RU2165921C2 - Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями - Google Patents
Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями Download PDFInfo
- Publication number
- RU2165921C2 RU2165921C2 RU98110565/04A RU98110565A RU2165921C2 RU 2165921 C2 RU2165921 C2 RU 2165921C2 RU 98110565/04 A RU98110565/04 A RU 98110565/04A RU 98110565 A RU98110565 A RU 98110565A RU 2165921 C2 RU2165921 C2 RU 2165921C2
- Authority
- RU
- Russia
- Prior art keywords
- ono
- inflammatory
- products
- cox
- group
- Prior art date
Links
- 0 *c1ccccc1 Chemical compound *c1ccccc1 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002263A IT1276071B1 (it) | 1995-10-31 | 1995-10-31 | Compositi ad attivita' anti-infiammatoria |
| ITM195A002263 | 1995-10-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98110565A RU98110565A (ru) | 2000-04-27 |
| RU2165921C2 true RU2165921C2 (ru) | 2001-04-27 |
Family
ID=11372460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98110565/04A RU2165921C2 (ru) | 1995-10-31 | 1996-10-29 | Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6040341A (enExample) |
| EP (1) | EP0871606B1 (enExample) |
| JP (1) | JP3880067B2 (enExample) |
| KR (1) | KR100546038B1 (enExample) |
| AT (1) | ATE193883T1 (enExample) |
| AU (1) | AU709338B2 (enExample) |
| BR (1) | BR9611175B1 (enExample) |
| CA (1) | CA2235996C (enExample) |
| DE (1) | DE69608916T2 (enExample) |
| DK (1) | DK0871606T3 (enExample) |
| ES (1) | ES2148808T3 (enExample) |
| GR (1) | GR3033827T3 (enExample) |
| HU (1) | HUP9802986A3 (enExample) |
| IT (1) | IT1276071B1 (enExample) |
| PT (1) | PT871606E (enExample) |
| RU (1) | RU2165921C2 (enExample) |
| SI (1) | SI0871606T1 (enExample) |
| WO (1) | WO1997016405A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2322434C2 (ru) * | 2002-09-20 | 2008-04-20 | Никокс С.А. | Способ получения no-донорных соединений, таких как no-донорный диклофенак |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| US5703073A (en) | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| US7115661B1 (en) | 1999-12-29 | 2006-10-03 | Queen's University At Kingston | Methods and compositions for mitigating pain |
| US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
| IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| US20040082652A1 (en) * | 1996-09-04 | 2004-04-29 | Nicox S.A. | Nitric ester derivatives and their use in treating gastrointestinal tumors |
| GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| US6136804A (en) | 1998-03-13 | 2000-10-24 | Merck & Co., Inc. | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions |
| EP1061908A4 (en) * | 1998-03-13 | 2007-01-24 | Merck & Co Inc | COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY MIXING SYNDROME AND ASSOCIATED CONDITIONS |
| ES2136581B1 (es) | 1998-05-27 | 2000-09-16 | Uriach & Cia Sa J | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
| US6395724B1 (en) | 1998-06-08 | 2002-05-28 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
| EP1117398A2 (en) * | 1998-09-28 | 2001-07-25 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a thrombin inhibitor |
| US6297260B1 (en) | 1998-10-30 | 2001-10-02 | Nitromed, Inc. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| IT1307928B1 (it) * | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
| IT1308633B1 (it) * | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| US6509377B1 (en) * | 1999-05-26 | 2003-01-21 | J. Uriach & Cia, S.A. | Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB |
| IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
| ITMI991517A1 (it) * | 1999-07-09 | 2001-01-09 | Nicox Sa | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
| IT1313596B1 (it) * | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
| CA2393724A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| US6538033B2 (en) * | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
| IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
| EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| ITMI20011240A1 (it) * | 2001-06-13 | 2002-12-13 | Nicox Sa | Farmaci per le vasculopatie |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20011308A1 (it) | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| JP2005519928A (ja) * | 2002-02-04 | 2005-07-07 | ハース,ベルナー | Co放出能力を有する化合物の投与によって哺乳動物を治療する方法と、co放出能力を有する化合物ならびにその医薬組成物 |
