RU2138500C1 - Производные ксантина и их фармакологически переносимые соли - Google Patents

Производные ксантина и их фармакологически переносимые соли Download PDF

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RU2138500C1
RU2138500C1 RU95109100A RU95109100A RU2138500C1 RU 2138500 C1 RU2138500 C1 RU 2138500C1 RU 95109100 A RU95109100 A RU 95109100A RU 95109100 A RU95109100 A RU 95109100A RU 2138500 C1 RU2138500 C1 RU 2138500C1
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carbon atoms
group
substituted
alkyl
formula
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RU95109100A
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RU95109100A (ru
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Кюфнер-Мюль Ульрике
Энзингер Хельмут
Мирау Йоахим
Кун Франц-Йозеф
Лер Эрих
Мюллер Энцио
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Берингер Ингельхайм КГ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laser Surgery Devices (AREA)
  • Radiation-Therapy Devices (AREA)
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RU95109100A 1992-08-10 1993-08-05 Производные ксантина и их фармакологически переносимые соли RU2138500C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEP4226371.9 1992-08-10
DE4226371 1992-08-10
DE4238423 1992-11-13
DEP4238423.0 1992-11-13
PCT/EP1993/002077 WO1994003456A1 (de) 1992-08-10 1993-08-05 Unsymmetrisch substituierte xanthine mit adenosinantagonistischen eigenschaften

Publications (2)

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RU95109100A RU95109100A (ru) 1996-12-27
RU2138500C1 true RU2138500C1 (ru) 1999-09-27

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RU95109100A RU2138500C1 (ru) 1992-08-10 1993-08-05 Производные ксантина и их фармакологически переносимые соли

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US (1) US5719279A (enExample)
EP (1) EP0654033A1 (enExample)
JP (1) JPH08500344A (enExample)
KR (1) KR950702988A (enExample)
CN (1) CN1043348C (enExample)
AU (1) AU681348B2 (enExample)
BG (1) BG62618B1 (enExample)
CA (1) CA2140883A1 (enExample)
CZ (1) CZ286459B6 (enExample)
FI (1) FI950542L (enExample)
HU (1) HUT65734A (enExample)
IL (1) IL106624A (enExample)
MX (1) MX9304819A (enExample)
NZ (1) NZ254804A (enExample)
PL (1) PL176389B1 (enExample)
RU (1) RU2138500C1 (enExample)
SG (1) SG55038A1 (enExample)
SK (1) SK18595A3 (enExample)
TW (1) TW252044B (enExample)
UA (1) UA46697C2 (enExample)
WO (1) WO1994003456A1 (enExample)

Cited By (7)

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RU2269529C2 (ru) * 2000-04-07 2006-02-10 Новартис Аг Производные 8-хинолинксантина и 8-изохинолинксантина в качестве ингибиторов фосфоэстеразы pde 5
RU2302420C2 (ru) * 2000-09-19 2007-07-10 Шеринг Корпорейшн Ингибиторы ксантин-фосфодиэстеразы v, способ их получения, фармацевтическая композиция, применение и способ лечения
RU2318825C2 (ru) * 2003-05-06 2008-03-10 Си Ви Терапьютикс, Инк. Производные ксантина в качестве антагонистов a2b аденозинового рецептора
RU2344137C1 (ru) * 2007-07-18 2009-01-20 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Производные 8-амино-7-(2-гидроксипропил-1)-1,3-диметилксантина гидрохлорида, проявляющие гемореологическую активность
RU2374247C2 (ru) * 2003-11-21 2009-11-27 Си Ви Терапьютикс, Инк. Способ получения антагонистов аденозиновых рецепторов a2b и промежуточные продукты
EA014684B1 (ru) * 2001-09-06 2010-12-30 Байоджен Айдек Ма Инк. Способы лечения легочных заболеваний
RU2415858C2 (ru) * 2005-06-16 2011-04-10 Си Ви Терапьютикс, Инк. Пролекарства антагонистов a2b рецептора аденозина

