RU2135471C1 - Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам - Google Patents

Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам Download PDF

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RU2135471C1
RU2135471C1 RU94040174A RU94040174A RU2135471C1 RU 2135471 C1 RU2135471 C1 RU 2135471C1 RU 94040174 A RU94040174 A RU 94040174A RU 94040174 A RU94040174 A RU 94040174A RU 2135471 C1 RU2135471 C1 RU 2135471C1
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nmr
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RU94040174A
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RU94040174A (ru
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Нацугари Хидеаки
Исхимару Такенори
Дои Такаюки
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Такеда Кемикал Индастриз, Лтд
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU94040174A 1993-11-10 1994-11-09 Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам RU2135471C1 (ru)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP281178-1993 1993-11-10
JP28117893 1993-11-10
JP337488-1993 1993-12-28
JP33748893 1993-12-28
JP033637-1994 1994-03-03
JP3363794 1994-03-03
JP138551-1994 1994-06-21
JP13855194 1994-06-21

Publications (2)

Publication Number Publication Date
RU94040174A RU94040174A (ru) 1996-10-10
RU2135471C1 true RU2135471C1 (ru) 1999-08-27

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RU94040174A RU2135471C1 (ru) 1993-11-10 1994-11-09 Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам

Country Status (16)

Country Link
US (1) US5585385A (enExample)
EP (1) EP0652218B1 (enExample)
KR (1) KR950014108A (enExample)
CN (1) CN1052004C (enExample)
AT (1) ATE203024T1 (enExample)
AU (1) AU678295B2 (enExample)
BR (1) BR9404403A (enExample)
CA (1) CA2135440A1 (enExample)
DE (1) DE69427675T2 (enExample)
FI (1) FI945281L (enExample)
HU (1) HUT68810A (enExample)
IL (1) IL111590A0 (enExample)
NO (1) NO301764B1 (enExample)
NZ (1) NZ264887A (enExample)
RU (1) RU2135471C1 (enExample)
TW (1) TW263498B (enExample)

Cited By (4)

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RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2379305C2 (ru) * 2005-09-01 2010-01-20 Мицубиси Танабе Фарма Корпорейшн Соединение тиоморфолина и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида

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US5770590A (en) * 1995-03-24 1998-06-23 Takeda Chemical Industries, Ltd. Cyclic compounds, their prudiction and use
EP0733632B1 (en) * 1995-03-24 2003-06-04 Takeda Chemical Industries, Ltd. Cyclic compounds, their production and use as tachykinin receptor antagonists
FR2732221B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue
GB9524104D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
AU740447B2 (en) * 1997-09-23 2001-11-01 Merck & Co., Inc. Thrombin inhibitors
US6727258B2 (en) * 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
WO2000012503A1 (en) * 1998-08-26 2000-03-09 Tanabe Seiyaku Co., Ltd. Naphthyridine derivatives and process for the preparation thereof
AU6228499A (en) * 1998-10-22 2000-05-08 Akzo Nobel N.V. Tetrahydropyridopyridine derivatives and intermediates for producing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
CA2374654A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Thrombin inhibitors
US20040152727A1 (en) * 2001-05-18 2004-08-05 Hay Douglas William Pierre Novel use
EP1457493A4 (en) 2001-12-10 2005-11-30 Kyorin Seiyaku Kk CONDENSED, BICYCLIC PYRIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS
KR100887471B1 (ko) * 2002-01-18 2009-03-10 교린 세이야꾸 가부시키 가이샤 축합 바이사이클릭 피리미딘 유도체
US7402595B2 (en) * 2002-02-13 2008-07-22 Takeda Pharmaceutical Company Limited JNK inhibitor
WO2003077857A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
US7026309B2 (en) 2002-03-26 2006-04-11 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyridine derivative as tachykinin receptor antagonist
AU2003296984A1 (en) 2002-12-13 2004-07-09 Neurogen Corporation 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
US7781457B2 (en) 2003-09-23 2010-08-24 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors
CA2539760C (en) 2003-09-23 2011-01-25 Merck & Co., Inc. Quinoline potassium channel inhibitors
WO2005068427A1 (ja) * 2004-01-14 2005-07-28 Takeda Pharmaceutical Company Limited カルボキサミド誘導体およびその用途
KR100781704B1 (ko) * 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
CA2828456C (en) * 2011-03-03 2021-05-04 Zalicus Pharmaceuticals Ltd. N-benzl-amino-carboxamide inhibitors of the sodium channel
CN102358730A (zh) * 2011-08-24 2012-02-22 济南赛文医药技术有限公司 一种小分子mek蛋白激酶抑制剂
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
US9663533B2 (en) 2012-11-14 2017-05-30 Glaxosmithkline Llc Thieno[3,2-C]pyridin-4(5H)-ones as BET inhibitors
HK1223364A1 (zh) 2013-06-28 2017-07-28 Abbvie Inc. 布罗莫结构域抑制剂
RU2770050C2 (ru) * 2015-03-04 2022-04-14 Ванда Фармасьютиклз Инк. Способ лечения с применением традипитанта
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
AU2017251537B2 (en) 2016-04-15 2020-10-08 Abbvie Inc. Bromodomain inhibitors
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
CA3073998A1 (en) 2017-09-13 2019-03-21 Vanda Pharmaceuticals Inc. Improved treatment of atopic dermatitis with tradipitant
EP4327779A3 (en) 2019-04-26 2024-05-08 AMO Ireland System and method
KR20220145844A (ko) 2020-02-25 2022-10-31 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피탄트를 이용한 아토피 피부염의 개선된 치료
WO2021195205A1 (en) 2020-03-26 2021-09-30 Vanda Pharmaceuticals Inc. Treatment of lower respiratory tract infection with tradipitant
WO2021233800A1 (en) 2020-05-20 2021-11-25 Merck Patent Gmbh Azacoumarin and azathiocoumarin derivatives for use in optically active devices
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
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US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
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SU698532A3 (ru) * 1975-11-27 1979-11-15 Хиноин-Дьедьсер Еш Ведьесети Термекек Дьяра, Рт (Инопредприятие) Способ получени производных пиридо (1,2-а) пиримидина
SU1395143A3 (ru) * 1984-08-25 1988-05-07 Гедеке Аг,Западный Берлин (Фирма) Способ получени производных 1,6-нафтиридина в виде рацематов или энантиомеров,или их кислотно-аддитивных солей
EP0429366A1 (fr) * 1989-11-23 1991-05-29 Rhone-Poulenc Sante Nouveaux dérivés de l'isoindolone, leur préparation et les compositions pharmaceutiques qui les contiennent
EP0436334A2 (en) * 1990-01-04 1991-07-10 Pfizer Inc. 3-Aminopiperidine derivatives and related nitrogen containing heterocycles

