CN1052004C - 杂环化合物及其制备和应用 - Google Patents

杂环化合物及其制备和应用 Download PDF

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Publication number
CN1052004C
CN1052004C CN94113866A CN94113866A CN1052004C CN 1052004 C CN1052004 C CN 1052004C CN 94113866 A CN94113866 A CN 94113866A CN 94113866 A CN94113866 A CN 94113866A CN 1052004 C CN1052004 C CN 1052004C
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CN
China
Prior art keywords
ring
compound
alkyl
methyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94113866A
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English (en)
Chinese (zh)
Other versions
CN1107476A (zh
Inventor
夏苅英昭
石丸武范
土居孝行
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
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Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1107476A publication Critical patent/CN1107476A/zh
Application granted granted Critical
Publication of CN1052004C publication Critical patent/CN1052004C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN94113866A 1993-11-10 1994-11-10 杂环化合物及其制备和应用 Expired - Fee Related CN1052004C (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP281178/1993 1993-11-10
JP281178/93 1993-11-10
JP28117893 1993-11-10
JP33748893 1993-12-28
JP337488/1993 1993-12-28
JP337488/93 1993-12-28
JP033637/94 1994-03-03
JP033637/1994 1994-03-03
JP3363794 1994-03-03
JP138551/94 1994-06-21
JP13855194 1994-06-21
JP138551/1994 1994-06-21

Publications (2)

Publication Number Publication Date
CN1107476A CN1107476A (zh) 1995-08-30
CN1052004C true CN1052004C (zh) 2000-05-03

Family

ID=27459814

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94113866A Expired - Fee Related CN1052004C (zh) 1993-11-10 1994-11-10 杂环化合物及其制备和应用

Country Status (16)

Country Link
US (1) US5585385A (enExample)
EP (1) EP0652218B1 (enExample)
KR (1) KR950014108A (enExample)
CN (1) CN1052004C (enExample)
AT (1) ATE203024T1 (enExample)
AU (1) AU678295B2 (enExample)
BR (1) BR9404403A (enExample)
CA (1) CA2135440A1 (enExample)
DE (1) DE69427675T2 (enExample)
FI (1) FI945281L (enExample)
HU (1) HUT68810A (enExample)
IL (1) IL111590A0 (enExample)
NO (1) NO301764B1 (enExample)
NZ (1) NZ264887A (enExample)
RU (1) RU2135471C1 (enExample)
TW (1) TW263498B (enExample)

