ATE230732T1 - Imidazol-derivate mit biphenylsulfonylharnstoff- oder biphenylsulfonylurethan-seitenkette, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Imidazol-derivate mit biphenylsulfonylharnstoff- oder biphenylsulfonylurethan-seitenkette, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
ATE230732T1
ATE230732T1 AT93103301T AT93103301T ATE230732T1 AT E230732 T1 ATE230732 T1 AT E230732T1 AT 93103301 T AT93103301 T AT 93103301T AT 93103301 T AT93103301 T AT 93103301T AT E230732 T1 ATE230732 T1 AT E230732T1
Authority
AT
Austria
Prior art keywords
biphenylsulfonylurethane
biphenylsulfonylurea
production
side chain
imidazole derivatives
Prior art date
Application number
AT93103301T
Other languages
German (de)
English (en)
Inventor
Holger Dr Heitsch
Rainer Dr Henning
Adalbert Dr Wagner
Hermann Dr Gerhards
Reinhard Dr Becker
Bernward Prof Dr Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of ATE230732T1 publication Critical patent/ATE230732T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93103301T 1992-03-07 1993-03-02 Imidazol-derivate mit biphenylsulfonylharnstoff- oder biphenylsulfonylurethan-seitenkette, verfahren zu ihrer herstellung und ihre verwendung ATE230732T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207241 1992-03-07

Publications (1)

Publication Number Publication Date
ATE230732T1 true ATE230732T1 (de) 2003-01-15

Family

ID=6453463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93103301T ATE230732T1 (de) 1992-03-07 1993-03-02 Imidazol-derivate mit biphenylsulfonylharnstoff- oder biphenylsulfonylurethan-seitenkette, verfahren zu ihrer herstellung und ihre verwendung

Country Status (25)

Country Link
US (1) US5604251A (enExample)
EP (1) EP0560177B1 (enExample)
JP (1) JP3542813B2 (enExample)
KR (1) KR930019637A (enExample)
CN (1) CN1036341C (enExample)
AT (1) ATE230732T1 (enExample)
AU (1) AU663565B2 (enExample)
BR (1) BR9300761A (enExample)
CA (1) CA2091135A1 (enExample)
CZ (1) CZ281983B6 (enExample)
DE (1) DE59310323D1 (enExample)
DK (1) DK0560177T3 (enExample)
ES (1) ES2187501T3 (enExample)
FI (1) FI930970A7 (enExample)
HU (1) HUT64041A (enExample)
IL (1) IL104971A0 (enExample)
MA (1) MA22814A1 (enExample)
NO (1) NO303632B1 (enExample)
NZ (1) NZ247059A (enExample)
PH (1) PH31466A (enExample)
PL (1) PL173023B1 (enExample)
RU (1) RU2116300C1 (enExample)
SK (1) SK279109B6 (enExample)
TW (1) TW215434B (enExample)
ZA (1) ZA931585B (enExample)

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US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
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JPH09124620A (ja) 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
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PL328571A1 (en) 1996-02-20 1999-02-01 Bristol Myers Squibb Co Methods of obtaining biphenylisoxazol sulphonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
JP4269015B2 (ja) * 1996-12-13 2009-05-27 オステオスクリーン アイピー， エルエルシー 骨の成長を刺激する組成物および方法
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
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AU748334B2 (en) 1997-10-16 2002-05-30 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with NF-AT3 function
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
HK1039778A1 (zh) 1999-03-19 2002-05-10 Bristol-Myers Squibb Company 制造联苯异恶唑基磺胺的方法
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
WO2004002226A1 (en) * 2002-06-28 2004-01-08 Baylor College Of Medicine Modulators of cdk9 as a therapeutic target in cardiac hypertrophy
MXPA05012619A (es) * 2003-05-21 2006-02-08 Univ Texas Inhibicion de la proteina cinasa c-mu como un tratamiento para la hipertrofia cardiaca y la falla cardiaca.
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
WO2005003100A2 (en) * 2003-07-03 2005-01-13 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
AU2004285961A1 (en) * 2003-11-03 2005-05-12 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
DE602004015321D1 (de) * 2003-11-03 2008-09-04 Myogen Inc 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen
JP2007514665A (ja) * 2003-12-12 2007-06-07 ミオゲン インコーポレイティッド エノキシモン製剤ならびに心肥大および心不全の治療へのそれらの使用方法
CA2560538A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
WO2005092332A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
CA2572179A1 (en) * 2004-06-23 2006-01-19 Myogen, Inc. Enoximone formulations and their use in the treatment of pde-iii mediated diseases
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
WO2007014033A2 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Inhibition of extracellular signal-regulated kinase 1/2 as a treatment for cardiac hypertrophy and heart failure
CA2634437A1 (en) * 2005-12-20 2007-07-05 Gilead Colorado, Inc. 4,7-dihydrothieno¬2,3-b|pyridine compounds and pharmaceutical compositions
BRPI0714794A2 (pt) 2006-08-01 2013-05-21 Univ Texas identificaÇço de um micro-rna que ativa a expressço da cadeia pesada de beta-miosina
ES2621161T3 (es) 2007-07-31 2017-07-03 The Board Of Regents Of The University Of Texas System Familia de micro-ARN que modula la fibrosis y usos de la misma
JP5653899B2 (ja) 2008-03-17 2015-01-14 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 神経筋シナプスの維持および再生に関与するマイクロｒｎａの同定
US9539427B2 (en) 2010-11-08 2017-01-10 The Johns Hopkins University Methods for improving heart function
GB2605148A (en) * 2021-03-23 2022-09-28 Vicore Pharma Ab New compounds

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Also Published As

Publication number Publication date
PL297955A1 (en) 1993-09-20
RU2116300C1 (ru) 1998-07-27
MA22814A1 (fr) 1993-10-01
JP3542813B2 (ja) 2004-07-14
ES2187501T3 (es) 2003-06-16
DK0560177T3 (da) 2003-04-14
PL173023B1 (pl) 1998-01-30
CA2091135A1 (en) 1993-09-08
AU663565B2 (en) 1995-10-12
CN1036341C (zh) 1997-11-05
FI930970A7 (fi) 1993-09-08
FI930970A0 (fi) 1993-03-04
PH31466A (en) 1998-11-03
CZ281983B6 (cs) 1997-04-16
EP0560177B1 (de) 2003-01-08
DE59310323D1 (de) 2003-02-13
CN1076192A (zh) 1993-09-15
HUT64041A (en) 1993-11-29
SK381192A3 (en) 1998-06-03
AU3401193A (en) 1993-09-09
JPH069572A (ja) 1994-01-18
TW215434B (enExample) 1993-11-01
ZA931585B (en) 1993-09-27
HU9300618D0 (en) 1993-05-28
IL104971A0 (en) 1993-07-08
BR9300761A (pt) 1993-09-14
NZ247059A (en) 1995-03-28
NO930817D0 (no) 1993-03-05
CZ381192A3 (en) 1993-12-15
US5604251A (en) 1997-02-18
EP0560177A1 (de) 1993-09-15
NO303632B1 (no) 1998-08-10
SK279109B6 (sk) 1998-06-03
NO930817L (no) 1993-09-08
KR930019637A (ko) 1993-10-18

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