| EP1505985A1 (en) * | 2002-05-10 | 2005-02-16 | Merck & Co., Inc. | Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events |
| US20050215611A1 (en) * | 2002-05-10 | 2005-09-29 | Hunt Richard H | Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events |
| CA2487414A1 (en) * | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| AU2003247622A1 (en) * | 2002-06-27 | 2004-01-19 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| AU2003279622A1 (en) * | 2002-06-28 | 2004-01-19 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| US7163958B2 (en) * | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| CA2493082A1 (en) | 2002-07-26 | 2004-02-05 | Merck Frosst Canada & Co. | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| WO2004037843A2 (en) * | 2002-10-25 | 2004-05-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
| ITMI20022658A1 (it) | 2002-12-17 | 2004-06-18 | Nicox Sa | Farmaci per il dolore cronico. |
| US20070207217A1 (en) * | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
| US7166638B2 (en) * | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
| US7169805B2 (en) | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
| WO2004110432A1 (en) | 2003-06-19 | 2004-12-23 | Nicox S.A. | Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases |
| EP1709155B1 (en) * | 2003-12-31 | 2013-10-02 | Chesterford Enterprises Limited | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| MX2007002210A (es) | 2004-08-26 | 2007-05-07 | Nicholas Piramal India Ltd | Profarmacos que contienen enlazantes bioescindibles novedosos. |
| US7521435B2 (en) * | 2005-02-18 | 2009-04-21 | Pharma Diagnostics, N.V. | Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same |
| WO2007060112A1 (en) | 2005-11-23 | 2007-05-31 | Nicox S.A. | Salicylic acid derivatives |
| GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| JP2007275193A (ja) * | 2006-04-04 | 2007-10-25 | Fujifilm Corp | 光プローブおよび光断層画像化装置 |
| US8236820B2 (en) * | 2007-08-10 | 2012-08-07 | Basil Rigas | Anti-inflammatory compounds and uses thereof |
| WO2010118968A1 (en) | 2009-04-16 | 2010-10-21 | Nicox S.A. | No-donor aspirin derivatives |
| WO2011160974A2 (en) | 2010-06-21 | 2011-12-29 | Nicox S.A. | Statin derivatives |
| ES2656237T3 (es) | 2011-04-19 | 2018-02-26 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono y usos de las mismas |
| EP2734235B1 (en) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
| US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
| US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
| CN117843491A (zh) * | 2023-12-29 | 2024-04-09 | 陕西中医药大学 | 4-(2-(硝基氧基)乙基)-1,2-亚苯基二乙酸酯及其合成方法、应用和药物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001668A1 (en) * | 1990-07-26 | 1992-02-06 | Italfarmaco S.P.A. | Benzoic acid substituted derivatives having cardiovascular activity |
| WO1994012463A1 (en) * | 1992-11-26 | 1994-06-09 | Nicox Limited | Nitric esters having a pharmacological activity and process for their preparation |
| WO1995030641A1 (en) * | 1994-05-10 | 1995-11-16 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700947A (en) * | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
-
1995
- 1995-10-31 IT IT95MI002263A patent/IT1276071B1/it active IP Right Grant
-
1996
- 1996-10-29 HU HU9802986A patent/HUP9802986A3/hu unknown
- 1996-10-29 PT PT96937282T patent/PT871606E/pt unknown
- 1996-10-29 ES ES96937282T patent/ES2148808T3/es not_active Expired - Lifetime
- 1996-10-29 KR KR1019980703206A patent/KR100546038B1/ko not_active Expired - Fee Related
- 1996-10-29 RU RU98110565/04A patent/RU2165921C2/ru not_active IP Right Cessation
- 1996-10-29 DE DE69608916T patent/DE69608916T2/de not_active Expired - Fee Related
- 1996-10-29 SI SI9630170T patent/SI0871606T1/xx unknown
- 1996-10-29 AT AT96937282T patent/ATE193883T1/de not_active IP Right Cessation
- 1996-10-29 DK DK96937282T patent/DK0871606T3/da active
- 1996-10-29 WO PCT/EP1996/004696 patent/WO1997016405A1/en not_active Ceased
- 1996-10-29 US US09/066,344 patent/US6040341A/en not_active Expired - Fee Related
- 1996-10-29 JP JP51706097A patent/JP3880067B2/ja not_active Expired - Fee Related
- 1996-10-29 CA CA002235996A patent/CA2235996C/en not_active Expired - Fee Related
- 1996-10-29 BR BRPI9611175-5A patent/BR9611175B1/pt not_active IP Right Cessation
