NO964905L - Substituted benzenedicarboxylic acid diguanidides, process for their preparation, their use as drug or diagnostic, and drug containing the compound - Google Patents

Substituted benzenedicarboxylic acid diguanidides, process for their preparation, their use as drug or diagnostic, and drug containing the compound

Info

Publication number
NO964905L
NO964905L NO964905A NO964905A NO964905L NO 964905 L NO964905 L NO 964905L NO 964905 A NO964905 A NO 964905A NO 964905 A NO964905 A NO 964905A NO 964905 L NO964905 L NO 964905L
Authority
NO
Norway
Prior art keywords
drug
atoms
alkyl
diagnostic
compound
Prior art date
Application number
NO964905A
Other languages
Norwegian (no)
Other versions
NO964905D0 (en
Inventor
Heinz-Werner Kleemann
Joachim Brendel
Jan-Robert Schwark
Andreas Weichert
Hans Jochen Lang
Udo Albus
Wolfgang Scholz
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19543194A external-priority patent/DE19543194A1/en
Priority claimed from DE1996124064 external-priority patent/DE19624064A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO964905D0 publication Critical patent/NO964905D0/en
Publication of NO964905L publication Critical patent/NO964905L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det er beskrevet benzendlkarboksylsyre-diguanidider med formel (I) hvor en av restene R(l), R(2). R(3) og R(4) betyr -C0-N-C(NH2)2; og de andre restene R(l), R(2), R(3) og R(4) kan ha forskjellige betydninger og f.eks. kan R(l) bety hydrogen eller alkyl med 1, 2, 3 eller 4 C-atomer, R(2) og R(4) kan uavhengig av hverandre f.eks. bety hydrogen, OH, CF3, alkyl med 1, 2, 3 eller 4 C-atomer, R(3) kan f.eks. bety hydrogen eller -OH, R(5) kan f.eks. bety alkyl med 1, 2, 3 eller 4 C-atomer, F, Cl eller CF3. Disse forbindelsene er verdifulle antlarytmlske legemidler med kardlobeskyttende komponenter, også for forebyggelse av ischemisk induserte skader, spesielt ved utløsningen av ischemisk induserte hjertearytmier. De anvendes på grunn av inhiberingen av den cellulære Na+/H+-utveksler-n)ekanisroen for behandling av akutte og kroniske, ved ischemi utløste skader. Videre utmerket de seg ved sterkt inhiberende virkning på proliferasjonen av celler. De er egnede for å forebygge genesen ved høyt blodtrykk.There are disclosed benzene / carboxylic acid diguanidides of formula (I) wherein one of the residues R (1), R (2). R (3) and R (4) represent -CO-N-C (NH 2) 2; and the other residues R (1), R (2), R (3) and R (4) may have different meanings and e.g. for example, R (1) may be hydrogen or alkyl of 1, 2, 3 or 4 C atoms; R (2) and R (4) may independently e.g. means hydrogen, OH, CF3, alkyl of 1, 2, 3 or 4 C atoms, R (3) may e.g. means hydrogen or -OH, R (5) may e.g. means alkyl having 1, 2, 3 or 4 C atoms, F, Cl or CF3. These compounds are valuable antiarrhythmic drugs with cardioprotective components, also for the prevention of ischemic induced damage, especially in the triggering of ischemically induced cardiac arrhythmias. They are used because of the inhibition of the cellular Na + / H + exchanger (n) ekanisroen for the treatment of acute and chronic ischemia-induced injuries. Furthermore, they distinguished themselves by strongly inhibitory effect on cell proliferation. They are suitable for preventing the gene at high blood pressure.

NO964905A 1995-11-20 1996-11-19 Substituted benzenedicarboxylic acid diguanidides, process for their preparation, their use as drug or diagnostic, and drug containing the compound NO964905L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19543194A DE19543194A1 (en) 1995-11-20 1995-11-20 New benzene-di:carboxylic acid di:guanidide derivs.
DE1996124064 DE19624064A1 (en) 1996-06-17 1996-06-17 New benzene-di:carboxylic acid di:guanidide derivatives

Publications (2)

Publication Number Publication Date
NO964905D0 NO964905D0 (en) 1996-11-19
NO964905L true NO964905L (en) 1997-05-21

Family

ID=26020502

Family Applications (2)

Application Number Title Priority Date Filing Date
NO964905A NO964905L (en) 1995-11-20 1996-11-19 Substituted benzenedicarboxylic acid diguanidides, process for their preparation, their use as drug or diagnostic, and drug containing the compound
NO964903A NO964903D0 (en) 1995-11-20 1996-11-19 Substituted benzenedicarboxylic acid diguanidide, process for their preparation, their use as a drug or diagnostic as well as drug containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO964903A NO964903D0 (en) 1995-11-20 1996-11-19 Substituted benzenedicarboxylic acid diguanidide, process for their preparation, their use as a drug or diagnostic as well as drug containing them

Country Status (18)

Country Link
EP (1) EP0774458A1 (en)
JP (1) JPH09169719A (en)
KR (1) KR980002018A (en)
AR (1) AR004331A1 (en)
AU (1) AU703352B2 (en)
BR (1) BR9605617A (en)
CA (1) CA2190693A1 (en)
CZ (1) CZ338296A3 (en)
HR (1) HRP960547A2 (en)
HU (1) HUP9603201A3 (en)
IL (1) IL119637A0 (en)
MX (1) MX9605674A (en)
NO (2) NO964905L (en)
NZ (1) NZ299772A (en)
PL (1) PL316438A1 (en)
SK (1) SK148796A3 (en)
TR (1) TR199600916A2 (en)
TW (1) TW353657B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819548A1 (en) 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenyl derivatives
DE10044732A1 (en) * 2000-09-09 2002-03-21 Mahle Ventiltrieb Gmbh Roller tappet for an internal combustion engine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59302959D1 (en) * 1992-02-15 1996-07-25 Hoechst Ag 3,5-Substituted benzoylguanidines, with antiarrhythmic effects and inhibitory effects on cell proliferation
IL109570A0 (en) 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
IL114670A0 (en) * 1994-08-05 1995-11-27 Fujisawa Pharmaceutical Co Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof

Also Published As

Publication number Publication date
HRP960547A2 (en) 1998-02-28
TR199600916A2 (en) 1997-06-21
BR9605617A (en) 1998-08-18
MX9605674A (en) 1997-05-31
HU9603201D0 (en) 1997-01-28
CZ338296A3 (en) 1998-05-13
EP0774458A1 (en) 1997-05-21
TW353657B (en) 1999-03-01
AU703352B2 (en) 1999-03-25
NO964905D0 (en) 1996-11-19
NO964903D0 (en) 1996-11-19
PL316438A1 (en) 1997-05-26
CA2190693A1 (en) 1997-05-21
JPH09169719A (en) 1997-06-30
SK148796A3 (en) 1997-10-08
NZ299772A (en) 1998-12-23
HUP9603201A3 (en) 1997-11-28
HUP9603201A2 (en) 1997-05-28
AU7180496A (en) 1997-05-29
IL119637A0 (en) 1997-02-18
KR980002018A (en) 1998-03-30
AR004331A1 (en) 1998-11-04

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