RU2138482C1 - Производные аминостильбазола или их гидраты, или их соли и фармацевтическая композиция на их основе - Google Patents

Производные аминостильбазола или их гидраты, или их соли и фармацевтическая композиция на их основе Download PDF

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RU2138482C1
RU2138482C1 RU96121800A RU96121800A RU2138482C1 RU 2138482 C1 RU2138482 C1 RU 2138482C1 RU 96121800 A RU96121800 A RU 96121800A RU 96121800 A RU96121800 A RU 96121800A RU 2138482 C1 RU2138482 C1 RU 2138482C1
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Russia
Prior art keywords
ethenyl
amino
phenyl
sulfonyl
carbon atoms
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RU96121800A
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English (en)
Russian (ru)
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RU96121800A (ru
Inventor
Хидака Хиройоси
Мацуура Акира
Мацуда Масато
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Ниппон Синяку Ко., Лтд.
Хидака Хиройоси
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
RU96121800A 1994-04-06 1995-04-05 Производные аминостильбазола или их гидраты, или их соли и фармацевтическая композиция на их основе RU2138482C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6825294 1994-04-06
JPHEI-6/068252 1994-04-06
PCT/JP1995/000658 WO1995027699A1 (en) 1994-04-06 1995-04-05 Aminostilbazole derivative and medicine

Publications (2)

Publication Number Publication Date
RU96121800A RU96121800A (ru) 1999-02-10
RU2138482C1 true RU2138482C1 (ru) 1999-09-27

Family

ID=13368389

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96121800A RU2138482C1 (ru) 1994-04-06 1995-04-05 Производные аминостильбазола или их гидраты, или их соли и фармацевтическая композиция на их основе

Country Status (14)

Country Link
US (1) US5972976A (https=)
EP (1) EP0754682B9 (https=)
JP (1) JP3080405B2 (https=)
KR (1) KR100293867B1 (https=)
CN (1) CN1053658C (https=)
AT (1) ATE207057T1 (https=)
CA (1) CA2187214C (https=)
DE (1) DE69523298T2 (https=)
DK (1) DK0754682T3 (https=)
ES (1) ES2165911T3 (https=)
PT (1) PT754682E (https=)
RU (1) RU2138482C1 (https=)
TW (1) TW308586B (https=)
WO (1) WO1995027699A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2282446C2 (ru) * 2001-04-10 2006-08-27 Ниппон Синяку Ко., Лтд. Лекарственное средство для хронического суставного ревматизма
EA007965B1 (ru) * 2002-04-11 2007-02-27 Авентис Фарма С.А. Способ получения комбретастатинов
RU2793411C1 (ru) * 2013-12-13 2023-04-03 Еврокем Агро Гмбх Смесь удобрений, содержащая ингибитор нитрификации
US11767273B2 (en) 2013-12-13 2023-09-26 Eurochem Agro Gmbh Fertilizer mixture containing nitrification inhibitor
US12060307B2 (en) 2017-02-01 2024-08-13 Eurochem Agro Gmbh Mixture containing 3,4-dimethylpyrazole and use thereof