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FR2732221B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue
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JP2001517623A (ja) * 1997-09-23 2001-10-09 メルク エンド カムパニー インコーポレーテッド トロンビン阻害薬
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
AU5305299A (en) * 1998-08-26 2000-03-21 Tanabe Seiyaku Co., Ltd. Naphthyridine derivatives and process for the preparation thereof
WO2000023443A1 (en) * 1998-10-22 2000-04-27 Akzo Nobel N.V. Tetrahydropyridopyridine derivatives and intermediates for producing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
JP2003501389A (ja) 1999-06-04 2003-01-14 メルク エンド カムパニー インコーポレーテッド トロンビン阻害物質
US20040152727A1 (en) * 2001-05-18 2004-08-05 Hay Douglas William Pierre Novel use
US7030107B2 (en) 2001-12-10 2006-04-18 Kyorin Pharmaceutical.Co., Ltd. Fused bicyclic pyridine derivatives as tachykinin receptor antagonists
DE60326933D1 (de) * 2002-01-18 2009-05-14 Kyorin Seiyaku Kk Kondensierte bicyclische pyrimidinderivate
US7402595B2 (en) * 2002-02-13 2008-07-22 Takeda Pharmaceutical Company Limited JNK inhibitor
CA2478310A1 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors
WO2003080626A1 (en) * 2002-03-26 2003-10-02 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyridine derivative as tachykinin receptor antagonist
JP2006515846A (ja) * 2002-12-13 2006-06-08 ニューロジェン・コーポレーション カプサイシン受容体モジュレーターとしての２−置換キナゾリン−４−イルアミン類似体
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
CN1856470A (zh) * 2003-09-23 2006-11-01 默克公司 喹啉钾通道抑制剂
CA2539541C (en) 2003-09-23 2010-06-29 Merck & Co., Inc. Isoquinolinone potassium channel inhibitors
US20090186874A1 (en) * 2004-01-14 2009-07-23 Yoshinori Ikeura Carboxamide derivative and use thereof
KR100781704B1 (ko) * 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR056048A1 (es) * 2005-09-01 2007-09-12 Tanabe Seiyaku Co Compuesto tiomorfolina y procedimiento para preparar el mismo
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида
EP3009427B1 (en) * 2011-03-03 2019-12-18 Zalicus Pharmaceuticals Ltd. Benzimidazole inhibitors of the sodium channel
CN102358730A (zh) * 2011-08-24 2012-02-22 济南赛文医药技术有限公司 一种小分子mek蛋白激酶抑制剂
WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
ES2625945T3 (es) 2012-11-14 2017-07-21 Glaxosmithkline Llc Tieno[3,2-c]piridin-4(5H)-onas como inhibidores de bet
HK1223364A1 (zh) 2013-06-28 2017-07-28 Abbvie Inc. 布罗莫结构域抑制剂
PT3265087T (pt) * 2015-03-04 2020-10-15 Vanda Pharmaceuticals Inc Método de tratamento com tradipitant
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
KR102250415B1 (ko) 2016-04-15 2021-05-11 애브비 인코포레이티드 브로모도메인 저해제
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
CA3073998A1 (en) 2017-09-13 2019-03-21 Vanda Pharmaceuticals Inc. Improved treatment of atopic dermatitis with tradipitant
BR112022023523A2 (pt) 2020-05-20 2023-01-17 AMO Ireland Derivados de azacumarina e azatiocumarina para uso em dispositivos opticamente ativos
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
ES3035284T3 (en) 2020-07-02 2025-09-01 Incyte Corp Tricyclic urea compounds as jak2 v617f inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
WO2022182839A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
CR20240447A (es) 2022-03-17 2025-01-29 Incyte Corp Compuestos de urea tricíclica como inhibidores de v617f de jak2.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472116A1 (en) * 1990-08-17 1992-02-26 Takeda Chemical Industries, Ltd. Thienopyridine Derivatives, their production and use
EP0481383A1 (en) * 1990-10-16 1992-04-22 Takeda Chemical Industries, Ltd. Heterocyclic amine derivatives, their production and use
EP0566069A1 (en) * 1992-04-15 1993-10-20 Takeda Chemical Industries, Ltd. Tachykinin receptor antagonists, isoquinolones and their production

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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472116A1 (en) * 1990-08-17 1992-02-26 Takeda Chemical Industries, Ltd. Thienopyridine Derivatives, their production and use
EP0481383A1 (en) * 1990-10-16 1992-04-22 Takeda Chemical Industries, Ltd. Heterocyclic amine derivatives, their production and use
EP0566069A1 (en) * 1992-04-15 1993-10-20 Takeda Chemical Industries, Ltd. Tachykinin receptor antagonists, isoquinolones and their production

Also Published As

Publication number Publication date
DE69427675T2 (de) 2002-05-16
EP0652218B1 (en) 2001-07-11
US5585385A (en) 1996-12-17
EP0652218A1 (en) 1995-05-10
AU678295B2 (en) 1997-05-22
CA2135440A1 (en) 1995-05-11
FI945281A7 (fi) 1995-05-11
NO944252D0 (no) 1994-11-08
DE69427675D1 (de) 2001-08-16
CN1107476A (zh) 1995-08-30
IL111590A0 (en) 1995-01-24
NZ264887A (en) 1996-12-20
FI945281A0 (fi) 1994-11-09
KR950014108A (ko) 1995-06-15
RU2135471C1 (ru) 1999-08-27
BR9404403A (pt) 1995-07-18
FI945281L (fi) 1995-05-11
TW263498B (enExample) 1995-11-21
NO301764B1 (no) 1997-12-08
ATE203024T1 (de) 2001-07-15
HUT68810A (en) 1995-05-19
AU7773894A (en) 1995-05-18
RU94040174A (ru) 1996-10-10
HU9403230D0 (en) 1995-01-30
NO944252L (no) 1995-05-11

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