MEP28908A - Pentafluorosulfanyl-benzoylguanidine, method for the production thereof and its utilization as medicament or diagnostic agent and medicament containing same - Google Patents
Pentafluorosulfanyl-benzoylguanidine, method for the production thereof and its utilization as medicament or diagnostic agent and medicament containing sameInfo
- Publication number
- MEP28908A MEP28908A MEP-289/08A MEP28908A MEP28908A ME P28908 A MEP28908 A ME P28908A ME P28908 A MEP28908 A ME P28908A ME P28908 A MEP28908 A ME P28908A
- Authority
- ME
- Montenegro
- Prior art keywords
- medicament
- pentafluorosulfanyl
- benzoylguanidine
- utilization
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Pentafl uorsulfanil-benzoilgvanidini, postupak za njihovu proizvodnju, njihova primjena u svojstvu lijeka ili dijagnosti čkog sredstva kao I lijek koji sadrži ova jedinjenja Pronalazak se odnosi na pentafl uorsulfanil-benzoilgvanidne formule (I) i (II) u kojima R1 R4 imaju značenja koja su navedena u zahtjevima. Ova jedinjenja su pogodna kao anti aritmijdki ljekovi sa kardioprotekti vnom komponentom za profi laksu ili liječenje srčanog infarkta, isto tako za liječenje angine pectoris. Ona inhibiraju preventi vno i patofi ziološke procese pri pojavi ishemijski indukovanih oštećenja, naročito pri pojavi ishemijski indukovanih srčanih aritmija.The invention relates to pentafluorosulfanyl-benzoylguanidines of formula (I) and (II) in which R1 and R4 have the meanings which are specified in the requirements. These compounds are suitable as antiarrhythmic drugs with a cardioprotective component for the prophylaxis or treatment of myocardial infarction, as well as for the treatment of angina pectoris. They inhibit preventive and pathophysiological processes in the occurrence of ischemically induced damage, especially in the occurrence of ischemically induced cardiac arrhythmias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10222192A DE10222192A1 (en) | 2002-05-18 | 2002-05-18 | New pentafluorosulfanylbenzoylguanidine compound useful for treating e.g. infarction, angina pectoris and stroke |
PCT/EP2003/004669 WO2003097591A1 (en) | 2002-05-18 | 2003-05-05 | Pentafluorosulfanyl-benzoylguanidine, method for the production thereof and its utilization as medicament or diagnostic agent and medicament containing same |
Publications (1)
Publication Number | Publication Date |
---|---|
MEP28908A true MEP28908A (en) | 2010-10-10 |
Family
ID=29285565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-289/08A MEP28908A (en) | 2002-05-18 | 2003-05-05 | Pentafluorosulfanyl-benzoylguanidine, method for the production thereof and its utilization as medicament or diagnostic agent and medicament containing same |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP1509498B1 (en) |
JP (1) | JP4383341B2 (en) |
KR (1) | KR100977676B1 (en) |
CN (1) | CN100506791C (en) |
AR (1) | AR040034A1 (en) |
AT (1) | ATE343563T1 (en) |
AU (1) | AU2003242531B2 (en) |
BR (1) | BR0311128A (en) |
CA (1) | CA2486336C (en) |
CY (1) | CY1105867T1 (en) |
DE (2) | DE10222192A1 (en) |
DK (1) | DK1509498T3 (en) |
ES (1) | ES2274264T3 (en) |
HK (1) | HK1076095A1 (en) |
HR (1) | HRP20041078B1 (en) |
IL (2) | IL165213A0 (en) |
MA (1) | MA27277A1 (en) |
ME (1) | MEP28908A (en) |
MX (1) | MXPA04011497A (en) |
MY (1) | MY139310A (en) |
NO (1) | NO333288B1 (en) |
PE (1) | PE20040452A1 (en) |
PL (1) | PL209700B1 (en) |
PT (1) | PT1509498E (en) |
RS (1) | RS50772B (en) |
RU (1) | RU2315752C2 (en) |
TW (1) | TWI281467B (en) |
WO (1) | WO2003097591A1 (en) |
ZA (1) | ZA200408886B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7501440B2 (en) | 2003-03-07 | 2009-03-10 | Sanofi-Aventis Deutschland Gmbh | Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use |
DE10338554A1 (en) * | 2003-08-22 | 2005-03-31 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylphenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE10353204A1 (en) * | 2003-11-13 | 2005-06-16 | Aventis Pharma Deutschland Gmbh | Process for the preparation of 4-pentafluorosulfanyl-benzoylguanidines |
OA13285A (en) * | 2003-11-13 | 2007-01-31 | Sanofi Aventis Deutschland | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same. |
