RU2135471C1 - Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам - Google Patents

Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам Download PDF

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RU2135471C1
RU2135471C1 RU94040174A RU94040174A RU2135471C1 RU 2135471 C1 RU2135471 C1 RU 2135471C1 RU 94040174 A RU94040174 A RU 94040174A RU 94040174 A RU94040174 A RU 94040174A RU 2135471 C1 RU2135471 C1 RU 2135471C1
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RU94040174A
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RU94040174A (ru
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Нацугари Хидеаки
Исхимару Такенори
Дои Такаюки
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Такеда Кемикал Индастриз, Лтд
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU94040174A 1993-11-10 1994-11-09 Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам RU2135471C1 (ru)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP28117893 1993-11-10
JP281178-1993 1993-11-10
JP337488-1993 1993-12-28
JP33748893 1993-12-28
JP3363794 1994-03-03
JP033637-1994 1994-03-03
JP13855194 1994-06-21
JP138551-1994 1994-06-21

Publications (2)

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RU94040174A RU94040174A (ru) 1996-10-10
RU2135471C1 true RU2135471C1 (ru) 1999-08-27

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RU94040174A RU2135471C1 (ru) 1993-11-10 1994-11-09 Гетероциклические соединения, способ их получения, композиция на их основе и способ противодействия тахикининовым рецепторам

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US (1) US5585385A (enExample)
EP (1) EP0652218B1 (enExample)
KR (1) KR950014108A (enExample)
CN (1) CN1052004C (enExample)
AT (1) ATE203024T1 (enExample)
AU (1) AU678295B2 (enExample)
BR (1) BR9404403A (enExample)
CA (1) CA2135440A1 (enExample)
DE (1) DE69427675T2 (enExample)
FI (1) FI945281A7 (enExample)
HU (1) HUT68810A (enExample)
IL (1) IL111590A0 (enExample)
NO (1) NO301764B1 (enExample)
NZ (1) NZ264887A (enExample)
RU (1) RU2135471C1 (enExample)
TW (1) TW263498B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2379305C2 (ru) * 2005-09-01 2010-01-20 Мицубиси Танабе Фарма Корпорейшн Соединение тиоморфолина и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW394773B (en) * 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
US5770590A (en) * 1995-03-24 1998-06-23 Takeda Chemical Industries, Ltd. Cyclic compounds, their prudiction and use
FR2732221B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue
GB9524104D0 (en) 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
CA2301614A1 (en) * 1997-09-23 1999-04-01 Merck & Co., Inc. Thrombin inhibitors
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
US6727258B2 (en) * 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
WO2000012503A1 (en) * 1998-08-26 2000-03-09 Tanabe Seiyaku Co., Ltd. Naphthyridine derivatives and process for the preparation thereof
AU6228499A (en) * 1998-10-22 2000-05-08 Akzo Nobel N.V. Tetrahydropyridopyridine derivatives and intermediates for producing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
CA2374654A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Thrombin inhibitors
US20040152727A1 (en) * 2001-05-18 2004-08-05 Hay Douglas William Pierre Novel use
JPWO2003050123A1 (ja) 2001-12-10 2005-04-21 杏林製薬株式会社 タキキニン受容体拮抗剤としての縮合二環式ピリジン誘導体
MXPA04006571A (es) * 2002-01-18 2004-10-04 Kyorin Seiyaku Kk Derivado de pirimidina biciclica fusionada.
US7402595B2 (en) * 2002-02-13 2008-07-22 Takeda Pharmaceutical Company Limited JNK inhibitor
US7323460B2 (en) 2002-03-15 2008-01-29 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
EP1489083B1 (en) 2002-03-26 2007-06-06 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyridine derivative as tachykinin receptor antagonist
WO2004055004A1 (en) 2002-12-13 2004-07-01 Neurogen Corporation Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
CN1856470A (zh) * 2003-09-23 2006-11-01 默克公司 喹啉钾通道抑制剂
WO2005030727A1 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Isoquinolinone potassium channel inhibitors
CA2552965A1 (en) * 2004-01-14 2005-07-28 Takeda Pharmaceutical Company Limited Carboxamide derivative and use thereof
KR100781704B1 (ko) * 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
EP2681200A4 (en) * 2011-03-03 2015-05-27 Zalicus Pharmaceuticals Ltd INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL
CN102358730A (zh) * 2011-08-24 2012-02-22 济南赛文医药技术有限公司 一种小分子mek蛋白激酶抑制剂
WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
EP2920183B1 (en) 2012-11-14 2017-03-08 Glaxosmithkline LLC Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors
SG11201510678TA (en) * 2013-06-28 2016-01-28 Abbvie Inc Bromodomain inhibitors
KR102860817B1 (ko) 2015-03-04 2025-09-16 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피턴트에 의한 치료 방법
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
WO2017177955A1 (en) 2016-04-15 2017-10-19 Abbvie Inc. Bromodomain inhibitors
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
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WO2021233800A1 (en) 2020-05-20 2021-11-25 Merck Patent Gmbh Azacoumarin and azathiocoumarin derivatives for use in optically active devices
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US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
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US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
WO2022182839A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
JP2025509672A (ja) 2022-03-17 2025-04-11 インサイト・コーポレイション Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU698532A3 (ru) * 1975-11-27 1979-11-15 Хиноин-Дьедьсер Еш Ведьесети Термекек Дьяра, Рт (Инопредприятие) Способ получени производных пиридо (1,2-а) пиримидина
SU1395143A3 (ru) * 1984-08-25 1988-05-07 Гедеке Аг,Западный Берлин (Фирма) Способ получени производных 1,6-нафтиридина в виде рацематов или энантиомеров,или их кислотно-аддитивных солей
EP0429366A1 (fr) * 1989-11-23 1991-05-29 Rhone-Poulenc Sante Nouveaux dérivés de l'isoindolone, leur préparation et les compositions pharmaceutiques qui les contiennent
EP0436334A2 (en) * 1990-01-04 1991-07-10 Pfizer Inc. 3-Aminopiperidine derivatives and related nitrogen containing heterocycles

