RU2079489C1 - Стабильные соли (+)-(1s,2r)-2[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]-карбонил]циклогексан-1-карбоновой кислоты, способ их получения и фармацевтическая композиция - Google Patents

Стабильные соли (+)-(1s,2r)-2[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]-карбонил]циклогексан-1-карбоновой кислоты, способ их получения и фармацевтическая композиция Download PDF

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RU2079489C1
RU2079489C1 RU9293052414A RU93052414A RU2079489C1 RU 2079489 C1 RU2079489 C1 RU 2079489C1 RU 9293052414 A RU9293052414 A RU 9293052414A RU 93052414 A RU93052414 A RU 93052414A RU 2079489 C1 RU2079489 C1 RU 2079489C1
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RU
Russia
Prior art keywords
oxoethyl
methylamino
cyclohexane
carbonyl
carboxylic acid
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RU9293052414A
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English (en)
Russian (ru)
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RU93052414A (ru
Inventor
Джорджи Раффаэло
Субисси Алессандро
Турбанти Луиджи
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Лаборатори Гвидотти С.П.А.
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Publication of RU93052414A publication Critical patent/RU93052414A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
RU9293052414A 1991-12-23 1992-12-12 Стабильные соли (+)-(1s,2r)-2[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]-карбонил]циклогексан-1-карбоновой кислоты, способ их получения и фармацевтическая композиция RU2079489C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITM191A003448 1991-12-23
ITMI913448A IT1252708B (it) 1991-12-23 1991-12-23 Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
PCT/EP1992/002903 WO1993013056A1 (en) 1991-12-23 1992-12-12 Stable salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
RU93052414A RU93052414A (ru) 1996-06-20
RU2079489C1 true RU2079489C1 (ru) 1997-05-20

Family

ID=11361409

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9293052414A RU2079489C1 (ru) 1991-12-23 1992-12-12 Стабильные соли (+)-(1s,2r)-2[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]-карбонил]циклогексан-1-карбоновой кислоты, способ их получения и фармацевтическая композиция

Country Status (26)

Country Link
EP (1) EP0575572A1 (pt)
JP (1) JPH06506002A (pt)
CN (1) CN1079474A (pt)
AU (1) AU657591B2 (pt)
BG (1) BG98050A (pt)
BR (1) BR9205652A (pt)
CA (1) CA2104372A1 (pt)
CZ (1) CZ379692A3 (pt)
EE (1) EE9400006A (pt)
FI (1) FI933685A (pt)
HR (1) HRP921454A2 (pt)
HU (1) HUT69287A (pt)
IT (1) IT1252708B (pt)
LV (1) LV10426B (pt)
MA (1) MA22749A1 (pt)
MX (1) MX9207543A (pt)
NZ (1) NZ245547A (pt)
PL (1) PL169086B1 (pt)
PT (1) PT101156A (pt)
RU (1) RU2079489C1 (pt)
SI (1) SI9200409A (pt)
SK (1) SK379692A3 (pt)
TN (1) TNSN92117A1 (pt)
WO (1) WO1993013056A1 (pt)
YU (1) YU110892A (pt)
ZA (1) ZA9210004B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264860B1 (it) * 1993-06-21 1996-10-17 Guidotti & C Spa Labor Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
FR2817241B1 (fr) 2000-11-30 2003-03-07 Cebal Tube aluminium avec embout secable
CN101516191A (zh) * 2006-09-28 2009-08-26 默克公司 Saha的胺碱盐和其多晶型物
MX2022005016A (es) * 2020-04-27 2022-05-16 Carter Hoffmann LLC Sistema de movimiento de puerta para gabinete.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1224627B (it) * 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Европейская заявка N 0337348, кл. C 07 C 83/10, 1989. *

Also Published As

Publication number Publication date
MX9207543A (es) 1993-08-01
FI933685A0 (fi) 1993-08-20
CZ379692A3 (en) 1993-09-15
LV10426A (lv) 1995-02-20
HUT69287A (en) 1995-09-28
NZ245547A (en) 1995-12-21
CA2104372A1 (en) 1993-06-24
AU657591B2 (en) 1995-03-16
MA22749A1 (fr) 1993-07-01
YU110892A (sh) 1996-01-08
WO1993013056A1 (en) 1993-07-08
ITMI913448A0 (it) 1991-12-23
PL169086B1 (pl) 1996-05-31
PT101156A (pt) 1994-06-30
ZA9210004B (en) 1993-12-13
CN1079474A (zh) 1993-12-15
SK379692A3 (en) 1995-04-12
TNSN92117A1 (fr) 1993-06-08
BR9205652A (pt) 1994-05-03
IT1252708B (it) 1995-06-26
EE9400006A (et) 1995-12-15
FI933685A (fi) 1993-08-20
HU9302389D0 (en) 1993-11-29
AU3087192A (en) 1993-07-28
LV10426B (en) 1995-08-20
PL297118A1 (en) 1993-09-06
BG98050A (bg) 1994-04-29
EP0575572A1 (en) 1993-12-29
ITMI913448A1 (it) 1993-06-23
JPH06506002A (ja) 1994-07-07
HRP921454A2 (en) 1995-02-28
SI9200409A (en) 1993-09-30

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