NO972406L - Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds - Google Patents
Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compoundsInfo
- Publication number
- NO972406L NO972406L NO972406A NO972406A NO972406L NO 972406 L NO972406 L NO 972406L NO 972406 A NO972406 A NO 972406A NO 972406 A NO972406 A NO 972406A NO 972406 L NO972406 L NO 972406L
- Authority
- NO
- Norway
- Prior art keywords
- bis
- compounds
- processes
- atomicr
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bis-orio-substituerte benzoylguanidiner, k a r a k t c r i ved formel I R(1) s e r t (I). N. ^NH, hvor substituentene kan ha flere betydninger og f eks. kan R(l), R(2)og R(3) uavhengig av hverandre bety R(10)-SOa-, hvor a er null, 1 eller 2 og R(10) Leks. kan bety alkyl med 1, 2, 3, 4, 5, 6. 7 eller 8 C-atomcr, eller R(l), R(2) og R(3) kan fcks. uavhengig av hverandre bety hydrogen. F, Cl. OI I, CN, CF3, alkyl med 1,2,3 eller C-atomcr, R(4) og R(5) kan likeledes ha flere betydninger og blant annt, uavhengig av hverandre, bcly alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1, 2, 3 eller 4 C-atomcr, OH, F, Cl, DN cllcr -CF3. Disse forbindelsene cr egnede som antiarytmiske legemidler med kardio- bcskyttcndc komponenter for infarkt-profylaksc og infarkt-bchandling saml for be- handling av angina pectoris. De inhiberer også prc\cnti\l de patofyslologiske prosessene ved opptreden av ischcmisk induserte skader, spesiell ved utlesningen av ischcmisk induserte hjertearytmier.Bis-orio-substituted benzoylguanidines, k a r a k t c r i by formula I R (1) s e r t (I). N. ^ NH, where the substituents may have several meanings and e.g. for example, R (1), R (2) and R (3) can independently mean R (10) -SOa, where a is zero, 1 or 2 and R (10) Ex. may be alkyl of 1, 2, 3, 4, 5, 6. 7 or 8 C atomicr, or R (1), R (2) and R (3) may be obtained. independently means hydrogen. F, Cl. OI I, CN, CF 3, alkyl of 1,2,3 or C atomicr, R (4) and R (5) can also have several meanings and among others, independently, bcly alkyl of 1,2,3 or 4 C atoms, alkoxy of 1, 2, 3 or 4 C atomicr, OH, F, Cl, DN cllcr -CF3. These compounds are useful as antiarrhythmic drugs with cardioprotective components for infarct prophylaxis and infarct drug collection for the treatment of angina pectoris. They also inhibit precisely the pathophyslological processes in the occurrence of ischemic-induced damage, especially in the reading of ischemic-induced cardiac arrhythmias.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19621319A DE19621319A1 (en) | 1996-05-28 | 1996-05-28 | Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972406D0 NO972406D0 (en) | 1997-05-27 |
NO972406L true NO972406L (en) | 1997-12-01 |
Family
ID=7795458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972406A NO972406L (en) | 1996-05-28 | 1997-05-27 | Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0810207A1 (en) |
JP (1) | JPH1081662A (en) |
KR (1) | KR970074756A (en) |
CN (1) | CN1170716A (en) |
AR (1) | AR007497A1 (en) |
AU (1) | AU2359897A (en) |
BR (1) | BR9703326A (en) |
CA (1) | CA2206198A1 (en) |
CZ (1) | CZ161697A3 (en) |
DE (1) | DE19621319A1 (en) |
HR (1) | HRP970293A2 (en) |
HU (1) | HUP9700953A3 (en) |
ID (1) | ID16988A (en) |
IL (1) | IL120908A0 (en) |
NO (1) | NO972406L (en) |
NZ (1) | NZ314900A (en) |
PL (1) | PL318722A1 (en) |
SK (1) | SK66497A3 (en) |
TR (1) | TR199700423A2 (en) |