DE10353205A1 (en) * | 2003-11-13 | 2005-06-16 | Aventis Pharma Deutschland Gmbh | Ortho-substituted pentafluorosulfurane-benzenes, processes for their preparation and their use as valuable synthesis intermediates |
DE102004043938A1 (en) * | 2004-09-11 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylphenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE102004043937A1 (en) * | 2004-09-11 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Ortho-substituted pentafluorosulfurane-benzenes, processes for their preparation and their use as synthesis intermediates |
JP4592819B2 (en) * | 2007-02-09 | 2010-12-08 | ファイザー・リミテッド | Antiparasitic agent |
UA105354C2 (en) * | 2007-03-23 | 2014-05-12 | Юби Индастриз, Лтд. | Process for preparing arylsulfur pentafluorides |
WO2009028514A1 (en) * | 2007-08-28 | 2009-03-05 | Ube Industries, Ltd. | Method for producing pentafluorosulfanylbenzene compound and novel pentafluorosulfanylbenzene compound |
JP5439745B2 (en) * | 2008-05-27 | 2014-03-12 | 宇部興産株式会社 | Halogenomethylpentafluorosulfanylbenzene compound and method for producing the same |
JP6124015B2 (en) * | 2011-12-06 | 2017-05-10 | 宇部興産株式会社 | Method for producing pentafluorosulfanylbenzoic acid |
CN108003034B (en) * | 2017-12-26 | 2020-07-03 | 金凯(辽宁)化工有限公司 | Preparation method of 2-methyl-5-amino benzotrifluoride |
RU2765117C2 (en) * | 2019-09-24 | 2022-01-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Use of sodium salt of diethyl ester of 4-oxo-1,4-dihydropyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid, monohydrate as drug for treatment and prevention of late complications of diabetes mellitus |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4417004A1 (en) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE19517848A1 (en) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorine-containing benzoylguanidines |
DE19526381A1 (en) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
GB9606015D0 (en) * | 1996-03-22 | 1996-05-22 | Rhone Poulenc Agriculture | New herbicides |
-
2002
- 2002-05-18 DE DE10222192A patent/DE10222192A1/en not_active Withdrawn
-
2003
- 2003-04-25 PE PE2003000415A patent/PE20040452A1/en not_active Application Discontinuation
- 2003-05-05 JP JP2004505324A patent/JP4383341B2/en not_active Expired - Fee Related
- 2003-05-05 DE DE50305498T patent/DE50305498D1/en not_active Expired - Lifetime
- 2003-05-05 RU RU2004137115/04A patent/RU2315752C2/en not_active IP Right Cessation
- 2003-05-05 AT AT03752723T patent/ATE343563T1/en active
- 2003-05-05 MX MXPA04011497A patent/MXPA04011497A/en active IP Right Grant
- 2003-05-05 PL PL371784A patent/PL209700B1/en unknown
- 2003-05-05 BR BR0311128-8A patent/BR0311128A/en not_active IP Right Cessation
- 2003-05-05 IL IL16521303A patent/IL165213A0/en unknown
- 2003-05-05 PT PT03752723T patent/PT1509498E/en unknown
- 2003-05-05 CA CA2486336A patent/CA2486336C/en not_active Expired - Fee Related
- 2003-05-05 ME MEP-289/08A patent/MEP28908A/en unknown
- 2003-05-05 DK DK03752723T patent/DK1509498T3/en active
- 2003-05-05 RS YUP-990/04A patent/RS50772B/en unknown
- 2003-05-05 WO PCT/EP2003/004669 patent/WO2003097591A1/en active IP Right Grant
- 2003-05-05 AU AU2003242531A patent/AU2003242531B2/en not_active Ceased
- 2003-05-05 KR KR1020047018590A patent/KR100977676B1/en not_active IP Right Cessation
- 2003-05-05 EP EP03752723A patent/EP1509498B1/en not_active Expired - Lifetime
- 2003-05-05 CN CNB038113198A patent/CN100506791C/en not_active Expired - Fee Related
- 2003-05-05 ES ES03752723T patent/ES2274264T3/en not_active Expired - Lifetime
- 2003-05-15 TW TW092113151A patent/TWI281467B/en not_active IP Right Cessation
- 2003-05-16 MY MYPI20031822A patent/MY139310A/en unknown
- 2003-05-16 AR ARP030101716A patent/AR040034A1/en active IP Right Grant
-
2004
- 2004-11-03 ZA ZA2004/08886A patent/ZA200408886B/en unknown
- 2004-11-15 IL IL165213A patent/IL165213A/en not_active IP Right Cessation
- 2004-11-16 MA MA27949A patent/MA27277A1/en unknown
- 2004-11-17 HR HRP20041078AA patent/HRP20041078B1/en not_active IP Right Cessation
- 2004-12-14 NO NO20045447A patent/NO333288B1/en not_active IP Right Cessation
-
2005
- 2005-09-16 HK HK05108117.6A patent/HK1076095A1/en not_active IP Right Cessation
-
2006
- 2006-12-20 CY CY20061101825T patent/CY1105867T1/en unknown
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