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SU698532A3 (ru) * 1975-11-27 1979-11-15 Хиноин-Дьедьсер Еш Ведьесети Термекек Дьяра, Рт (Инопредприятие) Способ получени производных пиридо (1,2-а) пиримидина
SU1395143A3 (ru) * 1984-08-25 1988-05-07 Гедеке Аг,Западный Берлин (Фирма) Способ получени производных 1,6-нафтиридина в виде рацематов или энантиомеров,или их кислотно-аддитивных солей
EP0429366A1 (fr) * 1989-11-23 1991-05-29 Rhone-Poulenc Sante Nouveaux dérivés de l'isoindolone, leur préparation et les compositions pharmaceutiques qui les contiennent
EP0436334A2 (en) * 1990-01-04 1991-07-10 Pfizer Inc. 3-Aminopiperidine derivatives and related nitrogen containing heterocycles
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
RU2379305C2 (ru) * 2005-09-01 2010-01-20 Мицубиси Танабе Фарма Корпорейшн Соединение тиоморфолина и способ его получения
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида

Also Published As

Publication number Publication date
AU7773894A (en) 1995-05-18
BR9404403A (pt) 1995-07-18
HU9403230D0 (en) 1995-01-30
KR950014108A (ko) 1995-06-15
FI945281A0 (fi) 1994-11-09
FI945281A7 (fi) 1995-05-11
ATE203024T1 (de) 2001-07-15
IL111590A0 (en) 1995-01-24
EP0652218B1 (en) 2001-07-11
HUT68810A (en) 1995-05-19
DE69427675T2 (de) 2002-05-16
CN1107476A (zh) 1995-08-30
DE69427675D1 (de) 2001-08-16
RU94040174A (ru) 1996-10-10
NO944252D0 (no) 1994-11-08
CN1052004C (zh) 2000-05-03
NO301764B1 (no) 1997-12-08
EP0652218A1 (en) 1995-05-10
AU678295B2 (en) 1997-05-22
CA2135440A1 (en) 1995-05-11
NO944252L (no) 1995-05-11
US5585385A (en) 1996-12-17
FI945281L (fi) 1995-05-11
NZ264887A (en) 1996-12-20
TW263498B (enExample) 1995-11-21

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