ZA (1) | ZA974607B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19859727A1 (en) * | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | The use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the prevention of age-related organ dysfunctions, age-related illnesses for the prolongation of life |
DE10001879A1 (en) | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | New benzoylguanidine derivatives are Na+/H+ exchange inhibitors useful for the treatment and prevention of e.g. ischemic disorders, infarction, arrhythmia, angina pectoris and stroke |
EP1610778A4 (en) | 2003-01-17 | 2006-05-31 | Threshold Pharmaceuticals Inc | Treatment of benign prostatic hyperplasia |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0556673B1 (en) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them |
DE4318756A1 (en) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
DE4328869A1 (en) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE4417004A1 (en) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE4422685A1 (en) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
DE4432106A1 (en) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Heterocyclic N-oxide-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic, medicament containing them and intermediates for their preparation |
DE4432101A1 (en) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Amino acid-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
-
1996
- 1996-05-28 DE DE19621319A patent/DE19621319A1/en not_active Withdrawn
-
1997
- 1997-02-28 PL PL97318722A patent/PL318722A1/en unknown
- 1997-05-15 EP EP97107903A patent/EP0810207A1/en not_active Withdrawn
- 1997-05-26 SK SK664-97A patent/SK66497A3/en unknown
- 1997-05-26 NZ NZ314900A patent/NZ314900A/en unknown
- 1997-05-26 AU AU23598/97A patent/AU2359897A/en not_active Abandoned
- 1997-05-26 IL IL12090897A patent/IL120908A0/en unknown
- 1997-05-26 TR TR97/00423A patent/TR199700423A2/en unknown
- 1997-05-26 CZ CZ971616A patent/CZ161697A3/en unknown
- 1997-05-26 CN CN97113032A patent/CN1170716A/en active Pending
- 1997-05-26 AR ARP970102237A patent/AR007497A1/en unknown
- 1997-05-27 NO NO972406A patent/NO972406L/en unknown
- 1997-05-27 JP JP9136223A patent/JPH1081662A/en active Pending
- 1997-05-27 HR HR19621319.3A patent/HRP970293A2/en not_active Application Discontinuation
- 1997-05-27 ZA ZA9704607A patent/ZA974607B/en unknown
- 1997-05-27 HU HU9700953A patent/HUP9700953A3/en unknown
- 1997-05-27 CA CA002206198A patent/CA2206198A1/en not_active Abandoned
- 1997-05-28 KR KR1019970021105A patent/KR970074756A/en not_active Application Discontinuation
- 1997-05-28 ID IDP971812A patent/ID16988A/en unknown
- 1997-05-28 BR BR9703326A patent/BR9703326A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HU9700953D0 (en) | 1997-07-28 |
DE19621319A1 (en) | 1997-12-04 |
HUP9700953A2 (en) | 1998-03-02 |
BR9703326A (en) | 1998-09-22 |
TR199700423A2 (en) | 1997-12-21 |
KR970074756A (en) | 1997-12-10 |
HUP9700953A3 (en) | 1998-04-28 |
ZA974607B (en) | 1997-11-28 |
AU2359897A (en) | 1997-12-04 |
IL120908A0 (en) | 1997-09-30 |
EP0810207A1 (en) | 1997-12-03 |
NZ314900A (en) | 1998-02-26 |
ID16988A (en) | 1997-11-27 |
HRP970293A2 (en) | 1998-04-30 |
PL318722A1 (en) | 1997-12-08 |
CA2206198A1 (en) | 1997-11-28 |
NO972406D0 (en) | 1997-05-27 |
JPH1081662A (en) | 1998-03-31 |
CZ161697A3 (en) | 1998-06-17 |
MX9703871A (en) | 1997-11-29 |
SK66497A3 (en) | 1997-12-10 |
AR007497A1 (en) | 1999-11-10 |
CN1170716A (en) | 1998-01-21 |
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