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
TW205037B (enExample) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
DE69106499T2 (de) * 1990-02-10 1995-06-29 Takeda Chemical Industries, Ltd., Osaka Chromenderivate, deren herstellung und verwendung.
US5143919A (en) * 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
DE69110828T2 (de) * 1990-10-16 1995-11-30 Takeda Chemical Industries Ltd Heterozyklische Aminderivate, deren Herstellung und deren Verwendung.
TW241258B (enExample) * 1992-04-15 1995-02-21 Takeda Pharm Industry Co Ltd
DE4215588A1 (de) * 1992-05-12 1993-11-18 Bayer Ag Biphenylmethyl-substituierte Pyridone
DE4215587A1 (de) * 1992-05-12 1993-11-18 Bayer Ag Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone
NO179904C (no) * 1992-09-04 1997-01-08 Takeda Chemical Industries Ltd Kondenserte heterocykliske forbindelser og deres anvendelse
JPH06298757A (ja) * 1993-04-15 1994-10-25 Kissei Pharmaceut Co Ltd ピペリジノ−３，４−ジヒドロカルボスチリル誘導体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU698532A3 (ru) * 1975-11-27 1979-11-15 Хиноин-Дьедьсер Еш Ведьесети Термекек Дьяра, Рт (Инопредприятие) Способ получени производных пиридо (1,2-а) пиримидина
SU1395143A3 (ru) * 1984-08-25 1988-05-07 Гедеке Аг,Западный Берлин (Фирма) Способ получени производных 1,6-нафтиридина в виде рацематов или энантиомеров,или их кислотно-аддитивных солей
EP0429366A1 (fr) * 1989-11-23 1991-05-29 Rhone-Poulenc Sante Nouveaux dérivés de l'isoindolone, leur préparation et les compositions pharmaceutiques qui les contiennent
EP0436334A2 (en) * 1990-01-04 1991-07-10 Pfizer Inc. 3-Aminopiperidine derivatives and related nitrogen containing heterocycles
WO1991009844A1 (en) * 1990-01-04 1991-07-11 Pfizer Inc. Substance p antagonists

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
RU2379305C2 (ru) * 2005-09-01 2010-01-20 Мицубиси Танабе Фарма Корпорейшн Соединение тиоморфолина и способ его получения
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида

Also Published As

Publication number Publication date
CN1052004C (zh) 2000-05-03
KR950014108A (ko) 1995-06-15
TW263498B (enExample) 1995-11-21
AU678295B2 (en) 1997-05-22
ATE203024T1 (de) 2001-07-15
NO944252D0 (no) 1994-11-08
NO301764B1 (no) 1997-12-08
DE69427675D1 (de) 2001-08-16
FI945281A0 (fi) 1994-11-09
NO944252L (no) 1995-05-11
EP0652218A1 (en) 1995-05-10
RU94040174A (ru) 1996-10-10
IL111590A0 (en) 1995-01-24
CA2135440A1 (en) 1995-05-11
DE69427675T2 (de) 2002-05-16
HU9403230D0 (en) 1995-01-30
FI945281L (fi) 1995-05-11
EP0652218B1 (en) 2001-07-11
CN1107476A (zh) 1995-08-30
NZ264887A (en) 1996-12-20
AU7773894A (en) 1995-05-18
FI945281A7 (fi) 1995-05-11
HUT68810A (en) 1995-05-19
BR9404403A (pt) 1995-07-18
US5585385A (en) 1996-12-17

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