- 1996-10-29 EP EP96937282A patent/EP0871606B1/en not_active Expired - Lifetime
- 1996-10-29 AU AU74950/96A patent/AU709338B2/en not_active Ceased
-
2000
- 2000-06-30 GR GR20000401528T patent/GR3033827T3/el not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001668A1 (en) * | 1990-07-26 | 1992-02-06 | Italfarmaco S.P.A. | Benzoic acid substituted derivatives having cardiovascular activity |
| WO1994012463A1 (en) * | 1992-11-26 | 1994-06-09 | Nicox Limited | Nitric esters having a pharmacological activity and process for their preparation |
| WO1995030641A1 (en) * | 1994-05-10 | 1995-11-16 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2322434C2 (ru) * | 2002-09-20 | 2008-04-20 | Никокс С.А. | Способ получения no-донорных соединений, таких как no-донорный диклофенак |
Also Published As
| Publication number | Publication date |
|---|---|
| SI0871606T1 (en) | 2000-08-31 |
| KR19990067247A (ko) | 1999-08-16 |
| HUP9802986A2 (hu) | 1999-04-28 |
| KR100546038B1 (ko) | 2006-10-04 |
| JPH11514636A (ja) | 1999-12-14 |
| GR3033827T3 (en) | 2000-10-31 |
| JP3880067B2 (ja) | 2007-02-14 |
| AU709338B2 (en) | 1999-08-26 |
| ITMI952263A1 (it) | 1997-05-01 |
| BR9611175A (pt) | 1999-03-30 |
| DE69608916D1 (de) | 2000-07-20 |
| ES2148808T3 (es) | 2000-10-16 |
| ITMI952263A0 (enExample) | 1995-10-31 |
| CA2235996A1 (en) | 1997-05-09 |
| HUP9802986A3 (en) | 1999-12-28 |
| WO1997016405A1 (en) | 1997-05-09 |
| DE69608916T2 (de) | 2001-01-11 |
| US6040341A (en) | 2000-03-21 |
| DK0871606T3 (da) | 2000-07-31 |
| IT1276071B1 (it) | 1997-10-24 |
| ATE193883T1 (de) | 2000-06-15 |
| CA2235996C (en) | 2007-01-02 |
| BR9611175B1 (pt) | 2009-01-13 |
| EP0871606A1 (en) | 1998-10-21 |
| AU7495096A (en) | 1997-05-22 |
| PT871606E (pt) | 2000-11-30 |
| EP0871606B1 (en) | 2000-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2165921C2 (ru) | Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями | |
| JP4043046B2 (ja) | 消炎、鎮痛および抗血栓活性を有するニトロ化合物およびそれらの組成物 | |
| CA2173582C (en) | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation | |
| CA2150229C (en) | Nitric esters having a pharmacological activity and process for their preparation | |
| RU2240997C2 (ru) | Соли нитроксипроизводных и фармацевтические составы на их основе | |
| EP2057139B1 (en) | Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs | |
| PT1215201E (pt) | Processo para a preparação de ariloctanoil amidas | |
| JP2000511175A (ja) | ビフェニルスルホンアミドマトリックスメタロプロテイナーゼ阻害剤 | |
| MC1231A1 (fr) | Nouveaux benzamides heterocycliques substitues,leurs procedes de preparation et leur application comme modificateurs du comportement | |
| ES2354979T3 (es) | Derivado de tacrina como inhibidores de acetilcolinesterasa. | |
| WO2005033059A1 (es) | Compuestos útiles para el tratamiento de enfermedades asociadas a la formación de fibrilas amiloides | |
| IL128020A (en) | Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them | |
| PL171844B1 (pl) | P ochodne 2-amino-1,2,3,4-tetrahydronaftalenu PL PL PL | |
| FR2532647A1 (fr) | Thioesters d'acide acetylsalicylique, procede pour les preparer et compositions pharmaceutiques qui en renferment | |
| Paliwal et al. | Synthesis and biological evaluation of mutual prodrugs of carboxylic group containing some non-steroidal anti-inflammatory drugs and propyphenazone | |
| JPS6039069B2 (ja) | アミン誘導体 | |
| JPH05500214A (ja) | ターシヤリーアルキルエステル類の新規な合成方法 | |
| AU661906B2 (en) | 5-amino-2-phenoxysulfonanilide compound | |
| GB2134111A (en) | Pyrrole-2-acetylamino acid derivatives | |
| NZ262219A (en) | 3-hydroxyanthranilic acid derivatives, preparation, intermediates and pharmaceutical compositions thereof | |
| WO1988009785A1 (en) | Butenoic acid amides, their salts, pharmaceutical compositions containing them and process for preparing same | |
| FR2552427A1 (fr) | Nouveau procede de preparation de l'hydroxy-2 (hydroxy-1((methyl-1 phenyl-3 propyl) amino)-2 ethyl)-5 benzamide et compositions therapeutiques a base du compose obtenu selon ce nouveau procede | |
| WO2007110876A2 (en) | Novel sulfonanilide derivatives, pharmaceutical compositions comprising the same and process thereof | |
| CA2155666C (en) | Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof | |
| JP3721583B2 (ja) | 抗炎症剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20091030 |