ZA974607B - Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them. - Google Patents

Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them.

Info

Publication number
ZA974607B
ZA974607B ZA9704607A ZA974607A ZA974607B ZA 974607 B ZA974607 B ZA 974607B ZA 9704607 A ZA9704607 A ZA 9704607A ZA 974607 A ZA974607 A ZA 974607A ZA 974607 B ZA974607 B ZA 974607B
Authority
ZA
South Africa
Prior art keywords
medicament
ortho
diagnostic
bis
processes
Prior art date
Application number
ZA9704607A
Inventor
Udo Albus
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Wolfgang Scholz
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA974607B publication Critical patent/ZA974607B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA9704607A 1996-05-28 1997-05-27 Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them. ZA974607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19621319A DE19621319A1 (en) 1996-05-28 1996-05-28 Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them

Publications (1)

Publication Number Publication Date
ZA974607B true ZA974607B (en) 1997-11-28

Family

ID=7795458

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704607A ZA974607B (en) 1996-05-28 1997-05-27 Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them.

Country Status (20)

Country Link
EP (1) EP0810207A1 (en)
JP (1) JPH1081662A (en)
KR (1) KR970074756A (en)
CN (1) CN1170716A (en)
AR (1) AR007497A1 (en)
AU (1) AU2359897A (en)
BR (1) BR9703326A (en)
CA (1) CA2206198A1 (en)
CZ (1) CZ161697A3 (en)
DE (1) DE19621319A1 (en)
HR (1) HRP970293A2 (en)
HU (1) HUP9700953A3 (en)
ID (1) ID16988A (en)
IL (1) IL120908A0 (en)
NO (1) NO972406L (en)
NZ (1) NZ314900A (en)
PL (1) PL318722A1 (en)
SK (1) SK66497A3 (en)
TR (1) TR199700423A2 (en)
ZA (1) ZA974607B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19859727A1 (en) 1998-12-23 2000-06-29 Aventis Pharma Gmbh The use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the prevention of age-related organ dysfunctions, age-related illnesses for the prolongation of life
DE10001879A1 (en) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh New benzoylguanidine derivatives are Na+/H+ exchange inhibitors useful for the treatment and prevention of e.g. ischemic disorders, infarction, arrhythmia, angina pectoris and stroke
WO2004064736A2 (en) 2003-01-17 2004-08-05 Threshold Pharmaceuticals, Inc. Treatment of benign prostatic hyperplasia using energolytic agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE158278T1 (en) * 1992-02-15 1997-10-15 Hoechst Ag ORTHO-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION OR DIAGNOSTIC AND A MEDICINE CONTAINING THEM
DE4318756A1 (en) * 1993-06-05 1994-12-08 Hoechst Ag Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them
DE4328869A1 (en) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE4417004A1 (en) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE4422685A1 (en) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DE4432106A1 (en) * 1994-09-09 1996-03-14 Hoechst Ag Heterocyclic N-oxide-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic, medicament containing them and intermediates for their preparation
DE4432101A1 (en) * 1994-09-09 1996-03-14 Hoechst Ag Amino acid-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them

Also Published As

Publication number Publication date
HRP970293A2 (en) 1998-04-30
ID16988A (en) 1997-11-27
BR9703326A (en) 1998-09-22
HUP9700953A3 (en) 1998-04-28
MX9703871A (en) 1997-11-29
DE19621319A1 (en) 1997-12-04
TR199700423A2 (en) 1997-12-21
IL120908A0 (en) 1997-09-30
AU2359897A (en) 1997-12-04
HUP9700953A2 (en) 1998-03-02
CA2206198A1 (en) 1997-11-28
PL318722A1 (en) 1997-12-08
NZ314900A (en) 1998-02-26
EP0810207A1 (en) 1997-12-03
CN1170716A (en) 1998-01-21
NO972406D0 (en) 1997-05-27
KR970074756A (en) 1997-12-10
HU9700953D0 (en) 1997-07-28
AR007497A1 (en) 1999-11-10
SK66497A3 (en) 1997-12-10
JPH1081662A (en) 1998-03-31
CZ161697A3 (en) 1998-06-17
NO972406L (en) 1997-12-01

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