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2328719A1 (en) * 1998-04-15 1999-10-21 Hiroyoshi Hidaka Method for in vivo detecting target protein gene by drug
ATE366114T1 (de) * 1998-05-12 2007-07-15 Greenville Hospital System Verwendung von anti-prolaktin agentien zur behandlung von krebs
US6994283B1 (en) * 1999-04-23 2006-02-07 Nippon Shinyaku Co., Ltd. Method for pulverizing to fine powder
US6521658B1 (en) 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
EP1238974B1 (en) * 1999-12-14 2007-05-23 Nippon Shinyaku Co., Ltd. Heterocycle derivatives and drugs
JP2004359545A (ja) * 2001-03-08 2004-12-24 D Western Therapeutics Institute 抗癌剤耐性克服剤
US7148244B2 (en) 2001-04-26 2006-12-12 Nippon Shinyaku Co. Ltd. Medicines in controlling Vpr function
US6951875B2 (en) * 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
EP1547596A4 (en) * 2002-09-06 2008-11-19 Western Therapeutics Inst Inc MEDICAL COMPOSITION AND METHOD FOR THE TREATMENT OF MALIGNANT TUMORS AND THE USE THEREOF
WO2006078941A2 (en) * 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Novel sirtuin activating compounds and methods of use thereof
WO2007137196A2 (en) * 2006-05-19 2007-11-29 Threshold Pharmaceuticals, Inc. Tubulin binding anti cancer compounds and prodrugs thereof
US20100198262A1 (en) * 2009-01-30 2010-08-05 Mckinley Laurence M Axial offset bone fastener system
AU2014254078A1 (en) 2013-04-19 2015-10-15 Bioventures, Llc Combretastatin analogs
WO2015153635A1 (en) 2014-03-31 2015-10-08 Board Of Trustees Of The University Of Arkansas Disubstituted triazole analogs
WO2018144910A1 (en) 2017-02-02 2018-08-09 Bioventures, Llc Methods of protecting against neurodegeneration
CN112110829B (zh) * 2019-06-19 2023-08-01 复旦大学 一种能结合α-突触核蛋白聚集体的小分子化合物、其制备方法及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570594A1 (en) * 1991-12-10 1993-11-24 Shionogi & Co., Ltd. Hydroxamic acid derivative based on aromatic sulfonamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2790926B2 (ja) * 1990-08-20 1998-08-27 エーザイ株式会社 スルホンアミド誘導体
DE69129611T2 (de) * 1990-08-20 1998-12-17 Eisai Co., Ltd., Tokio/Tokyo Sulfonamid-Derivate
JP2692467B2 (ja) * 1991-12-09 1997-12-17 ダイキン工業株式会社 空調制御装置の電力供給装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570594A1 (en) * 1991-12-10 1993-11-24 Shionogi & Co., Ltd. Hydroxamic acid derivative based on aromatic sulfonamide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные средства. - М.: Медицина, 1987, ч.2, с.428. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2282446C2 (ru) * 2001-04-10 2006-08-27 Ниппон Синяку Ко., Лтд. Лекарственное средство для хронического суставного ревматизма
EA007965B1 (ru) * 2002-04-11 2007-02-27 Авентис Фарма С.А. Способ получения комбретастатинов
RU2793411C1 (ru) * 2013-12-13 2023-04-03 Еврокем Агро Гмбх Смесь удобрений, содержащая ингибитор нитрификации
US11767273B2 (en) 2013-12-13 2023-09-26 Eurochem Agro Gmbh Fertilizer mixture containing nitrification inhibitor
US12060307B2 (en) 2017-02-01 2024-08-13 Eurochem Agro Gmbh Mixture containing 3,4-dimethylpyrazole and use thereof

Also Published As

Publication number Publication date
TW308586B (https=) 1997-06-21
EP0754682B1 (en) 2001-10-17
CN1053658C (zh) 2000-06-21
US5972976A (en) 1999-10-26
WO1995027699A1 (en) 1995-10-19
CA2187214A1 (en) 1995-10-19
ATE207057T1 (de) 2001-11-15
PT754682E (pt) 2002-03-28
CA2187214C (en) 2002-03-12
DE69523298D1 (de) 2001-11-22
MX9604540A (es) 1997-09-30
DE69523298T2 (de) 2002-06-27
DK0754682T3 (da) 2002-02-04
EP0754682B9 (en) 2003-09-17
JP3080405B2 (ja) 2000-08-28
CN1145066A (zh) 1997-03-12
ES2165911T3 (es) 2002-04-01
EP0754682A1 (en) 1997-01-22
KR970702253A (ko) 1997-05-13
EP0754682A4 (en) 1998-03-04
KR100293867B1 (ko) 2001-09-17

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