NO303632B1 - Imidazolderivater med bifenylsulfonylurea- eller bifenylsulfonyluretan-sidekjeder samt preparat inneholdende et slikt derivat - Google Patents

Imidazolderivater med bifenylsulfonylurea- eller bifenylsulfonyluretan-sidekjeder samt preparat inneholdende et slikt derivat

Info

Publication number
NO303632B1
NO303632B1 NO930817A NO930817A NO303632B1 NO 303632 B1 NO303632 B1 NO 303632B1 NO 930817 A NO930817 A NO 930817A NO 930817 A NO930817 A NO 930817A NO 303632 B1 NO303632 B1 NO 303632B1
Authority
NO
Norway
Prior art keywords
biphenylsulfonylurethane
biphenylsulfonylurea
derivative
side chains
preparations containing
Prior art date
Application number
NO930817A
Other languages
English (en)
Norwegian (no)
Other versions
NO930817D0 (no
NO930817L (no
Inventor
Holger Heitsch
Rainer Henning
Adalbert Wagner
Hermann Gerhards
Reinhard Becker
Bernward Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO930817D0 publication Critical patent/NO930817D0/no
Publication of NO930817L publication Critical patent/NO930817L/no
Publication of NO303632B1 publication Critical patent/NO303632B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO930817A 1992-03-07 1993-03-05 Imidazolderivater med bifenylsulfonylurea- eller bifenylsulfonyluretan-sidekjeder samt preparat inneholdende et slikt derivat NO303632B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207241 1992-03-07

Publications (3)

Publication Number Publication Date
NO930817D0 NO930817D0 (no) 1993-03-05
NO930817L NO930817L (no) 1993-09-08
NO303632B1 true NO303632B1 (no) 1998-08-10

Family

ID=6453463

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930817A NO303632B1 (no) 1992-03-07 1993-03-05 Imidazolderivater med bifenylsulfonylurea- eller bifenylsulfonyluretan-sidekjeder samt preparat inneholdende et slikt derivat

Country Status (25)

