ECSP045472A - "derivados de n-((3-oxo-2,3-dihidro-1h-isoindol-1-il)acetil)guanidina en calidad de inhibidores de nhe-1 para el tratamiento del infarto y la angina de pecho" - Google Patents
"derivados de n-((3-oxo-2,3-dihidro-1h-isoindol-1-il)acetil)guanidina en calidad de inhibidores de nhe-1 para el tratamiento del infarto y la angina de pecho"Info
- Publication number
- ECSP045472A ECSP045472A ECSP045472A ECSP045472A EC SP045472 A ECSP045472 A EC SP045472A EC SP045472 A ECSP045472 A EC SP045472A EC SP045472 A ECSP045472 A EC SP045472A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- derivatives
- infarto
- dihidro
- nhe
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title 1
- 102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 title 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title 1
- 108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 206010061216 Infarction Diseases 0.000 abstract 2
- 230000007574 infarction Effects 0.000 abstract 2
- 208000028867 ischemia Diseases 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000003293 cardioprotective effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- XTBAPWCYTNCZTO-UHFFFAOYSA-N isoindol-1-one Chemical class C1=CC=C2C(=O)N=CC2=C1 XTBAPWCYTNCZTO-UHFFFAOYSA-N 0.000 abstract 1
- 230000035778 pathophysiological process Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La presente invención se refiere a los nuevos compuestos de isoindolona de la fórmula I:en la cual R1 a R6 tienen los significados indicados en las reivindicaciones. Los compuestos de la invención son adecuados como medicamentos antiarrítmicos con un componente cardioprotector para la profilaxis del infarto y el tratamiento del infarto y para el tratamiento de la angina de pecho. Dichos derivados inhiben también de manera preventiva los procesos patofisiológicos asociados con el desarrollo del daño inducido por isquemia, en particular en el desencadenamiento de arritmias cardíacas inducidas por isquemia y de la insuficiencia cardíaca.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0206783A FR2840302B1 (fr) | 2002-06-03 | 2002-06-03 | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045472A true ECSP045472A (es) | 2005-01-28 |
Family
ID=29558914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045472 ECSP045472A (es) | 2002-06-03 | 2004-12-02 | "derivados de n-((3-oxo-2,3-dihidro-1h-isoindol-1-il)acetil)guanidina en calidad de inhibidores de nhe-1 para el tratamiento del infarto y la angina de pecho" |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US7078428B2 (es) |
| EP (1) | EP1528923B1 (es) |
| JP (1) | JP4634793B2 (es) |
| KR (1) | KR101149771B1 (es) |
| CN (1) | CN1290833C (es) |
| AR (1) | AR039927A1 (es) |
| AT (1) | ATE324889T1 (es) |
| AU (1) | AU2003240677B2 (es) |
| BR (1) | BR0311556A (es) |
| CA (1) | CA2488373C (es) |
| CY (1) | CY1105115T1 (es) |
| DE (1) | DE60305042T2 (es) |
| DK (1) | DK1528923T3 (es) |
| EC (1) | ECSP045472A (es) |
| EG (1) | EG24784A (es) |
| ES (1) | ES2261939T3 (es) |
| FR (1) | FR2840302B1 (es) |
| HN (1) | HN2003000162A (es) |
| HR (1) | HRP20041151B1 (es) |
| IL (1) | IL165520A (es) |
| JO (1) | JO2357B1 (es) |
| MA (1) | MA27308A1 (es) |
| ME (1) | MEP27508A (es) |
| MX (1) | MXPA04011931A (es) |
| MY (1) | MY142502A (es) |
| NO (1) | NO329224B1 (es) |
| NZ (1) | NZ536953A (es) |
| OA (1) | OA12864A (es) |
| PA (1) | PA8574701A1 (es) |
| PE (1) | PE20040531A1 (es) |
| PL (1) | PL372188A1 (es) |
| PT (1) | PT1528923E (es) |
| RS (1) | RS51636B (es) |
| RU (1) | RU2318809C2 (es) |
| SI (1) | SI1528923T1 (es) |
| TN (1) | TNSN04237A1 (es) |
| TW (1) | TWI286545B (es) |
| UA (1) | UA81118C2 (es) |
| UY (1) | UY27835A1 (es) |
| WO (1) | WO2003101450A1 (es) |
| ZA (1) | ZA200409094B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7531569B2 (en) | 2003-12-02 | 2009-05-12 | Sanofi-Aventis Deutschland Gmbh | Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives |
| DE10356717A1 (de) * | 2003-12-02 | 2005-07-07 | Aventis Pharma Deutschland Gmbh | Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten |
| KR100518184B1 (ko) * | 2003-12-27 | 2005-10-04 | 한국화학연구원 | 퓨란카보닐구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물 |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| US20070161648A1 (en) * | 2005-10-14 | 2007-07-12 | Hughes Terry V | Substituted dihydro-isoindolones useful in treating kinase disorders |
| TW200812962A (en) * | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
| SA109300358B1 (ar) | 2008-06-06 | 2012-11-03 | استرازينيكا ايه بي | مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون |
| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| EP2588104B1 (en) * | 2010-07-01 | 2014-12-10 | Merck Sharp & Dohme Corp. | Isoindolone m1 receptor positive allosteric modulators |
| WO2013056015A1 (en) | 2011-10-14 | 2013-04-18 | Incyte Corporation | Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors |
