NO972406L - Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds - Google Patents

Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds

Info

Publication number
NO972406L
NO972406L NO972406A NO972406A NO972406L NO 972406 L NO972406 L NO 972406L NO 972406 A NO972406 A NO 972406A NO 972406 A NO972406 A NO 972406A NO 972406 L NO972406 L NO 972406L
Authority
NO
Norway
Prior art keywords
bis
compounds
processes
atomicr
alkyl
Prior art date
Application number
NO972406A
Other languages
Norwegian (no)
Other versions
NO972406D0 (en
Inventor
Udo Albus
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Wolfgang Scholz
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO972406D0 publication Critical patent/NO972406D0/en
Publication of NO972406L publication Critical patent/NO972406L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bis-orio-substituerte benzoylguanidiner, k a r a k t c r i ved formel I R(1) s e r t (I). N. ^NH, hvor substituentene kan ha flere betydninger og f eks. kan R(l), R(2)og R(3) uavhengig av hverandre bety R(10)-SOa-, hvor a er null, 1 eller 2 og R(10) Leks. kan bety alkyl med 1, 2, 3, 4, 5, 6. 7 eller 8 C-atomcr, eller R(l), R(2) og R(3) kan fcks. uavhengig av hverandre bety hydrogen. F, Cl. OI I, CN, CF3, alkyl med 1,2,3 eller C-atomcr, R(4) og R(5) kan likeledes ha flere betydninger og blant annt, uavhengig av hverandre, bcly alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1, 2, 3 eller 4 C-atomcr, OH, F, Cl, DN cllcr -CF3. Disse forbindelsene cr egnede som antiarytmiske legemidler med kardio- bcskyttcndc komponenter for infarkt-profylaksc og infarkt-bchandling saml for be- handling av angina pectoris. De inhiberer også prc\cnti\l de patofyslologiske prosessene ved opptreden av ischcmisk induserte skader, spesiell ved utlesningen av ischcmisk induserte hjertearytmier.Bis-orio-substituted benzoylguanidines, k a r a k t c r i by formula I R (1) s e r t (I). N. ^ NH, where the substituents may have several meanings and e.g. for example, R (1), R (2) and R (3) can independently mean R (10) -SOa, where a is zero, 1 or 2 and R (10) Ex. may be alkyl of 1, 2, 3, 4, 5, 6. 7 or 8 C atomicr, or R (1), R (2) and R (3) may be obtained. independently means hydrogen. F, Cl. OI I, CN, CF 3, alkyl of 1,2,3 or C atomicr, R (4) and R (5) can also have several meanings and among others, independently, bcly alkyl of 1,2,3 or 4 C atoms, alkoxy of 1, 2, 3 or 4 C atomicr, OH, F, Cl, DN cllcr -CF3. These compounds are useful as antiarrhythmic drugs with cardioprotective components for infarct prophylaxis and infarct drug collection for the treatment of angina pectoris. They also inhibit precisely the pathophyslological processes in the occurrence of ischemic-induced damage, especially in the reading of ischemic-induced cardiac arrhythmias.

NO972406A 1996-05-28 1997-05-27 Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds NO972406L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19621319A DE19621319A1 (en) 1996-05-28 1996-05-28 Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them

Publications (2)

Publication Number Publication Date
NO972406D0 NO972406D0 (en) 1997-05-27
NO972406L true NO972406L (en) 1997-12-01

Family

ID=7795458

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972406A NO972406L (en) 1996-05-28 1997-05-27 Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds

Country Status (20)

Country Link
EP (1) EP0810207A1 (en)
JP (1) JPH1081662A (en)
KR (1) KR970074756A (en)
CN (1) CN1170716A (en)
AR (1) AR007497A1 (en)
AU (1) AU2359897A (en)
BR (1) BR9703326A (en)
CA (1) CA2206198A1 (en)
CZ (1) CZ161697A3 (en)
DE (1) DE19621319A1 (en)
HR (1) HRP970293A2 (en)
HU (1) HUP9700953A3 (en)
ID (1) ID16988A (en)
IL (1) IL120908A0 (en)
NO (1) NO972406L (en)
NZ (1) NZ314900A (en)
PL (1) PL318722A1 (en)
SK (1) SK66497A3 (en)
TR (1) TR199700423A2 (en)
ZA (1) ZA974607B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19859727A1 (en) * 1998-12-23 2000-06-29 Aventis Pharma Gmbh The use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the prevention of age-related organ dysfunctions, age-related illnesses for the prolongation of life
DE10001879A1 (en) 2000-01-19 2001-07-19 Aventis Pharma Gmbh New benzoylguanidine derivatives are Na+/H+ exchange inhibitors useful for the treatment and prevention of e.g. ischemic disorders, infarction, arrhythmia, angina pectoris and stroke
EP1610778A4 (en) 2003-01-17 2006-05-31 Threshold Pharmaceuticals Inc Treatment of benign prostatic hyperplasia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0556673B1 (en) * 1992-02-15 1997-09-17 Hoechst Aktiengesellschaft Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them
DE4318756A1 (en) * 1993-06-05 1994-12-08 Hoechst Ag Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them
DE4328869A1 (en) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE4417004A1 (en) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE4422685A1 (en) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DE4432106A1 (en) * 1994-09-09 1996-03-14 Hoechst Ag Heterocyclic N-oxide-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic, medicament containing them and intermediates for their preparation
DE4432101A1 (en) * 1994-09-09 1996-03-14 Hoechst Ag Amino acid-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them

Also Published As

Publication number Publication date
HU9700953D0 (en) 1997-07-28
DE19621319A1 (en) 1997-12-04
HUP9700953A2 (en) 1998-03-02
BR9703326A (en) 1998-09-22
TR199700423A2 (en) 1997-12-21
KR970074756A (en) 1997-12-10
HUP9700953A3 (en) 1998-04-28
ZA974607B (en) 1997-11-28
AU2359897A (en) 1997-12-04
IL120908A0 (en) 1997-09-30
EP0810207A1 (en) 1997-12-03
NZ314900A (en) 1998-02-26
ID16988A (en) 1997-11-27
HRP970293A2 (en) 1998-04-30
PL318722A1 (en) 1997-12-08
CA2206198A1 (en) 1997-11-28
NO972406D0 (en) 1997-05-27
JPH1081662A (en) 1998-03-31
CZ161697A3 (en) 1998-06-17
MX9703871A (en) 1997-11-29
SK66497A3 (en) 1997-12-10
AR007497A1 (en) 1999-11-10
CN1170716A (en) 1998-01-21

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