Country Link
US (1) US5604251A (enExample)
EP (1) EP0560177B1 (enExample)
JP (1) JP3542813B2 (enExample)
KR (1) KR930019637A (enExample)
CN (1) CN1036341C (enExample)
AT (1) ATE230732T1 (enExample)
AU (1) AU663565B2 (enExample)
BR (1) BR9300761A (enExample)
CA (1) CA2091135A1 (enExample)
CZ (1) CZ281983B6 (enExample)
DE (1) DE59310323D1 (enExample)
DK (1) DK0560177T3 (enExample)
ES (1) ES2187501T3 (enExample)
FI (1) FI930970A7 (enExample)
HU (1) HUT64041A (enExample)
IL (1) IL104971A0 (enExample)
MA (1) MA22814A1 (enExample)
NO (1) NO303632B1 (enExample)
NZ (1) NZ247059A (enExample)
PH (1) PH31466A (enExample)
PL (1) PL173023B1 (enExample)
RU (1) RU2116300C1 (enExample)
SK (1) SK279109B6 (enExample)
TW (1) TW215434B (enExample)
ZA (1) ZA931585B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
HU219598B (hu) * 1992-12-17 2001-05-28 Sankyo Co. Ltd. Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
FR2716883B1 (fr) * 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
AU717230B2 (en) 1996-02-20 2000-03-23 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US6022887A (en) * 1996-12-13 2000-02-08 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
CA2306448A1 (en) 1997-10-16 1999-04-22 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with nf-at3 function
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CA2367916A1 (en) 1999-03-19 2000-09-28 Ambarish Singh Methods for the preparation of biphenyl isoxazole sulfonamides
AU2003280090A1 (en) * 2002-06-28 2004-01-19 Baylor College Of Medicine Modulators of cdk9 as a therapeutic target in cardiac hypertrophy
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
BRPI0410787A (pt) * 2003-05-21 2006-06-20 Univ Texas inibição da proteìna cinase c-mu (pkd) como um tratamento para hipertrofia cardìaca e insuficiência cardìaca
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CA2531327A1 (en) * 2003-07-03 2005-01-13 Myriad Genetics, Inc. Compounds and therapeutical use thereof
WO2005042487A1 (en) * 2003-11-03 2005-05-12 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
EP1685107B1 (en) * 2003-11-03 2008-09-10 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
US20060018970A1 (en) * 2003-12-12 2006-01-26 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
EP1737448A1 (en) * 2004-03-22 2007-01-03 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
JP2007530566A (ja) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド （ｒ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
US20060292213A1 (en) * 2004-06-23 2006-12-28 Myogen, Inc. Enoximone formulations and their use in the treatment of PDE-III mediated diseases
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
WO2007014029A2 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Yin yang 1 as a treatment for cardiac hypertrophy and heart failure
WO2007073555A1 (en) * 2005-12-20 2007-06-28 Gilead Colorado, Inc. Use of 4, 7-dihydrothieno [2, 3-b] pyridine compounds in the treatment of cardiovascular diseases
DK2056882T3 (da) 2006-08-01 2012-11-19 Univ Texas Identifikation af en mikro-rna, som aktiverer ekspression af en tung kæde med beta-myosin
DK2182969T3 (en) 2007-07-31 2017-02-27 Univ Texas Micro-RNA family that modulates fibrosis and its applications
WO2009117418A2 (en) 2008-03-17 2009-09-24 The Board Of Regents Of The University Of Texas System Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration
WO2012064743A2 (en) 2010-11-08 2012-05-18 The Johns Hopkins University Methods for improving heart function
GB2605148A (en) * 2021-03-23 2022-09-28 Vicore Pharma Ab New compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4355044A (en) * 1980-12-19 1982-10-19 Bernardo Heller D-Phenylalanine treatment
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
SU1518949A1 (ru) * 1987-04-09 1995-04-30 Всесоюзный научно-исследовательский институт химии и технологии лекарственных средств Способ получения инъекционного раствора 5-этокси-2-этилтиобензимидазола
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US5135197A (en) * 1990-08-30 1992-08-04 Qualtec Data Products, Inc. Equipment security method and apparatus
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
US5236928A (en) * 1991-03-19 1993-08-17 Merck & Co., Inc. Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists
CZ36294A3 (en) * 1991-08-19 1994-07-13 Du Pont Substituted imidazilonone derivatives and pharmaceutical preparations based thereon
DE4221009A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
HU219598B (hu) * 1992-12-17 2001-05-28 Sankyo Co. Ltd. Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
US5604251A (en) 1997-02-18
JPH069572A (ja) 1994-01-18
ATE230732T1 (de) 2003-01-15
PH31466A (en) 1998-11-03
AU663565B2 (en) 1995-10-12
HU9300618D0 (en) 1993-05-28
PL297955A1 (en) 1993-09-20
CN1076192A (zh) 1993-09-15
DE59310323D1 (de) 2003-02-13
CZ381192A3 (en) 1993-12-15
RU2116300C1 (ru) 1998-07-27
NO930817D0 (no) 1993-03-05
FI930970A0 (fi) 1993-03-04
NZ247059A (en) 1995-03-28
KR930019637A (ko) 1993-10-18
ZA931585B (en) 1993-09-27
NO930817L (no) 1993-09-08
JP3542813B2 (ja) 2004-07-14
PL173023B1 (pl) 1998-01-30
SK381192A3 (en) 1998-06-03
CA2091135A1 (en) 1993-09-08
DK0560177T3 (da) 2003-04-14
FI930970A7 (fi) 1993-09-08
SK279109B6 (sk) 1998-06-03
IL104971A0 (en) 1993-07-08
AU3401193A (en) 1993-09-09
CN1036341C (zh) 1997-11-05
EP0560177B1 (de) 2003-01-08
TW215434B (enExample) 1993-11-01
ES2187501T3 (es) 2003-06-16
BR9300761A (pt) 1993-09-14
EP0560177A1 (de) 1993-09-15
HUT64041A (en) 1993-11-29
MA22814A1 (fr) 1993-10-01
CZ281983B6 (cs) 1997-04-16

Similar Documents

Publication Publication Date Title
ZA931585B (en) Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use.
ATE247644T1 (de) Imidazo-annellierte iso- und heterocyclen, antagonisten als angiotensin ii
ATE183182T1 (de) S-triazinderivate als lichtschutzmittel
NO308300B1 (no) Heterosykliske forbindelser med tachykininreseptorantagonistaktivitet, og preparat inneholdende disse
DE69628804D1 (de) Substitutierte heterozyclische Derivate als CRF Antagonisten
FI943948L (fi) Heterosykliset hiilihappojohdannaiset
RU93004577A (ru) Производные имидазола с боковой цепью бифенилсульфонилмочевины
DE69628276D1 (de) Zubereitung von xanthinderivaten als feste dispersion
FI990418L (fi) Typpeä sisältävien heterosyklisten yhdisteiden fluorialkoksibentsyyliaminojohdannaiset
YU101791A (sh) Supstituisani ftalidi i heterociklični ftalidi
ES2176204T3 (es) Antidepresivos que contienen un derivado de xantina.
DE69734321D1 (de) Non-peptidische vasopressin via antagonisten
NO932607D0 (no) Piperidinderivater og anvendelse av disse
AU9011091A (en) Azole derivatives, process for their preparation, and their use
ES2161713T3 (es) Derivado de metotrexato.
DE69528983D1 (de) Indolalkaloide als antientzündliche wirkstoffe
AU2876292A (en) 2-((imidazol-2-yl)methyl)-isoindole derivatives as alpha-2-adrenoceptor antagonists
FI963568A0 (fi) Peptidijohdannaisia
DE59505429D1 (de) Alkyl-5-methylsulfonyl-benzoyl-guanidin-Derivate
MD287B1 (ro) Preparat pentru indicarea catalazei microbiene
ITMI921148A0 (it) Derivati imidazolidinonici come agenti nootropici