| CN103193794B (zh) * | 2013-04-12 | 2016-04-06 | 中国药科大学 | 一种异吲哚酮并异噁唑类稠环化合物及其合成方法 |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| CN106316922B (zh) * | 2016-08-17 | 2019-02-01 | 华东师范大学 | 一种含c-3全取代氧化吲哚衍生物及其合成方法和应用 |
| WO2018058109A1 (en) | 2016-09-26 | 2018-03-29 | Nusirt Sciences, Inc. | Compositions and methods for treating metabolic disorders |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN110664803B (zh) * | 2019-09-19 | 2023-08-29 | 中山大学 | 异吲哚酮类化合物在制备防治溶骨性疾病药物中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| DE59403818D1 (de) | 1993-02-20 | 1997-10-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament |
| FR2735166B1 (fr) * | 1995-06-08 | 1997-08-29 | Aerospatiale | Procede de fabrication d'un panneau ou analogue a proprietes structurale et acoustique et panneau ainsi obtenu |
| DE19737224A1 (de) | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
| DE19737463A1 (de) | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
| DE19738604A1 (de) | 1997-09-04 | 1999-03-11 | Hoechst Marion Roussel De Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe |
| JP2002504546A (ja) | 1998-02-27 | 2002-02-12 | ファイザー・プロダクツ・インク | 虚血の治療のためのｎ−［（置換５員ジもしくはトリアザ二不飽和環）カルボニル］グアニジン誘導体 |
| DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| US6534651B2 (en) * | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
| NZ521348A (en) * | 2000-04-28 | 2004-09-24 | Pfizer Prod Inc | Sodium-hydrogen exchanger type 1 inhibitor (NHE-1) |
| DE10046993A1 (de) | 2000-09-22 | 2002-04-11 | Aventis Pharma Gmbh | Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament |
| WO2002081443A1 (en) * | 2001-04-09 | 2002-10-17 | Chiron Corporation | Novel guanidino compounds |
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2002
- 2002-06-03 FR FR0206783A patent/FR2840302B1/fr not_active Expired - Fee Related
-
2003
- 2003-05-07 JO JO200351A patent/JO2357B1/en active
- 2003-05-20 RU RU2004138789A patent/RU2318809C2/ru not_active IP Right Cessation
- 2003-05-20 OA OA1200400323A patent/OA12864A/en unknown
- 2003-05-20 NZ NZ536953A patent/NZ536953A/en not_active IP Right Cessation
- 2003-05-20 EP EP20030730076 patent/EP1528923B1/en not_active Expired - Lifetime
- 2003-05-20 MX MXPA04011931A patent/MXPA04011931A/es active IP Right Grant
- 2003-05-20 AU AU2003240677A patent/AU2003240677B2/en not_active Ceased
- 2003-05-20 BR BR0311556A patent/BR0311556A/pt not_active IP Right Cessation
- 2003-05-20 RS YUP104804 patent/RS51636B/sr unknown
- 2003-05-20 ME MEP27508 patent/MEP27508A/xx unknown
- 2003-05-20 PL PL37218803A patent/PL372188A1/xx unknown
- 2003-05-20 KR KR1020047019619A patent/KR101149771B1/ko not_active Expired - Fee Related
- 2003-05-20 HR HRP20041151AA patent/HRP20041151B1/hr not_active IP Right Cessation
- 2003-05-20 ES ES03730076T patent/ES2261939T3/es not_active Expired - Lifetime
- 2003-05-20 CN CNB038128500A patent/CN1290833C/zh not_active Expired - Fee Related
- 2003-05-20 CA CA 2488373 patent/CA2488373C/en not_active Expired - Fee Related
- 2003-05-20 AT AT03730076T patent/ATE324889T1/de active
- 2003-05-20 JP JP2004508808A patent/JP4634793B2/ja not_active Expired - Fee Related
- 2003-05-20 DE DE2003605042 patent/DE60305042T2/de not_active Expired - Lifetime
- 2003-05-20 UA UA20041211001A patent/UA81118C2/uk unknown
- 2003-05-20 DK DK03730076T patent/DK1528923T3/da active
- 2003-05-20 PT PT03730076T patent/PT1528923E/pt unknown
- 2003-05-20 WO PCT/EP2003/005279 patent/WO2003101450A1/en not_active Ceased
- 2003-05-20 SI SI200330302T patent/SI1528923T1/sl unknown
- 2003-05-27 US US10/445,618 patent/US7078428B2/en not_active Expired - Lifetime
- 2003-05-29 PE PE2003000523A patent/PE20040531A1/es not_active Application Discontinuation
- 2003-05-30 AR ARP030101923 patent/AR039927A1/es active IP Right Grant
- 2003-05-30 TW TW92114642A patent/TWI286545B/zh not_active IP Right Cessation
- 2003-05-30 HN HN2003000162A patent/HN2003000162A/es unknown
- 2003-06-01 EG EG2003060521A patent/EG24784A/xx active
- 2003-06-02 MY MYPI20032036 patent/MY142502A/en unknown
- 2003-06-02 PA PA8574701A patent/PA8574701A1/es unknown
- 2003-06-03 UY UY27835A patent/UY27835A1/es unknown
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2004
- 2004-11-10 ZA ZA2004/09094A patent/ZA200409094B/en unknown
- 2004-11-16 MA MA27951A patent/MA27308A1/fr unknown
- 2004-11-30 TN TNP2004000237A patent/TNSN04237A1/en unknown
- 2004-12-02 IL IL165520A patent/IL165520A/en not_active IP Right Cessation
- 2004-12-02 EC ECSP045472 patent/ECSP045472A/es unknown
- 2004-12-27 NO NO20045660A patent/NO329224B1/no not_active IP Right Cessation
-
2006
- 2006-03-01 US US11/365,319 patent/US7589117B2/en not_active Expired - Fee Related
- 2006-07-28 CY CY20061101057T patent/CY1105115T1/el unknown
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