RU2116300C1 - Производные имидазола или их физиологически совместимые соли, способ их получения, средство для снижения высокого давления крови и фармацевтическая композиция для снижения кровяного давления - Google Patents

Производные имидазола или их физиологически совместимые соли, способ их получения, средство для снижения высокого давления крови и фармацевтическая композиция для снижения кровяного давления Download PDF

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Publication number
RU2116300C1
RU2116300C1 RU93004577A RU93004577A RU2116300C1 RU 2116300 C1 RU2116300 C1 RU 2116300C1 RU 93004577 A RU93004577 A RU 93004577A RU 93004577 A RU93004577 A RU 93004577A RU 2116300 C1 RU2116300 C1 RU 2116300C1
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Russia
Prior art keywords
general formula
compound
alkyl
mmol
imidazole
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RU93004577A
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English (en)
Russian (ru)
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RU93004577A (ru
Inventor
Хайч Холгер
Хеннинг Раинер
Вагнер Адальберт
Герхардс Херманн
Бекер Райнхард
Шелькенс Бернвард
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Хехст АГ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU93004577A 1992-03-07 1993-03-05 Производные имидазола или их физиологически совместимые соли, способ их получения, средство для снижения высокого давления крови и фармацевтическая композиция для снижения кровяного давления RU2116300C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4207241 1992-03-07
DEP4207241.7 1992-03-07

Publications (2)

Publication Number Publication Date
RU93004577A RU93004577A (ru) 1996-02-27
RU2116300C1 true RU2116300C1 (ru) 1998-07-27

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ID=6453463

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RU93004577A RU2116300C1 (ru) 1992-03-07 1993-03-05 Производные имидазола или их физиологически совместимые соли, способ их получения, средство для снижения высокого давления крови и фармацевтическая композиция для снижения кровяного давления

Country Status (25)

Country Link
US (1) US5604251A (enExample)
EP (1) EP0560177B1 (enExample)
JP (1) JP3542813B2 (enExample)
KR (1) KR930019637A (enExample)
CN (1) CN1036341C (enExample)
AT (1) ATE230732T1 (enExample)
AU (1) AU663565B2 (enExample)
BR (1) BR9300761A (enExample)
CA (1) CA2091135A1 (enExample)
CZ (1) CZ281983B6 (enExample)
DE (1) DE59310323D1 (enExample)
DK (1) DK0560177T3 (enExample)
ES (1) ES2187501T3 (enExample)
FI (1) FI930970A7 (enExample)
HU (1) HUT64041A (enExample)
IL (1) IL104971A0 (enExample)
MA (1) MA22814A1 (enExample)
NO (1) NO303632B1 (enExample)
NZ (1) NZ247059A (enExample)
PH (1) PH31466A (enExample)
PL (1) PL173023B1 (enExample)
RU (1) RU2116300C1 (enExample)
SK (1) SK279109B6 (enExample)
TW (1) TW215434B (enExample)
ZA (1) ZA931585B (enExample)

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CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
FR2716883B1 (fr) * 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
BR9708151A (pt) 1996-02-20 1999-07-27 Bristol Myers Squibb Co Processo para a preparaç o de bifenil isoxazol sulfonamidas
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
DE69734832T2 (de) * 1996-12-13 2006-08-31 Zymogenetics, Inc., Seattle Zusammensetzungen und verfahren zum stimulieren von knochenwachstum
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
AU6187898A (en) * 1997-01-30 1998-08-25 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
AU748334B2 (en) 1997-10-16 2002-05-30 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with NF-AT3 function
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP1165472A4 (en) 1999-03-19 2002-11-20 Bristol Myers Squibb Co METHOD FOR PRODUCING BIPHENYL ISOXAZOLE
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
WO2004002226A1 (en) * 2002-06-28 2004-01-08 Baylor College Of Medicine Modulators of cdk9 as a therapeutic target in cardiac hypertrophy
EP1631268A2 (en) * 2003-05-21 2006-03-08 Board Of Regents The University Of Texas System Inhibition of protein kinase c-mu (pkd) as a treatment for cardiac hypertrophy and heart failure
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CN1984660B (zh) 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
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US20060030611A1 (en) * 2004-03-22 2006-02-09 Myogen, Inc. Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
CA2572179A1 (en) * 2004-06-23 2006-01-19 Myogen, Inc. Enoximone formulations and their use in the treatment of pde-iii mediated diseases
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US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
WO2007014029A2 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Yin yang 1 as a treatment for cardiac hypertrophy and heart failure
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ES2397439T3 (es) 2006-08-01 2013-03-07 Board Of Regents Of The University Of Texas System Identificación de un microARN que activa la expresión de la cadena pesada beta de la miosina
US8440636B2 (en) 2007-07-31 2013-05-14 The Board Of Regents, The University Of Texas System Micro-RNA family that modulates fibrosis and uses thereof
EP2265291B1 (en) 2008-03-17 2016-10-19 The Board of Regents of The University of Texas System Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration
US9539427B2 (en) 2010-11-08 2017-01-10 The Johns Hopkins University Methods for improving heart function
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SU1518949A1 (ru) * 1987-04-09 1995-04-30 Всесоюзный научно-исследовательский институт химии и технологии лекарственных средств Способ получения инъекционного раствора 5-этокси-2-этилтиобензимидазола

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Also Published As

Publication number Publication date
CZ381192A3 (en) 1993-12-15
NO930817L (no) 1993-09-08
DK0560177T3 (da) 2003-04-14
PH31466A (en) 1998-11-03
BR9300761A (pt) 1993-09-14
DE59310323D1 (de) 2003-02-13
KR930019637A (ko) 1993-10-18
SK381192A3 (en) 1998-06-03
NO930817D0 (no) 1993-03-05
ES2187501T3 (es) 2003-06-16
PL173023B1 (pl) 1998-01-30
CA2091135A1 (en) 1993-09-08
JP3542813B2 (ja) 2004-07-14
HUT64041A (en) 1993-11-29
AU663565B2 (en) 1995-10-12
SK279109B6 (sk) 1998-06-03
HU9300618D0 (en) 1993-05-28
ZA931585B (en) 1993-09-27
PL297955A1 (en) 1993-09-20
NZ247059A (en) 1995-03-28
AU3401193A (en) 1993-09-09
ATE230732T1 (de) 2003-01-15
FI930970A0 (fi) 1993-03-04
TW215434B (enExample) 1993-11-01
MA22814A1 (fr) 1993-10-01
US5604251A (en) 1997-02-18
CN1036341C (zh) 1997-11-05
EP0560177A1 (de) 1993-09-15
NO303632B1 (no) 1998-08-10
EP0560177B1 (de) 2003-01-08
FI930970A7 (fi) 1993-09-08
JPH069572A (ja) 1994-01-18
CZ281983B6 (cs) 1997-04-16
IL104971A0 (en) 1993-07-08
CN1076192A (zh) 1993-09-15

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