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AU6781194A (en) * 1993-05-03 1994-11-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
DE4316576A1 (de) * 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
US5646156A (en) * 1994-04-25 1997-07-08 Merck & Co., Inc. Inhibition of eosinophil activation through A3 adenosine receptor antagonism
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
GB9415529D0 (en) 1994-08-01 1994-09-21 Wellcome Found Phenyl xanthine derivatives
EP0799040B1 (en) 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
JPH10508032A (ja) * 1994-12-13 1998-08-04 ユーロ−セルティーク，エス．エイ． アリールチオキサンチン類
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
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US5786360A (en) 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
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US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
WO1999031101A1 (en) * 1997-12-17 1999-06-24 University Of South Florida Adenosine receptor antagonists with improved bioactivity
DE19816857A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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DE60018216T2 (de) * 1999-12-24 2006-02-16 Kyowa Hakko Kogyo Co., Ltd. Kondensierte purinderivate
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WO2004009091A1 (en) 2002-06-17 2004-01-29 Glaxo Group Limited Purine derivatives as liver x receptor agonists
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7495005B2 (en) 2002-08-22 2009-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, their preparation and their use in pharmaceutical compositions
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US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
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JP2006518390A (ja) * 2003-02-19 2006-08-10 エンダシア，インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
CN1859913A (zh) 2003-04-25 2006-11-08 美国诺华卡迪亚公司 改善肾功能损伤个体多尿症的方法
EP1636229A4 (en) * 2003-06-06 2008-07-30 Endacea Inc ADENOSINE A1 RECEPTOR ANTAGONISTS
EP1636230A4 (en) * 2003-06-09 2010-06-16 Endacea Inc ADENOSINE A1 RECEPTOR ANTAGONISTS
US7566707B2 (en) 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
DE10355304A1 (de) 2003-11-27 2005-06-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004009039A1 (de) 2004-02-23 2005-09-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
US7393847B2 (en) 2004-03-13 2008-07-01 Boehringer Ingleheim International Gmbh Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions
US7179809B2 (en) * 2004-04-10 2007-02-20 Boehringer Ingelheim International Gmbh 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions
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DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
DE102004043944A1 (de) 2004-09-11 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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Cited By (8)

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Publication number Priority date Publication date Assignee Title
RU2269529C2 (ru) * 2000-04-07 2006-02-10 Новартис Аг Производные 8-хинолинксантина и 8-изохинолинксантина в качестве ингибиторов фосфоэстеразы pde 5
RU2302420C2 (ru) * 2000-09-19 2007-07-10 Шеринг Корпорейшн Ингибиторы ксантин-фосфодиэстеразы v, способ их получения, фармацевтическая композиция, применение и способ лечения
RU2302420C9 (ru) * 2000-09-19 2008-12-10 Шеринг Корпорейшн Ингибиторы ксантин-фосфодиэстеразы v, способ их получения, фармацевтическая композиция, применение и способ лечения
EA014684B1 (ru) * 2001-09-06 2010-12-30 Байоджен Айдек Ма Инк. Способы лечения легочных заболеваний
RU2318825C2 (ru) * 2003-05-06 2008-03-10 Си Ви Терапьютикс, Инк. Производные ксантина в качестве антагонистов a2b аденозинового рецептора
RU2374247C2 (ru) * 2003-11-21 2009-11-27 Си Ви Терапьютикс, Инк. Способ получения антагонистов аденозиновых рецепторов a2b и промежуточные продукты
RU2415858C2 (ru) * 2005-06-16 2011-04-10 Си Ви Терапьютикс, Инк. Пролекарства антагонистов a2b рецептора аденозина
RU2344137C1 (ru) * 2007-07-18 2009-01-20 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Производные 8-амино-7-(2-гидроксипропил-1)-1,3-диметилксантина гидрохлорида, проявляющие гемореологическую активность

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HU9302302D0 (en) 1993-10-28
KR950702988A (ko) 1995-08-23
IL106624A (en) 1999-01-26
BG99489A (bg) 1996-01-31
JPH08500344A (ja) 1996-01-16
SK18595A3 (en) 1995-07-11
SG55038A1 (en) 1998-12-21
WO1994003456A1 (de) 1994-02-17
NZ254804A (en) 1997-01-29
PL307397A1 (en) 1995-05-15
RU95109100A (ru) 1996-12-27
MX9304819A (es) 1994-02-28
FI950542A0 (fi) 1995-02-08
CZ286459B6 (en) 2000-04-12
UA46697C2 (uk) 2002-06-17
PL176389B1 (pl) 1999-05-31
HUT65734A (en) 1994-07-28
TW252044B (enExample) 1995-07-21
US5719279A (en) 1998-02-17
EP0654033A1 (de) 1995-05-24
CN1043348C (zh) 1999-05-12
CA2140883A1 (en) 1994-02-17
FI950542A7 (fi) 1995-02-08
BG62618B1 (bg) 2000-03-31
CN1086818A (zh) 1994-05-18
AU681348B2 (en) 1997-08-28
FI950542L (fi) 1995-02-08
IL106624A0 (en) 1993-12-08
CZ34895A3 (en) 1995-10-18
AU4707193A (en) 1994-03-03

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