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2000126970/04A 1999-10-29 2000-10-27 Способ получения мономезилатной соли n-(5-циклопропил-1-хинолин-5-ил-1н-пиразол-4-карбонил)гуанидина RU2190605C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16237799P 1999-10-29 1999-10-29
US60/162,377 1999-10-29

Publications (2)

Publication Number Publication Date
RU2000126970A RU2000126970A (ru) 2002-08-27
RU2190605C2 true RU2190605C2 (ru) 2002-10-10

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RU2000126970/04A RU2190605C2 (ru) 1999-10-29 2000-10-27 Способ получения мономезилатной соли n-(5-циклопропил-1-хинолин-5-ил-1н-пиразол-4-карбонил)гуанидина

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US (1) US6441176B1 (enExample)
EP (1) EP1101763A3 (enExample)
JP (1) JP3342475B2 (enExample)
KR (2) KR100449595B1 (enExample)
CN (1) CN1146557C (enExample)
AR (1) AR029188A1 (enExample)
AU (1) AU779106B2 (enExample)
BR (1) BR0005122A (enExample)
CA (1) CA2324640A1 (enExample)
CZ (1) CZ20004018A3 (enExample)
HU (1) HUP0004187A2 (enExample)
ID (1) ID27904A (enExample)
IL (1) IL139198A0 (enExample)
PL (1) PL343542A1 (enExample)
RU (1) RU2190605C2 (enExample)
TR (1) TR200003143A2 (enExample)
TW (1) TWI221152B (enExample)
YU (1) YU62900A (enExample)
ZA (1) ZA200006007B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852733B2 (en) 2000-04-28 2005-02-08 Pfizer Inc. Sodium-hydrogen exchanger type 1 inhibitor
CZ20032017A3 (cs) * 2001-01-31 2004-05-12 Pfizeráproductsáinc Ethanoláty inhibitoru sodík@vodík měniče typu �Ź způsob jejich přípravyŹ jejich použití a farmaceutický prostředekŹ který je obsahuje
WO2003051845A1 (en) * 2001-12-19 2003-06-26 Pfizer Products Inc. Methods for preparing sodium-hydrogen exchanger type-1 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2009129C1 (ru) * 1991-12-16 1994-03-15 Центр по химии лекарственных средств Арилгидразоны 5,6,7,8-тетрагидрохинолиндионы-2,5, обладающие кардиотонической активностью
RU2103261C1 (ru) * 1992-08-12 1998-01-27 Байер Аг Изобутилзамещенные амиды метансульфонилхинолилметоксифенилциклоалкилуксусной кислоты или их фармацевтически приемлемые соли

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028381A (en) * 1975-05-05 1977-06-07 Ciba-Geigy Corporation Pyrazolobenzazepines
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
TR200002480T2 (tr) 1998-02-27 2000-12-21 Pfizer Products Inc. İzaşemi tedavisi için guanidin türevleri
UA72002C2 (en) 1999-10-29 2005-01-17 Pfizer Prod Inc Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2009129C1 (ru) * 1991-12-16 1994-03-15 Центр по химии лекарственных средств Арилгидразоны 5,6,7,8-тетрагидрохинолиндионы-2,5, обладающие кардиотонической активностью
RU2103261C1 (ru) * 1992-08-12 1998-01-27 Байер Аг Изобутилзамещенные амиды метансульфонилхинолилметоксифенилциклоалкилуксусной кислоты или их фармацевтически приемлемые соли

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem. 1997, 40, р. 2017-2034 "(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na + /H + Antiporter Inhibitors". *

Also Published As

Publication number Publication date
CZ20004018A3 (cs) 2002-04-17
TR200003143A2 (tr) 2001-05-21
KR100443851B1 (ko) 2004-08-11
IL139198A0 (en) 2001-11-25
CN1295070A (zh) 2001-05-16
AU779106B2 (en) 2005-01-06
PL343542A1 (en) 2001-05-07
JP3342475B2 (ja) 2002-11-11
ID27904A (id) 2001-05-03
BR0005122A (pt) 2001-06-19
JP2001158784A (ja) 2001-06-12
CA2324640A1 (en) 2001-04-29
AR029188A1 (es) 2003-06-18
US6441176B1 (en) 2002-08-27
CN1146557C (zh) 2004-04-21
TWI221152B (en) 2004-09-21
HU0004187D0 (enExample) 2001-01-29
ZA200006007B (en) 2002-04-26
EP1101763A2 (en) 2001-05-23
HUP0004187A2 (hu) 2002-11-28
EP1101763A3 (en) 2002-04-24
AU6133300A (en) 2001-05-03
HK1036057A1 (en) 2003-07-10
YU62900A (sh) 2003-08-29
KR20010060211A (ko) 2001-07-06
KR20030061767A (ko) 2003-07-22
KR100449595B1 (ko) 2004-09-21

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20051028