RU2165921C2 - Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями - Google Patents

Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями Download PDF

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Publication number
RU2165921C2
RU2165921C2 RU98110565/04A RU98110565A RU2165921C2 RU 2165921 C2 RU2165921 C2 RU 2165921C2 RU 98110565/04 A RU98110565/04 A RU 98110565/04A RU 98110565 A RU98110565 A RU 98110565A RU 2165921 C2 RU2165921 C2 RU 2165921C2
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Russia
Prior art keywords
ono
inflammatory
products
cox
group
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RU98110565/04A
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English (en)
Russian (ru)
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RU98110565A (ru
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Солдато Пьеро Дел
Франческо Санниколо
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Никокс С.А.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU98110565/04A 1995-10-31 1996-10-29 Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями RU2165921C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002263A IT1276071B1 (it) 1995-10-31 1995-10-31 Compositi ad attivita' anti-infiammatoria
ITM195A002263 1995-10-31

Publications (2)

Publication Number Publication Date
RU98110565A RU98110565A (ru) 2000-04-27
RU2165921C2 true RU2165921C2 (ru) 2001-04-27

Family

ID=11372460

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98110565/04A RU2165921C2 (ru) 1995-10-31 1996-10-29 Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями

Country Status (18)

Country Link
US (1) US6040341A (enExample)
EP (1) EP0871606B1 (enExample)
JP (1) JP3880067B2 (enExample)
KR (1) KR100546038B1 (enExample)
AT (1) ATE193883T1 (enExample)
AU (1) AU709338B2 (enExample)
BR (1) BR9611175B1 (enExample)
CA (1) CA2235996C (enExample)
DE (1) DE69608916T2 (enExample)
DK (1) DK0871606T3 (enExample)
ES (1) ES2148808T3 (enExample)
GR (1) GR3033827T3 (enExample)
HU (1) HUP9802986A3 (enExample)
IT (1) IT1276071B1 (enExample)
PT (1) PT871606E (enExample)
RU (1) RU2165921C2 (enExample)
SI (1) SI0871606T1 (enExample)
WO (1) WO1997016405A1 (enExample)

Cited By (1)

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RU2322434C2 (ru) * 2002-09-20 2008-04-20 Никокс С.А. Способ получения no-донорных соединений, таких как no-донорный диклофенак

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US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
US20040082652A1 (en) * 1996-09-04 2004-04-29 Nicox S.A. Nitric ester derivatives and their use in treating gastrointestinal tumors
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
US6136804A (en) 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
JP2002506024A (ja) * 1998-03-13 2002-02-26 メルク エンド カムパニー インコーポレーテッド 急性冠動脈虚血症候群および関連状態に対する併用療法および組成物
ES2136581B1 (es) 1998-05-27 2000-09-16 Uriach & Cia Sa J Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
WO1999063939A2 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of cyclooxygenase-2
AU760735B2 (en) * 1998-09-28 2003-05-22 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1307928B1 (it) * 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
IT1308633B1 (it) * 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US6509377B1 (en) * 1999-05-26 2003-01-21 J. Uriach & Cia, S.A. Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB
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ITMI991517A1 (it) 1999-07-09 2001-01-09 Nicox Sa Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
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ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
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US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
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JP5198063B2 (ja) 2004-08-26 2013-05-15 アッパラオ・サティアム 新規バイオ開裂性リンカー
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WO1992001668A1 (en) * 1990-07-26 1992-02-06 Italfarmaco S.P.A. Benzoic acid substituted derivatives having cardiovascular activity
WO1994012463A1 (en) * 1992-11-26 1994-06-09 Nicox Limited Nitric esters having a pharmacological activity and process for their preparation
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2322434C2 (ru) * 2002-09-20 2008-04-20 Никокс С.А. Способ получения no-донорных соединений, таких как no-донорный диклофенак

Also Published As

Publication number Publication date
CA2235996C (en) 2007-01-02
HUP9802986A2 (hu) 1999-04-28
WO1997016405A1 (en) 1997-05-09
KR19990067247A (ko) 1999-08-16
EP0871606A1 (en) 1998-10-21
CA2235996A1 (en) 1997-05-09
BR9611175A (pt) 1999-03-30
SI0871606T1 (en) 2000-08-31
PT871606E (pt) 2000-11-30
ES2148808T3 (es) 2000-10-16
HUP9802986A3 (en) 1999-12-28
ITMI952263A0 (enExample) 1995-10-31
DE69608916T2 (de) 2001-01-11
JPH11514636A (ja) 1999-12-14
EP0871606B1 (en) 2000-06-14
ITMI952263A1 (it) 1997-05-01
GR3033827T3 (en) 2000-10-31
ATE193883T1 (de) 2000-06-15
KR100546038B1 (ko) 2006-10-04
DE69608916D1 (de) 2000-07-20
IT1276071B1 (it) 1997-10-24
AU709338B2 (en) 1999-08-26
US6040341A (en) 2000-03-21
AU7495096A (en) 1997-05-22
JP3880067B2 (ja) 2007-02-14
BR9611175B1 (pt) 2009-01-13
DK0871606T3 (da) 2000-07-31

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Effective date: 20091030