AR029188A1 - Procedimiento para preparar un inhibidor del intercambiador de sodio-hidrogeno tipo 1 - Google Patents

Procedimiento para preparar un inhibidor del intercambiador de sodio-hidrogeno tipo 1

Info

Publication number
AR029188A1
AR029188A1 ARP000105697A ARP000105697A AR029188A1 AR 029188 A1 AR029188 A1 AR 029188A1 AR P000105697 A ARP000105697 A AR P000105697A AR P000105697 A ARP000105697 A AR P000105697A AR 029188 A1 AR029188 A1 AR 029188A1
Authority
AR
Argentina
Prior art keywords
procedure
prepare
sodium
type
hydrogen exchanger
Prior art date
Application number
ARP000105697A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR029188A1 publication Critical patent/AR029188A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento para preparar inhibidores de NHE-1 que son utiles para reducir la lesion en los tejidos originada por una isquemia en los tejidos. Las lesiones isquémicas en el miocardio pueden presentarse en pacientes ambulatorios, así como en procesos perioperatorios y pueden conducir al desarrollo de muerte subita, infarto de miocardio o insuficiencia cardíaca congestiva. Se describe también la preparacion de la sal de monomesilato de N-(5-ciclopropil-1-quinolin-5-il-1H-pirazol-4-carbonil) guanidina.
ARP000105697A 1999-10-29 2000-10-27 Procedimiento para preparar un inhibidor del intercambiador de sodio-hidrogeno tipo 1 AR029188A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16237799P 1999-10-29 1999-10-29

Publications (1)

Publication Number Publication Date
AR029188A1 true AR029188A1 (es) 2003-06-18

Family

ID=22585372

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000105697A AR029188A1 (es) 1999-10-29 2000-10-27 Procedimiento para preparar un inhibidor del intercambiador de sodio-hidrogeno tipo 1

Country Status (20)

Country Link
US (1) US6441176B1 (es)
EP (1) EP1101763A3 (es)
JP (1) JP3342475B2 (es)
KR (2) KR100449595B1 (es)
CN (1) CN1146557C (es)
AR (1) AR029188A1 (es)
AU (1) AU779106B2 (es)
BR (1) BR0005122A (es)
CA (1) CA2324640A1 (es)
CZ (1) CZ20004018A3 (es)
HK (1) HK1036057A1 (es)
HU (1) HUP0004187A2 (es)
ID (1) ID27904A (es)
IL (1) IL139198A0 (es)
PL (1) PL343542A1 (es)
RU (1) RU2190605C2 (es)
TR (1) TR200003143A2 (es)
TW (1) TWI221152B (es)
YU (1) YU62900A (es)
ZA (1) ZA200006007B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852733B2 (en) 2000-04-28 2005-02-08 Pfizer Inc. Sodium-hydrogen exchanger type 1 inhibitor
EP1355899A1 (en) * 2001-01-31 2003-10-29 Pfizer Products Inc. Ethanolates of sodium-hydrogen exchanger type-1 inhibitor
AU2002337460A1 (en) * 2001-12-19 2003-06-30 Pfizer Products Inc. Methods for preparing sodium-hydrogen exchanger type-1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028381A (en) * 1975-05-05 1977-06-07 Ciba-Geigy Corporation Pyrazolobenzazepines
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
EP1454902A1 (en) 1998-02-27 2004-09-08 Pfizer Products Inc. N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia
UA72002C2 (en) 1999-10-29 2005-01-17 Pfizer Prod Inc Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage

Also Published As

Publication number Publication date
YU62900A (sh) 2003-08-29
RU2190605C2 (ru) 2002-10-10
US6441176B1 (en) 2002-08-27
HU0004187D0 (es) 2001-01-29
KR20010060211A (ko) 2001-07-06
HUP0004187A2 (hu) 2002-11-28
TR200003143A2 (tr) 2001-05-21
PL343542A1 (en) 2001-05-07
AU779106B2 (en) 2005-01-06
EP1101763A3 (en) 2002-04-24
KR100449595B1 (ko) 2004-09-21
ZA200006007B (en) 2002-04-26
IL139198A0 (en) 2001-11-25
EP1101763A2 (en) 2001-05-23
CA2324640A1 (en) 2001-04-29
CN1146557C (zh) 2004-04-21
JP3342475B2 (ja) 2002-11-11
KR20030061767A (ko) 2003-07-22
CZ20004018A3 (cs) 2002-04-17
ID27904A (id) 2001-05-03
AU6133300A (en) 2001-05-03
HK1036057A1 (en) 2003-07-10
JP2001158784A (ja) 2001-06-12
TWI221152B (en) 2004-09-21
BR0005122A (pt) 2001-06-19
KR100443851B1 (ko) 2004-08-11
CN1295070A (zh) 2001-05-16

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